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Spontaneous Resorption of Chronic Subdural Hematoma with Curative Thrombolysis and Atorvastatin

Received: 7 January 2021     Accepted: 14 January 2021     Published: 22 January 2021
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Abstract

The aim of this study is to report a case of chronic subdural hematoma with antivitamin K curative dose, treated by Atorvastatin. Clinical case: A 48-year-old man was admitted for motor deficit of the left complete hemiparesis, associated with dysarthria. He was followed in Neurology and cardiology for ischemic stroke due to atrial fibrillation, and was treated with antivitamin K treatment for 2 years. The clinical examination showed a Glasgow score at 15, a left hemiparesis with left facial paralysis. Sensitivity was preserved. Brain CT-scan showed a right fronto-parietal subacute hematoma with mass effect and a recent ischemic stroke of a central branch of the left middle cerebral artery. Angio-MRI shows an occlusion of the right vertebral artery and right communicating artery. A curative anticoagulation was initiated. Atorvastatin was administered at 20 mg per night for 8 weeks associated with functional rehabilitation. The evolution had been favorable, with the regression of headaches and hemiparesis, however the persistence of facial paralysis. After 8 months, the patient was asymptomatic. Cerebral CT control showed complete regression of subdural hematoma. Conclusion: Atorvastatin may constitute a non-surgical and effective treatment of chronic subdural hematoma among the patients whose curative anticoagulation cannot be interrupted. It is very important to really value the report risks / profits of every therapeutic option before making a decision.

Published in International Journal of Neurosurgery (Volume 5, Issue 1)
DOI 10.11648/j.ijn.20210501.12
Page(s) 4-7
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Chronic Subdural Hematoma, Atorvastatin, Nonsurgical Treatment, Anticoagulant

References
[1] Kumar A, Marabathina NR. The Role of medical treatment in chronic subdural hematoma. Asian J Neurosurg. 2018 13 (4): 975-983.
[2] Liu W, Bakker NA, Groen RJ. Chronic subdural hematoma: a systematic review and meta-analysis of surgical procedures. J Neurosurg. 2014; 121 (3): 665-673.
[3] Chan DYC, Sun TFD, Poon WS. Steroid for chronic subdural hematoma? A prospective phase IIB pilot randomized controlled trial on the use of dexamethasone with surgical drainage for the reduction of recurrence with reoperation. Chinese Neurosurg J 2015; 1: 2.
[4] Jiang R, Zhao S, Wang R, Feng H, Zhang J, Li X and al. Safety and Efficacy of Atorvastatin for Chronic Subdural Hematoma in Chinese Patients. A Randomized Clinical Trial. JAMA Neurol. 2018; 75 (11): 1338-1346.
[5] Brennan PM, Kolias AG, Joannides AJ, Shapey J, Marcus HJ, Gregson BA and al. The management and outcome for patients with chronic subdural hematoma: a prospective, multicenter, observational cohort study in the United Kingdom. J Neurosurg. 2017; 127 (4): 732-739.
[6] Tang R, Shi J, Li X, Zou Y, Wang L, Chen Y and al. Effects of Atorvastatin on Surgical Treatments of Chronic Subdural Hematoma, World Neurosurgery (2018), doi: 10.1016/j.wneu.2018.06.047.
[7] Chan DY, Chan DT, Sun TF, Ng SC, Wong GK, Poon WS. The use of atorvastatin for chronic subdural haematoma: a retrospective cohort comparison study. Br J Neurosurg. 2017; 31: 72-77.
[8] Wang D, Li T, Tian Y, Wang S, Jin C, Wei H and al. Effects of atorvastatin on chronic subdural hematoma: A preliminary report from three medical centers. J Neurol Sci. 2014; 336: 237–42.
[9] Almenawer SA, Farrokhyar F, Hong C, Alhazzani W, Manoranjan B, Yarascavitch B and al. Chronic subdural hematoma management: a systematic review and meta-analysis of 34,829 patients. Ann Surg 2014; 259: 449–57.
[10] Ratre S, Yadav Y, Choudhary S, Parihar V. Spontaneous resolution of chronic subdural haematoma in a patient receiving anticoagulant therapy. J Assoc Physicians India. 2015; 63 (8): 79-80.
[11] Tanaka Y, Ohno K. Chronic subdural hematoma - an up-to-date concept. J Med Dent Sci. 2013; 60: 55–61.
[12] Qiu S, Zhuo W, Sun C, Su Z, Yan A, Shen L. Effects of atorvastatin on chronic subdural hematoma: a systematic review. Medicine (Baltimore). 2017; 96 (26): e7290.
[13] Lee KS. How to treat Chronic Subdural hematoma? Past and Now. J Korean Neurosurg Soc. 2019; 62 (2): 144-152.
[14] Jiang R, Wang D, Poon WS and al. Effect of Atorvastatin On Chronic Subdural Hematoma (ATOCH): a study protocol for a randomized controlled trial. Trials 2015; 16: 528.
[15] Xu M, Chen P, Zhu X and al. Effects of atorvastatin on conservative and surgical treatments of chronic subdural hematoma in patients. World Neurosurg 2016; 91: 23–8.
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  • APA Style

    Ouiminga Habib Abdoul Karim, Kabore Raphael Marie, Li Mengyou, Sankara Desire Harouna, Wang Hongbo, et al. (2021). Spontaneous Resorption of Chronic Subdural Hematoma with Curative Thrombolysis and Atorvastatin. International Journal of Neurosurgery, 5(1), 4-7. https://doi.org/10.11648/j.ijn.20210501.12

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    ACS Style

    Ouiminga Habib Abdoul Karim; Kabore Raphael Marie; Li Mengyou; Sankara Desire Harouna; Wang Hongbo, et al. Spontaneous Resorption of Chronic Subdural Hematoma with Curative Thrombolysis and Atorvastatin. Int. J. Neurosurg. 2021, 5(1), 4-7. doi: 10.11648/j.ijn.20210501.12

