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Digestive Cancers at the Conakry University Hospital Center: Epidemiological, Clinical, Histological, and Therapeutic Aspects

Received: 25 January 2026     Accepted: 5 February 2026     Published: 24 February 2026
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Abstract

Aim: The aim of this study was to investigate the epidemiological, anatomo-clinical and therapeutic aspects of cancers of the digestive tract. Material and Methods: This was a retrospective descriptive study lasting 6 years (January 1, 2014 to December 31, 2019), based on the complete records of patients hospitalized and operated on for histologically proven digestive tract cancers. Results: Out of 4681 patient records, we collected 297 cases of digestive cancers (6.34%). The mean age was 52.70 years. Male predominance was noted, with a sex ratio of 1.17. Fifty-seven percent of patients resided in Conakry, and 64.30% of cases were treated at the Donka oncology unit. Housewives were most represented, with a predominance of married patients; alcohol was the most common vice (7.07%). Gastro-duodenal ulcer was the most common comorbidity. The average consultation time was 9.86 ±10.4 months; 29.62% of patients were seen after more than 9 months. The clinical picture was dominated by epigastralgia, nausea and vomiting. The stomach was the predominant site, followed by the colon. For histological analysis, surgical specimens were the most common. Adenocarcinoma was the most frequent histological type, and macroscopically, the infiltrating type was the most common. Surgical treatment was the most common, with tumor resection the most frequently performed procedure. Follow-up was uncomplicated in 71.04% of cases, with morbidity of 5.05% and mortality of 23.91%. Conclusion: Cancers of the digestive tract are frequent, of late diagnosis and of poor prognosis. Equipping hospitals, screening and early treatment, as well as raising public awareness, could improve prognosis.

Published in Journal of Surgery (Volume 14, Issue 1)
DOI 10.11648/j.js.20261401.14
Page(s) 16-20
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2026. Published by Science Publishing Group

Keywords

Cancers, Digestive Tract, Epidemiology, Histology

1. Introduction
Digestive cancers were rare in developing countries, but with the advent of diagnostic tools and changes in lifestyle habits in these countries, we are seeing an increase in the frequency of this disease . The lack of diagnostic, therapeutic, and preventive resources makes it difficult to manage these digestive cancers in developing countries . Numerous epidemiological studies have recently focused on cancers of the digestive tract due to their increasing frequency and severity . In Niger, despite relatively frequent endoscopic examinations, digestive cancers are diagnosed late because most patients seek medical attention when symptoms are obvious and worrying, thus worsening the prognosis. The aim of this study was to examine the epidemiological, clinical, and therapeutic aspects of digestive tract cancers at the Conakry University Hospital.
2. Materials and Methods
This was a retrospective, descriptive, and analytical study conducted over a six-year period, from January 1, 2014, to December 31, 2019. The study was conducted in the general and visceral surgery departments and the oncology unit of the Conakry University Hospital, which are the referral centers for the treatment of digestive cancers in Guinea.
The study population consisted of all patients hospitalized and/or operated on for primary cancer of the digestive tract during the study period. Patients with complete medical records containing usable clinical data and formal histological confirmation of the diagnosis of digestive cancer were included. Incomplete records, secondary cancers of the digestive tract, and patients without histological evidence were excluded.
Data were collected from several sources: consultation records, the oncology unit database, individual patient medical records, surgical records, and pathology reports. A standardized survey form was used to systematically collect information.
The variables studied included: sociodemographic data (age, gender, place of residence, occupation, marital status); risk factors and medical history (alcohol, tobacco, digestive comorbidities, particularly peptic ulcer disease); clinical parameters (reasons for consultation, time to consultation, general condition according to the WHO (performance index); anatomopathological data (tumor location, histological type, macroscopic appearance, nature of samples); therapeutic modalities (surgery, type of procedure performed, adjuvant treatments when available); postoperative course (morbidity and mortality, complications, clinical outcome).
Statistical analysis was performed using Epi Info software version 7.2.2.3 and Excel 2013 spreadsheet software. Quantitative variables were expressed as mean ± standard deviation and qualitative variables as numbers and percentages.
3. Results
Over the four-year period, we collected 297 cases (n=4681) of digestive cancers, representing 6.34% of all cancers. The average age of our patients was 52.70 years, with extremes of 13 and 84 years; the most affected age group was those over 60 years of age. We noted a male predominance with a sex ratio of 1.17. Fifty-seven percent of patients resided in Conakry, and 64.30% of cases were treated at the Donka oncology unit. Housewives were the most represented (32.66%); there was a predominance of married patients (66.33%); alcohol was the most common vice (7.07%). Gastroduodenal ulcer was the most common comorbidity (28.96%). The average time to consultation was 9.86 months ±10.4 months, with extremes of 1 month and 5 years; 29.62% of patients were seen after more than 9 months of progression. The clinical signs are shown in Table 1. In 32.32% of cases, the WHO performance status index on admission was not specified, and 27.27% of patients had an index of 3. Table 2 shows the different sites of cancer in the diges[tive tract. For histological analysis, surgical specimens were the most commonly received (59.93%), but in 33% of cases there was no specification. The histological types are shown in Table 3; macroscopically, the infiltrating type was the most common (41.41%). We noted the predominance of surgical treatment (85.19%). The surgical procedures are shown in Table 4. The outcome was favorable in 71.04%; the morbidity rate was 5.05% and the mortality rate was 23.91%. Sixty-one point ninety-seven percent of deaths occurred after surgical treatment.
Table 1. Frequency of patients according to reason for consultation.

