Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain

Siamak Yaghubi; Vahideh Rashtchi; Farzaneh Karamitanha

doi:doi:10.11648/j.ja.20160401.11

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Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain

Siamak Yaghubi, Vahideh Rashtchi, Farzaneh Karamitanha

Published in Journal of Anesthesiology (Volume 4, Issue 1)

Received: 7 March 2016 Accepted: 25 April 2016 Published: 8 June 2016

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Abstract

Background and purpose: The main and the most known complication of intravenous regional anesthesia (IVRA) is systemic toxicity due to local anesthetics that occurs following the accidental tourniquet release immediately after injection. This study aims to evaluate the effect of adding ketamine to lower dose of lidocaine on reducing the dose and side effects of lidocaine. Materials and Methods: In this randomized clinical trial, 60 patients undergoing the surgery of upper limb below the elbow under IVRA were randomly divided into two groups. In group 1 (control group), 40 ml lidocaine 0.5% (200 mg) and in group 2 (intervention group), 40 ml lidocaine 0.25% (100 mg) plus 40 mg of ketamine 0.1% injected intravenously. Outcomes included postoperative pain at 15, 30 and 60 minutes after surgery. The pain of the patients was assessed by using the Visual Analogue Scale (VAS Score). Results: Both groups were comparable in demographic and surgical parameters. The average pain based on the VAS score at 15, 30 and 60 minutes after surgery was similar in both groups and there was no significant difference between the two groups (p> 0.05). Moreover, postoperative complications including unconsciousness, restlessness, dizziness, nausea, vomiting, tinnitus, seizure, delirium and hallucination had no significant differences (p> 0.05). Conclusion: Results of this study showed that the addition of ketamine to lower dose of lidocaine in patients receiving IVRA significantly reduced postoperative pain, and reduces the likelihood of systemic toxicity with lidocaine without causing significant adverse effects.

Published in	Journal of Anesthesiology (Volume 4, Issue 1)
DOI	10.11648/j.ja.20160401.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Regional Anesthesia, Analgesic Effect, Lidocaine, Ketamine

References

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APA Style

Siamak Yaghubi, Vahideh Rashtchi, Farzaneh Karamitanha. (2016). Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain. International Journal of Anesthesia and Clinical Medicine, 4(1), 1-4. https://doi.org/10.11648/j.ja.20160401.11

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ACS Style

Siamak Yaghubi; Vahideh Rashtchi; Farzaneh Karamitanha. Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain. Int. J. Anesth. Clin. Med. 2016, 4(1), 1-4. doi: 10.11648/j.ja.20160401.11

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AMA Style

Siamak Yaghubi, Vahideh Rashtchi, Farzaneh Karamitanha. Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain. Int J Anesth Clin Med. 2016;4(1):1-4. doi: 10.11648/j.ja.20160401.11

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@article{10.11648/j.ja.20160401.11,
  author = {Siamak Yaghubi and Vahideh Rashtchi and Farzaneh Karamitanha},
  title = {Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {4},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ja.20160401.11},
  url = {https://doi.org/10.11648/j.ja.20160401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20160401.11},
  abstract = {Background and purpose: The main and the most known complication of intravenous regional anesthesia (IVRA) is systemic toxicity due to local anesthetics that occurs following the accidental tourniquet release immediately after injection. This study aims to evaluate the effect of adding ketamine to lower dose of lidocaine on reducing the dose and side effects of lidocaine. Materials and Methods: In this randomized clinical trial, 60 patients undergoing the surgery of upper limb below the elbow under IVRA were randomly divided into two groups. In group 1 (control group), 40 ml lidocaine 0.5% (200 mg) and in group 2 (intervention group), 40 ml lidocaine 0.25% (100 mg) plus 40 mg of ketamine 0.1% injected intravenously. Outcomes included postoperative pain at 15, 30 and 60 minutes after surgery. The pain of the patients was assessed by using the Visual Analogue Scale (VAS Score). Results: Both groups were comparable in demographic and surgical parameters. The average pain based on the VAS score at 15, 30 and 60 minutes after surgery was similar in both groups and there was no significant difference between the two groups (p> 0.05). Moreover, postoperative complications including unconsciousness, restlessness, dizziness, nausea, vomiting, tinnitus, seizure, delirium and hallucination had no significant differences (p> 0.05). Conclusion: Results of this study showed that the addition of ketamine to lower dose of lidocaine in patients receiving IVRA significantly reduced postoperative pain, and reduces the likelihood of systemic toxicity with lidocaine without causing significant adverse effects.},
 year = {2016}
}

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TY  - JOUR
T1  - Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain
AU  - Siamak Yaghubi
AU  - Vahideh Rashtchi
AU  - Farzaneh Karamitanha
Y1  - 2016/06/08
PY  - 2016
N1  - https://doi.org/10.11648/j.ja.20160401.11
DO  - 10.11648/j.ja.20160401.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20160401.11
AB  - Background and purpose: The main and the most known complication of intravenous regional anesthesia (IVRA) is systemic toxicity due to local anesthetics that occurs following the accidental tourniquet release immediately after injection. This study aims to evaluate the effect of adding ketamine to lower dose of lidocaine on reducing the dose and side effects of lidocaine. Materials and Methods: In this randomized clinical trial, 60 patients undergoing the surgery of upper limb below the elbow under IVRA were randomly divided into two groups. In group 1 (control group), 40 ml lidocaine 0.5% (200 mg) and in group 2 (intervention group), 40 ml lidocaine 0.25% (100 mg) plus 40 mg of ketamine 0.1% injected intravenously. Outcomes included postoperative pain at 15, 30 and 60 minutes after surgery. The pain of the patients was assessed by using the Visual Analogue Scale (VAS Score). Results: Both groups were comparable in demographic and surgical parameters. The average pain based on the VAS score at 15, 30 and 60 minutes after surgery was similar in both groups and there was no significant difference between the two groups (p> 0.05). Moreover, postoperative complications including unconsciousness, restlessness, dizziness, nausea, vomiting, tinnitus, seizure, delirium and hallucination had no significant differences (p> 0.05). Conclusion: Results of this study showed that the addition of ketamine to lower dose of lidocaine in patients receiving IVRA significantly reduced postoperative pain, and reduces the likelihood of systemic toxicity with lidocaine without causing significant adverse effects.
VL  - 4
IS  - 1
ER  -

