Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with <i>Schistosoma mansoni</i>

Fayez A. Bakry; Somaya M Ismail

doi:doi:10.11648/j.jb.20170101.12

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Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni

Fayez A. Bakry, Somaya M Ismail

Published in Journal of Biomaterials (Volume 1, Issue 1)

Received: 7 March 2017 Accepted: 29 March 2017 Published: 3 May 2017

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Abstract

This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.

Published in	Journal of Biomaterials (Volume 1, Issue 1)
DOI	10.11648/j.jb.20170101.12
Page(s)	10-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Phoenix dactylifera, Zingiber officinal, Schistosoma mansoni, Male Mice, Glycolytic Enzymes,Histological Changes

References

[1]	King CH, Dickman K, Tisch DJ(2005) Reassessment of the cost of chronic helminthic infection: a meta-analysis of disability- related outcomes in endemic schistosomiasi. Lancet 365: 1561-1569.
[2]	Gryseels B, Polman K, Clerinx J, Kestens L(2006) Human schistosomiasi. Lancet 368: 1106-18.
[3]	Steinmann P, Keiser J, Bos R, Tanner M, Utzinger J. (2006) Schistosomiasis and water resources development: Systematic review, meta-analysis and estimates of people at risk. Lancet infec. Dis 6:411-25.
[4]	Sayed AA, Simeonov A, Thomas CJ, Inglese J, Austin CP, Williams DL.(2008) Identification of oxadiazoles as new drug leads for the control of schistosomiasis. Nat Med, 4: 407-412.
[5]	Greenberg RM (2005). Are Ca²⁺ channels target of praziquantel action? Int J Parasitol, 35: 1-9.
[6]	Utzinger J, Keiser J. (2004) Schistosomiasis and soil-transmitted helminthiasis: common drugs for treatment and control. Expert Opin.Pharmacother 5, 263-285.
[7]	World Health Organization(2006) Preventive chemotherapy in human helminthiasis. World Health Organization, Geneva, Switzerland.
[8]	World Health Organization(2011) Schistosomiasis: number of people treated in 2009. Wkly. Epidemiol. Rec.86: 73-80.
[9]	Xiao SH, Yue WJ, Yang YO, You JQ (1987): Susceptibility of Schistosomajaponicumto different developmental stages to praziquantel. Chin. Med J 100: 759-768.
[10]	Caffrey CR. (2007) Chemotherapy of schistosomiasis: present and fyture. Curr Opin Chem Biol 11: 433-99.influences of IL-1, IL-18 and HMGB1, Cytokine69(1): 136–145.
[11]	Hoareau L, Dasilva EJ (1996), Medicinal plant: a re-emerging health aid. Electron J Biotecnol 2: 60-5.
[12]	Tanwer BS, Vijayvergia R (2010): Phytochemical evaluation and quantification of primary metabolites of Alangiumsalviifolium. Int J Pharm Biosci 1: 1-6.
[13]	Kamel EG, EL-Emam MA, Mahmoud SS, Fouda FM, Bayoumy FE (2011): Parasitological and biochemical parameters in Schistosomamansoni infected mice treated with methanol extract from the plant Chenopodiumambrosioides, Conyzadioscorides and Sesbaniasesban. Parasitol. Int J 60: 388-392.
[14]	Aly HF, Mantawy MM (2013): Efficiency of ginger (Zingiberofficinale) against Schistosomamansoni infection during host parasit association. Parasitol. Int J 62: 380-389.
[15]	MCClintock E.(2007) Arecaceae palm family. The Jepson Manual: http:// ucjeps.berkeley.edu/cgi-bin/get_JM_treatment.pl? Phoenix dactylifera (Accessed on October 18, 2007).
