Role of <i>P53</i> p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome

Navneet Kaur; Mohamed Eltom; Karen Cheung; Siddharth Banka; Lamiya Mohiyiddeen

doi:doi:10.11648/j.ijgg.20200803.11

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Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome

Navneet Kaur, Mohamed Eltom, Karen Cheung, Siddharth Banka, Lamiya Mohiyiddeen

Published in International Journal of Genetics and Genomics (Volume 8, Issue 3)

Received: 17 June 2020 Accepted: 27 July 2020 Published: 8 September 2020

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Abstract

The role of p53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome is controversial and research so far has yielded inconsistent results. This systematic review aims to summarise the literature on the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss following natural and assisted conception. A comprehensive literature search was conducted on MEDLINE, EMBASE and CENTRAL electronic databases for literature published between 1998 and April 2020. Inclusion and exclusion criteria and search terms were established. References of retrieved articles were hand searched to identify other relevant papers including conference abstracts. In total, 9 case control studies (1041 patients), 6 case control studies (382 patients) and 7 studies (3403) were included examining the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome respectively. Combined genotype frequencies suggest that there may be an association between Pro/Pro genotype and recurrent pregnancy loss and Arg/Pro genotype and recurrent implantation failure. However, the association between TP53 p.Arg72Pro variant and recurrent pregnancy loss, recurrent implantation failure or IVF outcomes has not been clearly established. In conclusion, genotyping patients for the TP53 variant may enable us to identify an aetiology for patients experiencing unexplained recurrent pregnancy loss and detect individuals at risk of recurrent implantation failure before IVF treatment is initiated. Furthermore, exploring the mechanisms of action of the p53 protein may provide us with an insight into potential treatments.

Published in	International Journal of Genetics and Genomics (Volume 8, Issue 3)
DOI	10.11648/j.ijgg.20200803.11
Page(s)	94-101
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

P53, Gene Polymorphism, Gene Variant, Recurrent Miscarriage, Recurrent Implantation Failure, IVF

References

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APA Style

Navneet Kaur, Mohamed Eltom, Karen Cheung, Siddharth Banka, Lamiya Mohiyiddeen. (2020). Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome. International Journal of Genetics and Genomics, 8(3), 94-101. https://doi.org/10.11648/j.ijgg.20200803.11

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ACS Style

Navneet Kaur; Mohamed Eltom; Karen Cheung; Siddharth Banka; Lamiya Mohiyiddeen. Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome. Int. J. Genet. Genomics 2020, 8(3), 94-101. doi: 10.11648/j.ijgg.20200803.11

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AMA Style

Navneet Kaur, Mohamed Eltom, Karen Cheung, Siddharth Banka, Lamiya Mohiyiddeen. Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome. Int J Genet Genomics. 2020;8(3):94-101. doi: 10.11648/j.ijgg.20200803.11

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@article{10.11648/j.ijgg.20200803.11,
  author = {Navneet Kaur and Mohamed Eltom and Karen Cheung and Siddharth Banka and Lamiya Mohiyiddeen},
  title = {Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome},
  journal = {International Journal of Genetics and Genomics},
  volume = {8},
  number = {3},
  pages = {94-101},
  doi = {10.11648/j.ijgg.20200803.11},
  url = {https://doi.org/10.11648/j.ijgg.20200803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20200803.11},
  abstract = {The role of p53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome is controversial and research so far has yielded inconsistent results. This systematic review aims to summarise the literature on the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss following natural and assisted conception. A comprehensive literature search was conducted on MEDLINE, EMBASE and CENTRAL electronic databases for literature published between 1998 and April 2020. Inclusion and exclusion criteria and search terms were established. References of retrieved articles were hand searched to identify other relevant papers including conference abstracts. In total, 9 case control studies (1041 patients), 6 case control studies (382 patients) and 7 studies (3403) were included examining the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome respectively. Combined genotype frequencies suggest that there may be an association between Pro/Pro genotype and recurrent pregnancy loss and Arg/Pro genotype and recurrent implantation failure. However, the association between TP53 p.Arg72Pro variant and recurrent pregnancy loss, recurrent implantation failure or IVF outcomes has not been clearly established. In conclusion, genotyping patients for the TP53 variant may enable us to identify an aetiology for patients experiencing unexplained recurrent pregnancy loss and detect individuals at risk of recurrent implantation failure before IVF treatment is initiated. Furthermore, exploring the mechanisms of action of the p53 protein may provide us with an insight into potential treatments.},
 year = {2020}
}

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TY  - JOUR
T1  - Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome
AU  - Navneet Kaur
AU  - Mohamed Eltom
AU  - Karen Cheung
AU  - Siddharth Banka
AU  - Lamiya Mohiyiddeen
Y1  - 2020/09/08
PY  - 2020
N1  - https://doi.org/10.11648/j.ijgg.20200803.11
DO  - 10.11648/j.ijgg.20200803.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 94
EP  - 101
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20200803.11
AB  - The role of p53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome is controversial and research so far has yielded inconsistent results. This systematic review aims to summarise the literature on the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss following natural and assisted conception. A comprehensive literature search was conducted on MEDLINE, EMBASE and CENTRAL electronic databases for literature published between 1998 and April 2020. Inclusion and exclusion criteria and search terms were established. References of retrieved articles were hand searched to identify other relevant papers including conference abstracts. In total, 9 case control studies (1041 patients), 6 case control studies (382 patients) and 7 studies (3403) were included examining the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome respectively. Combined genotype frequencies suggest that there may be an association between Pro/Pro genotype and recurrent pregnancy loss and Arg/Pro genotype and recurrent implantation failure. However, the association between TP53 p.Arg72Pro variant and recurrent pregnancy loss, recurrent implantation failure or IVF outcomes has not been clearly established. In conclusion, genotyping patients for the TP53 variant may enable us to identify an aetiology for patients experiencing unexplained recurrent pregnancy loss and detect individuals at risk of recurrent implantation failure before IVF treatment is initiated. Furthermore, exploring the mechanisms of action of the p53 protein may provide us with an insight into potential treatments.
VL  - 8
IS  - 3
ER  -

