Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood

Jong-Hwa Lee; Yoo-Jin Cho; Myung-Sup Chae; Wang-Jae Lee; U-Hyun Park; Euishin Edmund Kim

doi:doi:10.11648/j.jctr.20180602.13

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Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood

Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, Euishin Edmund Kim

Published in Journal of Cancer Treatment and Research (Volume 6, Issue 2)

Received: 24 May 2018 Accepted: 19 July 2018 Published: 14 August 2018

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Abstract

Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3^rd, 4^th, 5^th and 6^th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.

Published in	Journal of Cancer Treatment and Research (Volume 6, Issue 2)
DOI	10.11648/j.jctr.20180602.13
Page(s)	25-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Initial Effects, The SB Natural Anticancer Drug, NK Cells, CD4+ and CD8+ T Lymphocytes, Human Peripheral Blood

References

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APA Style

Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, et al. (2018). Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. Journal of Cancer Treatment and Research, 6(2), 25-30. https://doi.org/10.11648/j.jctr.20180602.13

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ACS Style

Jong-Hwa Lee; Yoo-Jin Cho; Myung-Sup Chae; Wang-Jae Lee; U-Hyun Park, et al. Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. J. Cancer Treat. Res. 2018, 6(2), 25-30. doi: 10.11648/j.jctr.20180602.13

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AMA Style

Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, et al. Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. J Cancer Treat Res. 2018;6(2):25-30. doi: 10.11648/j.jctr.20180602.13

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@article{10.11648/j.jctr.20180602.13,
  author = {Jong-Hwa Lee and Yoo-Jin Cho and Myung-Sup Chae and Wang-Jae Lee and U-Hyun Park and Euishin Edmund Kim},
  title = {Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood},
  journal = {Journal of Cancer Treatment and Research},
  volume = {6},
  number = {2},
  pages = {25-30},
  doi = {10.11648/j.jctr.20180602.13},
  url = {https://doi.org/10.11648/j.jctr.20180602.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180602.13},
  abstract = {Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.},
 year = {2018}
}

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TY  - JOUR
T1  - Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood
AU  - Jong-Hwa Lee
AU  - Yoo-Jin Cho
AU  - Myung-Sup Chae
AU  - Wang-Jae Lee
AU  - U-Hyun Park
AU  - Euishin Edmund Kim
Y1  - 2018/08/14
PY  - 2018
N1  - https://doi.org/10.11648/j.jctr.20180602.13
DO  - 10.11648/j.jctr.20180602.13
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 25
EP  - 30
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20180602.13
AB  - Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.
VL  - 6
IS  - 2
ER  -

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Author Information

Jong-Hwa Lee

Department of Internal Medicine, Sahmyook Cancer Center, Sahmyook Seoul Hospital, Seoul, Korea
Yoo-Jin Cho

Department of Internal Medicine, Sahmyook Cancer Center, Sahmyook Seoul Hospital, Seoul, Korea
Myung-Sup Chae

Department of Family Medicine, Sahmyook Seoul Hospital, Seoul, Korea
Wang-Jae Lee

Department of Anatomy, College of Medicine, Seoul National University, Seoul, Korea
U-Hyun Park

Department of Medical Oncology, Kyunghee University Hospital, Seoul, Korea
Euishin Edmund Kim

Department of Medical Oncology, Kyunghee University Hospital, Seoul, Korea

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APA Style

Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, et al. (2018). Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. Journal of Cancer Treatment and Research, 6(2), 25-30. https://doi.org/10.11648/j.jctr.20180602.13

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ACS Style

Jong-Hwa Lee; Yoo-Jin Cho; Myung-Sup Chae; Wang-Jae Lee; U-Hyun Park, et al. Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. J. Cancer Treat. Res. 2018, 6(2), 25-30. doi: 10.11648/j.jctr.20180602.13

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AMA Style

Jong-Hwa Lee, Yoo-Jin Cho, Myung-Sup Chae, Wang-Jae Lee, U-Hyun Park, et al. Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood. J Cancer Treat Res. 2018;6(2):25-30. doi: 10.11648/j.jctr.20180602.13

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@article{10.11648/j.jctr.20180602.13,
  author = {Jong-Hwa Lee and Yoo-Jin Cho and Myung-Sup Chae and Wang-Jae Lee and U-Hyun Park and Euishin Edmund Kim},
  title = {Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood},
  journal = {Journal of Cancer Treatment and Research},
  volume = {6},
  number = {2},
  pages = {25-30},
  doi = {10.11648/j.jctr.20180602.13},
  url = {https://doi.org/10.11648/j.jctr.20180602.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20180602.13},
  abstract = {Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.},
 year = {2018}
}

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TY  - JOUR
T1  - Initial Effects of the SB Natural Anticancer Drug on the Number of NK Cells, CD4+ and CD8+ T Lymphocytes in Human Peripheral Blood
AU  - Jong-Hwa Lee
AU  - Yoo-Jin Cho
AU  - Myung-Sup Chae
AU  - Wang-Jae Lee
AU  - U-Hyun Park
AU  - Euishin Edmund Kim
Y1  - 2018/08/14
PY  - 2018
N1  - https://doi.org/10.11648/j.jctr.20180602.13
DO  - 10.11648/j.jctr.20180602.13
T2  - Journal of Cancer Treatment and Research
JF  - Journal of Cancer Treatment and Research
JO  - Journal of Cancer Treatment and Research
SP  - 25
EP  - 30
PB  - Science Publishing Group
SN  - 2376-7790
UR  - https://doi.org/10.11648/j.jctr.20180602.13
AB  - Most anticancer drugs produce cytotoxicites in cancer cells, but also generate effects in normal cells that create undesirable side effects, especially for immune functioning cells which have already been suppressed by cancer invasion or biological effects. The SB natural anticancer drug is a root extract of the Pulsatilla koreana plant that has been used in Korea as an effective anticancer agent for more than 20 different malignant tumors without triggering significant adverse reactions. We investigated the effects of the SB anticancer drug on human immune cells in cancer patients. 24 consecutive patients, with histologically proven cancers, received SB drug treatments and 20 control patients did not receive SB administrations. Both groups were immunologically tested before and after their SB treatments for 14 days and then weekly for the 3rd, 4th, 5th and 6th weeks thereafter. The total number of white blood cells with differential counts including monocytes and lymphocytes were checked. Immunoassay and flow cytometry were used to analyse CD4 and CD8 T cell percentages, total cell counts with their ratios, as well as CD16/56 natural killer cell percentages and cell counts. Total white blood cell counts normalized within 10 days after the SB drug administrations. The total lymphocyte counts were slightly increased, but remained within normal parameters. CD4 and CD8 T cells, as well as CD 16/56 NK cell percentages, became normal within 10 days; their total cell counts were initially increased (26.3%, 45.2%, and 16.7%, respectively) and then became normal. The SB drug was found to be effective cytoapoptotically and was also effective for immune cell recovery in cancer patients in their initial period of the SB drug treatment. These were patients who had already had a bone marrow suppression by cancer invasion and/or prior chemotherapy.
VL  - 6
IS  - 2
ER  -

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