Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients

Soukaina Haddougui; Salma Bajjouk; Mounia Bouchaar; Mehdi Khamaily; Yassine Mouzari; Karim Reda; Abdelbarre Oubaaz

doi:doi:10.11648/j.ijovs.20220704.12

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Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, Karim Reda, Abdelbarre Oubaaz

Published in International Journal of Ophthalmology & Visual Science (Volume 7, Issue 4)

Received: 11 October 2022 Accepted: 31 October 2022 Published: 11 November 2022

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Abstract

Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.

Published in	International Journal of Ophthalmology & Visual Science (Volume 7, Issue 4)
DOI	10.11648/j.ijovs.20220704.12
Page(s)	106-110
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

POAG, RNFL, Ganglion Cells, Diabetes, Loss

References

[1]	European Glaucoma Society Terminology and Guidelines for Glaucoma. (2017). -Chapter 2: Classification and terminology Supported by the EGS Foundation: Part 1: Foreword; Introduction; Glossary; Chapter 2 Classification and Terminology. Br J Ophthalmol, 101 (5), 73-127. Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004; 363: 1711–20.
[2]	Weinreb RN, Khaw PT. Primary open-angle glaucoma. Lancet. 2004; 363: 1711–20.
[3]	Tham YC, Cheng CY. Associations between chronic systemic diseases and primary open angle glaucoma: an epidemiological perspective. Clin Exp Ophthalmol. 2017; 45: 24–32.
[4]	Song BJ, Aiello LP, Pasquale LR. Presence and Risk Factors for Glaucoma in Patients with Diabetes. Curr Diab Rep. 2016; 16: 124.
[5]	Reusch JE, Manson JE. Management of Type 2 Diabetes in 2017: Getting to Goal. JAMA. 2017; 317: 1015–1016.
[6]	Quigley HA, Addicks EM, Green WR, Maumenee AE. Lésions du nerf optique dans le glaucome humain, II: le site de la blessure et la susceptibilité aux dommages. Arch Ophtalmol. 1981; 99 (4): 635–649.
[7]	Almasieh M, Wilson AM, Morquette B, Cueva Vargas JL, Di Polo A. La base moléculaire de la mort des cellules ganglionnaires rétiniennes dans le glaucome. Prog Retin Eye Res. 2012; 31 (2): 152–181.
[8]	Foxton RH, Finkelstein A, Vijay S, et al. VEGF-A is necessary and sufficient for retinal neuroprotection in models of experimental glaucoma. Am J Pathol. 2013; 182: 1379–90.
[9]	Hernandez C, Dal Monte M, Simo R, Casini G. Neuroprotection as a Therapeutic Target for Diabetic Retinopathy. J Diabetes Res. 2016; 2016: 9508541.
[10]	Gordon MO, Beiser JA, Brandt JD, et al. The Ocular Hypertension Treatment Study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120: 714–20. discussion 829–30.
[11]	Gordon MO, Beiser JA, Kass MA, Ocular Hypertension Treatment Study G Is a history of diabetes mellitus protective against developing primary open-angle glaucoma? Arch Ophthalmol. 2008; 126: 280–1.
[12]	Chopra V, Varma R, Francis BA, et al. Type 2 diabetes mellitus and the risk of open-angle glaucoma the Los Angeles Latino Eye Study. Ophthalmology. 2008; 115: 227–232 e1.
[13]	Investigators A. The Advanced Glaucoma Intervention Study (AGIS): 12. Baseline risk factors for sustained loss of visual field and visual acuity in patients with advanced glaucoma. Am J Ophthalmol. 2002; 134: 499–512.
[14]	Lichter PR, Musch DC, Gillespie BW, et al. Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery. Ophthalmology. 2001; 108: 1943–53.
[15]	Drance S, Anderson DR, Schulzer M, Collaborative Normal-Tension Glaucoma Study G Risk factors for progression of visual field abnormalities in normal-tension glaucoma. Am J Ophthalmol. 2001; 131: 699–708.
[16]	Leske MC, Heijl A, Hyman L, Bengtsson B. Early Manifest Glaucoma Trial: design and baseline data. Ophthalmology. 1999; 106: 2144–53.
[17]	Gardiner SK, Mansberger SL. Effect of Restricting Perimetry Testing Algorithms to Reliable Sensitivities on Test-Retest Variability. Invest Ophthalmol Vis Sci. 2016; 57: 5631–5636.
[18]	Abe RY, Diniz-Filho A, Zangwill LM, et al. The Relative Odds of Progressing by Structural and Functional Tests in Glaucoma. Invest Ophthalmol Vis Sci. 2016 Oct; 57: 421–8.
[19]	Akkaya S, Can E, Ozturk F. Comparison of the corneal biomechanical properties, optic nerve head topographic parameters, and retinal nerve fiber layer thickness measurements in diabetic and non-diabetic primary open-angle glaucoma. Int Ophthalmol. 2016; 36: 727–36.
[20]	Akkaya S, Can E, Ozturk F. Comparison of Optic Nerve Head Topographic Parameters in Patients With Primary Open-Angle Glaucoma With and Without Diabetes Mellitus. J Glaucoma. 2016; 25: 49–53.
[21]	Huiyuan Hou, Takuhei Shoji, [...], and Robert N. Weinreb Progression of Primary Open Angle Glaucoma in Diabetic and Non-diabetic Patients Am J Ophthalmol. 2018 May; 189: 1–9.
[22]	Kong, G. Y. X.; Van Bergen, N. J.; Trounce, I. A.; Crowston, J. G. Mitochondrial dysfunction and glaucoma. J. Glaucoma 2009, 18, 93–100.
[23]	Clermont, A. C.; Bursell, S.-E. Retinal blood flow in diabetes. Microcirculation 2007, 14, 49–61.
[24]	Roberts, M. D.; Grau, V.; Grimm, J.; Reynaud, J.; Bellezza, A. J.; Burgoyne, C. F.; Downs, J. C. Remodeling of the connective tissue microarchitecture of the lamina cribrosa in early experimental glaucoma. Investig. Ophthalmol. Vis. Sci. 2009, 50, 681–690.
[25]	Francis-Sedlak, M. E.; Uriel, S.; Larson, J. C.; Greisler, H. P.; Venerus, D. C.; Brey, E. M. Characterization of type I collagen gels modified by glycation. Biomaterials 2009, 30, 1851–1856.
[26]	Elisaf, M.; Kitsos, G.; Bairaktari, E.; Kalaitzidis, R.; Kalogeropoulos, C.; Psilas, K. Metabolic abnormalities in patients with primary open-angle glaucoma. Acta Ophthalmol. Scand. 2001, 79, 129–132.
[27]	Bonovas, S.; Peponis, V.; Filioussi, K. Diabetes mellitus as a risk factor for primary open-angle glaucoma: A meta-analysis. Diabet. Med. 2004, 21, 609–614.
[28]	Zhou, M.; Wang, W.; Huang, W.; Zhang, X. Diabetes mellitus as a risk factor for open-angle glaucoma: A systematic review and meta-analysis. PLoS ONE 2014, 9, e102972.
[29]	Zhao, Y. X.; Chen, X. W. Diabetes and risk of glaucoma: Systematic review and a Meta-analysis of prospective cohort studies. Int. J. Ophthalmol. 2017, 10, 1430.
[30]	Zhao, D.; Cho, J.; Kim, M. H.; Friedman, D. S.; Guallar, E. Diabetes, fasting glucose, and the risk of glaucoma: A meta-analysis. Ophthalmology 2015, 122, 72–78.
[31]	Rim, T. H.; Lee, S. Y.; Bae, H. W.; Seong, G. J.; Kim, S. S.; Kim, C. Y. Increased risk of open-angle glaucoma among patients with diabetes mellitus: A 10-year follow-up nationwide cohort study. Acta Ophthalmol. 2018, 96, e1025–e1030.
[32]	Kopec, J. A.; Esdaile, J. M. Bias in case-control studies. A review. J. Epidemiol. Community Health 1990, 44, 179–186.
[33]	Kern, Timothy S, and Alistair J Barber. “Retinal ganglion cells in diabetes.” The Journal of physiology vol. 586, 18 (2008): 4401-8. doi: 10.1113/jphysiol.2008.156695.

