Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%.
| Published in | World Journal of Applied Chemistry (Volume 2, Issue 4) |
| DOI | 10.11648/j.wjac.20170204.14 |
| Page(s) | 134-139 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Trityl Candesartan, Tin, UV-VIS Spectrophotometer, Phenylflourone
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APA Style
Yusuf Yildiz, Angela Jan, Lokesh Pendyala, Berrak Yildiz. (2017). Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone. World Journal of Applied Chemistry, 2(4), 134-139. https://doi.org/10.11648/j.wjac.20170204.14
ACS Style
Yusuf Yildiz; Angela Jan; Lokesh Pendyala; Berrak Yildiz. Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone. World J. Appl. Chem. 2017, 2(4), 134-139. doi: 10.11648/j.wjac.20170204.14
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Download@article{10.11648/j.wjac.20170204.14,
author = {Yusuf Yildiz and Angela Jan and Lokesh Pendyala and Berrak Yildiz},
title = {Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone},
journal = {World Journal of Applied Chemistry},
volume = {2},
number = {4},
pages = {134-139},
doi = {10.11648/j.wjac.20170204.14},
url = {https://doi.org/10.11648/j.wjac.20170204.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.wjac.20170204.14},
abstract = {Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%.},
year = {2017}
}
TY - JOUR T1 - Determination of Tin in Trityl Candesartan by UV-VIS Spectrophotometer Using Phenylfluorone AU - Yusuf Yildiz AU - Angela Jan AU - Lokesh Pendyala AU - Berrak Yildiz Y1 - 2017/10/20 PY - 2017 N1 - https://doi.org/10.11648/j.wjac.20170204.14 DO - 10.11648/j.wjac.20170204.14 T2 - World Journal of Applied Chemistry JF - World Journal of Applied Chemistry JO - World Journal of Applied Chemistry SP - 134 EP - 139 PB - Science Publishing Group SN - 2637-5982 UR - https://doi.org/10.11648/j.wjac.20170204.14 AB - Trityl Candesartan (TCand), a benzimidazole derivative, is widely used in the preparation of Candesartan Cilexitil, a pharmaceutical prodrug created to treat hypertension and to help lower blood pressure. One major concern in the preparation process is the usage of tin compounds, specifically tributyl tin oxide, which can cause harm to both human and environmental health. In this study, UV-VIS Spectrophotometry was used for the simple and accurate determination of tin (Sn) in Trityl Candesartan. The study of Sn in Trityl Candesartan found the Sn content to be within the limit of 10 mg/Kg, with a correlation coefficient (R2) of 0.9929, average percent recovery (%R) of 96.0%, and relative percentage difference (%RPD) of 0.35%. VL - 2 IS - 4 ER -
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