Neonatal hyperbilirubinemia is a common clinical condition in the first week of neonatal life. The common causes are haemolytic disease of the newborn (rhesus), ABO incompatibility, glucose-6-phosphate dehydrogenase deficiency, spherocytosis and infection. Any study was not conducted in Bangladesh to find out the correlation between neonatal hyperbilirubinemia and zinc level. So, the objective of this was to evaluate the correlation between the level of serum zinc and neonatal hyperbilirubinemia in Dhaka city of Bangladesh. This cross sectional study was done at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Total 594 numbers of sample were collected from neonatology department of BSMMU from January 2016 to April 2019 and samples were divided in two groups. Case group and control group consists 319 and 275 numbers of sample respectively. All the laboratory parameters were done at clinical pathology department of BSMMU by automated analyzer machine and strictly followed quality control. Data obtained were analyzed using the Statistical Package for the Social Science (SPSS) version 20. Results were considered statistically significant if p<0.05. The result showed that the level of serum bilirubin was 171.14 mg/L and 35.42 mg/L and the level of serum zinc was (0.50 mg/L) and (0.68mg/L) in case and control group respectively. The bilirubin level was significantly (p<0.001) high in case group and zinc level was significantly (p<0.001) decreased in case group when compared with control group. Is also showed there was a significant (p value<0.001) correlation between hyperbilirubinemia and serum zinc level in this study. Therefore, it can be concluded, the deficiency of zinc may have a relationship followed by in neonatal hyperbilirubinemia.
| Published in | American Journal of Laboratory Medicine (Volume 5, Issue 6) |
| DOI | 10.11648/j.ajlm.20200506.14 |
| Page(s) | 174-179 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Neonatal, Hyperbilirubinemia, Serum Zinc, Severe Neonatal Jaundice (NNJ)
| [1] | Medical Definition of Neonatal hyperbilirubinemia [Internet] 2019 June 4 [updated 2018 October 6; cited 2019 Nov 13]. Available from: https://www.medicinenet.com/script/main/art.asp?articlekey=16385 |
| [2] | Olusanya BO, Kaplan M, Hansen TWR. Neonatal hyperbilirubinaemia: a global perspective. Lancet Child Adolesc Health. 2018 Aug; 2 (8): 610-620. |
| [3] | Brits H, Adendorff J, Huisamen D, Beukes D, Botha K, Herbst H, Joubert G. The prevalence of neonatal jaundice and risk factors in healthy term neonates at National District Hospital in Bloemfontein. Afr J Prm Health Care Fam Med. 2018; 10 (1), a1582. |
| [4] | Abd El Moktader AM., Hussein SK., Boraik Mohamed GM. Hyperbilirubinemia in Neonatal Intensive Care Unit: Incidence and Etiology at Fayoum University Hospital. Fayoum University Medical Journal, 2019; 3 (2): 8-14. |
| [5] | El-Mazary AA, Abdel Aziz RA, Sayed MA, Mahmoud RA, Saidii AA. Effect of Intensive Phototherapy and Exchange Transfusion on Copper, Zinc and Magnesium Serum Levels in Neonates with Indirect Hyperbilirubinemia. Int J Pediatr 2017; 5 (2): 4371-83. |
| [6] | Ali SR, Abdel-aal M, Elsamanoudy M, Ibrahim S. Serum Zinc Level in Neonates with Indirect Hyperbilirubinemia. IJMA 2020; 2 (1): 217-222. |
| [7] | Ahmadpour-Kacho M, Zahed Pasha Y, Khafri S, Omidbakhsh-Amiri S, Tehrani S. Correlation between Prolonged Hyperbilirubinemia and Serum Zinc Level in Term Neonates. Iranian Journal of Neonatology. 2019 Dec: 10 (4). DOI: 10.22038/ijn.2019.37384.1578 |
| [8] | Olusanya BO, Teeple S, Kassebaum NJ. The Contribution of Neonatal Jaundice to Global Child Mortality: Findings from the GBD 2016 Study. Pediatrics. 2018; 141 (2): e20171471. |
