@article{10.11648/j.ijpc.20230905.12,
  author = {Nina Carine Ablé and Deto Ursul Jean-Paul N’guessan and Mariette Désirée Yéhé and Songuigama Coulibaly and Jean-Kisito Kouamé and Claude Bérenger Ngalemo Ngantchouko and Laurent Kipré Séri and Aïsséta Kourouma and Gildas Komenan Gbassi},
  title = {Determination of Analytical Parameters of Some 2-arylvinyl Benzimidazole Derivatives by Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC/MS/MS)},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {9},
  number = {5},
  pages = {67-77},
  doi = {10.11648/j.ijpc.20230905.12},
  url = {https://doi.org/10.11648/j.ijpc.20230905.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20230905.12},
  abstract = {The Benzimidazole nucleus is a heterocyclic with many pharmacological activities due to its pharmacophore power. Given the specific nature of this nucleus, researchers and the pharmaceutical industry are trying to develop new molecules based on it in order to broaden the therapeutic arsenal for recurring diseases throughout the world, and particularly in Africa. The present study aimed to identify and characterize some derivatives of 2-arylvinyl Benzimidazole synthesized by chemists from the Department of medicinal chemistry and Organic Chemistry of the Training and Research Unit of Pharmaceutical and Biological Sciences of the Felix Houphouët Boigny University from Abidjan (Ivory Coast). The technique used to carry out the study was liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). The ZORBAX Eclipse plus C18 type column (2.1 X 50 mm-1.8 µm) was used for the chromatographic separation of the compounds. The majority of compounds were eluted isocratically in the proportions (80%:20%) for ten compounds, (90%:10%) for eight compounds and (75%:25%) for one compound. The mobile phase used to elute the compounds consisted of: (Water + Formic Acid (0.1%) / Acetonitrile + Formic Acid (0.1%)). The elution flow rates were set at 0.30 and 0.45 mL/min and the injection volume was set at 3 µL to separate most of the compounds. The ms/ms detector parameters corresponding to each of these derivatives were also determined and used to deduce the retention time (rt) and mass spectrum (m/z) of each of these derivatives. Of these, eighteen compounds had theoretical molecular weights (Theoretical MW) that were close to their experimental molecular weights (Experimental MW), unlike one compound. Analytical parameters (chromatographic (LC) and ms/ms) were therefore used to identify and characterize the various synthesis products that were the subject of this study.
},
 year = {2023}
}

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TY  - JOUR
T1  - Determination of Analytical Parameters of Some 2-arylvinyl Benzimidazole Derivatives by Liquid Chromatography Coupled with Tandem Mass Spectrometry (LC/MS/MS)
AU  - Nina Carine Ablé
AU  - Deto Ursul Jean-Paul N’guessan
AU  - Mariette Désirée Yéhé
AU  - Songuigama Coulibaly
AU  - Jean-Kisito Kouamé
AU  - Claude Bérenger Ngalemo Ngantchouko
AU  - Laurent Kipré Séri
AU  - Aïsséta Kourouma
AU  - Gildas Komenan Gbassi
Y1  - 2023/11/21
PY  - 2023
N1  - https://doi.org/10.11648/j.ijpc.20230905.12
DO  - 10.11648/j.ijpc.20230905.12
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 67
EP  - 77
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20230905.12
AB  - The Benzimidazole nucleus is a heterocyclic with many pharmacological activities due to its pharmacophore power. Given the specific nature of this nucleus, researchers and the pharmaceutical industry are trying to develop new molecules based on it in order to broaden the therapeutic arsenal for recurring diseases throughout the world, and particularly in Africa. The present study aimed to identify and characterize some derivatives of 2-arylvinyl Benzimidazole synthesized by chemists from the Department of medicinal chemistry and Organic Chemistry of the Training and Research Unit of Pharmaceutical and Biological Sciences of the Felix Houphouët Boigny University from Abidjan (Ivory Coast). The technique used to carry out the study was liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS). The ZORBAX Eclipse plus C18 type column (2.1 X 50 mm-1.8 µm) was used for the chromatographic separation of the compounds. The majority of compounds were eluted isocratically in the proportions (80%:20%) for ten compounds, (90%:10%) for eight compounds and (75%:25%) for one compound. The mobile phase used to elute the compounds consisted of: (Water + Formic Acid (0.1%) / Acetonitrile + Formic Acid (0.1%)). The elution flow rates were set at 0.30 and 0.45 mL/min and the injection volume was set at 3 µL to separate most of the compounds. The ms/ms detector parameters corresponding to each of these derivatives were also determined and used to deduce the retention time (rt) and mass spectrum (m/z) of each of these derivatives. Of these, eighteen compounds had theoretical molecular weights (Theoretical MW) that were close to their experimental molecular weights (Experimental MW), unlike one compound. Analytical parameters (chromatographic (LC) and ms/ms) were therefore used to identify and characterize the various synthesis products that were the subject of this study.

VL  - 9
IS  - 5
ER  - 

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