Electrospun Chitosan-based Fibers for Wound Healing Applications

Sameer Sapkota; Shih-Feng Chou

doi:doi:10.11648/j.jb.20200402.13

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Electrospun Chitosan-based Fibers for Wound Healing Applications

Sameer Sapkota, Shih-Feng Chou

Published in Journal of Biomaterials (Volume 4, Issue 2)

Received: 14 November 2020 Accepted: 25 November 2020 Published: 4 December 2020

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Abstract

Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.

Published in	Journal of Biomaterials (Volume 4, Issue 2)
DOI	10.11648/j.jb.20200402.13
Page(s)	51-57
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Electrospinning, Chitosan, Fibers, Drug Delivery, Wound Healing

References

[1]	C.-C. Sun, S.-F. Chou, J.-Y. Lai, C.-H. Cho, C.-H. Lee, Dependence of corneal keratocyte adhesion, spreading, and integrin β1 expression on deacetylated chitosan coating, Materials Science and Engineering: C. 63 (2016) 222–230. doi: 10.1016/j.msec.2016.02.069.
[2]	S.-F. Chou, J.-Y. Lai, C.-H. Cho, C.-H. Lee, Relationships between surface roughness/stiffness of chitosan coatings and fabrication of corneal keratocyte spheroids: Effect of degree of deacetylation, Colloids and Surfaces B: Biointerfaces. 142 (2016) 105–113. doi: 10.1016/j.colsurfb.2016.02.051.
[3]	J. Venkatesan, S.-K. Kim, Chitosan composites for bone tissue engineering—An overview, Marine Drugs. 8 (2010) 2252–2266. doi: 10.3390/md8082252.
[4]	E. V. R. Campos, J. L. Oliveira, L. F. Fraceto, Poly (ethylene glycol) and cyclodextrin-grafted chitosan: From methodologies to preparation and potential biotechnological applications, Frontiers in Chemistry. 5 (2017) 93. doi: 10.3389/fchem.2017.00093.
[5]	S. V. Madihally, H. W. T. Matthew, Porous chitosan scaffolds for tissue engineering, Biomaterials. 20 (1999) 1133–1142. doi: 10.1016/S0142-9612(99)00011-3.
[6]	S. Ahmed, Annu, A. Ali, J. Sheikh, A review on chitosan centred scaffolds and their applications in tissue engineering, International Journal of Biological Macromolecules. 116 (2018) 849–862. doi: 10.1016/j.ijbiomac.2018.04.176.
[7]	T. Dai, M. Tanaka, Y.-Y. Huang, M. R. Hamblin, Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects, Expert Review of Anti-Infective Therapy. 9 (2011) 857–879. doi: 10.1586/eri.11.59.
[8]	H. Liu, C. Wang, C. Li, Y. Qin, Z. Wang, F. Yang, et al., A functional chitosan-based hydrogel as a wound dressing and drug delivery system in the treatment of wound healing, RSC Advances. 8 (2018) 7533–7549. doi: 10.1039/C7RA13510F.
[9]	R. Jayakumar, M. Prabaharan, P. T. Sudheesh Kumar, S. V. Nair, H. Tamura, Biomaterials based on chitin and chitosan in wound dressing applications, Biotechnology Advances. 29 (2011) 322–337. doi: 10.1016/j.biotechadv.2011.01.005.
[10]	R. A. A. Muzzarelli, P. Morganti, G. Morganti, P. Palombo, M. Palombo, G. Biagini, et al., Chitin nanofibrils/chitosan glycolate composites as wound medicaments, Carbohydrate Polymers. 70 (2007) 274–284. doi: 10.1016/j.carbpol.2007.04.008.
[11]	D. Fong, C. D. Hoemann, Chitosan immunomodulatory properties: perspectives on the impact of structural properties and dosage, Future Science OA. 4 (2018) FSO225. doi: 10.4155/fsoa-2017-0064.
[12]	M. Amidi, E. Mastrobattista, W. Jiskoot, W. E. Hennink, Chitosan-based delivery systems for protein therapeutics and antigens, Advanced Drug Delivery Reviews. 62 (2010) 59–82. doi: 10.1016/j.addr.2009.11.009.
[13]	F. Sami El-banna, M.E. Mahfouz, S. Leporatti, M. El-Kemary, N. A. N. Hanafy, Chitosan as a natural copolymer with unique properties for the development of hydrogels, Applied Sciences. 9 (2019) 2193. doi: 10.3390/app9112193.
[14]	S.-F. Chou, D. Carson, K. A. Woodrow, Current strategies for sustaining drug release from electrospun nanofibers, Journal of Controlled Release. 220 (2015) 584–591. doi: 10.1016/j.jconrel.2015.09.008.
[15]	V. Beachley, X. Wen, Effect of electrospinning parameters on the nanofiber diameter and length, Materials Science and Engineering: C. 29 (2009) 663–668. doi: 10.1016/j.msec.2008.10.037.
