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Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad)

Received: 23 September 2021     Accepted: 13 October 2021     Published: 21 October 2021
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Abstract

Background and Objective: Artemisinin-based combination therapies are the first-line antimalarial drugs used to treat uncomplicated Plasmodium falciparum malaria in many endemic countries worldwide. This study was conducted to assess the efficacy and tolerability of two fixed-dose formulations of artesunate-amodiaquine and artemether-lumefantrine for the treatment of Plasmodium falciparum malaria in Chad. Méthodology and Results: A two-arm single cohort study was conducted assessing the efficacy artesunate-amodiaquine and artemether-lumefantrine for the treatment of children with uncomplicated falciparum malaria. This study was carried out from December 14, 2019 to March 14, 2020 at the Massakory I Health Center in Chad. Primary efficacy endpoint was day 28, parasitological cure rate. Secondary endpoints were parasite and fever clearance times and tolerability. A total of 113 patients were included, including 56 in the artesunate-amodiaquine arm and 57 in the artemether-lumefantrine arm. In intention to treat these patients, the Adequate Clinical and Parasitological Response on day 28 were 100% for the two groups. No early treatment failure was observed. The drugs were well tolerated and no serious adverse events were noted. Conclusion: Both forms of Artemisinin-based combination therapy were still effective and safe in the treatment of uncomplicated P. falciparum malaria in Chad. Further studies are warranted in different regions of Chad for monitoring of drug resistance.

Published in American Journal of Biomedical and Life Sciences (Volume 9, Issue 5)
DOI 10.11648/j.ajbls.20210905.16
Page(s) 259-266
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Simple Malaria, Artésunate-Amodiaquine, Artemether-Lumefantrine, Plasmodium falciparum, Massakory, Chad

References
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[22] Odhiambo G, Bergmann-Leitner E, Maraka M, Wanjala CNL, Duncan E, Waitumbi J, et al (2019) Correlation Between Malaria-Specific Antibody Profiles and Responses to Artemisinin Combination Therapy for Treatment of Uncomplicated Malaria in Western Kenya. J Infect Dis; 219 (12): 1969-79.
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Cite This Article
  • APA Style

    Mahamat Moussa Hassane Taïsso, Issa Mahamat Souleymane, Hamit Mahamat Alio, Mahamat Saleh Issakha Diar, Djiddi Ali Sougoudi, et al. (2021). Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad). American Journal of Biomedical and Life Sciences, 9(5), 259-266. https://doi.org/10.11648/j.ajbls.20210905.16

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    ACS Style

    Mahamat Moussa Hassane Taïsso; Issa Mahamat Souleymane; Hamit Mahamat Alio; Mahamat Saleh Issakha Diar; Djiddi Ali Sougoudi, et al. Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad). Am. J. Biomed. Life Sci. 2021, 9(5), 259-266. doi: 10.11648/j.ajbls.20210905.16

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    AMA Style

    Mahamat Moussa Hassane Taïsso, Issa Mahamat Souleymane, Hamit Mahamat Alio, Mahamat Saleh Issakha Diar, Djiddi Ali Sougoudi, et al. Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad). Am J Biomed Life Sci. 2021;9(5):259-266. doi: 10.11648/j.ajbls.20210905.16

