Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report

Kai-Jie Chia; Cheng-Shyuan Rau; Wu-Fu Chen; Li-Han Lin; Jui-Wei Lin; Jih-Jun Ho

doi:doi:10.11648/j.ijn.20220601.15

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Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report

Kai-Jie Chia, Cheng-Shyuan Rau, Wu-Fu Chen, Li-Han Lin, Jui-Wei Lin, Jih-Jun Ho

Published in International Journal of Neurosurgery (Volume 6, Issue 1)

Received: 5 May 2022 Accepted: 23 May 2022 Published: 31 May 2022

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Abstract

Central neurocytoma (CN) is a rare and elusive tumor. The relationship between clinical outcome, tumor nature, and treatment of CN remains controversial. There were eight CN patients in our hospital from 2014 to 2021, and the prevalence of CN accounted for 0.36% of brain tumors. All of them underwent surgical removal, and two of them were combined with adjuvant radiotherapy (RT). We found that four patients without surgical complications had small tumors (33.0 ± 19.5 cm³), while the other four patients with surgical complications had larger tumors (89.8 ± 14.2 cm³). This suggests that large tumors are prone to surgical complications. One particular patient with a large CN suffered from intraventricular hemorrhage (IVH) caused by damage to the internal cerebral vein (figure 3). Regarding the effect of total removal (TR) and subtotal removal (SR) on surgical complications, two patients with large CNs died of IVH after TR. However, two other patients with large CN had a good prognosis after SR. Regarding the effect of adjuvant RT on surgical complications, one patient with large CN who received RT after SR and one patient with atypical small CN (MIB-1 LI 5.3%) who received RT after TR had a good prognosis without recurrence. Therefore, we suggest SR combined with RT for large CNs in the deep-site ventricle, TR for small CNs, and TR combined with RT for atypical small CNs. Clinical features of patients due to hydrocephalus subsided after surgical treatment. We also review literature and discuss clinical outcomes and treatment associated with CNs. Further investigation with a larger sample size is warranted for the optimal treatment.

Published in	International Journal of Neurosurgery (Volume 6, Issue 1)
DOI	10.11648/j.ijn.20220601.15
Page(s)	23-27
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Central Neurocytoma, MIB-1 Labeling Index, Internal Cerebral Vein, Transcallosal Surgery, Radiotherapy

References

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APA Style

Kai-Jie Chia, Cheng-Shyuan Rau, Wu-Fu Chen, Li-Han Lin, Jui-Wei Lin, et al. (2022). Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report. International Journal of Neurosurgery, 6(1), 23-27. https://doi.org/10.11648/j.ijn.20220601.15

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ACS Style

Kai-Jie Chia; Cheng-Shyuan Rau; Wu-Fu Chen; Li-Han Lin; Jui-Wei Lin, et al. Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report. Int. J. Neurosurg. 2022, 6(1), 23-27. doi: 10.11648/j.ijn.20220601.15

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AMA Style

Kai-Jie Chia, Cheng-Shyuan Rau, Wu-Fu Chen, Li-Han Lin, Jui-Wei Lin, et al. Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report. Int J Neurosurg. 2022;6(1):23-27. doi: 10.11648/j.ijn.20220601.15

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@article{10.11648/j.ijn.20220601.15,
  author = {Kai-Jie Chia and Cheng-Shyuan Rau and Wu-Fu Chen and Li-Han Lin and Jui-Wei Lin and Jih-Jun Ho},
  title = {Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report},
  journal = {International Journal of Neurosurgery},
  volume = {6},
  number = {1},
  pages = {23-27},
  doi = {10.11648/j.ijn.20220601.15},
  url = {https://doi.org/10.11648/j.ijn.20220601.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220601.15},
  abstract = {Central neurocytoma (CN) is a rare and elusive tumor. The relationship between clinical outcome, tumor nature, and treatment of CN remains controversial. There were eight CN patients in our hospital from 2014 to 2021, and the prevalence of CN accounted for 0.36% of brain tumors. All of them underwent surgical removal, and two of them were combined with adjuvant radiotherapy (RT). We found that four patients without surgical complications had small tumors (33.0 ± 19.5 cm³), while the other four patients with surgical complications had larger tumors (89.8 ± 14.2 cm³). This suggests that large tumors are prone to surgical complications. One particular patient with a large CN suffered from intraventricular hemorrhage (IVH) caused by damage to the internal cerebral vein (figure 3). Regarding the effect of total removal (TR) and subtotal removal (SR) on surgical complications, two patients with large CNs died of IVH after TR. However, two other patients with large CN had a good prognosis after SR. Regarding the effect of adjuvant RT on surgical complications, one patient with large CN who received RT after SR and one patient with atypical small CN (MIB-1 LI 5.3%) who received RT after TR had a good prognosis without recurrence. Therefore, we suggest SR combined with RT for large CNs in the deep-site ventricle, TR for small CNs, and TR combined with RT for atypical small CNs. Clinical features of patients due to hydrocephalus subsided after surgical treatment. We also review literature and discuss clinical outcomes and treatment associated with CNs. Further investigation with a larger sample size is warranted for the optimal treatment.},
 year = {2022}
}