| [9] | Zabeen B, Nahar J, Nabi N, Baki A, Tayyeb S, Azad K, Nahar N. Risk Factors and Outcome of Neonetal Jaundice in a Tertiary Hospital. Ibrahim Med. Coll. J. 2010; 4 (2): 70-73. |
| [10] | Siemens Healthcare Diagnostics Inc, Newark, DE 19714, U.S.A. Available at: www.siemens.com/diagnostics. |
| [11] | Johnsen O, Eliasson R. Evaluation of a commercially available kit for the colorimetric determination of zinc in human seminal plasma. Int J Androl, 1987; 10: 435-440. |
| [12] | Gregory MLP, Martin CR, Cloherty JP. Neonatal hyperbilirubinemia. In: Cloherty JP, Eichenwald EC and Stark AR (eds). Manual of Neonatal Care, 7th ed. Chapter 26, Lippincott- Raven Philadelphia 2012. 304-339. |
| [13] | Andree H. Koop, Omar Y. Mousa, Ly Elaine Pham, Juan E. Corral-Hurtado, Surakit Pungpapong, Andrew P. Keaveny. An Argument for Vitamin D, A, and Zinc Monitoring in Cirrhosis. Annals of Hepatology, 2018; 17 (6): 920-932. |
| [14] | Marreiro DD, Cruz KJ, Morais JB, Beserra JB, Severo JS, de Oliveira AR. Zinc and Oxidative Stress: Current Mechanisms. Antioxidants (Basel). 2017; 6 (2): 24. |
| [15] | Himoto T, Masaki T. Current Trends of Essential Trace Elements in Patients with Chronic Liver Diseases. Nutrients. 2020; 12 (7): 2084. |
| [16] | Kozeniecki M, Ludke R, Kerner J, Patterson B. Micronutrients in Liver Disease: Roles, Risk Factors for Deficiency, and Recommendations for Supplementation. Nutr Clin Pract. 2020 Feb; 35 (1): 50-62. |
| [17] | Méndez-Sánchez N, Martínez M, González V, Roldán-Valadez E, Flores MA, Uribe M. Zinc sulfate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert's syndrome. Ann Hepatol, 2002 Jan-Mar; 1 (1): 40-3. |
| [18] | Boskabadi H, Maamouri G, Mohsen Zadeh H, Shakeri M, Ghayour-Mobarhan M, et al. Comparison of Serum Zinc Level Between Neonates With Jaundice and Healthy Neonates, Shiraz E-Med J. 2015; 16: 11-12. |
APA Style
Mohammad Anwar Hossain, Mohammad Nazmul Huda, Mohammad Ekramul Islam, Ashik Mosaddik, Saiful Islam, et al. (2020). Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh. American Journal of Laboratory Medicine, 5(6), 174-179. https://doi.org/10.11648/j.ajlm.20200506.14
ACS Style
Mohammad Anwar Hossain; Mohammad Nazmul Huda; Mohammad Ekramul Islam; Ashik Mosaddik; Saiful Islam, et al. Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh. Am. J. Lab. Med. 2020, 5(6), 174-179. doi: 10.11648/j.ajlm.20200506.14
AMA Style
Mohammad Anwar Hossain, Mohammad Nazmul Huda, Mohammad Ekramul Islam, Ashik Mosaddik, Saiful Islam, et al. Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh. Am J Lab Med. 2020;5(6):174-179. doi: 10.11648/j.ajlm.20200506.14
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Download@article{10.11648/j.ajlm.20200506.14,
author = {Mohammad Anwar Hossain and Mohammad Nazmul Huda and Mohammad Ekramul Islam and Ashik Mosaddik and Saiful Islam and Quddusur Rahman and Firoza Begum and Sheikh Mizanur Rahman and Tarun Kanti Paul},
title = {Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh},
journal = {American Journal of Laboratory Medicine},
volume = {5},
number = {6},
pages = {174-179},
doi = {10.11648/j.ajlm.20200506.14},
url = {https://doi.org/10.11648/j.ajlm.20200506.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200506.14},