[16]	Barreveld WH. (2007) Date Palm Products. FAO Agricultural Services Bulletin No. 101. (http://www.fao.org/docrep/t0681E/t0681e00. htm#con). (Accessed on October 18, 2007).
[17]	Hamada JS, Hashim IB, Sharif FA(2002) Preliminary analysis and potential uses of date pits in foods. Food Chem 76: 135–7.
[18]	Afifi M, Abdou F, El-Sayed M. (1966).Date stone meal as a substitute for barley in chick rations. Trop. Agric; 43: 12–7.
[19]	Jumah HF, Al-Azzawi II, Al-Hashimi SA(1973). Some nutritional aspects of feeding ground date pits for broilers. Mesopotamia J Agric 8: 139–45.
[20]	Kamel BS, Diab MF, Ilian MA, Salman AJ. Nutritional value of whole dates and date pits in broiler rations. Poult Sci 1981; 60: 1005–11.
[21]	Hussein AS, Alhadrami GA (2003) Effect of enzyme supplementation and diets containing date pits on growth and feed utilization of broiler chicks. Agric Mar Sci8: 67–71.
[22]	Elgasim EA, Alyousif YA, Homeida AM(1992) Possible hormonal activity of date pits and flesh fed to meat animals. Food Chem52: 149–50.
[23]	Ali BH, Bashir AK, Al Hadrami G. (1999) Reproductive hormonal status of rats treated with date pits. Food Chem; 66: 437–41.
[24]	Marzouk HA, Kassem HA (2011). Improving fruit quality, nutritional value and yield of Zaghloul dates by the application of organic and/or mineral fertilizers. Scientia Horticulturae.127: 249–54.
[25]	Al-Farsi MA, Lee CY. (2008). Nutritional and functional properties of dates: a review. Crit Rev Food Sci Nutr. 48:877–87.
[26]	Al-Humaid AI, Mousa HM, El-Mergawi RA, Abdel-Salam AM. (2010) Chemical composition and antioxidant activity of dates and datecamel- milk mixtures as a protective meal against lipid peroxidation in rats.Am J Food Tech.5:22–30.
[27]	Goto C, Kasuya S, Koga K, Ohtomo H, Kagei N (1990). ethal efficacy of extract from Zingiberofficinale(traditional Chinese medicine)or [6]-shogaol and [6]-gingerol in Anisakis larvae in vitro. Parasitol. Res. 76:653–656.
[28]	Islam MS, Choi H (2008). Comparative effects of dietary ginger (Zingiber officinale) and garlic (Allium sativum) investigated in a type diabetes model of rats. J. Med. Food. 11:152–159.
[29]	Adewunmi CO, Oguntimein BO, Furu P (1990). Molluscicidal and 1492 J. Med. Plants Res. antischistosomal activities of Zingiber officinale. Planta. Med. 56: 374– 37.
[30]	Ali B H, Blunden G, Tanira M O, Nemmar A (2008). Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research. Food Chem. Toxicol. 46:409–420.
[31]	Hierro I, Valero A, Perez P, Gonzalez P, Cabo MM, Montilla MP, Navarro MC ( 2004). Action of different monoterpenic compounds against Anisakis simplex s.l,L3 larvae. Phytomedicine 11:77–82.
[32]	Holland JC, Pellegrino J, Cozinelli F (1974): Infection of mice with cercariae, schistosomula of S. mansoniby intravenous and subcutaneous routes. Rev Inst Med Trop Sao Paulo 16: 132-4.
[33]	Ahui MLB, Champy P, Ramadan A, Pham Van L, Araujo L, André K, Diem S, Damotte D, Kati-Coulibaly S, Michel Atté Offoumou M A, Dy M, Thieblemont N, Herbelin A (2008). Ginger prevents Th2-mediated immune responses in a mouse model of airway inflammation. Int. Immunopharmacol. 8:1626–1632.
[34]	Al-Qarawi AA, Mousa HM, Ali BEH, Abdel-Rahman H, El-Mougy AA (2004) Protective effect of extracts from dates (Phoenix dactylifera L.) on carbon tetrachloride–induced hepatotoxicity in rats. Int J Appl Res Vet Med 2: 176–80.
