Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode

Jayant Ira Gowda; Rohini Manohar Hanabaratti; Sharanappa Thotappa Nandibewoor

doi:doi:10.11648/j.sjac.20190705.11

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Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode

Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor

Published in Science Journal of Analytical Chemistry (Volume 7, Issue 5)

Received: 1 July 2019 Accepted: 12 August 2019 Published: 25 November 2019

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Abstract

Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm². Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k⁰) was obtained to be 1.332× 10³ s^-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10^-7 M to 10.0 × 10^-5 M by using DPV and limit of detection of 9.7 × 10^-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.

Published in	Science Journal of Analytical Chemistry (Volume 7, Issue 5)
DOI	10.11648/j.sjac.20190705.11
Page(s)	92-97
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Tripelennamine Hydrochloride, Glassy Carbon Electrode, Detection Limit, Calibration Plot

References

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APA Style

Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor. (2019). Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Science Journal of Analytical Chemistry, 7(5), 92-97. https://doi.org/10.11648/j.sjac.20190705.11

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ACS Style

Jayant Ira Gowda; Rohini Manohar Hanabaratti; Sharanappa Thotappa Nandibewoor. Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Sci. J. Anal. Chem. 2019, 7(5), 92-97. doi: 10.11648/j.sjac.20190705.11

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AMA Style

Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor. Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Sci J Anal Chem. 2019;7(5):92-97. doi: 10.11648/j.sjac.20190705.11

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@article{10.11648/j.sjac.20190705.11,
  author = {Jayant Ira Gowda and Rohini Manohar Hanabaratti and Sharanappa Thotappa Nandibewoor},
  title = {Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode},
  journal = {Science Journal of Analytical Chemistry},
  volume = {7},
  number = {5},
  pages = {92-97},
  doi = {10.11648/j.sjac.20190705.11},
  url = {https://doi.org/10.11648/j.sjac.20190705.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20190705.11},
  abstract = {Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.},
 year = {2019}
}

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TY  - JOUR
T1  - Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode
AU  - Jayant Ira Gowda
AU  - Rohini Manohar Hanabaratti
AU  - Sharanappa Thotappa Nandibewoor
Y1  - 2019/11/25
PY  - 2019
N1  - https://doi.org/10.11648/j.sjac.20190705.11
DO  - 10.11648/j.sjac.20190705.11
T2  - Science Journal of Analytical Chemistry
JF  - Science Journal of Analytical Chemistry
JO  - Science Journal of Analytical Chemistry
SP  - 92
EP  - 97
PB  - Science Publishing Group
SN  - 2376-8053
UR  - https://doi.org/10.11648/j.sjac.20190705.11
AB  - Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.
VL  - 7
IS  - 5
ER  -

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Author Information

Jayant Ira Gowda

Post Graduate Department of Studies in Chemistry, Parappa Channappa Jabin Science College, Hubballi, Karnataka, India
Rohini Manohar Hanabaratti

Department of Chemistry, Karnatak Science College, Dharwad, Karnataka, India
Sharanappa Thotappa Nandibewoor

Post Graduate Department of Studies in Chemistry, Karnatak University, Dharwad, Karnataka, India

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Plain Text BibTeX RIS

APA Style

Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor. (2019). Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Science Journal of Analytical Chemistry, 7(5), 92-97. https://doi.org/10.11648/j.sjac.20190705.11

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ACS Style

Jayant Ira Gowda; Rohini Manohar Hanabaratti; Sharanappa Thotappa Nandibewoor. Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Sci. J. Anal. Chem. 2019, 7(5), 92-97. doi: 10.11648/j.sjac.20190705.11

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AMA Style

Jayant Ira Gowda, Rohini Manohar Hanabaratti, Sharanappa Thotappa Nandibewoor. Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode. Sci J Anal Chem. 2019;7(5):92-97. doi: 10.11648/j.sjac.20190705.11

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@article{10.11648/j.sjac.20190705.11,
  author = {Jayant Ira Gowda and Rohini Manohar Hanabaratti and Sharanappa Thotappa Nandibewoor},
  title = {Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode},
  journal = {Science Journal of Analytical Chemistry},
  volume = {7},
  number = {5},
  pages = {92-97},
  doi = {10.11648/j.sjac.20190705.11},
  url = {https://doi.org/10.11648/j.sjac.20190705.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.sjac.20190705.11},
  abstract = {Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Electrochemical Detection of Tripelennamine Hydrochloride Voltammetrically at Glassy Carbon Electrode
AU  - Jayant Ira Gowda
AU  - Rohini Manohar Hanabaratti
AU  - Sharanappa Thotappa Nandibewoor
Y1  - 2019/11/25
PY  - 2019
N1  - https://doi.org/10.11648/j.sjac.20190705.11
DO  - 10.11648/j.sjac.20190705.11
T2  - Science Journal of Analytical Chemistry
JF  - Science Journal of Analytical Chemistry
JO  - Science Journal of Analytical Chemistry
SP  - 92
EP  - 97
PB  - Science Publishing Group
SN  - 2376-8053
UR  - https://doi.org/10.11648/j.sjac.20190705.11
AB  - Tripelennamine hydrochloride (TPA) primarily acts as first generation antihistamine psychoactive or H1 receptor antagonist and an antipruritic drug. In the present study, the voltammetric behavior of TPA was studied using glassy carbon electrode with pH ranging from 4.2 to 10.4. Cyclic voltammetry (CV) and Differential pulse voltammetric (DPV) techniques have beenemployed in order to elucidate an irreversible electrodic reaction with maximum anodic peak current at pH 7.0. Surface area of the electrode was calculated and was found to be 0.0202 cm2. Scan rate variation shows that electrodic reaction involves electron transfer with diffusion controlled mass transfer process. The heterogeneous electron transfer rate constant (k0) was obtained to be 1.332× 103 s-1. A linear relationship between peak current and TPA concentrations was obtained from 0.9×10-7 M to 10.0 × 10-5 M by using DPV and limit of detection of 9.7 × 10-8 M was estimated. In addition, a sensitive voltammetric method was developed, and it was successfully applied for TPA determination in pharmaceutical sample and human urine samples.The present method was also applied for the determination of TPA in pharmaceutical samples, with satisfactory recoveries from 95.32 % to 100.12 %.
VL  - 7
IS  - 5
ER  -

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