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  • @article{10.11648/j.ajbls.20210905.16,
      author = {Mahamat Moussa Hassane Taïsso and Issa Mahamat Souleymane and Hamit Mahamat Alio and Mahamat Saleh Issakha Diar and Djiddi Ali Sougoudi and Djimadoum Mbanga and Pascal Ringwald and Djimrassengarh Honoré and Issa Ali Haggar and Hassoumi Manah and Hassan Ahmat Mihedi and N’garadoum Olivier and David Koffi and Offianan André Touré and Djaman Allico Joseph},
      title = {Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad)},
      journal = {American Journal of Biomedical and Life Sciences},
      volume = {9},
      number = {5},
      pages = {259-266},
      doi = {10.11648/j.ajbls.20210905.16},
      url = {https://doi.org/10.11648/j.ajbls.20210905.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210905.16},
      abstract = {Background and Objective: Artemisinin-based combination therapies are the first-line antimalarial drugs used to treat uncomplicated Plasmodium falciparum malaria in many endemic countries worldwide. This study was conducted to assess the efficacy and tolerability of two fixed-dose formulations of artesunate-amodiaquine and artemether-lumefantrine for the treatment of Plasmodium falciparum malaria in Chad. Méthodology and Results: A two-arm single cohort study was conducted assessing the efficacy artesunate-amodiaquine and artemether-lumefantrine for the treatment of children with uncomplicated falciparum malaria. This study was carried out from December 14, 2019 to March 14, 2020 at the Massakory I Health Center in Chad. Primary efficacy endpoint was day 28, parasitological cure rate. Secondary endpoints were parasite and fever clearance times and tolerability. A total of 113 patients were included, including 56 in the artesunate-amodiaquine arm and 57 in the artemether-lumefantrine arm. In intention to treat these patients, the Adequate Clinical and Parasitological Response on day 28 were 100% for the two groups. No early treatment failure was observed. The drugs were well tolerated and no serious adverse events were noted. Conclusion: Both forms of Artemisinin-based combination therapy were still effective and safe in the treatment of uncomplicated P. falciparum malaria in Chad. Further studies are warranted in different regions of Chad for monitoring of drug resistance.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Effectiveness and Tolerability of the ASAQ versus AL Association in Children 6-59 Months for the Treatment of Uncomplicated P. falciparum Malaria in Massakory (Chad)
    AU  - Mahamat Moussa Hassane Taïsso
    AU  - Issa Mahamat Souleymane
    AU  - Hamit Mahamat Alio
    AU  - Mahamat Saleh Issakha Diar
    AU  - Djiddi Ali Sougoudi
    AU  - Djimadoum Mbanga
    AU  - Pascal Ringwald
    AU  - Djimrassengarh Honoré
    AU  - Issa Ali Haggar
    AU  - Hassoumi Manah
    AU  - Hassan Ahmat Mihedi
    AU  - N’garadoum Olivier
    AU  - David Koffi
    AU  - Offianan André Touré
    AU  - Djaman Allico Joseph
    Y1  - 2021/10/21
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ajbls.20210905.16
    DO  - 10.11648/j.ajbls.20210905.16
    T2  - American Journal of Biomedical and Life Sciences
    JF  - American Journal of Biomedical and Life Sciences
    JO  - American Journal of Biomedical and Life Sciences
    SP  - 259
    EP  - 266
    PB  - Science Publishing Group
    SN  - 2330-880X
    UR  - https://doi.org/10.11648/j.ajbls.20210905.16
    AB  - Background and Objective: Artemisinin-based combination therapies are the first-line antimalarial drugs used to treat uncomplicated Plasmodium falciparum malaria in many endemic countries worldwide. This study was conducted to assess the efficacy and tolerability of two fixed-dose formulations of artesunate-amodiaquine and artemether-lumefantrine for the treatment of Plasmodium falciparum malaria in Chad. Méthodology and Results: A two-arm single cohort study was conducted assessing the efficacy artesunate-amodiaquine and artemether-lumefantrine for the treatment of children with uncomplicated falciparum malaria. This study was carried out from December 14, 2019 to March 14, 2020 at the Massakory I Health Center in Chad. Primary efficacy endpoint was day 28, parasitological cure rate. Secondary endpoints were parasite and fever clearance times and tolerability. A total of 113 patients were included, including 56 in the artesunate-amodiaquine arm and 57 in the artemether-lumefantrine arm. In intention to treat these patients, the Adequate Clinical and Parasitological Response on day 28 were 100% for the two groups. No early treatment failure was observed. The drugs were well tolerated and no serious adverse events were noted. Conclusion: Both forms of Artemisinin-based combination therapy were still effective and safe in the treatment of uncomplicated P. falciparum malaria in Chad. Further studies are warranted in different regions of Chad for monitoring of drug resistance.
    VL  - 9
    IS  - 5
    ER  - 

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Author Information
  • Chad National Malaria Control Program, N’Djamena, Chad

  • Faculty of Science and Human Health, University of N’Djamena, N’Djamena, Chad

  • Chad National Malaria Control Program, N’Djamena, Chad

  • Ministry of Health, Public and Human Solidarity, N’Djamena, Chad

  • Faculty of Science and Human Health, University of N’Djamena, N’Djamena, Chad

  • World Health Organization, Geneva, Switzerland

  • World Health Organization, N’Djamena, Chad

  • Ministry of Health, Public and Human Solidarity, N’Djamena, Chad

  • Ministry of Health, Public and Human Solidarity, N’Djamena, Chad

  • Chad National Malaria Control Program, N’Djamena, Chad

  • Chad National Malaria Control Program, N’Djamena, Chad

  • Department of Parasitology Mycology, Institute Pasteur, Abidjan, C?te d’Ivoire

  • Department of Parasitology Mycology, Institute Pasteur, Abidjan, C?te d’Ivoire

  • Department of Parasitology Mycology, Institute Pasteur, Abidjan, C?te d’Ivoire

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