[35]	Saddiq A A, Bawazir A E. (2010) Antimicrobial Activity of Date Palm (Phoenix dactylifera) Pits extracts its role in reducing side effect of Methyl prednisolone on the someNeurotransmitter content in the Brain, Hormone Testosterone in adulthood. International Society for Horticultural Science (ISHS) 882: 665-690.
[36]	Xiao SH, Mei JY, Jiao PY (2011) Effect of mefloquine administrated orally at single, multiple or combined with artmether, artesunate or praziquantel in treatment of mice infected with Schistosomajaponicum. Parasitol Res 108: 399-406.
[37]	Smithers SE, Terry RJ (1965)The infection of laboratory hosts with cercariae of S. mansoni and recovery of worms. J Parasitol 55: 695- 700.
[38]	Secor WE (1996)Pattern of oogram and ovacount in infected mice with S. mansoni. J Infect Dis 174: 1131- 5.
[39]	Kamel IA, Cheever AW, Elwi A, Mosimann JE, Danner R (1977): S. mansoni and S. haematobium infection in Egyption technique for recovery of worms at necropsy. Am J Trop Med Hyg 26: 696- 701.
[40]	Uyeda, K. & Racker, E. (1965):Regulatory mechanisms in carbohydrate metabolism. VII. Hexokinase and phosphofructokinase. J. Biol. Chem. 240: 4682-4688.
[41]	McManus, D. P. & James, B. L. (1975): Anaerobic glucose metabolism in the digestive gland of Littorina saxatilis rudis (Maton) and the daughter sporocysts Microphallus similis (jag). Comp. Biochem. Physiol. 51(13): 293-297.
[42]	Cabaud, P. & Wroblewski, F. (1958): Colorimetric measurement of lactic dehydrogenase activity of body fluids. Am. J. Clin. Pathol. 30,234.
[43]	King, Y. S. (1974): Cultivation of Bulinus physopsis globsous (Morelt) and Biomphalaria pfeifferi (Krauss) snail hosts of schistosomiasis. Sterkiana, (7): 52-54.
[44]	Reitman, S. and Frankel, S.(1957): A colorimetric method for the determination of serum glutamic oxaloacetic and glutamic pyruvic transaminases. Amer. J. Clin.Pathol.,28:56.
[45]	Litchfield JT, Willcoxon F. (1949): A simplified method of evaluating dose-effect experiments. J PharmacolExpTher 96: 99- 113.
[46]	Ritchie, L. S., Lopez, V. A., Cora, J. M. (1974): prolonged applications of an organotin against Biomphalariaalexandrina and Schistosoma mansoni in molluscicides in Schistosomiasis control: TC. Change Ed Academic press New York and London: ppts: 77 - 88.
[47]	Viyanant,V., Thirachantra,S. and Sornmani,S (1982): The effect of controlled release copper sulphate and tributyltin fluoride on the mortality and infectivity of Schistosoma manson miracidia. Southeast Asian J.Trop .Med. Pub.Hilth., 13(2),225.
[48]	Gawish, F.M. (1997) Evaluation of combination of certain molluscicide against Biomphalaria alexandrina and the free living stages of Schistosoma mansoni. Ph.D. Thesis, Zoology Dep. Girls Coll. For Arts, Sci. & Education, Ain Shams University.
[49]	Mostafa OM, Eid RA, Adly MA (2011): Antischistosomal activity of ginger (Zingiberofficinale) against Schistosomamansoni harbored in C57 mice. Parasitol Res 109: 395- 403.
[50]	Seif el-Din SH, EL-Lakkany NM, Mohamed MA, Hamed MM, Sterner O, Botros SS (2013): Potential effect of the medicinal plants Calotropisprocera, Ficus elastic and Zingiberofficinale against Shistosomamansoni in mice. Pharm Biol, Online: 1-7.
[51]	WHO (1963) Data sheet on pesticides. No.63, Niclosamide. (1963) WHONBC/DC/88.63.
