Prostrate cancer is a common cancer in males with increasing rate of incidence these days. Two known markers prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) have been used for diagnosis and in the clinical management of prostate cancer patients. PAP and PSA tests are not specific and hence not reliable. Therefore, certain immunological tests need to be developed to aid the clinicians in early detection, metastasis and recurrence and also to follow clinical course of the disease and/or its response to therapy. The present study shows that the circulating immune complexes (CICs) may be associated with the pathogenesis of prostate cancer and their progression. CICs were investigated in 50 prostate cancer patients having different grades of the disease and 45 benign prostate hyperplasia patients (BPH). Estimation of CICs was done using 3.75% Polyethylene glycol 6000 (PEG) serum precipitation. The results obtained were compared with normal healthy individuals. 83.33% and 91.66% positivity was observed in Grade I and Grade II prostate carcinomas respectively, whereas 100% positivity was observed in Grade III and Grade IV prostate carcinoma. BPH patients showed 60% positivity. Strong positive correlation (r=0.5748) between Prostate specific antigen (PSA) and CIC was observed in prostate cancer patients. Present investigation shows CICs may be associated with the pathogenesis of prostate cancers. The further qualitative analysis of CICs may help us to formulate specific immunological tests for early detection, management and monitoring the efficacy of treatment in prostate cancers.
| Published in | Journal of Cancer Treatment and Research (Volume 5, Issue 3) |
| DOI | 10.11648/j.jctr.20170503.13 |
| Page(s) | 43-47 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Circulating Immune Complexes (CICs), Benign Prostate Hyperplasia Patients (BPH), Prostate Specific Antigen (PSA), Prostate Cancer (PCa), Polyethylene Glycol 6000 (PEG)
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APA Style
Alka Vishwas Nerurkar, Desai Jyotsna, Mukund Andankar, Annada Joshi, Sneha Shinde. (2017). Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer. Journal of Cancer Treatment and Research, 5(3), 43-47. https://doi.org/10.11648/j.jctr.20170503.13
ACS Style
Alka Vishwas Nerurkar; Desai Jyotsna; Mukund Andankar; Annada Joshi; Sneha Shinde. Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer. J. Cancer Treat. Res. 2017, 5(3), 43-47. doi: 10.11648/j.jctr.20170503.13
AMA Style
Alka Vishwas Nerurkar, Desai Jyotsna, Mukund Andankar, Annada Joshi, Sneha Shinde. Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer. J Cancer Treat Res. 2017;5(3):43-47. doi: 10.11648/j.jctr.20170503.13
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Download@article{10.11648/j.jctr.20170503.13,
author = {Alka Vishwas Nerurkar and Desai Jyotsna and Mukund Andankar and Annada Joshi and Sneha Shinde},
title = {Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer},
journal = {Journal of Cancer Treatment and Research},
volume = {5},
number = {3},
pages = {43-47},
doi = {10.11648/j.jctr.20170503.13},
url = {https://doi.org/10.11648/j.jctr.20170503.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170503.13},
abstract = {Prostrate cancer is a common cancer in males with increasing rate of incidence these days. Two known markers prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) have been used for diagnosis and in the clinical management of prostate cancer patients. PAP and PSA tests are not specific and hence not reliable. Therefore, certain immunological tests need to be developed to aid the clinicians in early detection, metastasis and recurrence and also to follow clinical course of the disease and/or its response to therapy. The present study shows that the circulating immune complexes (CICs) may be associated with the pathogenesis of prostate cancer and their progression. CICs were investigated in 50 prostate cancer patients having different grades of the disease and 45 benign prostate hyperplasia patients (BPH). Estimation of CICs was done using 3.75% Polyethylene glycol 6000 (PEG) serum precipitation. The results obtained were compared with normal healthy individuals. 83.33% and 91.66% positivity was observed in Grade I and Grade II prostate carcinomas respectively, whereas 100% positivity was observed in Grade III and Grade IV prostate carcinoma. BPH patients showed 60% positivity. Strong positive correlation (r=0.5748) between Prostate specific antigen (PSA) and CIC was observed in prostate cancer patients. Present investigation shows CICs may be associated with the pathogenesis of prostate cancers. The further qualitative analysis of CICs may help us to formulate specific immunological tests for early detection, management and monitoring the efficacy of treatment in prostate cancers.},
year = {2017}
}
TY - JOUR T1 - Comparison Between Circulating Immune Complexes and Prostate Specific Antigen to Assess the Pathogenesis of Prostate Cancer AU - Alka Vishwas Nerurkar AU - Desai Jyotsna AU - Mukund Andankar AU - Annada Joshi AU - Sneha Shinde Y1 - 2017/04/11 PY - 2017 N1 - https://doi.org/10.11648/j.jctr.20170503.13 DO - 10.11648/j.jctr.20170503.13 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 43 EP - 47 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20170503.13 AB - Prostrate cancer is a common cancer in males with increasing rate of incidence these days. Two known markers prostatic acid phosphatase (PAP) and prostate specific antigen (PSA) have been used for diagnosis and in the clinical management of prostate cancer patients. PAP and PSA tests are not specific and hence not reliable. Therefore, certain immunological tests need to be developed to aid the clinicians in early detection, metastasis and recurrence and also to follow clinical course of the disease and/or its response to therapy. The present study shows that the circulating immune complexes (CICs) may be associated with the pathogenesis of prostate cancer and their progression. CICs were investigated in 50 prostate cancer patients having different grades of the disease and 45 benign prostate hyperplasia patients (BPH). Estimation of CICs was done using 3.75% Polyethylene glycol 6000 (PEG) serum precipitation. The results obtained were compared with normal healthy individuals. 83.33% and 91.66% positivity was observed in Grade I and Grade II prostate carcinomas respectively, whereas 100% positivity was observed in Grade III and Grade IV prostate carcinoma. BPH patients showed 60% positivity. Strong positive correlation (r=0.5748) between Prostate specific antigen (PSA) and CIC was observed in prostate cancer patients. Present investigation shows CICs may be associated with the pathogenesis of prostate cancers. The further qualitative analysis of CICs may help us to formulate specific immunological tests for early detection, management and monitoring the efficacy of treatment in prostate cancers. VL - 5 IS - 3 ER -
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