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APA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. (2022). Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. International Journal of Ophthalmology & Visual Science, 7(4), 106-110. https://doi.org/10.11648/j.ijovs.20220704.12

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ACS Style

Soukaina Haddougui; Salma Bajjouk; Mounia Bouchaar; Mehdi Khamaily; Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int. J. Ophthalmol. Vis. Sci. 2022, 7(4), 106-110. doi: 10.11648/j.ijovs.20220704.12

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AMA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int J Ophthalmol Vis Sci. 2022;7(4):106-110. doi: 10.11648/j.ijovs.20220704.12

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@article{10.11648/j.ijovs.20220704.12,
  author = {Soukaina Haddougui and Salma Bajjouk and Mounia Bouchaar and Mehdi Khamaily and Yassine Mouzari and Karim Reda and Abdelbarre Oubaaz},
  title = {Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {7},
  number = {4},
  pages = {106-110},
  doi = {10.11648/j.ijovs.20220704.12},
  url = {https://doi.org/10.11648/j.ijovs.20220704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20220704.12},
  abstract = {Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.},
 year = {2022}
}

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TY  - JOUR
T1  - Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients
AU  - Soukaina Haddougui
AU  - Salma Bajjouk
AU  - Mounia Bouchaar
AU  - Mehdi Khamaily
AU  - Yassine Mouzari
AU  - Karim Reda
AU  - Abdelbarre Oubaaz
Y1  - 2022/11/11
PY  - 2022
N1  - https://doi.org/10.11648/j.ijovs.20220704.12
DO  - 10.11648/j.ijovs.20220704.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 106
EP  - 110
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20220704.12
AB  - Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.
VL  - 7
IS  - 4
ER  -

