Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane

Constance Sat Lin Liew; T. Kumaravadivel Dharmalingam; Nik Abdullah Nik Mohamad

doi:doi:10.11648/j.ja.20160402.11

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Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane

Constance Sat Lin Liew, T. Kumaravadivel Dharmalingam, Nik Abdullah Nik Mohamad

Published in Journal of Anesthesiology (Volume 4, Issue 2)

Received: 28 April 2016 Accepted: 10 May 2016 Published: 13 June 2016

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Abstract

This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were divided into 2 groups and this study was done in a double-blind manner. Patients received either Sevoflurane inhalational or Propofol infusion using Marsh model (target plasma concentration of 5 mcg/ml) during operation. All the patients received anaesthesia in a standard practice and blood samples were taken at every hour until completion of operation. The blood samples were tested for acid-base values and lactate level. There are significant differences in the mean values of serum lactate levels at 1^st, 2^nd, 3^rd and 4^th hour of surgery within propofol and sevoflurane group with p value of < 0.05. Nevertheless, when comparing differences in the mean values of serum lactate levels between propofol and sevoflurane group showed no significant difference of serum lactate change with p=0.186. In conclusion, our study shows that short term anaesthesia with sevoflurane is associated with an increase blood lactate levels more than lactate levels observed during high dose propofol anaesthesia.

Published in	Journal of Anesthesiology (Volume 4, Issue 2)
DOI	10.11648/j.ja.20160402.11
Page(s)	5-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Propofol, Sevoflurane, Lactate, Acidosis, Anaesthesia

References

[1]	Bryson, H. M., Fulton, B. R. & Faulds, D. (1995). Propofol. An update of its use in anaesthesia and conscious sedation. Drugs, 50(3), 513-59.
[2]	Smith, I., White, P. F., Nathanson, M. & Gouldson, R. (1994). Propofol. An update on its clinical use. Anesthesiology, 81(4), 1005-43.
[3]	Rozet, I., Tontisirin, N., Vavilala, M. S., Treggiari, M. M., Lee, L. A. & Lam, A. M. (2009). Prolonged propofol anesthesia is not associated with an increase in blood lactate. Anesth Analg, 109(4), 1105-10.
[4]	Luft, F. C. (2001). Lactic acidosis update for critical care clinicians. J Am Soc Nephrol, 12 Suppl 17, S15-9.
[5]	Makaryus, R., Lee, H., Yu, M., Zhang, S., Smith, S. D., Rebecchi, M., Glass, P. S. & Benveniste, H. (2011). The metabolomic profile during isoflurane anesthesia differs from propofol anesthesia in the live rodent brain. J Cereb Blood Flow Metab, 31(6), 1432-42.
[6]	Barash PG, Cullen BF, Stoelting RK (1997). Clinical Anaesthesia. 3^rd edition, 15: 364-71. Lipincott-Raven, New York.
[7]	Robert K. Stoelting, M., Simon C. Hillier, M. B. ChB, Frca 2006. Pharmacology & Physiology In Anaesthetic Practice, Philadelphia, Usa, Lippincott Williams And Wilkins.
[8]	Otterspoor LC, Kalkman CJ, Cremer OL. Update on the propofol infusion syndrome in ICU management of patients with head injury. Curr Opin Anaesthesiol 2008; 21: 544-51.
[9]	A. Bowdle, P. Richebe, L. Lee, R. Rostomily, and P. Gabikian, “Hypertriglyceridemia, lipemia, and elevated liver enzymes associated with prolonged propofol anesthesia for craniotomy,” Therapeutic Drug Monitoring, vol. 36, no. 5, pp. 556–559, 2014.
[10]	Acco A, Comar JF, Bracht A. Metabolic effects in isolated perfused rat liver. Basic Clin Pharmacol Toxicol 2004; 95: 166-74.
[11]	Cravens GT, Packer DL, Johnson ME. Incidence of propofol infusion syndrome during noninvasive radiofrequency ablation for atrial flutter or fibrillation. Anesthesiology. 2007; 106: 1134–1138.

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APA Style

Constance Sat Lin Liew, T. Kumaravadivel Dharmalingam, Nik Abdullah Nik Mohamad. (2016). Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane. International Journal of Anesthesia and Clinical Medicine, 4(2), 5-10. https://doi.org/10.11648/j.ja.20160402.11

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ACS Style

Constance Sat Lin Liew; T. Kumaravadivel Dharmalingam; Nik Abdullah Nik Mohamad. Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane. Int. J. Anesth. Clin. Med. 2016, 4(2), 5-10. doi: 10.11648/j.ja.20160402.11

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AMA Style

Constance Sat Lin Liew, T. Kumaravadivel Dharmalingam, Nik Abdullah Nik Mohamad. Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane. Int J Anesth Clin Med. 2016;4(2):5-10. doi: 10.11648/j.ja.20160402.11

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@article{10.11648/j.ja.20160402.11,
  author = {Constance Sat Lin Liew and T. Kumaravadivel Dharmalingam and Nik Abdullah Nik Mohamad},
  title = {Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {4},
  number = {2},
  pages = {5-10},
  doi = {10.11648/j.ja.20160402.11},
  url = {https://doi.org/10.11648/j.ja.20160402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20160402.11},
  abstract = {This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were divided into 2 groups and this study was done in a double-blind manner. Patients received either Sevoflurane inhalational or Propofol infusion using Marsh model (target plasma concentration of 5 mcg/ml) during operation. All the patients received anaesthesia in a standard practice and blood samples were taken at every hour until completion of operation. The blood samples were tested for acid-base values and lactate level. There are significant differences in the mean values of serum lactate levels at 1st, 2nd, 3rd and 4th hour of surgery within propofol and sevoflurane group with p value of < 0.05. Nevertheless, when comparing differences in the mean values of serum lactate levels between propofol and sevoflurane group showed no significant difference of serum lactate change with p=0.186. In conclusion, our study shows that short term anaesthesia with sevoflurane is associated with an increase blood lactate levels more than lactate levels observed during high dose propofol anaesthesia.},
 year = {2016}
}

