Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

Michael Chukwudi Ezeani; Charles Chinedum Onyenekwe; Samuel Chukwuemeka Meludu

doi:doi:10.11648/j.ijgg.20170501.11

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Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis

Michael Chukwudi Ezeani, Charles Chinedum Onyenekwe, Samuel Chukwuemeka Meludu

Published in International Journal of Genetics and Genomics (Volume 5, Issue 1)

Received: 13 December 2016 Accepted: 27 December 2016 Published: 29 January 2017

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Abstract

Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation and subsequent epigenetic cell alteration and tumourigenesis. This review looked into the immuno-physiological activities of circulating immune complexes to expose its possible epigenomic consequences and potential role in epimutation. The environmental link between epigenetic cell alteration and formation of circulating immune complexes makes this review a unique one but on the other hand, gives room for concern. Immune complexes have strong capacity to stimulate various immune responses, yet the immunological activities of these circulating immune complexes are over looked or under estimated. Immune complexes is a normal immunological phenomenon but its persistence and subsequent deposition could induce endogenous assaults that would continuously and adversely perturb the epigenomic activities by fuelling chronic inflammation, activating transcription factors (NFkB), generation of reactive oxygen species (ROS) and frequent release of cytokines leading to epigenetic cell alteration especially in developing countries where environmental pollution is a serious factor.

Published in	International Journal of Genetics and Genomics (Volume 5, Issue 1)
DOI	10.11648/j.ijgg.20170501.11
Page(s)	1-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Circulating Immune Complexes, Epimutation, Epigenome, Persistence, Poor Prognosis, Tumourigenesis, Cancer

References

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Michael Chukwudi Ezeani, Charles Chinedum Onyenekwe, Samuel Chukwuemeka Meludu. (2017). Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis. International Journal of Genetics and Genomics, 5(1), 1-13. https://doi.org/10.11648/j.ijgg.20170501.11

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ACS Style

Michael Chukwudi Ezeani; Charles Chinedum Onyenekwe; Samuel Chukwuemeka Meludu. Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis. Int. J. Genet. Genomics 2017, 5(1), 1-13. doi: 10.11648/j.ijgg.20170501.11

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AMA Style

Michael Chukwudi Ezeani, Charles Chinedum Onyenekwe, Samuel Chukwuemeka Meludu. Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis. Int J Genet Genomics. 2017;5(1):1-13. doi: 10.11648/j.ijgg.20170501.11

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@article{10.11648/j.ijgg.20170501.11,
  author = {Michael Chukwudi Ezeani and Charles Chinedum Onyenekwe and Samuel Chukwuemeka Meludu},
  title = {Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis},
  journal = {International Journal of Genetics and Genomics},
  volume = {5},
  number = {1},
  pages = {1-13},
  doi = {10.11648/j.ijgg.20170501.11},
  url = {https://doi.org/10.11648/j.ijgg.20170501.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20170501.11},
  abstract = {Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation and subsequent epigenetic cell alteration and tumourigenesis. This review looked into the immuno-physiological activities of circulating immune complexes to expose its possible epigenomic consequences and potential role in epimutation. The environmental link between epigenetic cell alteration and formation of circulating immune complexes makes this review a unique one but on the other hand, gives room for concern. Immune complexes have strong capacity to stimulate various immune responses, yet the immunological activities of these circulating immune complexes are over looked or under estimated. Immune complexes is a normal immunological phenomenon but its persistence and subsequent deposition could induce endogenous assaults that would continuously and adversely perturb the epigenomic activities by fuelling chronic inflammation, activating transcription factors (NFkB), generation of reactive oxygen species (ROS) and frequent release of cytokines leading to epigenetic cell alteration especially in developing countries where environmental pollution is a serious factor.},
 year = {2017}
}

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TY  - JOUR
T1  - Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis
AU  - Michael Chukwudi Ezeani
AU  - Charles Chinedum Onyenekwe
AU  - Samuel Chukwuemeka Meludu
Y1  - 2017/01/29
PY  - 2017
N1  - https://doi.org/10.11648/j.ijgg.20170501.11
DO  - 10.11648/j.ijgg.20170501.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 1
EP  - 13
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20170501.11
AB  - Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation and subsequent epigenetic cell alteration and tumourigenesis. This review looked into the immuno-physiological activities of circulating immune complexes to expose its possible epigenomic consequences and potential role in epimutation. The environmental link between epigenetic cell alteration and formation of circulating immune complexes makes this review a unique one but on the other hand, gives room for concern. Immune complexes have strong capacity to stimulate various immune responses, yet the immunological activities of these circulating immune complexes are over looked or under estimated. Immune complexes is a normal immunological phenomenon but its persistence and subsequent deposition could induce endogenous assaults that would continuously and adversely perturb the epigenomic activities by fuelling chronic inflammation, activating transcription factors (NFkB), generation of reactive oxygen species (ROS) and frequent release of cytokines leading to epigenetic cell alteration especially in developing countries where environmental pollution is a serious factor.
VL  - 5
IS  - 1
ER  -

