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Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat

Received: 13 September 2021     Accepted: 4 October 2021     Published: 19 October 2021
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Abstract

Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)
DOI 10.11648/j.ajbls.20210905.15
Page(s) 254-258
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Growth, Delay, Ethiologies, Stature-Weight, Children

References
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[2] Sempe M, Heanggeli CA, Sizonenko PC. (1996). Croissance et développement de l’enfant et de l’adolescent in : Sizonenki PC, Criscelli C précis de pédiatrie. Edition Payot Lausanne Paris : 67-69.
[3] Alan D Rogol, Gregory F Hayden. (2014). Etiologies and early diagnosis of short stature and growth failure in children and adolescents. J. Pediatr. 164 (5 Suppl): S1-14.
[4] Craig Barstow, Caitlyn Rerucha. (2015). Evaluation of Short and Tall Stature in Children. Am Fam Physician, 1; 92 (1): 43-50.
[5] Heshmat Moayeri and Yahya Aghighi. (2004) A prospective study of etiology of short stature in 426 short children and adolescents in Archives of iranian medicine, 7 (1): 23-27.
[6] Strufaldi MW, Silva EM, Puccini RF. (2005). Follow-up of children and adolescents with short stature: The importance of the growth rate. Sao Paulo Med J.; 123: 128–33.
[7] Papadimitriou A, Douros K, Papadimitriou DT, Kleanthous K, Karapanou O, Fretzayas A. (2012). Characteristics of the short Children referred to an academic pediatric endocrine clinic in Greece. J Paediatr Child Health, 48: 263-7.
[8] Ahmid M Perry CG, Ahmed SF, Shaikh MG. (2016). Growth hormone deficiency during young adulthood and the benefits of growth hormone replacement. Endocr Connect, 5: R1-11.
[9] Mazouzi H, Elguendaoui S, Chadli A, Elghomari H, Farouqi A. (2006). Les étiologies du retard de croissance expérience du service d’endocrinologie et maladie métabolique du CHU Ibn Rochd de Casablanca. Annales d’Endocrinologie, 67: 440.
[10] Salhi H , Lahlou A, Dante ML , El OuahabiH , Boujraf S , Ajdi F. (2018). Stature–weight growth delays: Clinical and etiological aspects. Journal of Family Medicine and Primary Care Volume 7: Issue 5: 963-966.
[11] Yassine Iman. (2012). Doctor of Medicine thesis: growth hormone deficiency in children (about 32cases).
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[13] M de Onis, C Garza, A W Onyango, M-F Rolland-Cachera. (2009). [WHO growth standards for infants and young children]. Arch Pediatr, 16 (1): 47-53.
[14] Barros FC, Victora CG, Scherpbier RW, Gwatkin D. (2010). Health and nutrition of children: equity and social determinants. In: Blas E, Kurup AS, editors. Equity, Social Determinants and Public Health Programmes Geneva: World Health Organisation.49-75. (http://Whqlibdoc.who.int/publications/2010/97824156397 0_eng.pdf.
[15] Synthesis of guiding principles on agriculture programming for nutrition. (2013). Final Draft. Rome: Food and Agriculture organization; (http://www.fao.org/fileadmin/user_upload/wa_workshop/doc s/Synthesis_of_Ag-utr_Guidance_FAO_IssuePaper_Draft.pdf.
[16] UNICEF, Improving child nutrition: an imperative and achievable goal for global progress, New York, UNICEF, 2013. (http://www.unicef.org/french/publications/files/French_UNICEF- NutritionReport_low_res_30May2013.pdf.
[17] Anastasios Papadimitriou, Konstantinos Douros, Dimitrios Papadimitriou, Kleanthis Kleanthous, Olga Karapanou, Andreas Fretzayas. Characteristics of the short children referred to an academic pediatric endocrine clinic in Greece. J Paediatr Child Health. 2012; 48 (3): 263-7.
[18] Nora soumya Fedala. Ali El Mahdi Haddam b, Akila Zenati c, Farida Chentli a. (2009). Le déficit en hormone de croissance chez l’enfant : formes cliniques et biologiques Revue francophone des laboratoires, 411: 63-70.
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  • APA Style

    Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, et al. (2021). Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. American Journal of Biomedical and Life Sciences, 9(5), 254-258. https://doi.org/10.11648/j.ajbls.20210905.15

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    ACS Style

    Touzani Asmae; Tahri Joutei Abderrafie; Khaliss Hajar; Dami Abdellah; Balouch Lhousaine, et al. Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. Am. J. Biomed. Life Sci. 2021, 9(5), 254-258. doi: 10.11648/j.ajbls.20210905.15

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    AMA Style

    Touzani Asmae, Tahri Joutei Abderrafie, Khaliss Hajar, Dami Abdellah, Balouch Lhousaine, et al. Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat. Am J Biomed Life Sci. 2021;9(5):254-258. doi: 10.11648/j.ajbls.20210905.15

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  • @article{10.11648/j.ajbls.20210905.15,
      author = {Touzani Asmae and Tahri Joutei Abderrafie and Khaliss Hajar and Dami Abdellah and Balouch Lhousaine and Kriouile Yamna and Zineb Imane and Gaouzi Ahmed},
      title = {Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {9},
      number = {5},
      pages = {254-258},
      doi = {10.11648/j.ajbls.20210905.15},
      url = {https://doi.org/10.11648/j.ajbls.20210905.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.15},
      abstract = {Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Growth Delay in Children: Experience of the Department of Metabolic and Endocrine Diseases at the Children's Hospital of Rabat
    AU  - Touzani Asmae
    AU  - Tahri Joutei Abderrafie
    AU  - Khaliss Hajar
    AU  - Dami Abdellah
    AU  - Balouch Lhousaine
    AU  - Kriouile Yamna
    AU  - Zineb Imane
    AU  - Gaouzi Ahmed
    Y1  - 2021/10/19
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajbls.20210905.15
    DO  - 10.11648/j.ajbls.20210905.15
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 254
    EP  - 258
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20210905.15
    AB  - Objective: The aim of our study is to describe the epidemiological, clinical and biological aspects of staturo-ponderal delay and to deduce the main etiologies. Material and Methods: the study was carried out on 141 patients (78 boys and 63 girls). Patients ranged in age from 9 months to 17 years (mean: 9 years 1 month) with a statural delay that varied from -2DS to -5DS (mean: -2.5DS). Results: Analysis of the data showed a frequency of 13.5% of patients with severe growth retardation, 35% of whom had a growth hormone deficiency. The hormonal assessment showed a GH deficiency in 43% of patients with a greater difference in chronological age and bone age (2.5 years) than in non-deficient patients (2 years). Among them, 51% of patients have an elevated TSH. Magnetic resonance imaging performed in 37 cases was in favor of a pituitary anomaly in 12% of cases, including interruption of the pituitary stem (4% of cases), hypoplasia (3% of cases), an adenoma (1% of cases) and an empty sella turcica in 4% of cases. Conclusion: Severe central growth retardation is common. Systematic monitoring and follow-up of growth is essential in children, as is vaccination, in order to identify and manage early any causal pathology that may disrupt the child's growth.
    VL  - 9
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Author Information
  • Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco

  • Department of Biology, University Mohamed V Faculty of Sciences, Rabat, Morocco

  • Department of Biology, University Mohamed V Faculty of Sciences, Rabat, Morocco

  • Laboratory, Biochemistry and Molecular Biology, University Mohamed V, Faculty of Medicine and Pharmacy, Rabat, Morocco

  • Laboratory, Biochemistry and Molecular Biology, University Mohamed V, Faculty of Medicine and Pharmacy, Rabat, Morocco

  • Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco

  • Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco

  • Endocrinology-Diabetology-Neurology-II-CHIS-Children’s Hospital-Rabat, Faculty of Medicine and Pharmacy, University of Rabat, Rabat, Morocco

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