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TY  - JOUR
T1  - Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane
AU  - Constance Sat Lin Liew
AU  - T. Kumaravadivel Dharmalingam
AU  - Nik Abdullah Nik Mohamad
Y1  - 2016/06/13
PY  - 2016
N1  - https://doi.org/10.11648/j.ja.20160402.11
DO  - 10.11648/j.ja.20160402.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 5
EP  - 10
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20160402.11
AB  - This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were divided into 2 groups and this study was done in a double-blind manner. Patients received either Sevoflurane inhalational or Propofol infusion using Marsh model (target plasma concentration of 5 mcg/ml) during operation. All the patients received anaesthesia in a standard practice and blood samples were taken at every hour until completion of operation. The blood samples were tested for acid-base values and lactate level. There are significant differences in the mean values of serum lactate levels at 1st, 2nd, 3rd and 4th hour of surgery within propofol and sevoflurane group with p value of < 0.05. Nevertheless, when comparing differences in the mean values of serum lactate levels between propofol and sevoflurane group showed no significant difference of serum lactate change with p=0.186. In conclusion, our study shows that short term anaesthesia with sevoflurane is associated with an increase blood lactate levels more than lactate levels observed during high dose propofol anaesthesia.
VL  - 4
IS  - 2
ER  -

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Author Information

Constance Sat Lin Liew

Department of Anaesthesiology, Universiti Malaysia Sabah, Sabah, Malaysia
T. Kumaravadivel Dharmalingam

Department of Anaesthesiology, Hospital Universiti Sains Malaysia, Kelantan, Malaysia
Nik Abdullah Nik Mohamad

Department of Anaesthesiology, Hospital Universiti Sains Malaysia, Kelantan, Malaysia

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APA Style

Constance Sat Lin Liew, T. Kumaravadivel Dharmalingam, Nik Abdullah Nik Mohamad. (2016). Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane. International Journal of Anesthesia and Clinical Medicine, 4(2), 5-10. https://doi.org/10.11648/j.ja.20160402.11

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ACS Style

Constance Sat Lin Liew; T. Kumaravadivel Dharmalingam; Nik Abdullah Nik Mohamad. Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane. Int. J. Anesth. Clin. Med. 2016, 4(2), 5-10. doi: 10.11648/j.ja.20160402.11

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AMA Style

Constance Sat Lin Liew, T. Kumaravadivel Dharmalingam, Nik Abdullah Nik Mohamad. Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane. Int J Anesth Clin Med. 2016;4(2):5-10. doi: 10.11648/j.ja.20160402.11

Copy | Download

@article{10.11648/j.ja.20160402.11,
  author = {Constance Sat Lin Liew and T. Kumaravadivel Dharmalingam and Nik Abdullah Nik Mohamad},
  title = {Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {4},
  number = {2},
  pages = {5-10},
  doi = {10.11648/j.ja.20160402.11},
  url = {https://doi.org/10.11648/j.ja.20160402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20160402.11},
  abstract = {This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were divided into 2 groups and this study was done in a double-blind manner. Patients received either Sevoflurane inhalational or Propofol infusion using Marsh model (target plasma concentration of 5 mcg/ml) during operation. All the patients received anaesthesia in a standard practice and blood samples were taken at every hour until completion of operation. The blood samples were tested for acid-base values and lactate level. There are significant differences in the mean values of serum lactate levels at 1st, 2nd, 3rd and 4th hour of surgery within propofol and sevoflurane group with p value of < 0.05. Nevertheless, when comparing differences in the mean values of serum lactate levels between propofol and sevoflurane group showed no significant difference of serum lactate change with p=0.186. In conclusion, our study shows that short term anaesthesia with sevoflurane is associated with an increase blood lactate levels more than lactate levels observed during high dose propofol anaesthesia.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Short Term Propofol Anaesthesia Is Not Associated with an Increase in Blood Lactate: A Comparative Study with Sevoflurane
AU  - Constance Sat Lin Liew
AU  - T. Kumaravadivel Dharmalingam
AU  - Nik Abdullah Nik Mohamad
Y1  - 2016/06/13
PY  - 2016
N1  - https://doi.org/10.11648/j.ja.20160402.11
DO  - 10.11648/j.ja.20160402.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 5
EP  - 10
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20160402.11
AB  - This research was conducted considering the fact that today, there are still very few studies comparing Sevoflurane or Target Controlled Infusion using Propofol in term of serum lactate accumulation during general anaesthesia. There were 92 patients aged 18-65 years old, classified under ASA I, were involved in this prospective study. They were divided into 2 groups and this study was done in a double-blind manner. Patients received either Sevoflurane inhalational or Propofol infusion using Marsh model (target plasma concentration of 5 mcg/ml) during operation. All the patients received anaesthesia in a standard practice and blood samples were taken at every hour until completion of operation. The blood samples were tested for acid-base values and lactate level. There are significant differences in the mean values of serum lactate levels at 1st, 2nd, 3rd and 4th hour of surgery within propofol and sevoflurane group with p value of < 0.05. Nevertheless, when comparing differences in the mean values of serum lactate levels between propofol and sevoflurane group showed no significant difference of serum lactate change with p=0.186. In conclusion, our study shows that short term anaesthesia with sevoflurane is associated with an increase blood lactate levels more than lactate levels observed during high dose propofol anaesthesia.
VL  - 4
IS  - 2
ER  -

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