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The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives

Received: 20 March 2015     Accepted: 31 March 2015     Published: 9 April 2015
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Abstract

High productivity of agriculture goods is closely associated with the use of fungicides to reduce losses caused by the fungal plant diseases. However, appearance of resistant population of pathogens to several commercial fungicides is a common phenomenon that requires control. There is, therefore, need for developing novel fungicide compounds that are environmentally safe with low toxicity to wild life and humans. In this study novel organotin(IV) derivatives of bis(pyrimidin-2-ylthio)methane (ptm), bis(pyrimidin-2-ylthio)ethane (pte) and bis(pyrimidin-2-ylthio)hexane (pth) were tested against phytopathogens to evaluate their activity as potential fungicides. The bis(pyrimidin-2-ylthio)alkanes were not active in contrast with the organotin(IV) derivatives. The 5-coordinate triphenyltin(IV) derivatives were the most active compounds in a wide range of concentration. This study shows that the microorganisms were susceptible to the acid character of the organotin(IV) precursors.

Published in American Journal of Applied Chemistry (Volume 3, Issue 2)
DOI 10.11648/j.ajac.20150302.17
Page(s) 77-82
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Antifungal, Organotin, Bis(Pyrimidin-2-Ylthio)Alkanes, Storage Fungus, Fungicide, Phytopathogens

References
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    Fernanda Andrade Mendonça, Geraldo José da Silva Junior, José Roberto da Silveira Maia, Onkar Dev Dhingra, Rosimeire Coura Barcelos. (2015). The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives. American Journal of Applied Chemistry, 3(2), 77-82. https://doi.org/10.11648/j.ajac.20150302.17

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    ACS Style

    Fernanda Andrade Mendonça; Geraldo José da Silva Junior; José Roberto da Silveira Maia; Onkar Dev Dhingra; Rosimeire Coura Barcelos. The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives. Am. J. Appl. Chem. 2015, 3(2), 77-82. doi: 10.11648/j.ajac.20150302.17

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    AMA Style

    Fernanda Andrade Mendonça, Geraldo José da Silva Junior, José Roberto da Silveira Maia, Onkar Dev Dhingra, Rosimeire Coura Barcelos. The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives. Am J Appl Chem. 2015;3(2):77-82. doi: 10.11648/j.ajac.20150302.17

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  • @article{10.11648/j.ajac.20150302.17,
      author = {Fernanda Andrade Mendonça and Geraldo José da Silva Junior and José Roberto da Silveira Maia and Onkar Dev Dhingra and Rosimeire Coura Barcelos},
      title = {The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives},
      journal = {American Journal of Applied Chemistry},
      volume = {3},
      number = {2},
      pages = {77-82},
      doi = {10.11648/j.ajac.20150302.17},
      url = {https://doi.org/10.11648/j.ajac.20150302.17},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20150302.17},
      abstract = {High productivity of agriculture goods is closely associated with the use of fungicides to reduce losses caused by the fungal plant diseases. However, appearance of resistant population of pathogens to several commercial fungicides is a common phenomenon that requires control. There is, therefore, need for developing novel fungicide compounds that are environmentally safe with low toxicity to wild life and humans. In this study novel organotin(IV) derivatives of bis(pyrimidin-2-ylthio)methane (ptm), bis(pyrimidin-2-ylthio)ethane (pte) and bis(pyrimidin-2-ylthio)hexane (pth) were tested against phytopathogens to evaluate their activity as potential fungicides. The bis(pyrimidin-2-ylthio)alkanes were not active in contrast with the organotin(IV) derivatives. The 5-coordinate triphenyltin(IV) derivatives were the most active compounds in a wide range of concentration. This study shows that the microorganisms were susceptible to the acid character of the organotin(IV) precursors.},
     year = {2015}
    }
    

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  • TY  - JOUR
    T1  - The Coordination Chemistry in the Antifungal Effect of Tin(IV)-Bis(Pyrimidin-2-Ylthio)Alkane Derivatives
    AU  - Fernanda Andrade Mendonça
    AU  - Geraldo José da Silva Junior
    AU  - José Roberto da Silveira Maia
    AU  - Onkar Dev Dhingra
    AU  - Rosimeire Coura Barcelos
    Y1  - 2015/04/09
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ajac.20150302.17
    DO  - 10.11648/j.ajac.20150302.17
    T2  - American Journal of Applied Chemistry
    JF  - American Journal of Applied Chemistry
    JO  - American Journal of Applied Chemistry
    SP  - 77
    EP  - 82
    PB  - Science Publishing Group
    SN  - 2330-8745
    UR  - https://doi.org/10.11648/j.ajac.20150302.17
    AB  - High productivity of agriculture goods is closely associated with the use of fungicides to reduce losses caused by the fungal plant diseases. However, appearance of resistant population of pathogens to several commercial fungicides is a common phenomenon that requires control. There is, therefore, need for developing novel fungicide compounds that are environmentally safe with low toxicity to wild life and humans. In this study novel organotin(IV) derivatives of bis(pyrimidin-2-ylthio)methane (ptm), bis(pyrimidin-2-ylthio)ethane (pte) and bis(pyrimidin-2-ylthio)hexane (pth) were tested against phytopathogens to evaluate their activity as potential fungicides. The bis(pyrimidin-2-ylthio)alkanes were not active in contrast with the organotin(IV) derivatives. The 5-coordinate triphenyltin(IV) derivatives were the most active compounds in a wide range of concentration. This study shows that the microorganisms were susceptible to the acid character of the organotin(IV) precursors.
    VL  - 3
    IS  - 2
    ER  - 

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Author Information
  • Departamento de Fitopatologia, CCA / Universidade Federal de Vi?osa, 36570-900, Vi?osa, MG, Brasil

  • Departamento de Química, CCET / Universidade Federal de Vi?osa, 36570-900, Vi?osa, MG, Brasil

  • Departamento de Fitopatologia, CCA / Universidade Federal de Vi?osa, 36570-900, Vi?osa, MG, Brasil

  • Departamento de Química, CCET / Universidade Federal de Vi?osa, 36570-900, Vi?osa, MG, Brasil

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