[16]	A. Haider, S. Haider, I.-K. Kang, A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology, Arabian Journal of Chemistry. 11 (2018) 1165–1188. doi: 10.1016/j.arabjc.2015.11.015.
[17]	H. Nie, A. He, J. Zheng, S. Xu, J. Li, C. C. Han, Effects of chain conformation and entanglement on the electrospinning of pure alginate, Biomacromolecules. 9 (2008) 1362–1365. doi: 10.1021/bm701349j.
[18]	M. Barchuk, P. Čapková, Z. Kolská, J. Matoušek, D. Poustka, L. Šplíchalová, et al., Structure and surface properties of chitosan/PEO/gelatin nanofibrous membrane, Journal of Polymer Research. 23 (2016) 20. doi: 10.1007/s10965-015-0906-0.
[19]	N. Bhattarai, D. Edmondson, O. Veiseh, F. A. Matsen, M. Zhang, Electrospun chitosan-based nanofibers and their cellular compatibility, Biomaterials. 26 (2005) 6176–6184. doi: 10.1016/j.biomaterials.2005.03.027.
[20]	C.-W. Lou, J.-H. Lin, K.-C. Yen, C.-T. Lu, C.-Y. Lee, Preparation of polyethylene oxide/chitosan fiber membranes by electrospinning and the evaluation of biocompatibility, Textile Research Journal. 78 (2008) 254–257. doi: 10.1177/0040517507089752.
[21]	B. Duan, C. Dong, X. Yuan, K. Yao, Electrospinning of chitosan solutions in acetic acid with poly (ethylene oxide), Journal of Biomaterials Science, Polymer Edition. 15 (2004) 797–811. doi: 10.1163/156856204774196171.
[22]	J. Vondran, M. Rodriguez, C. Schauer, W. Sun, Preparation of electrospun chitosan-PEO fibers, in: Proceedings of the IEEE 32nd Annual Northeast Bioengineering Conference, IEEE, Easton, PA, USA, 2006: pp. 87–88. doi: 10.1109/NEBC.2006.1629765.
[23]	A. Subramanian, D. Vu, G. F. Larsen, H.-Y. Lin, Preparation and evaluation of the electrospun chitosan/PEO fibers for potential applications in cartilage tissue engineering, Journal of Biomaterials Science, Polymer Edition. 16 (2005) 861–873. doi: 10.1163/1568562054255682.
[24]	S. G. Kuntzler, J. A. V. Costa, M. G. de Morais, Development of electrospun nanofibers containing chitosan/PEO blend and phenolic compounds with antibacterial activity, International Journal of Biological Macromolecules. 117 (2018) 800–806. doi: 10.1016/j.ijbiomac.2018.05.224.
[25]	R. W. J. Millner, A. S. Lockhart, H. Bird, C. Alexiou, A new hemostatic agent: Initial life-saving experience with Celox (chitosan) in cardiothoracic surgery, The Annals of Thoracic Surgery. 87 (2009) e13–e14. doi: 10.1016/j.athoracsur.2008.09.046.
[26]	T. T. Yuan, A. M. DiGeorge Foushee, M. C. Johnson, A. R. Jockheck-Clark, J. M. Stahl, Development of electrospun chitosan-polyethylene oxide/fibrinogen biocomposite for potential wound healing applications, Nanoscale Research Letters. 13 (2018). doi: 10.1186/s11671-018-2491-8.
[27]	M. A. Zarandi, P. Zahedi, I. Rezaeian, A. Salehpour, M. Gholami, B. Motealleh, Drug release, cell adhesion and wound healing evaluations of electrospun carboxymethyl chitosan/polyethylene oxide nanofibres containing phenytoin sodium and vitamin C, IET Nanobiotechnology. 9 (2015) 191–200. doi: 10.1049/iet-nbt.2014.0030.
[28]	B. Veleirinho, F. V. Berti, P. F. Dias, M. Maraschin, R. M. Ribeiro-do-Valle, J. A. Lopes-da-Silva, Manipulation of chemical composition and architecture of non-biodegradable poly (ethylene terephthalate)/chitosan fibrous scaffolds and their effects on L929 cell behavior, Materials Science and Engineering: C. 33 (2013) 37–46. doi: 10.1016/j.msec.2012.07.047.
[29]	A. C. Alavarse, F. W. de Oliveira Silva, J. T. Colque, V. M. da Silva, T. Prieto, E. C. Venancio, et al., Tetracycline hydrochloride-loaded electrospun nanofibers mats based on PVA and chitosan for wound dressing, Materials Science and Engineering: C. 77 (2017) 271–281. doi: 10.1016/j.msec.2017.03.199.
[30]	X. Wang, F. Cheng, J. Gao, L. Wang, Antibacterial wound dressing from chitosan/polyethylene oxide nanofibers mats embedded with silver nanoparticles, Journal of Biomaterials Applications. 29 (2015) 1086–1095. doi: 10.1177/0885328214554665.
[31]	A. Zarghami, M. Irani, A. Mostafazadeh, M. Golpour, A. Heidarinasab, I. Haririan, Fabrication of PEO/chitosan/PCL/olive oil nanofibrous scaffolds for wound dressing applications, Fibers and Polymers. 16 (2015) 1201–1212. doi: 10.1007/s12221-015-1201-8.