[52]	Bakry F. A., Eleiwa E. M., Taha S. A., and Ismil S. M. (2016). Comparative toxicity of Paraquat herbicide and some plant extracts in Lymnaeanatalensis snails Toxicology and Industrial Health 2016, Vol. 32(1) 143-153.
[53]	Fahmy S. R., Abdel-Ghaffar F., Bakry F. A. , Sayed D. A.(2014).Ecotoxicological Effect of Sublethal Exposure to Zinc Oxide Nanoparticles on Freshwater Snail Biomphalariaalexandrina. Arch Environ ContamToxicol (2014) 67:192–202.
[54]	Bakry F. A., El-Hommossany K., Ismil S. M. (2016). Alterations in the fatty acid profile, antioxidant enzymes and protein pattern of Biomphalaria alexandrina snails exposed to the pesticides Basudin and Selecron Toxicology and Industrial Health, 2016, Vol. 32(4) 666–676.
[55]	Ahmed, S. A. and Gad, M. Z. (1995) Effect of schistosomal infection and its treatment on some key enzymesof glucose metabolism in mice livers Arznein. Forsch, 45, 1324-1330.
[56]	Tielens, A. G. (1997) Biochemistry of Trematode. In: Fried, B. and Graczyk, T.K. Eds., Advances in Trematode Biology, CRC Press, Boca Raton, 309-343.
[57]	Tielens, A. G (1997) Biochemistry of Trematode.In:Advances in Trematode Biology (Fried, B and Graczyk, T. K. Ed). pp 309-343.
[58]	Kuser, P. R; Krauchrenco, S; Antunes, O. A., Polikarpov, I (2000) The high resolution crystal structure of yeast Hexokinase with the correct primary sequence provides new insights into its mechanism of action. J. Biol. Chem. 275, 20814.
[59]	ElAasar A. A; ElMerzabani, M. M; Zakhary, N. I; Farag H. I; Abdeen A. M; Abd El-Salam, I. and Mokhtar, N. M (1989) Biochemical and biophysical studies on schistosomal liver of mice. Egypt. J. Bilh. 11,19.
[60]	El-Shazly, A. M; Soliman, M; ElKalla, M. R; Rezk, H; ElNemr, H. E; Handousa, A. E. and Helmy, M. MStudies on patients with Schistosoma mansoni; HCV and/or typhoid fever. J. Egypt. Soc. Parasitol. 2001, 31, 583.
[61]	Mansour, M. M;, Farid Z, Bassily, S, Salah LH., and Watten, R. H (1982) Serum enzyme tests in Hepatosplenic schistosomiasis. Trans. R. Soc. Trop. Med. Hyg. 76,109.
[62]	Zaidi, S. M. and Banu, N. (2004) Antioxidant potential vitamin A, E and C in modulating oxidative stress in rat brain. Clinica Chimica Acta, 33, 229-340.
[63]	Ajith, T. A., Usha, S. and Nivitha, V. (2007) Ascorbic acid and α-Tocopherol protect renal damage. Clinical and Experimental Nephrology, 9, 24-30.
[64]	Abath FG, Morais CN, Montenegro CE, Wynn TA (2006) Montenegro SM Immunopathogenic mechanisms in schistosomasis: what can be learnt from human studies? Trends Parasitol. 22: 85-91.
[65]	Cassiman D, Lib brecht L, Desnet V, Denef C, Roskams T (2002). Hepatic Stelalte cell/myofibroblast subpopulations in fibrotic human and rat livers. J. Hepatol. 36: 200-209.
[66]	Mann J, Mann DA (2009). Transcriptional regulation of hepatic stellate cells. Advanced drug delivery reviews 61: 497-512.
[67]	Rollino C, GuzmanH, Beltrame G, FerroM, QuattrocchioG, BellisD, QuarelloF (2008) Retroperitoneal fibrosis and schistosomiasis: A causal relationship? Europ. J. Inter. Med., 19: 297 - 299.
[68]	Spicher VM, GeninB, JordanAR, BrandtLR, CoultreCL (2004) Peritoneal schistosomiasis: An unusual Laparoscopic Finding. J. pediat. Surg., 39: 631-633.
[69]	MichaelJD, AnthonyEB (1998)Schistosomiasis. School Biol. Sc., Univ. Wales, Bangor, Gwynedd, UK., pps: 2139-2140.

