Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage

Mohamed Awad Mohamed Hassan; Emad Mohammad Abdelhamid Hassan; Tariq Ahmed Saeed; Ghalib Almesedin; Saggaf Alawi Assaggaf

doi:doi:10.11648/j.ijn.20220601.16

Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage

Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf

Published in International Journal of Neurosurgery (Volume 6, Issue 1)

Received: 27 May 2022 Accepted: 13 June 2022 Published: 21 June 2022

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Abstract

Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.

Published in	International Journal of Neurosurgery (Volume 6, Issue 1)
DOI	10.11648/j.ijn.20220601.16
Page(s)	28-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Third Ventricle, Glioblastoma Multiforme, Haemorrhagic, Acute Hydrocephalus, Cyst

References

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[3]	Sarikafa, Y., Akcakaya, M. O., Sarikafa, S., Ozkaya, F., Akdemir, O., & Celik, S. E. 2015; 26 (3): 147-50. Intraventricular glioblastoma multiforme: Case report. https://doi.org/10.1016/j.neucir.2014.09.001. Neurocirugia (Astur).
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APA Style

Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf. (2022). Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. International Journal of Neurosurgery, 6(1), 28-31. https://doi.org/10.11648/j.ijn.20220601.16

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ACS Style

Mohamed Awad Mohamed Hassan; Emad Mohammad Abdelhamid Hassan; Tariq Ahmed Saeed; Ghalib Almesedin; Saggaf Alawi Assaggaf. Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. Int. J. Neurosurg. 2022, 6(1), 28-31. doi: 10.11648/j.ijn.20220601.16

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AMA Style

Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf. Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. Int J Neurosurg. 2022;6(1):28-31. doi: 10.11648/j.ijn.20220601.16

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@article{10.11648/j.ijn.20220601.16,
  author = {Mohamed Awad Mohamed Hassan and Emad Mohammad Abdelhamid Hassan and Tariq Ahmed Saeed and Ghalib Almesedin and Saggaf Alawi Assaggaf},
  title = {Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage},
  journal = {International Journal of Neurosurgery},
  volume = {6},
  number = {1},
  pages = {28-31},
  doi = {10.11648/j.ijn.20220601.16},
  url = {https://doi.org/10.11648/j.ijn.20220601.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220601.16},
  abstract = {Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.},
 year = {2022}
}

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TY  - JOUR
T1  - Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage
AU  - Mohamed Awad Mohamed Hassan
AU  - Emad Mohammad Abdelhamid Hassan
AU  - Tariq Ahmed Saeed
AU  - Ghalib Almesedin
AU  - Saggaf Alawi Assaggaf
Y1  - 2022/06/21
PY  - 2022
N1  - https://doi.org/10.11648/j.ijn.20220601.16
DO  - 10.11648/j.ijn.20220601.16
T2  - International Journal of Neurosurgery
JF  - International Journal of Neurosurgery
JO  - International Journal of Neurosurgery
SP  - 28
EP  - 31
PB  - Science Publishing Group
SN  - 2640-1959
UR  - https://doi.org/10.11648/j.ijn.20220601.16
AB  - Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.
VL  - 6
IS  - 1
ER  -

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Author Information

Mohamed Awad Mohamed Hassan

Neurosurgery Department, King Khalid Hospital, Hail, Kingdom of Saudi Arabia
Emad Mohammad Abdelhamid Hassan

Neurosurgery, King Khalid Hospital, Hail, Kingdom of Saudi Arabia
Tariq Ahmed Saeed

Neurosurerg, King Abdulaziz Airbase Militay Hospital, Kingdom of Saudi Arabia
Ghalib Almesedin

Neurosurgery, King Khalid Hospital, Hail, Kingdom of Saudi Arabia
Saggaf Alawi Assaggaf

Neurosurgery, King Khalid Hospital, Hail, Kingdom of Saudi Arabia

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APA Style

Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf. (2022). Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. International Journal of Neurosurgery, 6(1), 28-31. https://doi.org/10.11648/j.ijn.20220601.16

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ACS Style

Mohamed Awad Mohamed Hassan; Emad Mohammad Abdelhamid Hassan; Tariq Ahmed Saeed; Ghalib Almesedin; Saggaf Alawi Assaggaf. Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. Int. J. Neurosurg. 2022, 6(1), 28-31. doi: 10.11648/j.ijn.20220601.16

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AMA Style

Mohamed Awad Mohamed Hassan, Emad Mohammad Abdelhamid Hassan, Tariq Ahmed Saeed, Ghalib Almesedin, Saggaf Alawi Assaggaf. Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage. Int J Neurosurg. 2022;6(1):28-31. doi: 10.11648/j.ijn.20220601.16

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@article{10.11648/j.ijn.20220601.16,
  author = {Mohamed Awad Mohamed Hassan and Emad Mohammad Abdelhamid Hassan and Tariq Ahmed Saeed and Ghalib Almesedin and Saggaf Alawi Assaggaf},
  title = {Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage},
  journal = {International Journal of Neurosurgery},
  volume = {6},
  number = {1},
  pages = {28-31},
  doi = {10.11648/j.ijn.20220601.16},
  url = {https://doi.org/10.11648/j.ijn.20220601.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220601.16},
  abstract = {Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.},
 year = {2022}
}

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TY  - JOUR
T1  - Cystic Glioblastoma of the Third Ventricle: Diagnostic Challenges and Poor Functional Outcome Related to Cystic Haemorrhage
AU  - Mohamed Awad Mohamed Hassan
AU  - Emad Mohammad Abdelhamid Hassan
AU  - Tariq Ahmed Saeed
AU  - Ghalib Almesedin
AU  - Saggaf Alawi Assaggaf
Y1  - 2022/06/21
PY  - 2022
N1  - https://doi.org/10.11648/j.ijn.20220601.16
DO  - 10.11648/j.ijn.20220601.16
T2  - International Journal of Neurosurgery
JF  - International Journal of Neurosurgery
JO  - International Journal of Neurosurgery
SP  - 28
EP  - 31
PB  - Science Publishing Group
SN  - 2640-1959
UR  - https://doi.org/10.11648/j.ijn.20220601.16
AB  - Background: Glioblastoma multiforme (GBM) is the most common intra-axial primary brain tumour in adults, and prognosis is poor. Spontaneous haemorrhage is an uncommon but recognized initial presenting sign of primary brain tumour. Moreover, intra-cystic haemorrhage is frequent, further can affect functional outcome and even reducing survival duration. Most GBM tumours arise in the frontotemporal region, haemorrhagic cystic GBM arise in the third ventricle of the brain is very rare and create a diagnostic dilemma and surgical challenges. Third ventricular GBM can arise from structures on or near the third ventricle wall. Patients with massive intra-cystic haemorrhage can present with a wide spectrum of clinical signs and symptoms related to increased intracranial pressure (ICP), ranging from headache to sudden acute neurological deterioration, coma, and death. Acute deterioration frequently results from massive acute haemorrhage inside the cystic component leading to hydrocephalus, especially when the tumour mass obstructs the foramen of Monro. Due to high tumour-related mortality and sudden death related to acute hydrocephalus, A high index of suspicion is required to avoid misdiagnosis and delayed surgical treatment due to the atypical anatomic and radiologic presentation of cystic haemorrhagic GBM. This case presentation highlights the significant role of haemorrhage inside the GBM cystic component on both diagnosis and clinical course of the disease.
VL  - 6
IS  - 1
ER  -

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