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Author Information

Siamak Yaghubi

Department of Anesthesiology, Medical Faculty, Qazvin University of Medical Sciences, Qazvin, Iran
Vahideh Rashtchi

Department of Anesthesiology, School of Nursing and Midwifery, Zanjan University of Medical Sciences, Zanjan, Iran
Farzaneh Karamitanha

Department of Community Medicine, Medical Faculty, Zanjan University of Medical Sciences, Zanjan, Iran

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APA Style

Siamak Yaghubi, Vahideh Rashtchi, Farzaneh Karamitanha. (2016). Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain. International Journal of Anesthesia and Clinical Medicine, 4(1), 1-4. https://doi.org/10.11648/j.ja.20160401.11

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ACS Style

Siamak Yaghubi; Vahideh Rashtchi; Farzaneh Karamitanha. Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain. Int. J. Anesth. Clin. Med. 2016, 4(1), 1-4. doi: 10.11648/j.ja.20160401.11

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AMA Style

Siamak Yaghubi, Vahideh Rashtchi, Farzaneh Karamitanha. Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain. Int J Anesth Clin Med. 2016;4(1):1-4. doi: 10.11648/j.ja.20160401.11

Copy | Download

@article{10.11648/j.ja.20160401.11,
  author = {Siamak Yaghubi and Vahideh Rashtchi and Farzaneh Karamitanha},
  title = {Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {4},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ja.20160401.11},
  url = {https://doi.org/10.11648/j.ja.20160401.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20160401.11},
  abstract = {Background and purpose: The main and the most known complication of intravenous regional anesthesia (IVRA) is systemic toxicity due to local anesthetics that occurs following the accidental tourniquet release immediately after injection. This study aims to evaluate the effect of adding ketamine to lower dose of lidocaine on reducing the dose and side effects of lidocaine. Materials and Methods: In this randomized clinical trial, 60 patients undergoing the surgery of upper limb below the elbow under IVRA were randomly divided into two groups. In group 1 (control group), 40 ml lidocaine 0.5% (200 mg) and in group 2 (intervention group), 40 ml lidocaine 0.25% (100 mg) plus 40 mg of ketamine 0.1% injected intravenously. Outcomes included postoperative pain at 15, 30 and 60 minutes after surgery. The pain of the patients was assessed by using the Visual Analogue Scale (VAS Score). Results: Both groups were comparable in demographic and surgical parameters. The average pain based on the VAS score at 15, 30 and 60 minutes after surgery was similar in both groups and there was no significant difference between the two groups (p> 0.05). Moreover, postoperative complications including unconsciousness, restlessness, dizziness, nausea, vomiting, tinnitus, seizure, delirium and hallucination had no significant differences (p> 0.05). Conclusion: Results of this study showed that the addition of ketamine to lower dose of lidocaine in patients receiving IVRA significantly reduced postoperative pain, and reduces the likelihood of systemic toxicity with lidocaine without causing significant adverse effects.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Comparing the Analgesic Effects of Lidocaine and Lidocaine with Ketamine in Intravenous Regional Anesthesia on Postoperative Pain
AU  - Siamak Yaghubi
AU  - Vahideh Rashtchi
AU  - Farzaneh Karamitanha
Y1  - 2016/06/08
PY  - 2016
N1  - https://doi.org/10.11648/j.ja.20160401.11
DO  - 10.11648/j.ja.20160401.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 1
EP  - 4
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20160401.11
AB  - Background and purpose: The main and the most known complication of intravenous regional anesthesia (IVRA) is systemic toxicity due to local anesthetics that occurs following the accidental tourniquet release immediately after injection. This study aims to evaluate the effect of adding ketamine to lower dose of lidocaine on reducing the dose and side effects of lidocaine. Materials and Methods: In this randomized clinical trial, 60 patients undergoing the surgery of upper limb below the elbow under IVRA were randomly divided into two groups. In group 1 (control group), 40 ml lidocaine 0.5% (200 mg) and in group 2 (intervention group), 40 ml lidocaine 0.25% (100 mg) plus 40 mg of ketamine 0.1% injected intravenously. Outcomes included postoperative pain at 15, 30 and 60 minutes after surgery. The pain of the patients was assessed by using the Visual Analogue Scale (VAS Score). Results: Both groups were comparable in demographic and surgical parameters. The average pain based on the VAS score at 15, 30 and 60 minutes after surgery was similar in both groups and there was no significant difference between the two groups (p> 0.05). Moreover, postoperative complications including unconsciousness, restlessness, dizziness, nausea, vomiting, tinnitus, seizure, delirium and hallucination had no significant differences (p> 0.05). Conclusion: Results of this study showed that the addition of ketamine to lower dose of lidocaine in patients receiving IVRA significantly reduced postoperative pain, and reduces the likelihood of systemic toxicity with lidocaine without causing significant adverse effects.
VL  - 4
IS  - 1
ER  -

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