A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †

Rathod Aravind Kumar; Nayaki Salvanna; Biswanath Das; Jajula Kashanna

doi:doi:10.11648/j.wjac.20190401.13

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A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †

Rathod Aravind Kumar, Nayaki Salvanna, Biswanath Das, Jajula Kashanna

Published in World Journal of Applied Chemistry (Volume 4, Issue 1)

Received: 23 February 2019 Accepted: 23 April 2019 Published: 17 June 2019

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Abstract

The formation of amides from carboxylic acids and amines has been catalyzed efficiently with sodium hydrogen sulfate adsorbed on silica gel (NaHSO4.SiO2) at room temperature to give the products in high yields. The conversion carried out under reflux requires less reaction times and forms the products in higher yields. The reaction is highly selective as it has been found that either or both of the substrates should be aliphatic but it is failure when the acid as well as the amine is aromatic. The method has been utilized for the preparation of a natural phenethyl amide derivative and its analogues.

Published in	World Journal of Applied Chemistry (Volume 4, Issue 1)
DOI	10.11648/j.wjac.20190401.13
Page(s)	14-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Heterogeneous Catalysis, Carboxylic Acids, Amines, Amides, Nucleophilic Substitution

References

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APA Style

Rathod Aravind Kumar, Nayaki Salvanna, Biswanath Das, Jajula Kashanna. (2019). A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †. World Journal of Applied Chemistry, 4(1), 14-18. https://doi.org/10.11648/j.wjac.20190401.13

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ACS Style

Rathod Aravind Kumar; Nayaki Salvanna; Biswanath Das; Jajula Kashanna. A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †. World J. Appl. Chem. 2019, 4(1), 14-18. doi: 10.11648/j.wjac.20190401.13

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AMA Style

Rathod Aravind Kumar, Nayaki Salvanna, Biswanath Das, Jajula Kashanna. A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †. World J Appl Chem. 2019;4(1):14-18. doi: 10.11648/j.wjac.20190401.13

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@article{10.11648/j.wjac.20190401.13,
  author = {Rathod Aravind Kumar and Nayaki Salvanna and Biswanath Das and Jajula Kashanna},
  title = {A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †},
  journal = {World Journal of Applied Chemistry},
  volume = {4},
  number = {1},
  pages = {14-18},
  doi = {10.11648/j.wjac.20190401.13},
  url = {https://doi.org/10.11648/j.wjac.20190401.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20190401.13},
  abstract = {The formation of amides from carboxylic acids and amines has been catalyzed efficiently with sodium hydrogen sulfate adsorbed on silica gel (NaHSO4.SiO2) at room temperature to give the products in high yields. The conversion carried out under reflux requires less reaction times and forms the products in higher yields. The reaction is highly selective as it has been found that either or both of the substrates should be aliphatic but it is failure when the acid as well as the amine is aromatic. The method has been utilized for the preparation of a natural phenethyl amide derivative and its analogues.},
 year = {2019}
}

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TY  - JOUR
T1  - A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †
AU  - Rathod Aravind Kumar
AU  - Nayaki Salvanna
AU  - Biswanath Das
AU  - Jajula Kashanna
Y1  - 2019/06/17
PY  - 2019
N1  - https://doi.org/10.11648/j.wjac.20190401.13
DO  - 10.11648/j.wjac.20190401.13
T2  - World Journal of Applied Chemistry
JF  - World Journal of Applied Chemistry
JO  - World Journal of Applied Chemistry
SP  - 14
EP  - 18
PB  - Science Publishing Group
SN  - 2637-5982
UR  - https://doi.org/10.11648/j.wjac.20190401.13
AB  - The formation of amides from carboxylic acids and amines has been catalyzed efficiently with sodium hydrogen sulfate adsorbed on silica gel (NaHSO4.SiO2) at room temperature to give the products in high yields. The conversion carried out under reflux requires less reaction times and forms the products in higher yields. The reaction is highly selective as it has been found that either or both of the substrates should be aliphatic but it is failure when the acid as well as the amine is aromatic. The method has been utilized for the preparation of a natural phenethyl amide derivative and its analogues.
VL  - 4
IS  - 1
ER  -

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Author Information

Rathod Aravind Kumar

Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India
Nayaki Salvanna

Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India
Biswanath Das

Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India
Jajula Kashanna

Natural Products Chemistry Division, CSIR- Indian Institute of Chemical Technology, Hyderabad, India

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APA Style

Rathod Aravind Kumar, Nayaki Salvanna, Biswanath Das, Jajula Kashanna. (2019). A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †. World Journal of Applied Chemistry, 4(1), 14-18. https://doi.org/10.11648/j.wjac.20190401.13

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ACS Style

Rathod Aravind Kumar; Nayaki Salvanna; Biswanath Das; Jajula Kashanna. A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †. World J. Appl. Chem. 2019, 4(1), 14-18. doi: 10.11648/j.wjac.20190401.13

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AMA Style

Rathod Aravind Kumar, Nayaki Salvanna, Biswanath Das, Jajula Kashanna. A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †. World J Appl Chem. 2019;4(1):14-18. doi: 10.11648/j.wjac.20190401.13

Copy | Download

@article{10.11648/j.wjac.20190401.13,
  author = {Rathod Aravind Kumar and Nayaki Salvanna and Biswanath Das and Jajula Kashanna},
  title = {A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †},
  journal = {World Journal of Applied Chemistry},
  volume = {4},
  number = {1},
  pages = {14-18},
  doi = {10.11648/j.wjac.20190401.13},
  url = {https://doi.org/10.11648/j.wjac.20190401.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20190401.13},
  abstract = {The formation of amides from carboxylic acids and amines has been catalyzed efficiently with sodium hydrogen sulfate adsorbed on silica gel (NaHSO4.SiO2) at room temperature to give the products in high yields. The conversion carried out under reflux requires less reaction times and forms the products in higher yields. The reaction is highly selective as it has been found that either or both of the substrates should be aliphatic but it is failure when the acid as well as the amine is aromatic. The method has been utilized for the preparation of a natural phenethyl amide derivative and its analogues.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - A Highly Selective and Efficient Method for the Preparation of Amides from Carboxylic Acids and Amines Using Sodium Hydrogen Sulfate Adsorbed on Silica Gel †
AU  - Rathod Aravind Kumar
AU  - Nayaki Salvanna
AU  - Biswanath Das
AU  - Jajula Kashanna
Y1  - 2019/06/17
PY  - 2019
N1  - https://doi.org/10.11648/j.wjac.20190401.13
DO  - 10.11648/j.wjac.20190401.13
T2  - World Journal of Applied Chemistry
JF  - World Journal of Applied Chemistry
JO  - World Journal of Applied Chemistry
SP  - 14
EP  - 18
PB  - Science Publishing Group
SN  - 2637-5982
UR  - https://doi.org/10.11648/j.wjac.20190401.13
AB  - The formation of amides from carboxylic acids and amines has been catalyzed efficiently with sodium hydrogen sulfate adsorbed on silica gel (NaHSO4.SiO2) at room temperature to give the products in high yields. The conversion carried out under reflux requires less reaction times and forms the products in higher yields. The reaction is highly selective as it has been found that either or both of the substrates should be aliphatic but it is failure when the acid as well as the amine is aromatic. The method has been utilized for the preparation of a natural phenethyl amide derivative and its analogues.
VL  - 4
IS  - 1
ER  -

Copy | Download