A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients

Sidharth Sraban Routray; Khagaswar Raut; Debadas Biswal; Kamalakanta Pradhan; Debasis Mishra

doi:doi:10.11648/j.ja.20140204.11

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A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients

Sidharth Sraban Routray, Khagaswar Raut, Debadas Biswal, Kamalakanta Pradhan, Debasis Mishra

Published in Journal of Anesthesiology (Volume 2, Issue 4)

Received: 14 October 2014 Accepted: 22 October 2014 Published: 30 October 2014

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Abstract

Introduction: Endotracheal intubation may create a period of hemodynamic instability in normotensive patients but more so in hypertensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines leading to hypertensive crisis. Objectives: The objective of study is to evaluate and compare the efficacy of fentanyl- clonidine and fentanyl – lidocaine combine in attenuating the stress responses to laryngoscopy and endotracheal intubation in hypertensive patients. Material and Methods: We conducted a prospective, randomized, double-blind study in 40 patients with controlled hypertension. All patients were randomly divided into two groups, fentanyl-clonidine (FC) group and fentanyl – lidocaine (FL) group. The FC group received Fentanyl 2 mcg/kg and clonidine 2mcg/kg and the FL group received lidocaine1.5mg/kg and fentanyl 2mcg/kg , 3 min prior to intubation. Hemodynamic parameters were recorded at baseline, before giving induction agents, and 1, 3 and 5 minutes after endotracheal intubation. Results: There were no significant differences between the two groups regarding hemodynamic parameters like heart rate, systolic blood pressure, diastolic and mean arterial blood pressure at before induction, 1, 3 and 5 minutes after intubation. Conclusions: Both fentanyl – clonidine and fentanyl – lidocaine combine effectively decreased the stress response to endotracheal intubation.

Published in	Journal of Anesthesiology (Volume 2, Issue 4)
DOI	10.11648/j.ja.20140204.11
Page(s)	27-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2014. Published by Science Publishing Group

Keywords

Fentanyl, Hemodynamic Stress, Intubation, Lidocaine, Clonidine

References

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APA Style

Sidharth Sraban Routray, Khagaswar Raut, Debadas Biswal, Kamalakanta Pradhan, Debasis Mishra. (2014). A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. International Journal of Anesthesia and Clinical Medicine, 2(4), 27-31. https://doi.org/10.11648/j.ja.20140204.11

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ACS Style

Sidharth Sraban Routray; Khagaswar Raut; Debadas Biswal; Kamalakanta Pradhan; Debasis Mishra. A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. Int. J. Anesth. Clin. Med. 2014, 2(4), 27-31. doi: 10.11648/j.ja.20140204.11

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AMA Style

Sidharth Sraban Routray, Khagaswar Raut, Debadas Biswal, Kamalakanta Pradhan, Debasis Mishra. A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. Int J Anesth Clin Med. 2014;2(4):27-31. doi: 10.11648/j.ja.20140204.11

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@article{10.11648/j.ja.20140204.11,
  author = {Sidharth Sraban Routray and Khagaswar Raut and Debadas Biswal and Kamalakanta Pradhan and Debasis Mishra},
  title = {A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {2},
  number = {4},
  pages = {27-31},
  doi = {10.11648/j.ja.20140204.11},
  url = {https://doi.org/10.11648/j.ja.20140204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20140204.11},
  abstract = {Introduction: Endotracheal intubation may create a period of hemodynamic instability in normotensive patients but more so in hypertensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines leading to hypertensive crisis. Objectives: The objective of study is to evaluate and compare the efficacy of fentanyl- clonidine and fentanyl – lidocaine combine in attenuating the stress responses to laryngoscopy and endotracheal intubation in hypertensive patients. Material and Methods: We conducted a prospective, randomized, double-blind study in 40 patients with controlled hypertension. All patients were randomly divided into two groups, fentanyl-clonidine (FC) group and fentanyl – lidocaine (FL) group. The FC group received Fentanyl 2 mcg/kg and clonidine 2mcg/kg and the FL group received lidocaine1.5mg/kg and fentanyl 2mcg/kg , 3 min prior to intubation. Hemodynamic parameters were recorded at baseline, before giving induction agents, and 1, 3 and 5 minutes after endotracheal intubation. Results: There were no significant differences between the two groups regarding hemodynamic parameters like heart rate, systolic blood pressure, diastolic and mean arterial blood pressure at before induction, 1, 3 and 5 minutes after intubation. Conclusions: Both fentanyl – clonidine and fentanyl – lidocaine combine effectively decreased the stress response to endotracheal intubation.},
 year = {2014}
}