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TY - JOUR
T1 - Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report
AU - Kai-Jie Chia
AU - Cheng-Shyuan Rau
AU - Wu-Fu Chen
AU - Li-Han Lin
AU - Jui-Wei Lin
AU - Jih-Jun Ho
Y1 - 2022/05/31
PY - 2022
N1 - https://doi.org/10.11648/j.ijn.20220601.15
DO - 10.11648/j.ijn.20220601.15
T2 - International Journal of Neurosurgery
JF - International Journal of Neurosurgery
JO - International Journal of Neurosurgery
SP - 23
EP - 27
PB - Science Publishing Group
SN - 2640-1959
UR - https://doi.org/10.11648/j.ijn.20220601.15
AB - Central neurocytoma (CN) is a rare and elusive tumor. The relationship between clinical outcome, tumor nature, and treatment of CN remains controversial. There were eight CN patients in our hospital from 2014 to 2021, and the prevalence of CN accounted for 0.36% of brain tumors. All of them underwent surgical removal, and two of them were combined with adjuvant radiotherapy (RT). We found that four patients without surgical complications had small tumors (33.0 ± 19.5 cm³), while the other four patients with surgical complications had larger tumors (89.8 ± 14.2 cm³). This suggests that large tumors are prone to surgical complications. One particular patient with a large CN suffered from intraventricular hemorrhage (IVH) caused by damage to the internal cerebral vein (figure 3). Regarding the effect of total removal (TR) and subtotal removal (SR) on surgical complications, two patients with large CNs died of IVH after TR. However, two other patients with large CN had a good prognosis after SR. Regarding the effect of adjuvant RT on surgical complications, one patient with large CN who received RT after SR and one patient with atypical small CN (MIB-1 LI 5.3%) who received RT after TR had a good prognosis without recurrence. Therefore, we suggest SR combined with RT for large CNs in the deep-site ventricle, TR for small CNs, and TR combined with RT for atypical small CNs. Clinical features of patients due to hydrocephalus subsided after surgical treatment. We also review literature and discuss clinical outcomes and treatment associated with CNs. Further investigation with a larger sample size is warranted for the optimal treatment.
VL - 6
IS - 1
ER -

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Author Information

Kai-Jie Chia

Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
Cheng-Shyuan Rau

Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
Wu-Fu Chen

Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
Li-Han Lin

Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
Jui-Wei Lin

Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC
Jih-Jun Ho

Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan, ROC

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APA Style

Kai-Jie Chia, Cheng-Shyuan Rau, Wu-Fu Chen, Li-Han Lin, Jui-Wei Lin, et al. (2022). Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report. International Journal of Neurosurgery, 6(1), 23-27. https://doi.org/10.11648/j.ijn.20220601.15

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ACS Style

Kai-Jie Chia; Cheng-Shyuan Rau; Wu-Fu Chen; Li-Han Lin; Jui-Wei Lin, et al. Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report. Int. J. Neurosurg. 2022, 6(1), 23-27. doi: 10.11648/j.ijn.20220601.15

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AMA Style

Kai-Jie Chia, Cheng-Shyuan Rau, Wu-Fu Chen, Li-Han Lin, Jui-Wei Lin, et al. Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report. Int J Neurosurg. 2022;6(1):23-27. doi: 10.11648/j.ijn.20220601.15

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@article{10.11648/j.ijn.20220601.15,
  author = {Kai-Jie Chia and Cheng-Shyuan Rau and Wu-Fu Chen and Li-Han Lin and Jui-Wei Lin and Jih-Jun Ho},
  title = {Central Neurocytoma on the Treatment and Outcome: Clinical Case Series Report},
  journal = {International Journal of Neurosurgery},
  volume = {6},
  number = {1},
  pages = {23-27},
  doi = {10.11648/j.ijn.20220601.15},
  url = {https://doi.org/10.11648/j.ijn.20220601.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20220601.15},
  abstract = {Central neurocytoma (CN) is a rare and elusive tumor. The relationship between clinical outcome, tumor nature, and treatment of CN remains controversial. There were eight CN patients in our hospital from 2014 to 2021, and the prevalence of CN accounted for 0.36% of brain tumors. All of them underwent surgical removal, and two of them were combined with adjuvant radiotherapy (RT). We found that four patients without surgical complications had small tumors (33.0 ± 19.5 cm³), while the other four patients with surgical complications had larger tumors (89.8 ± 14.2 cm³). This suggests that large tumors are prone to surgical complications. One particular patient with a large CN suffered from intraventricular hemorrhage (IVH) caused by damage to the internal cerebral vein (figure 3). Regarding the effect of total removal (TR) and subtotal removal (SR) on surgical complications, two patients with large CNs died of IVH after TR. However, two other patients with large CN had a good prognosis after SR. Regarding the effect of adjuvant RT on surgical complications, one patient with large CN who received RT after SR and one patient with atypical small CN (MIB-1 LI 5.3%) who received RT after TR had a good prognosis without recurrence. Therefore, we suggest SR combined with RT for large CNs in the deep-site ventricle, TR for small CNs, and TR combined with RT for atypical small CNs. Clinical features of patients due to hydrocephalus subsided after surgical treatment. We also review literature and discuss clinical outcomes and treatment associated with CNs. Further investigation with a larger sample size is warranted for the optimal treatment.},
 year = {2022}
}

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