| Peer-Reviewed

Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia

Received: 10 July 2018     Accepted: 20 July 2018     Published: 14 August 2018
Views:       Downloads:
Abstract

Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.

Published in Journal of Surgery (Volume 6, Issue 4)
DOI 10.11648/j.js.20180604.16
Page(s) 107-111
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Acute Abdomen, Mesenteric Ischemia, α -glutathione S-transferase

References
[1] Sise MJ. Acute mesenteric ischemia. Surg Clin North Am. 2014; 94:165–81.
[2] Demir IE, Ceyhan GO, Friess H. Beyond lactate: is there a role for serum lactate measurement in diagnosing acute mesenteric ischemia? Dig Surg. 2012; 29:226–35.
[3] Hagspiel KD, Flors L, Hanley M, et al. Computed tomography angiography and magnetic resonance angiography imaging of the mesenteric vasculature. Tech Vasc Interv Radiol. 2015; 18(1):2-13.
[4] Van den Heijkant TC, Aerts BA, Teijink JA, et al. Challenges in diagnosing mesenteric ischemia. World J Gastroenterol. 2013; 19:1338–41.
[5] Yusuf Tanrıkulu, Ceren Şen Tanrıkulu, Mehmet Zafer et al. Diagnostic utility of the neutrophil-lymphocyte ratio in patients with acute mesenteric ischemia: A retrospective cohort study. Ulus Travma Acil Cerrahi Derg. 2016; 22(4):344–9.
[6] Whalen R, Boyer TD. Human Glutathione S Transferases. Semin Liver Dis 1998; 18(4):345-58.
[7] Delaney CP1, O'Neill S, Manning F, et al. Plasma concentrations of glutathione S-transferase isoenzyme are raised in patients with intestinal ischaemia. Br J Surg. 1999; 86(10):1349-53.
[8] Clair DG, Beach JM. Mesenteric ischemia. N Engl J Med. 2016; 374:959-68.
[9] Derikx J. P. M., Dirk Schellekens, Stefan Acosta. Serological markers for human intestinal ischemia: A systematic Review. Best Practice & Research Clinical Gastroenterology. 2017; 31: 69-74
[10] Wiesner W, Hauser A, Steinbrich W. Accuracy of multidetector row computed tomography for the diagnosis of acute bowel ischemia in a non-selected study population. Eur Radiol. 2004; 14:2347-56.
[11] Tilsed JV, Casamassima A, Kurihara H, et al. ESTES guidelines: acute mesenteric ischaemia. Eur J Trauma Emerg Surg, 2016; 42: 253-270.
[12] Gearhart S, Delaney C, Senagore A et al. Prospective assessment of the predictive value of alpha-glutathione S-transferase for intestinal ischemia. Am Surg. 2003; 69(4):324-9.
[13] Duran M, Grabitz K, Schelzig H et al. The importance of open emergency surgery in the treatment of acute mesenteric ischemia. World journal of emergency surgery, 2015; 10: 45.
[14] Shuofei Yang, Xinxin Fan, Weiwei Ding, et al. D-Dimer as an Early Marker of Severity in Patients with Acute Superior Mesenteric Venous Thrombosis. Medicine 2014; 93 (29): 270.
[15] Acosta S and Nilsson T. Current status on plasma biomarkers for acute mesenteric ischemia. J Thromb Thrombolysis. 2012; 33: 355-61.
[16] Block T., Nilsson T. K., Acosta S. Diagnostic accuracy of plasma biomarkers for intestinal ischaemia. The Scandinavian Journal of Clinical & Laboratory Investigation. 2008; 3(68): 242–248.
[17] Cudnik MT, Darbha S, Jones J, et al. The diagnosis of acute mesenteric ischemia: a systematic review and meta-analysis. Acad Emerg Med. 2013; 20: 1087-1100.
[18] Powell A and Armstrong P. Plasma biomarkers for early diagnosis of acute intestinal ischemia. Semin Vasc Surg. 2014; 27(3-4):170-5.
[19] Björnsson S, Resch T and Acosta S. Symptomatic mesenteric atherosclerotic disease – lessons learned from the diagnostic workup. J Gastrointest Surg. 2013; 17: 973–980.
[20] Hoensch H, Morgenstern I, Petereit G, et al. Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system. Gut 2002; 50:235-40.
Cite This Article
  • APA Style

    Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. (2018). Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. Journal of Surgery, 6(4), 107-111. https://doi.org/10.11648/j.js.20180604.16

    Copy | Download

    ACS Style

    Ahmed Abdel Fattah Elshoura; Hala Desouky Ibrahim; Sahar Mohey Hazzaa; Ola Abdel Fattah Elshora; Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J. Surg. 2018, 6(4), 107-111. doi: 10.11648/j.js.20180604.16

    Copy | Download

    AMA Style

    Ahmed Abdel Fattah Elshoura, Hala Desouky Ibrahim, Sahar Mohey Hazzaa, Ola Abdel Fattah Elshora, Gamal Ibrahim Moussa. Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia. J Surg. 2018;6(4):107-111. doi: 10.11648/j.js.20180604.16

    Copy | Download

  • @article{10.11648/j.js.20180604.16,
      author = {Ahmed Abdel Fattah Elshoura and Hala Desouky Ibrahim and Sahar Mohey Hazzaa and Ola Abdel Fattah Elshora and Gamal Ibrahim Moussa},
      title = {Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia},
      journal = {Journal of Surgery},
      volume = {6},
      number = {4},
      pages = {107-111},
      doi = {10.11648/j.js.20180604.16},
      url = {https://doi.org/10.11648/j.js.20180604.16},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.js.20180604.16},
      abstract = {Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.},
     year = {2018}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Diagnostic Value of α-Glutathione S-transferase in Acute Mesenteric Ischemia
    AU  - Ahmed Abdel Fattah Elshoura
    AU  - Hala Desouky Ibrahim
    AU  - Sahar Mohey Hazzaa
    AU  - Ola Abdel Fattah Elshora
    AU  - Gamal Ibrahim Moussa
    Y1  - 2018/08/14
    PY  - 2018
    N1  - https://doi.org/10.11648/j.js.20180604.16
    DO  - 10.11648/j.js.20180604.16
    T2  - Journal of Surgery
    JF  - Journal of Surgery
    JO  - Journal of Surgery
    SP  - 107
    EP  - 111
    PB  - Science Publishing Group
    SN  - 2330-0930
    UR  - https://doi.org/10.11648/j.js.20180604.16
    AB  - Background: Acute mesenteric ischemia (AMI) is a life-threatening problem, and the early clinical manifestations of it are non-specific. Despite the advances in laboratory & radiological diagnostic procedures, the mortality rate of AMI is still high. Aim: The purpose of the study to evaluate the ability of α-glutathione S-transferase (α- GST) to predict AMI in patients with abdominal pain. Methods: This prospective study was conducted in Tanta University Hospitals between November 2014 and December 2017. Nighty patients were included after clinical suspicious of AMI. Serum levels of α- GST were measured in the collected stored samples, and other biochemical markers were performed (e.g. LDH, PH, and WBC). AMI was confirmed by CT angiography or laparotomy. Patients without ischemic bowel were considered to be controls. Results: A total of 90 patients in the study, the ischemic group included 52 patients, and the non-ischemic group included 38 patients. Patients with intestinal ischemia had significant higher serum values of D-dimer, LDH and α –GST. Where α –GST diagnosed AMI by accuracy of 84.4%. Conclusion: Measurement of plasma α -GST is a simple, early, easy, and effective procedure making it a useful serum biomarker for early diagnosis of AMI.
    VL  - 6
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Emergency & Traumatology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • General Surgery Department, Faculty of Medicine, Tanta University, Tanta, Egypt

  • Sections