Lyell syndrome is a rare and potentially fatal condition. It represents a serious cutaneous adverse drug reaction, often caused by drugs. Lyell syndrome and Steven-Johnson syndrome have an identical clinical expression and differ from each other only in the body surface area involved. They are characterized by the sudden destruction and detachment of the epidermis and mucous membranes. This is a drug allergy for which the mechanisms of onset are complex and involve many poorly understood pathophysiological factors. A 3-year-old girl presented with vulvar pruritus and a rash two days after self-medication with antibiotics and paracetamol to combat a fever. Phlyctenes and bullae then developed all over the body. The chronology of the occurrence of the signs, the spread of the lesions led to the diagnosis of Lyell syndrome. Lyell's syndrome is a rare condition and despite its low incidence, it is increasingly reported on the African continent. Although high, its mortality depends on several factors including the age of the patient, gender, and extent of lesions. Multidisciplinary collaboration and follow-up of the sequelae are crucial for the survival of the patient. Lyell syndrome is potentially fatal, but treatable with concerted management even in rural areas. The community and health workers should be warned of the potential danger of self-medication and irrational use of drugs.
| Published in | International Journal of Medical Case Reports (Volume 3, Issue 1) |
| DOI | 10.11648/j.ijmcr.20240301.11 |
| Page(s) | 1-4 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Lyell Syndrome, Children, Drug-Induced Toxic Epidermal Necrolysis, Pharmacovigilance, DR Congo
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APA Style
Ngale, M., Mpengani, T., Velela, P., Mbebo, J., Kilara, T., et al. (2024). A Case of Amoxycillin-Induced Pediatric Lyell Syndrome in a Provincial Hospital in the Democratic Republic of the Congo. International Journal of Medical Case Reports, 3(1), 1-4. https://doi.org/10.11648/j.ijmcr.20240301.11
ACS Style
Ngale, M.; Mpengani, T.; Velela, P.; Mbebo, J.; Kilara, T., et al. A Case of Amoxycillin-Induced Pediatric Lyell Syndrome in a Provincial Hospital in the Democratic Republic of the Congo. Int. J. Med. Case Rep. 2024, 3(1), 1-4. doi: 10.11648/j.ijmcr.20240301.11
AMA Style
Ngale M, Mpengani T, Velela P, Mbebo J, Kilara T, et al. A Case of Amoxycillin-Induced Pediatric Lyell Syndrome in a Provincial Hospital in the Democratic Republic of the Congo. Int J Med Case Rep. 2024;3(1):1-4. doi: 10.11648/j.ijmcr.20240301.11
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author = {Mireille Ngale and Thierry Mpengani and Percy Velela and Jean-Jacques Mbebo and Tarcisse Kilara and Silva Kasereka and Gauthier Mesia and Nsengi Ntamabyaliro and Samuel Mampunza and Gaston Tona},
title = {A Case of Amoxycillin-Induced Pediatric Lyell Syndrome in a Provincial Hospital in the Democratic Republic of the Congo},
journal = {International Journal of Medical Case Reports},
volume = {3},
number = {1},
pages = {1-4},
doi = {10.11648/j.ijmcr.20240301.11},
url = {https://doi.org/10.11648/j.ijmcr.20240301.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijmcr.20240301.11},
abstract = {Lyell syndrome is a rare and potentially fatal condition. It represents a serious cutaneous adverse drug reaction, often caused by drugs. Lyell syndrome and Steven-Johnson syndrome have an identical clinical expression and differ from each other only in the body surface area involved. They are characterized by the sudden destruction and detachment of the epidermis and mucous membranes. This is a drug allergy for which the mechanisms of onset are complex and involve many poorly understood pathophysiological factors. A 3-year-old girl presented with vulvar pruritus and a rash two days after self-medication with antibiotics and paracetamol to combat a fever. Phlyctenes and bullae then developed all over the body. The chronology of the occurrence of the signs, the spread of the lesions led to the diagnosis of Lyell syndrome. Lyell's syndrome is a rare condition and despite its low incidence, it is increasingly reported on the African continent. Although high, its mortality depends on several factors including the age of the patient, gender, and extent of lesions. Multidisciplinary collaboration and follow-up of the sequelae are crucial for the survival of the patient. Lyell syndrome is potentially fatal, but treatable with concerted management even in rural areas. The community and health workers should be warned of the potential danger of self-medication and irrational use of drugs.
},
year = {2024}
}
TY - JOUR T1 - A Case of Amoxycillin-Induced Pediatric Lyell Syndrome in a Provincial Hospital in the Democratic Republic of the Congo AU - Mireille Ngale AU - Thierry Mpengani AU - Percy Velela AU - Jean-Jacques Mbebo AU - Tarcisse Kilara AU - Silva Kasereka AU - Gauthier Mesia AU - Nsengi Ntamabyaliro AU - Samuel Mampunza AU - Gaston Tona Y1 - 2024/01/18 PY - 2024 N1 - https://doi.org/10.11648/j.ijmcr.20240301.11 DO - 10.11648/j.ijmcr.20240301.11 T2 - International Journal of Medical Case Reports JF - International Journal of Medical Case Reports JO - International Journal of Medical Case Reports SP - 1 EP - 4 PB - Science Publishing Group SN - 2994-7049 UR - https://doi.org/10.11648/j.ijmcr.20240301.11 AB - Lyell syndrome is a rare and potentially fatal condition. It represents a serious cutaneous adverse drug reaction, often caused by drugs. Lyell syndrome and Steven-Johnson syndrome have an identical clinical expression and differ from each other only in the body surface area involved. They are characterized by the sudden destruction and detachment of the epidermis and mucous membranes. This is a drug allergy for which the mechanisms of onset are complex and involve many poorly understood pathophysiological factors. A 3-year-old girl presented with vulvar pruritus and a rash two days after self-medication with antibiotics and paracetamol to combat a fever. Phlyctenes and bullae then developed all over the body. The chronology of the occurrence of the signs, the spread of the lesions led to the diagnosis of Lyell syndrome. Lyell's syndrome is a rare condition and despite its low incidence, it is increasingly reported on the African continent. Although high, its mortality depends on several factors including the age of the patient, gender, and extent of lesions. Multidisciplinary collaboration and follow-up of the sequelae are crucial for the survival of the patient. Lyell syndrome is potentially fatal, but treatable with concerted management even in rural areas. The community and health workers should be warned of the potential danger of self-medication and irrational use of drugs. VL - 3 IS - 1 ER -
Kimpese Health Research Centre, Evangelical Medical Institute, Kimpese, DR Congo; Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, DR Congo; National Centre of Pharmacovigilance, Ministry of Health, Kinshasa, DR Congo
Department of Specialties, Otolaryngology Service, University of Kinshasa, Kinshasa, DR Congo; Medical Evangelic Institute, The Church of Christ in the Congo, Kimpese, DR Congo
National Centre of Pharmacovigilance, Ministry of Health, Kinshasa, DR Congo
Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, DR Congo
Dermatology Department of the Uele University Clinics, University of Uele, Isiro, DR Congo
Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, DR Congo
Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, DR Congo; National Centre of Pharmacovigilance, Ministry of Health, Kinshasa, DR Congo
Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, DR Congo
Clinical Pharmacology and Pharmacovigilance Unit, University of Kinshasa, Kinshasa, DR Congo; National Centre of Pharmacovigilance, Ministry of Health, Kinshasa, DR Congo
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