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Difficult to Heal Wounds Intralesional Insulin Therapy Trial

Received: 14 January 2020     Accepted: 7 February 2020     Published: 9 November 2020
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Abstract

Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.

Published in Journal of Surgery (Volume 8, Issue 6)
DOI 10.11648/j.js.20200806.13
Page(s) 184-189
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Wound Healing, Insulin, Growth Factor Wounds and Injuries, Difficult Wound Healing, Insulin Therapy, Growth Factors

References
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Cite This Article
  • APA Style

    Neide Kalil Gaspar, Antonio Pedro de Andrade Gaspar. (2020). Difficult to Heal Wounds Intralesional Insulin Therapy Trial. Journal of Surgery, 8(6), 184-189. https://doi.org/10.11648/j.js.20200806.13

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    ACS Style

    Neide Kalil Gaspar; Antonio Pedro de Andrade Gaspar. Difficult to Heal Wounds Intralesional Insulin Therapy Trial. J. Surg. 2020, 8(6), 184-189. doi: 10.11648/j.js.20200806.13

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    AMA Style

    Neide Kalil Gaspar, Antonio Pedro de Andrade Gaspar. Difficult to Heal Wounds Intralesional Insulin Therapy Trial. J Surg. 2020;8(6):184-189. doi: 10.11648/j.js.20200806.13

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  • @article{10.11648/j.js.20200806.13,
      author = {Neide Kalil Gaspar and Antonio Pedro de Andrade Gaspar},
      title = {Difficult to Heal Wounds Intralesional Insulin Therapy Trial},
      journal = {Journal of Surgery},
      volume = {8},
      number = {6},
      pages = {184-189},
      doi = {10.11648/j.js.20200806.13},
      url = {https://doi.org/10.11648/j.js.20200806.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20200806.13},
      abstract = {Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Difficult to Heal Wounds Intralesional Insulin Therapy Trial
    AU  - Neide Kalil Gaspar
    AU  - Antonio Pedro de Andrade Gaspar
    Y1  - 2020/11/09
    PY  - 2020
    N1  - https://doi.org/10.11648/j.js.20200806.13
    DO  - 10.11648/j.js.20200806.13
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 184
    EP  - 189
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20200806.13
    AB  - Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.
    VL  - 8
    IS  - 6
    ER  - 

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Author Information
  • Departament of Dermatology, Universidade Federal Fluminense (UFF), Niterói (RJ), Brazil

  • Departament of Dermatology, Universidade Federal Fluminense (UFF), Niterói (RJ), Brazil

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