abstract = {Neonatal hyperbilirubinemia is a common clinical condition in the first week of neonatal life. The common causes are haemolytic disease of the newborn (rhesus), ABO incompatibility, glucose-6-phosphate dehydrogenase deficiency, spherocytosis and infection. Any study was not conducted in Bangladesh to find out the correlation between neonatal hyperbilirubinemia and zinc level. So, the objective of this was to evaluate the correlation between the level of serum zinc and neonatal hyperbilirubinemia in Dhaka city of Bangladesh. This cross sectional study was done at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Total 594 numbers of sample were collected from neonatology department of BSMMU from January 2016 to April 2019 and samples were divided in two groups. Case group and control group consists 319 and 275 numbers of sample respectively. All the laboratory parameters were done at clinical pathology department of BSMMU by automated analyzer machine and strictly followed quality control. Data obtained were analyzed using the Statistical Package for the Social Science (SPSS) version 20. Results were considered statistically significant if p<0.05. The result showed that the level of serum bilirubin was 171.14 mg/L and 35.42 mg/L and the level of serum zinc was (0.50 mg/L) and (0.68mg/L) in case and control group respectively. The bilirubin level was significantly (p<0.001) high in case group and zinc level was significantly (p<0.001) decreased in case group when compared with control group. Is also showed there was a significant (p value<0.001) correlation between hyperbilirubinemia and serum zinc level in this study. Therefore, it can be concluded, the deficiency of zinc may have a relationship followed by in neonatal hyperbilirubinemia.},
year = {2020}
}
TY - JOUR T1 - Association Between Neonatal Hyperbilirubinemia and Serum Zinc Levels in Dhaka City of Bangladesh AU - Mohammad Anwar Hossain AU - Mohammad Nazmul Huda AU - Mohammad Ekramul Islam AU - Ashik Mosaddik AU - Saiful Islam AU - Quddusur Rahman AU - Firoza Begum AU - Sheikh Mizanur Rahman AU - Tarun Kanti Paul Y1 - 2020/12/16 PY - 2020 N1 - https://doi.org/10.11648/j.ajlm.20200506.14 DO - 10.11648/j.ajlm.20200506.14 T2 - American Journal of Laboratory Medicine JF - American Journal of Laboratory Medicine JO - American Journal of Laboratory Medicine SP - 174 EP - 179 PB - Science Publishing Group SN - 2575-386X UR - https://doi.org/10.11648/j.ajlm.20200506.14 AB - Neonatal hyperbilirubinemia is a common clinical condition in the first week of neonatal life. The common causes are haemolytic disease of the newborn (rhesus), ABO incompatibility, glucose-6-phosphate dehydrogenase deficiency, spherocytosis and infection. Any study was not conducted in Bangladesh to find out the correlation between neonatal hyperbilirubinemia and zinc level. So, the objective of this was to evaluate the correlation between the level of serum zinc and neonatal hyperbilirubinemia in Dhaka city of Bangladesh. This cross sectional study was done at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Total 594 numbers of sample were collected from neonatology department of BSMMU from January 2016 to April 2019 and samples were divided in two groups. Case group and control group consists 319 and 275 numbers of sample respectively. All the laboratory parameters were done at clinical pathology department of BSMMU by automated analyzer machine and strictly followed quality control. Data obtained were analyzed using the Statistical Package for the Social Science (SPSS) version 20. Results were considered statistically significant if p<0.05. The result showed that the level of serum bilirubin was 171.14 mg/L and 35.42 mg/L and the level of serum zinc was (0.50 mg/L) and (0.68mg/L) in case and control group respectively. The bilirubin level was significantly (p<0.001) high in case group and zinc level was significantly (p<0.001) decreased in case group when compared with control group. Is also showed there was a significant (p value<0.001) correlation between hyperbilirubinemia and serum zinc level in this study. Therefore, it can be concluded, the deficiency of zinc may have a relationship followed by in neonatal hyperbilirubinemia. VL - 5 IS - 6 ER -
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