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    AMA Style

    Ouiminga Habib Abdoul Karim, Kabore Raphael Marie, Li Mengyou, Sankara Desire Harouna, Wang Hongbo, et al. Spontaneous Resorption of Chronic Subdural Hematoma with Curative Thrombolysis and Atorvastatin. Int J Neurosurg. 2021;5(1):4-7. doi: 10.11648/j.ijn.20210501.12

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  • @article{10.11648/j.ijn.20210501.12,
      author = {Ouiminga Habib Abdoul Karim and Kabore Raphael Marie and Li Mengyou and Sankara Desire Harouna and Wang Hongbo and Rabo Rasmane and Sakine Habiba Amira and Gaye Magatte},
      title = {Spontaneous Resorption of Chronic Subdural Hematoma with Curative Thrombolysis and Atorvastatin},
      journal = {International Journal of Neurosurgery},
      volume = {5},
      number = {1},
      pages = {4-7},
      doi = {10.11648/j.ijn.20210501.12},
      url = {https://doi.org/10.11648/j.ijn.20210501.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijn.20210501.12},
      abstract = {The aim of this study is to report a case of chronic subdural hematoma with antivitamin K curative dose, treated by Atorvastatin. Clinical case: A 48-year-old man was admitted for motor deficit of the left complete hemiparesis, associated with dysarthria. He was followed in Neurology and cardiology for ischemic stroke due to atrial fibrillation, and was treated with antivitamin K treatment for 2 years. The clinical examination showed a Glasgow score at 15, a left hemiparesis with left facial paralysis. Sensitivity was preserved. Brain CT-scan showed a right fronto-parietal subacute hematoma with mass effect and a recent ischemic stroke of a central branch of the left middle cerebral artery. Angio-MRI shows an occlusion of the right vertebral artery and right communicating artery. A curative anticoagulation was initiated. Atorvastatin was administered at 20 mg per night for 8 weeks associated with functional rehabilitation. The evolution had been favorable, with the regression of headaches and hemiparesis, however the persistence of facial paralysis. After 8 months, the patient was asymptomatic. Cerebral CT control showed complete regression of subdural hematoma. Conclusion: Atorvastatin may constitute a non-surgical and effective treatment of chronic subdural hematoma among the patients whose curative anticoagulation cannot be interrupted. It is very important to really value the report risks / profits of every therapeutic option before making a decision.},
     year = {2021}
    }
    

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  • TY  - JOUR
    T1  - Spontaneous Resorption of Chronic Subdural Hematoma with Curative Thrombolysis and Atorvastatin
    AU  - Ouiminga Habib Abdoul Karim
    AU  - Kabore Raphael Marie
    AU  - Li Mengyou
    AU  - Sankara Desire Harouna
    AU  - Wang Hongbo
    AU  - Rabo Rasmane
    AU  - Sakine Habiba Amira
    AU  - Gaye Magatte
    Y1  - 2021/01/22
    PY  - 2021
    N1  - https://doi.org/10.11648/j.ijn.20210501.12
    DO  - 10.11648/j.ijn.20210501.12
    T2  - International Journal of Neurosurgery
    JF  - International Journal of Neurosurgery
    JO  - International Journal of Neurosurgery
    SP  - 4
    EP  - 7
    PB  - Science Publishing Group
    SN  - 2640-1959
    UR  - https://doi.org/10.11648/j.ijn.20210501.12
    AB  - The aim of this study is to report a case of chronic subdural hematoma with antivitamin K curative dose, treated by Atorvastatin. Clinical case: A 48-year-old man was admitted for motor deficit of the left complete hemiparesis, associated with dysarthria. He was followed in Neurology and cardiology for ischemic stroke due to atrial fibrillation, and was treated with antivitamin K treatment for 2 years. The clinical examination showed a Glasgow score at 15, a left hemiparesis with left facial paralysis. Sensitivity was preserved. Brain CT-scan showed a right fronto-parietal subacute hematoma with mass effect and a recent ischemic stroke of a central branch of the left middle cerebral artery. Angio-MRI shows an occlusion of the right vertebral artery and right communicating artery. A curative anticoagulation was initiated. Atorvastatin was administered at 20 mg per night for 8 weeks associated with functional rehabilitation. The evolution had been favorable, with the regression of headaches and hemiparesis, however the persistence of facial paralysis. After 8 months, the patient was asymptomatic. Cerebral CT control showed complete regression of subdural hematoma. Conclusion: Atorvastatin may constitute a non-surgical and effective treatment of chronic subdural hematoma among the patients whose curative anticoagulation cannot be interrupted. It is very important to really value the report risks / profits of every therapeutic option before making a decision.
    VL  - 5
    IS  - 1
    ER  - 

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Author Information
  • Department of Orthopedics Traumatology and Neurosurgery, Tengandogo Teaching Hospital, Ouagadougou, Burkina Faso

  • Department of Neurology, Tengandogo Teaching Hospital, Ouagadougou, Burkina Faso

  • Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, People's Republic of China

  • Department of Neuro-imagery, Ouagadougou Medical Imaging Center, Ouagadougou, Burkina Faso

  • Department of Orthopedics, Zaozhuang Municipal Hospital, Zaozhuang, People's Republic of China

  • Department of Orthopedics Traumatology and Neurosurgery, Tengandogo Teaching Hospital, Ouagadougou, Burkina Faso

  • Department of Orthopedics Traumatology and Neurosurgery, Tengandogo Teaching Hospital, Ouagadougou, Burkina Faso

  • Department of Neurosurgery, Grand YOFF General Hospital, Dakar, Senegal

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