Reasons for consultation

Number

Percentages

Epigastric pain

191

64.31

Vomiting

131

44.11

Weight loss

81

27.27

Constipation

23

7.74

Abdominal pain

13

4.38

Abdominal mass

7

2.36

Table 2. Frequency of patients according to cancer site.

Site

Number

Percentage

Esophagus

23

7.74

Stomach

119

40.07

Small intestine

7

2.36

Colon

108

36.36

Anorectal

48

16.16

Table 3. Distribution of digestive tract cancers by histological type.

Histological type

Number

Percentage

Adenocarcinoma

196

65.99

Squamous cell carcinoma

98

33

Lymphoma

3

1.01

Total

297

100

Table 4. Distribution of cancers according to surgical procedure.

Surgical procedure

Number

Percentage

Tumor resection

231

91.30

Derivation

22

8.70

Colostomy

13

5.14

Gastrojejunal

09

3.56

Total

253

100

4. Discussion
Digestive tract cancers are a major public health problem in developing countries, with incidence rates continuing to rise. Globally, they account for a significant proportion of cancer incidence and mortality, with a particularly heavy burden in low- and middle-income countries . Several recent African studies report a high incidence of these cancers, reflecting changes in dietary habits, increasing urbanization, improved diagnostic methods, and the persistence of preventable risk factors . In our series, the frequency of digestive cancers (6.34%) is comparable to that reported by Bagny et al. in Togo and Salamatou et al. in Niger, but remains lower than that observed in Côte d'Ivoire by Kissi Anzouan-Kacou et al . This variability could be explained by methodological differences, the duration of the studies, access to specialized care, and the availability of pathology services, as also highlighted in global cancer surveillance analyses .
The male predominance observed in our study is consistent with data from African and international literature. This trend is often attributed to men's greater exposure to risk factors such as alcohol and tobacco, which are particularly implicated in esophageal and stomach cancers .
The relatively young average age of our patients, compared to Western countries, has also been reported in several African series. This situation could be explained by the young demographic structure of the African population, but also by early exposure to certain carcinogens, particularly Helicobacter pylori infection, which is recognized as a major factor in gastric carcinogenesis . Conversely, in developed countries, digestive cancers occur mainly at an older age, in line with the aging of the population and organized screening programs .
The majority of patients resided in Conakry, which could be linked to the concentration of specialized cancer diagnosis and treatment facilities in the capital. However, this centralization limits access to care for rural populations, contributing to the diagnostic delay observed in our series, a phenomenon widely described in resource-limited countries .
Housewives were the most represented in our series, which corroborates the study by Ouedraogo S, et al. in Burkina Faso in 2018. They reported that the population's unfavorable socioeconomic factors play a role in the occurrence of these cancers. Digestive cancers affect very low-income populations, limiting their access to health services for diagnosis and care, but also for prevention . Alcoholism and smoking have been implicated by authors in the occurrence of digestive cancers , and we made the same observation in our series. In our study, we found a 28.96% history of gastroduodenal ulcers; the same observation was made by Bagny A et al in their study.
Clinically, the average time to consultation was long, reflecting late diagnosis at an advanced stage of the disease. The main reasons for consultation were abdominal pain, vomiting, and deterioration in general health, symptoms that are generally indicative of advanced forms of the disease. This delay in diagnosis is one of the main factors contributing to the poor prognosis for digestive cancers in sub-Saharan Africa .