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Author Information

Soukaina Haddougui

Department of Ophthalmology, Cheikh Khalifa Ibn Zaid International University Hospital, Casablanca, Morocco
Salma Bajjouk

Department of Ophthalmology, Cheikh Khalifa Ibn Zaid International University Hospital, Casablanca, Morocco
Mounia Bouchaar

Department of Ophthalmology, Cheikh Khalifa Ibn Zaid International University Hospital, Casablanca, Morocco
Mehdi Khamaily

Faculty of Medicine, University Mohamed VI of Health Sciences, Casablanca, Morocco
Yassine Mouzari

Department of Ophtalmology of the Mohamed V Military Teaching Hospital, Rabat, Morocco
Karim Reda

Department of Ophtalmology of the Mohamed V Military Teaching Hospital, Rabat, Morocco
Abdelbarre Oubaaz

Department of Ophtalmology of the Mohamed V Military Teaching Hospital, Rabat, Morocco

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APA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. (2022). Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. International Journal of Ophthalmology & Visual Science, 7(4), 106-110. https://doi.org/10.11648/j.ijovs.20220704.12

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ACS Style

Soukaina Haddougui; Salma Bajjouk; Mounia Bouchaar; Mehdi Khamaily; Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int. J. Ophthalmol. Vis. Sci. 2022, 7(4), 106-110. doi: 10.11648/j.ijovs.20220704.12

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AMA Style

Soukaina Haddougui, Salma Bajjouk, Mounia Bouchaar, Mehdi Khamaily, Yassine Mouzari, et al. Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients. Int J Ophthalmol Vis Sci. 2022;7(4):106-110. doi: 10.11648/j.ijovs.20220704.12

Copy | Download

@article{10.11648/j.ijovs.20220704.12,
  author = {Soukaina Haddougui and Salma Bajjouk and Mounia Bouchaar and Mehdi Khamaily and Yassine Mouzari and Karim Reda and Abdelbarre Oubaaz},
  title = {Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients},
  journal = {International Journal of Ophthalmology & Visual Science},
  volume = {7},
  number = {4},
  pages = {106-110},
  doi = {10.11648/j.ijovs.20220704.12},
  url = {https://doi.org/10.11648/j.ijovs.20220704.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijovs.20220704.12},
  abstract = {Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - Diabete et Primary Open-Angle Glaucoma: Comparison of RNFL Progression and Ganglion Cell Loss in Diabetic and Non-diabetic Primary Open-Angle Glaucoma Patients
AU  - Soukaina Haddougui
AU  - Salma Bajjouk
AU  - Mounia Bouchaar
AU  - Mehdi Khamaily
AU  - Yassine Mouzari
AU  - Karim Reda
AU  - Abdelbarre Oubaaz
Y1  - 2022/11/11
PY  - 2022
N1  - https://doi.org/10.11648/j.ijovs.20220704.12
DO  - 10.11648/j.ijovs.20220704.12
T2  - International Journal of Ophthalmology & Visual Science
JF  - International Journal of Ophthalmology & Visual Science
JO  - International Journal of Ophthalmology & Visual Science
SP  - 106
EP  - 110
PB  - Science Publishing Group
SN  - 2637-3858
UR  - https://doi.org/10.11648/j.ijovs.20220704.12
AB  - Primary open-angle glaucoma is a progressive chronic optic neuropathy, typically bilateral, that occurs after the age of 40 years. It is the second leading cause of irreversible blindness in the world. Primary open-angle glaucoma corresponds to a progressive loss of retinal ganglion cell characterized by an excavation of the optic disc associated with typical visual field defects. Objective of the study: To evaluate the impact of diabetes on the evolution of RNFL thickness and ganglion cell layer in patients followed for primary open-angle glaucoma. Materiels and methods: Our 4-year retrospective study between 2017 and 2021 included 80 patients (160 eyes) with primary open-angle glaucoma divided into 2 comparable groups: the 1st group patients primary open-angle glaucoma without type 2 diabetes mellitus (DM-) and the 2nd group patientsprimary open-angle glaucomawith type 2 diabetes mellitus (DM+). Results: The average age was 59 years for the 1st group and 62 years for the 2nd group, the sex ratio was 1.2 for the 1st group and 1 for the 2nd group, an average follow-up between 3 and 4 years. Concerning the RNFL, the loss for the diabetic group was -3.33µm/year and significantly slower than that in the group with glaucoma alone which was 3.8 µm/year with a p less than 0.001. For ganglion cells, the loss for the diabetic group was 3.2 µm/year is significantly faster than that in the group with glaucoma alone which was -1.56µm/year with a p less than 0.001. Conclusion: Diabetes probably plays a confounding role in relation to RNFL prompting vigilance in the follow-up of primary open-angle glaucoma. A larger longitudinal study with a larger sample size is needed to accurately quantify the impact on RNFL.
VL  - 7
IS  - 4
ER  -

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