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Author Information

Michael Chukwudi Ezeani

Department of Immunology, Faculty of Medicine, Nnamdi Azikiwe University, Awka, Nigeria
Charles Chinedum Onyenekwe

Department of Medical Laboratory Science, Faculty of Health Sciences, Nnamdi Azikiwe University Awka, Nigeria
Samuel Chukwuemeka Meludu

Department of Human Biochemistry, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University Awka, Nigeria

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APA Style

Michael Chukwudi Ezeani, Charles Chinedum Onyenekwe, Samuel Chukwuemeka Meludu. (2017). Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis. International Journal of Genetics and Genomics, 5(1), 1-13. https://doi.org/10.11648/j.ijgg.20170501.11

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ACS Style

Michael Chukwudi Ezeani; Charles Chinedum Onyenekwe; Samuel Chukwuemeka Meludu. Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis. Int. J. Genet. Genomics 2017, 5(1), 1-13. doi: 10.11648/j.ijgg.20170501.11

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AMA Style

Michael Chukwudi Ezeani, Charles Chinedum Onyenekwe, Samuel Chukwuemeka Meludu. Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis. Int J Genet Genomics. 2017;5(1):1-13. doi: 10.11648/j.ijgg.20170501.11

Copy | Download

@article{10.11648/j.ijgg.20170501.11,
  author = {Michael Chukwudi Ezeani and Charles Chinedum Onyenekwe and Samuel Chukwuemeka Meludu},
  title = {Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis},
  journal = {International Journal of Genetics and Genomics},
  volume = {5},
  number = {1},
  pages = {1-13},
  doi = {10.11648/j.ijgg.20170501.11},
  url = {https://doi.org/10.11648/j.ijgg.20170501.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20170501.11},
  abstract = {Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation and subsequent epigenetic cell alteration and tumourigenesis. This review looked into the immuno-physiological activities of circulating immune complexes to expose its possible epigenomic consequences and potential role in epimutation. The environmental link between epigenetic cell alteration and formation of circulating immune complexes makes this review a unique one but on the other hand, gives room for concern. Immune complexes have strong capacity to stimulate various immune responses, yet the immunological activities of these circulating immune complexes are over looked or under estimated. Immune complexes is a normal immunological phenomenon but its persistence and subsequent deposition could induce endogenous assaults that would continuously and adversely perturb the epigenomic activities by fuelling chronic inflammation, activating transcription factors (NFkB), generation of reactive oxygen species (ROS) and frequent release of cytokines leading to epigenetic cell alteration especially in developing countries where environmental pollution is a serious factor.},
 year = {2017}
}

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TY  - JOUR
T1  - Persistent Circulating Immune Complexes: Potential Source of Epimutation and Cancer Poor Prognosis
AU  - Michael Chukwudi Ezeani
AU  - Charles Chinedum Onyenekwe
AU  - Samuel Chukwuemeka Meludu
Y1  - 2017/01/29
PY  - 2017
N1  - https://doi.org/10.11648/j.ijgg.20170501.11
DO  - 10.11648/j.ijgg.20170501.11
T2  - International Journal of Genetics and Genomics
JF  - International Journal of Genetics and Genomics
JO  - International Journal of Genetics and Genomics
SP  - 1
EP  - 13
PB  - Science Publishing Group
SN  - 2376-7359
UR  - https://doi.org/10.11648/j.ijgg.20170501.11
AB  - Estimation of serum level of circulating immune complexes and its use for monitoring treatments have been carried out extensively in various disease conditions including autoimmune diseases and cancer, but little or no work has considered persistent circulation of immune complexes consequent to physiological anomalies that could mediate epimutation and subsequent epigenetic cell alteration and tumourigenesis. This review looked into the immuno-physiological activities of circulating immune complexes to expose its possible epigenomic consequences and potential role in epimutation. The environmental link between epigenetic cell alteration and formation of circulating immune complexes makes this review a unique one but on the other hand, gives room for concern. Immune complexes have strong capacity to stimulate various immune responses, yet the immunological activities of these circulating immune complexes are over looked or under estimated. Immune complexes is a normal immunological phenomenon but its persistence and subsequent deposition could induce endogenous assaults that would continuously and adversely perturb the epigenomic activities by fuelling chronic inflammation, activating transcription factors (NFkB), generation of reactive oxygen species (ROS) and frequent release of cytokines leading to epigenetic cell alteration especially in developing countries where environmental pollution is a serious factor.
VL  - 5
IS  - 1
ER  -

Copy | Download