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TY  - JOUR
T1  - A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients
AU  - Sidharth Sraban Routray
AU  - Khagaswar Raut
AU  - Debadas Biswal
AU  - Kamalakanta Pradhan
AU  - Debasis Mishra
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ja.20140204.11
DO  - 10.11648/j.ja.20140204.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 27
EP  - 31
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20140204.11
AB  - Introduction: Endotracheal intubation may create a period of hemodynamic instability in normotensive patients but more so in hypertensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines leading to hypertensive crisis. Objectives: The objective of study is to evaluate and compare the efficacy of fentanyl- clonidine and fentanyl – lidocaine combine in attenuating the stress responses to laryngoscopy and endotracheal intubation in hypertensive patients. Material and Methods: We conducted a prospective, randomized, double-blind study in 40 patients with controlled hypertension. All patients were randomly divided into two groups, fentanyl-clonidine (FC) group and fentanyl – lidocaine (FL) group. The FC group received Fentanyl 2 mcg/kg and clonidine 2mcg/kg and the FL group received lidocaine1.5mg/kg and fentanyl 2mcg/kg , 3 min prior to intubation. Hemodynamic parameters were recorded at baseline, before giving induction agents, and 1, 3 and 5 minutes after endotracheal intubation. Results: There were no significant differences between the two groups regarding hemodynamic parameters like heart rate, systolic blood pressure, diastolic and mean arterial blood pressure at before induction, 1, 3 and 5 minutes after intubation. Conclusions: Both fentanyl – clonidine and fentanyl – lidocaine combine effectively decreased the stress response to endotracheal intubation.
VL  - 2
IS  - 4
ER  -

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Author Information

Sidharth Sraban Routray

Department of Anesthesiology and Critical Care, SCB Medical college hospital, Cuttack, Odisha, India
Khagaswar Raut

Department of Anesthesiology and Critical Care, SCB Medical college hospital, Cuttack, Odisha, India
Debadas Biswal

Department of Anesthesiology and Critical Care, SCB Medical college hospital, Cuttack, Odisha, India
Kamalakanta Pradhan

Department of Anesthesiology and Critical Care, SCB Medical college hospital, Cuttack, Odisha, India
Debasis Mishra

Department of Anesthesiology and Critical Care, SCB Medical college hospital, Cuttack, Odisha, India

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APA Style

Sidharth Sraban Routray, Khagaswar Raut, Debadas Biswal, Kamalakanta Pradhan, Debasis Mishra. (2014). A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. International Journal of Anesthesia and Clinical Medicine, 2(4), 27-31. https://doi.org/10.11648/j.ja.20140204.11

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ACS Style

Sidharth Sraban Routray; Khagaswar Raut; Debadas Biswal; Kamalakanta Pradhan; Debasis Mishra. A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. Int. J. Anesth. Clin. Med. 2014, 2(4), 27-31. doi: 10.11648/j.ja.20140204.11

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AMA Style

Sidharth Sraban Routray, Khagaswar Raut, Debadas Biswal, Kamalakanta Pradhan, Debasis Mishra. A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients. Int J Anesth Clin Med. 2014;2(4):27-31. doi: 10.11648/j.ja.20140204.11