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Author Information

Navneet Kaur

Department of Reproductive Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Mohamed Eltom

Department of Reproductive Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Karen Cheung

Department of Reproductive Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Siddharth Banka

Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom
Lamiya Mohiyiddeen

Department of Reproductive Medicine, Manchester University NHS Foundation Trust, Manchester, United Kingdom

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APA Style

Navneet Kaur, Mohamed Eltom, Karen Cheung, Siddharth Banka, Lamiya Mohiyiddeen. (2020). Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome. International Journal of Genetics and Genomics, 8(3), 94-101. https://doi.org/10.11648/j.ijgg.20200803.11

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ACS Style

Navneet Kaur; Mohamed Eltom; Karen Cheung; Siddharth Banka; Lamiya Mohiyiddeen. Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome. Int. J. Genet. Genomics 2020, 8(3), 94-101. doi: 10.11648/j.ijgg.20200803.11

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AMA Style

Navneet Kaur, Mohamed Eltom, Karen Cheung, Siddharth Banka, Lamiya Mohiyiddeen. Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome. Int J Genet Genomics. 2020;8(3):94-101. doi: 10.11648/j.ijgg.20200803.11

Copy | Download

@article{10.11648/j.ijgg.20200803.11,
  author = {Navneet Kaur and Mohamed Eltom and Karen Cheung and Siddharth Banka and Lamiya Mohiyiddeen},
  title = {Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome},
  journal = {International Journal of Genetics and Genomics},
  volume = {8},
  number = {3},
  pages = {94-101},
  doi = {10.11648/j.ijgg.20200803.11},
  url = {https://doi.org/10.11648/j.ijgg.20200803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20200803.11},
  abstract = {The role of p53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome is controversial and research so far has yielded inconsistent results. This systematic review aims to summarise the literature on the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss following natural and assisted conception. A comprehensive literature search was conducted on MEDLINE, EMBASE and CENTRAL electronic databases for literature published between 1998 and April 2020. Inclusion and exclusion criteria and search terms were established. References of retrieved articles were hand searched to identify other relevant papers including conference abstracts. In total, 9 case control studies (1041 patients), 6 case control studies (382 patients) and 7 studies (3403) were included examining the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome respectively. Combined genotype frequencies suggest that there may be an association between Pro/Pro genotype and recurrent pregnancy loss and Arg/Pro genotype and recurrent implantation failure. However, the association between TP53 p.Arg72Pro variant and recurrent pregnancy loss, recurrent implantation failure or IVF outcomes has not been clearly established. In conclusion, genotyping patients for the TP53 variant may enable us to identify an aetiology for patients experiencing unexplained recurrent pregnancy loss and detect individuals at risk of recurrent implantation failure before IVF treatment is initiated. Furthermore, exploring the mechanisms of action of the p53 protein may provide us with an insight into potential treatments.},
 year = {2020}
}

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TY  - JOUR
T1  - Role of P53 p.Arg72Pro Variant in Recurrent Pregnancy Loss, Recurrent Implantation Failure and IVF Outcome
AU  - Navneet Kaur
AU  - Mohamed Eltom
AU  - Karen Cheung
AU  - Siddharth Banka
AU  - Lamiya Mohiyiddeen
Y1  - 2020/09/08
PY  - 2020
N1  - https://doi.org/10.11648/j.ijgg.20200803.11
DO  - 10.11648/j.ijgg.20200803.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 94
EP  - 101
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20200803.11
AB  - The role of p53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome is controversial and research so far has yielded inconsistent results. This systematic review aims to summarise the literature on the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss following natural and assisted conception. A comprehensive literature search was conducted on MEDLINE, EMBASE and CENTRAL electronic databases for literature published between 1998 and April 2020. Inclusion and exclusion criteria and search terms were established. References of retrieved articles were hand searched to identify other relevant papers including conference abstracts. In total, 9 case control studies (1041 patients), 6 case control studies (382 patients) and 7 studies (3403) were included examining the role of TP53 p.Arg72Pro variant in recurrent pregnancy loss, recurrent implantation failure and IVF outcome respectively. Combined genotype frequencies suggest that there may be an association between Pro/Pro genotype and recurrent pregnancy loss and Arg/Pro genotype and recurrent implantation failure. However, the association between TP53 p.Arg72Pro variant and recurrent pregnancy loss, recurrent implantation failure or IVF outcomes has not been clearly established. In conclusion, genotyping patients for the TP53 variant may enable us to identify an aetiology for patients experiencing unexplained recurrent pregnancy loss and detect individuals at risk of recurrent implantation failure before IVF treatment is initiated. Furthermore, exploring the mechanisms of action of the p53 protein may provide us with an insight into potential treatments.
VL  - 8
IS  - 3
ER  -

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