Gastric cancer was the most common site in our study, followed by colon and anorectal cancers. This predominance of gastric cancer is widely described in African series, unlike in developed countries where the incidence of stomach cancer tends to decrease in favor of colorectal cancers . The role of Helicobacter pylori infection, peptic ulcer disease, and nutritional factors remains central to this anatomical distribution .
Histologically, adenocarcinoma was largely predominant, which is consistent with data from the global and African literature . The frequently observed infiltrating macroscopic appearance also reflects the advanced nature of the lesions at the time of diagnosis.
Surgery was the main treatment modality in our series, with tumor resection being the most frequently performed procedure when the patient's general condition allowed it. However, international recommendations advocate multimodal management combining surgery, chemotherapy, and/or radiotherapy depending on the tumor stage, options that are often limited in low-resource countries .
The mortality rate observed remains high, although lower than that reported in some West African series. It is mainly related to delayed consultation, advanced tumor stage, associated comorbidities, and the limitations of the available therapeutic arsenal. International studies have shown that survival rates for digestive cancers are closely correlated with the level of development of the healthcare system and access to specialized care .
5. Conclusion
Cancers of the digestive tract are common in Guinea and constitute a major public health problem. They are most often diagnosed at an advanced stage, due to significant delays in seeking medical advice. This late diagnosis limits treatment options and worsens the prognosis.
Mortality remains high in our context, reflecting the severity of these cancers. Treatment is mainly based on surgery. Adjuvant treatments, particularly chemotherapy and radiotherapy, are not widely available. In many cases, surgery is performed for palliative purposes.
The lack of diagnostic and therapeutic resources is a major constraint.
Early screening and rapid treatment could improve survival rates.
Raising public awareness remains essential to improving the prognosis.
Abbreviations

WHO

World Health Organization

Author Contributions
Naby Fofana: Conceptualization, Project administration, Data curation, Validation, Formal Analysis, Methodology
Ansoumane Conde: Data curation, Writing – review & editing, Formal Analysis, Methodology, Software, Visualization
Conflicts of Interest
The authors declare no conflicts of interest.
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Cite This Article
  • APA Style

    Fofana, N., Conde, A., Yattara, A., Youla, A. M., Fofana, A., et al. (2026). Digestive Cancers at the Conakry University Hospital Center: Epidemiological, Clinical, Histological, and Therapeutic Aspects. Journal of Surgery, 14(1), 16-20. https://doi.org/10.11648/j.js.20261401.14

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    ACS Style

    Fofana, N.; Conde, A.; Yattara, A.; Youla, A. M.; Fofana, A., et al. Digestive Cancers at the Conakry University Hospital Center: Epidemiological, Clinical, Histological, and Therapeutic Aspects. J. Surg. 2026, 14(1), 16-20. doi: 10.11648/j.js.20261401.14

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    AMA Style

    Fofana N, Conde A, Yattara A, Youla AM, Fofana A, et al. Digestive Cancers at the Conakry University Hospital Center: Epidemiological, Clinical, Histological, and Therapeutic Aspects. J Surg. 2026;14(1):16-20. doi: 10.11648/j.js.20261401.14

