Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug

Meghdad Payab; Mohammad Javad Chaichi; Ome Leila Nazari; Fatemeh Yousefnejad Maleki

doi:doi:10.11648/j.jddmc.20190502.11

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Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug

Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki

Published in Journal of Drug Design and Medicinal Chemistry (Volume 5, Issue 2)

Received: 29 May 2019 Accepted: 10 July 2019 Published: 6 August 2019

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Abstract

In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.

Published in	Journal of Drug Design and Medicinal Chemistry (Volume 5, Issue 2)
DOI	10.11648/j.jddmc.20190502.11
Page(s)	18-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Tannin, Oak Gall, Deferral, Iron chelation, Thalassemia

References

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APA Style

Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki. (2019). Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug. Journal of Drug Design and Medicinal Chemistry, 5(2), 18-25. https://doi.org/10.11648/j.jddmc.20190502.11

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ACS Style

Meghdad Payab; Mohammad Javad Chaichi; Ome Leila Nazari; Fatemeh Yousefnejad Maleki. Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug. J. Drug Des. Med. Chem. 2019, 5(2), 18-25. doi: 10.11648/j.jddmc.20190502.11

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AMA Style

Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki. Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug. J Drug Des Med Chem. 2019;5(2):18-25. doi: 10.11648/j.jddmc.20190502.11

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@article{10.11648/j.jddmc.20190502.11,
  author = {Meghdad Payab and Mohammad Javad Chaichi and Ome Leila Nazari and Fatemeh Yousefnejad Maleki},
  title = {Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {5},
  number = {2},
  pages = {18-25},
  doi = {10.11648/j.jddmc.20190502.11},
  url = {https://doi.org/10.11648/j.jddmc.20190502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20190502.11},
  abstract = {In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.},
 year = {2019}
}

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TY  - JOUR
T1  - Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug
AU  - Meghdad Payab
AU  - Mohammad Javad Chaichi
AU  - Ome Leila Nazari
AU  - Fatemeh Yousefnejad Maleki
Y1  - 2019/08/06
PY  - 2019
N1  - https://doi.org/10.11648/j.jddmc.20190502.11
DO  - 10.11648/j.jddmc.20190502.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 18
EP  - 25
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20190502.11
AB  - In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.
VL  - 5
IS  - 2
ER  -

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Author Information

Meghdad Payab

Department of Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Mohammad Javad Chaichi

Department of Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Ome Leila Nazari

Department of Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Fatemeh Yousefnejad Maleki

Department of Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran

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Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki. (2019). Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug. Journal of Drug Design and Medicinal Chemistry, 5(2), 18-25. https://doi.org/10.11648/j.jddmc.20190502.11

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ACS Style

Meghdad Payab; Mohammad Javad Chaichi; Ome Leila Nazari; Fatemeh Yousefnejad Maleki. Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug. J. Drug Des. Med. Chem. 2019, 5(2), 18-25. doi: 10.11648/j.jddmc.20190502.11

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AMA Style

Meghdad Payab, Mohammad Javad Chaichi, Ome Leila Nazari, Fatemeh Yousefnejad Maleki. Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug. J Drug Des Med Chem. 2019;5(2):18-25. doi: 10.11648/j.jddmc.20190502.11

Copy | Download

@article{10.11648/j.jddmc.20190502.11,
  author = {Meghdad Payab and Mohammad Javad Chaichi and Ome Leila Nazari and Fatemeh Yousefnejad Maleki},
  title = {Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug},
  journal = {Journal of Drug Design and Medicinal Chemistry},
  volume = {5},
  number = {2},
  pages = {18-25},
  doi = {10.11648/j.jddmc.20190502.11},
  url = {https://doi.org/10.11648/j.jddmc.20190502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jddmc.20190502.11},
  abstract = {In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug
AU  - Meghdad Payab
AU  - Mohammad Javad Chaichi
AU  - Ome Leila Nazari
AU  - Fatemeh Yousefnejad Maleki
Y1  - 2019/08/06
PY  - 2019
N1  - https://doi.org/10.11648/j.jddmc.20190502.11
DO  - 10.11648/j.jddmc.20190502.11
T2  - Journal of Drug Design and Medicinal Chemistry
JF  - Journal of Drug Design and Medicinal Chemistry
JO  - Journal of Drug Design and Medicinal Chemistry
SP  - 18
EP  - 25
PB  - Science Publishing Group
SN  - 2472-3576
UR  - https://doi.org/10.11648/j.jddmc.20190502.11
AB  - In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.
VL  - 5
IS  - 2
ER  -

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