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Sameer Sapkota, Shih-Feng Chou. (2020). Electrospun Chitosan-based Fibers for Wound Healing Applications. Journal of Biomaterials, 4(2), 51-57. https://doi.org/10.11648/j.jb.20200402.13

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ACS Style

Sameer Sapkota; Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J. Biomater. 2020, 4(2), 51-57. doi: 10.11648/j.jb.20200402.13

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AMA Style

Sameer Sapkota, Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J Biomater. 2020;4(2):51-57. doi: 10.11648/j.jb.20200402.13

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@article{10.11648/j.jb.20200402.13,
  author = {Sameer Sapkota and Shih-Feng Chou},
  title = {Electrospun Chitosan-based Fibers for Wound Healing Applications},
  journal = {Journal of Biomaterials},
  volume = {4},
  number = {2},
  pages = {51-57},
  doi = {10.11648/j.jb.20200402.13},
  url = {https://doi.org/10.11648/j.jb.20200402.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20200402.13},
  abstract = {Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.},
 year = {2020}
}

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TY  - JOUR
T1  - Electrospun Chitosan-based Fibers for Wound Healing Applications
AU  - Sameer Sapkota
AU  - Shih-Feng Chou
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.jb.20200402.13
DO  - 10.11648/j.jb.20200402.13
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 51
EP  - 57
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20200402.13
AB  - Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.
VL  - 4
IS  - 2
ER  -

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Author Information

Sameer Sapkota

Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, Texas, USA
Shih-Feng Chou

Department of Mechanical Engineering, College of Engineering, The University of Texas at Tyler, Tyler, Texas, USA

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APA Style

Sameer Sapkota, Shih-Feng Chou. (2020). Electrospun Chitosan-based Fibers for Wound Healing Applications. Journal of Biomaterials, 4(2), 51-57. https://doi.org/10.11648/j.jb.20200402.13

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ACS Style

Sameer Sapkota; Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J. Biomater. 2020, 4(2), 51-57. doi: 10.11648/j.jb.20200402.13

Copy | Download

AMA Style

Sameer Sapkota, Shih-Feng Chou. Electrospun Chitosan-based Fibers for Wound Healing Applications. J Biomater. 2020;4(2):51-57. doi: 10.11648/j.jb.20200402.13

Copy | Download

@article{10.11648/j.jb.20200402.13,
  author = {Sameer Sapkota and Shih-Feng Chou},
  title = {Electrospun Chitosan-based Fibers for Wound Healing Applications},
  journal = {Journal of Biomaterials},
  volume = {4},
  number = {2},
  pages = {51-57},
  doi = {10.11648/j.jb.20200402.13},
  url = {https://doi.org/10.11648/j.jb.20200402.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20200402.13},
  abstract = {Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.},
 year = {2020}
}

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TY  - JOUR
T1  - Electrospun Chitosan-based Fibers for Wound Healing Applications
AU  - Sameer Sapkota
AU  - Shih-Feng Chou
Y1  - 2020/12/04
PY  - 2020
N1  - https://doi.org/10.11648/j.jb.20200402.13
DO  - 10.11648/j.jb.20200402.13
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 51
EP  - 57
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20200402.13
AB  - Chitosan, a natural-occurring biopolymer, is biocompatible to tissues with excellent antibacterial and hemostatic properties, which makes it a great candidate among wound dressing materials. In this paper, electrospun fiber-based wound dressings from blend chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers were reviewed. The incorporation of these water-soluble copolymers allows the entanglement of the rigid chitosan molecular chains during electrospinning leading to the production of continuous nonwoven fibers having average diameters ranging from several tenths to hundredths of nanometers. Increasing chitosan composition in the fibers improves the bulk mechanical strength of the fiber mats due to the rigid molecular structure of chitosan. The nano-sized pores within the fiber mats promote permeability of the fiber dressings, which further enhances the exchange of oxygen and nutrients with outside environment. In addition, the porous fiber mat structure facilitates the absorption of wound exudates while reducing the possibility of bacterial infections. Several studies in antibacterial and anti-inflammatory responses of chitosan-based electrospun fibers were discussed in this short review. More importantly, inclusions of small molecule drugs and/or biological agents are possible in chitosan-based electrospun fibers, which provide a multi-purpose treatment capability for wound healing applications.
VL  - 4
IS  - 2
ER  -

Copy | Download