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  • @article{10.11648/j.js.20261401.14,
      author = {Naby Fofana and Ansoumane Conde and Abdoulaye Yattara and Alpha Mohamed Youla and Aminata Fofana and Mohamed Saliou Bangoura and Mamadou Sakoba Barry and Aboubacar Toure},
      title = {Digestive Cancers at the Conakry University Hospital Center: Epidemiological, Clinical, Histological, and Therapeutic Aspects},
      journal = {Journal of Surgery},
      volume = {14},
      number = {1},
      pages = {16-20},
      doi = {10.11648/j.js.20261401.14},
      url = {https://doi.org/10.11648/j.js.20261401.14},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20261401.14},
      abstract = {Aim: The aim of this study was to investigate the epidemiological, anatomo-clinical and therapeutic aspects of cancers of the digestive tract. Material and Methods: This was a retrospective descriptive study lasting 6 years (January 1, 2014 to December 31, 2019), based on the complete records of patients hospitalized and operated on for histologically proven digestive tract cancers. Results: Out of 4681 patient records, we collected 297 cases of digestive cancers (6.34%). The mean age was 52.70 years. Male predominance was noted, with a sex ratio of 1.17. Fifty-seven percent of patients resided in Conakry, and 64.30% of cases were treated at the Donka oncology unit. Housewives were most represented, with a predominance of married patients; alcohol was the most common vice (7.07%). Gastro-duodenal ulcer was the most common comorbidity. The average consultation time was 9.86 ±10.4 months; 29.62% of patients were seen after more than 9 months. The clinical picture was dominated by epigastralgia, nausea and vomiting. The stomach was the predominant site, followed by the colon. For histological analysis, surgical specimens were the most common. Adenocarcinoma was the most frequent histological type, and macroscopically, the infiltrating type was the most common. Surgical treatment was the most common, with tumor resection the most frequently performed procedure. Follow-up was uncomplicated in 71.04% of cases, with morbidity of 5.05% and mortality of 23.91%. Conclusion: Cancers of the digestive tract are frequent, of late diagnosis and of poor prognosis. Equipping hospitals, screening and early treatment, as well as raising public awareness, could improve prognosis.},
     year = {2026}
    }
    

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  • TY  - JOUR
    T1  - Digestive Cancers at the Conakry University Hospital Center: Epidemiological, Clinical, Histological, and Therapeutic Aspects
    AU  - Naby Fofana
    AU  - Ansoumane Conde
    AU  - Abdoulaye Yattara
    AU  - Alpha Mohamed Youla
    AU  - Aminata Fofana
    AU  - Mohamed Saliou Bangoura
    AU  - Mamadou Sakoba Barry
    AU  - Aboubacar Toure
    Y1  - 2026/02/24
    PY  - 2026
    N1  - https://doi.org/10.11648/j.js.20261401.14
    DO  - 10.11648/j.js.20261401.14
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 16
    EP  - 20
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20261401.14
    AB  - Aim: The aim of this study was to investigate the epidemiological, anatomo-clinical and therapeutic aspects of cancers of the digestive tract. Material and Methods: This was a retrospective descriptive study lasting 6 years (January 1, 2014 to December 31, 2019), based on the complete records of patients hospitalized and operated on for histologically proven digestive tract cancers. Results: Out of 4681 patient records, we collected 297 cases of digestive cancers (6.34%). The mean age was 52.70 years. Male predominance was noted, with a sex ratio of 1.17. Fifty-seven percent of patients resided in Conakry, and 64.30% of cases were treated at the Donka oncology unit. Housewives were most represented, with a predominance of married patients; alcohol was the most common vice (7.07%). Gastro-duodenal ulcer was the most common comorbidity. The average consultation time was 9.86 ±10.4 months; 29.62% of patients were seen after more than 9 months. The clinical picture was dominated by epigastralgia, nausea and vomiting. The stomach was the predominant site, followed by the colon. For histological analysis, surgical specimens were the most common. Adenocarcinoma was the most frequent histological type, and macroscopically, the infiltrating type was the most common. Surgical treatment was the most common, with tumor resection the most frequently performed procedure. Follow-up was uncomplicated in 71.04% of cases, with morbidity of 5.05% and mortality of 23.91%. Conclusion: Cancers of the digestive tract are frequent, of late diagnosis and of poor prognosis. Equipping hospitals, screening and early treatment, as well as raising public awareness, could improve prognosis.
    VL  - 14
    IS  - 1
    ER  - 

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Author Information
  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea

  • Department of General Surgery, Ignace Deen National Hospital, Conakry, Guinea