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Fayez A. Bakry, Somaya M Ismail. (2017). Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. Journal of Biomaterials, 1(1), 10-18. https://doi.org/10.11648/j.jb.20170101.12

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Fayez A. Bakry; Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J. Biomater. 2017, 1(1), 10-18. doi: 10.11648/j.jb.20170101.12

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Fayez A. Bakry, Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J Biomater. 2017;1(1):10-18. doi: 10.11648/j.jb.20170101.12

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@article{10.11648/j.jb.20170101.12,
  author = {Fayez A. Bakry and Somaya M Ismail},
  title = {Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni},
  journal = {Journal of Biomaterials},
  volume = {1},
  number = {1},
  pages = {10-18},
  doi = {10.11648/j.jb.20170101.12},
  url = {https://doi.org/10.11648/j.jb.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20170101.12},
  abstract = {This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.},
 year = {2017}
}

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TY  - JOUR
T1  - Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni
AU  - Fayez A. Bakry
AU  - Somaya M Ismail
Y1  - 2017/05/03
PY  - 2017
N1  - https://doi.org/10.11648/j.jb.20170101.12
DO  - 10.11648/j.jb.20170101.12
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20170101.12
AB  - This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.
VL  - 1
IS  - 1
ER  -

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Author Information

Fayez A. Bakry

Theodor Bilharz Research Institute, Giza, Egypt
Somaya M Ismail

Zoology Department- Faculty of Science, Cairo University, Giza, Egypt

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Fayez A. Bakry, Somaya M Ismail. (2017). Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. Journal of Biomaterials, 1(1), 10-18. https://doi.org/10.11648/j.jb.20170101.12

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ACS Style

Fayez A. Bakry; Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J. Biomater. 2017, 1(1), 10-18. doi: 10.11648/j.jb.20170101.12

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AMA Style

Fayez A. Bakry, Somaya M Ismail. Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni. J Biomater. 2017;1(1):10-18. doi: 10.11648/j.jb.20170101.12

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@article{10.11648/j.jb.20170101.12,
  author = {Fayez A. Bakry and Somaya M Ismail},
  title = {Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni},
  journal = {Journal of Biomaterials},
  volume = {1},
  number = {1},
  pages = {10-18},
  doi = {10.11648/j.jb.20170101.12},
  url = {https://doi.org/10.11648/j.jb.20170101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jb.20170101.12},
  abstract = {This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.},
 year = {2017}
}

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TY  - JOUR
T1  - Impact of Plant Extracts on Parasitological and Histological Parameters of Albino Mice Infected with Schistosoma mansoni
AU  - Fayez A. Bakry
AU  - Somaya M Ismail
Y1  - 2017/05/03
PY  - 2017
N1  - https://doi.org/10.11648/j.jb.20170101.12
DO  - 10.11648/j.jb.20170101.12
T2  - Journal of Biomaterials
JF  - Journal of Biomaterials
JO  - Journal of Biomaterials
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2640-2629
UR  - https://doi.org/10.11648/j.jb.20170101.12
AB  - This study elucidates the potential of the plant extract of Phoenix dactylifera and Zingiber officinal plantsin treating Schistosoma mansoni infected mice. The parasitological parameters, worm burden/mouse, number of ova/g tissue in the liver and intestine and the developmental stages of ova in infected treated mice were determined. In addition, glycolytic enzymes,liver function enzymes and histological changes in liver tissues of infected treated mice were studied.The present results showed a significant reduction in the number of worms in groups treated with plant extracts as well as in the number of mature and live ova in the treated group compared to the infected control group. In addition, the present results showed a significant reduction in Lactate dehydrogenase, Aspartate aminotransferase and alanine aminotransferase enzyme activity in Schistosoma mansoni infected group as compared to the normal, healthy control, while a significant increase was noticed in acid phosphatase, alkaline phosphatase level and other glycolytic enzymes as compared to the normal healthy control. Moreover, treatment of the infected mice with plant extracts recorded no significant difference in the level of liver function enzymes andall glycolytic enzymes as compared to the normal healthy control. A noticeable remark to the effect of Z. officinal and P. Dactylifera pointed out to that there is no side effects on liver function and all glycolytic enzymes and as compared to the normal, healthy control group. In conclusion, plant extracts can be applied clinically as a prophylactic treatment against schistosomiasis together with the ideal antischistosomal drug praziquantel.
VL  - 1
IS  - 1
ER  -

Copy | Download