Copy | Download

@article{10.11648/j.ja.20140204.11,
  author = {Sidharth Sraban Routray and Khagaswar Raut and Debadas Biswal and Kamalakanta Pradhan and Debasis Mishra},
  title = {A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients},
  journal = {International Journal of Anesthesia and Clinical Medicine},
  volume = {2},
  number = {4},
  pages = {27-31},
  doi = {10.11648/j.ja.20140204.11},
  url = {https://doi.org/10.11648/j.ja.20140204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ja.20140204.11},
  abstract = {Introduction: Endotracheal intubation may create a period of hemodynamic instability in normotensive patients but more so in hypertensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines leading to hypertensive crisis. Objectives: The objective of study is to evaluate and compare the efficacy of fentanyl- clonidine and fentanyl – lidocaine combine in attenuating the stress responses to laryngoscopy and endotracheal intubation in hypertensive patients. Material and Methods: We conducted a prospective, randomized, double-blind study in 40 patients with controlled hypertension. All patients were randomly divided into two groups, fentanyl-clonidine (FC) group and fentanyl – lidocaine (FL) group. The FC group received Fentanyl 2 mcg/kg and clonidine 2mcg/kg and the FL group received lidocaine1.5mg/kg and fentanyl 2mcg/kg , 3 min prior to intubation. Hemodynamic parameters were recorded at baseline, before giving induction agents, and 1, 3 and 5 minutes after endotracheal intubation. Results: There were no significant differences between the two groups regarding hemodynamic parameters like heart rate, systolic blood pressure, diastolic and mean arterial blood pressure at before induction, 1, 3 and 5 minutes after intubation. Conclusions: Both fentanyl – clonidine and fentanyl – lidocaine combine effectively decreased the stress response to endotracheal intubation.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - A Comparative Study of Fentanyl –Clonidine and Fentanyl - Lidocaine on Attenuation of Haemodynamic Stress Response to Laryngoscopy and Tracheal Intubation in Hypertensive Patients
AU  - Sidharth Sraban Routray
AU  - Khagaswar Raut
AU  - Debadas Biswal
AU  - Kamalakanta Pradhan
AU  - Debasis Mishra
Y1  - 2014/10/30
PY  - 2014
N1  - https://doi.org/10.11648/j.ja.20140204.11
DO  - 10.11648/j.ja.20140204.11
T2  - International Journal of Anesthesia and Clinical Medicine
JF  - International Journal of Anesthesia and Clinical Medicine
JO  - International Journal of Anesthesia and Clinical Medicine
SP  - 27
EP  - 31
PB  - Science Publishing Group
SN  - 2997-2698
UR  - https://doi.org/10.11648/j.ja.20140204.11
AB  - Introduction: Endotracheal intubation may create a period of hemodynamic instability in normotensive patients but more so in hypertensive patients. Endotracheal intubation produces stimulation of laryngeal and tracheal sensory receptors, resulting in a marked increase in the elaboration of sympathetic amines leading to hypertensive crisis. Objectives: The objective of study is to evaluate and compare the efficacy of fentanyl- clonidine and fentanyl – lidocaine combine in attenuating the stress responses to laryngoscopy and endotracheal intubation in hypertensive patients. Material and Methods: We conducted a prospective, randomized, double-blind study in 40 patients with controlled hypertension. All patients were randomly divided into two groups, fentanyl-clonidine (FC) group and fentanyl – lidocaine (FL) group. The FC group received Fentanyl 2 mcg/kg and clonidine 2mcg/kg and the FL group received lidocaine1.5mg/kg and fentanyl 2mcg/kg , 3 min prior to intubation. Hemodynamic parameters were recorded at baseline, before giving induction agents, and 1, 3 and 5 minutes after endotracheal intubation. Results: There were no significant differences between the two groups regarding hemodynamic parameters like heart rate, systolic blood pressure, diastolic and mean arterial blood pressure at before induction, 1, 3 and 5 minutes after intubation. Conclusions: Both fentanyl – clonidine and fentanyl – lidocaine combine effectively decreased the stress response to endotracheal intubation.
VL  - 2
IS  - 4
ER  -

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