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Endobronchial Schwannoma: Literature Review in Account of a Case Report

Received: 3 August 2022     Accepted: 19 August 2022     Published: 29 August 2022
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Abstract

Background: Schwannomas are benign mesenchymal tumor originated in the Schwan cells of peripheral, spinal, or cranial nerve sheaths. They represent approximately 0.2-2% of benign tumors in the tracheobronchial tree. To date, only sporadic case reports exist in western literature. Case presentation: We present a 35-year-old female, whose initial complaints were dyspnea, persistent cough, and chest pain for two months. In a chest CT-scan, a solid tumor was identified in the juncture of the right main bronchus and the emergence of the ipsilateral superior bronchus. Said tumor had both an intra and extra-luminal component, and its dimensions where 2.9×2.6×2.7cm. Results: A right posterolateral thoracotomy was performed with selective intubation. The possibility of preserving the right upper lobe was identified transoperatively, with the right upper bronchus being sutured to the right main bronchus, without complications. The histopathologic report was of a benign bronchial Schwannoma, with the formation of Verocay bodies in the HE stain, and intense positivity for the S100 protein in the subepithelial lesion. Patient follow-up was performed with a new CT-scan and flexible bronchoscopy 3 months after surgery, with no evidence of recurrence. 23 cases of endobronchial Schwannoma reported in the available literature were subsequently analyzed, with emphasis on clinical presentation, treatment offered and follow-up. Conclusions: Endobronchial Schwannomas are an uncommon type of airway tumor, and are rarely thought of as an initial diagnosis. Total resection of the tumor is of upmost importance to avoid recurrence. Surgical resections should be considered in all patients with high probability of residual tumor through endoscopic resection, most notably those with a known or suspected extraluminal component. More case reports are needed to develop a better understanding of the best diagnostic, treatment, and follow-up options.

Published in International Journal of Cardiovascular and Thoracic Surgery (Volume 8, Issue 4)
DOI 10.11648/j.ijcts.20220804.13
Page(s) 49-54
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Endobronchial Schwannomas, Lung Tumors, Endoscopic Resections

References
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[2] Stouffer CW, Allan RW, Shillingford MS, Klodell CT. Endobronchial schwannoma presenting with bronchial obstruction. Interactive CardioVascular and Thoracic Surgery 2010; 10: 133–134.
[3] Liao H, Song W, Chen N, et al. Left lower lobe sleeve resection for endobronchial schwannoma. Ann Transl Med 2019; 7 (3): 50.
[4] Jung YY, Hong ME, Han J, et al. Bronchial Schwannomas: Clinicopathologic Analysis of 7 Cases. The Korean Journal of Pathology 2013; 47: 326-331.
[5] Dumoulin E, Gui X, Stather DR, et al. Endobronchial Schwannoma. J Bronchol Intervent Pulmonol 2012; 19 (1): 75-77.
[6] Oliveira RC, Nogeuira T, Sousa V, Carvalho L. Bronchial schwannoma: a singular lesion as a cause of obstructive pneumonia. BMJ Case Rep 2016: 1-3.
[7] Landete P, Chiner E, Sancho-Chust JN, Pérez-Ferrer P. Bronchial Schwannoma: An Uncommon Tumor. Letters to the Editor / Arch Bronconeumol. 2015; 51 (9): 470–478.
[8] Elhassan UA, Jahangir S, Ahmed MH, et al. Endobronchial Schwannoma: Very Rare Tumor Discovered Accidently During FOB for Left Lower Lobe Collapse. Chest 2021; 160 (42): 1517A-1518A.
[9] Guerreiro C, Dionísio J, da Costa JD. Endobronchial Schwannoma Involving the Carina. Arch Bronconeumol. 2017; 53 (8): 452.
[10] Gupta R, Singh P. Endobronchial Schwannoma: A Rare Diagnosis. JK Science 2014; 16 (3): 134-136.
[11] Takeda S, Miyoshi S, Minami M, Matsuda H. Intrathoracic neurogenic tumors—50 years’ experience in a Japanese institution. European Journal of Cardio-thoracic Surgery 2004; 26: 807–812.
[12] Lee BR, Choi YD, Kim YI, et al. Endobronchial Schwannoma Treated by Rigid Bronchoscopy with Argon Plasma Coagulation. Tuberculosis and Respiratory Diseases 2012; 73 (3): 174-177.
[13] Tansel T, Toker A, Yilmazbayhan D, et al. Primary endobronchial schwannoma Journal of Pediatric Surgery 2010; 45: 2241–2243.
[14] Pandey K, Vaidya PJ, Kate AH, et al. Bronchoscopic and surgical management of rare endobronchial tumors. J Can Res Ther 2016; 12: 1093-1097.
[15] Kasahara K, Kukuoka K, Konishi M, et al. Two Cases of Endobronchial Neurilemmoma and Review of the Literature in Japan. Internal Medicine 2003: 42 (12): 1215-1218.
[16] Takeda S, Hashimoto T, Kusu T, et al. Management and surgical resection for tracheobronchial tumors – institutional experience with 12 patients. Interactive CardioVascular and Thoracic Surgery 2007; 6: 484–489.
[17] Zhang L, Tang W, Hong QS, et al. Case report: A tracheobronchial schwannoma in a child Respiratory Medicine Case Reports 2020; 30: 101047.
[18] Suzuki H, Sekine Y, Motohashi S, et al. Endobronchial Neurogenic Tumors Treated by Transbronchial Electrical Snaring and Nd-YAG Laser Abrasion: Report of Three Cases. Surg Today 2005; 35: 243–246.
[19] Melendez J, Cornwell L, Green L, Casal RF. Treatment of large subglottic tracheal microdebrider bronchoscopy. J Thorac Cardiovasc Surg 2012; 144: 510-512.
[20] Mizobuchi T, Iizasa T, Iyoda A, et al. A Strategy of Sequential Therapy with a Bronchoscopic Excision and Thoracotomy for Intra- and Extrabronchial Wall Schwannoma: Report of a Case. Surg Today 2005 35: 778–781.
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  • APA Style

    Jose Ruben Lopez Franco, Salvador Narvaez Fernandez, Tania Perez Marmolejo, Gibran Pliego Cervantes, Ventura Molina, et al. (2022). Endobronchial Schwannoma: Literature Review in Account of a Case Report. International Journal of Cardiovascular and Thoracic Surgery, 8(4), 49-54. https://doi.org/10.11648/j.ijcts.20220804.13

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    ACS Style

    Jose Ruben Lopez Franco; Salvador Narvaez Fernandez; Tania Perez Marmolejo; Gibran Pliego Cervantes; Ventura Molina, et al. Endobronchial Schwannoma: Literature Review in Account of a Case Report. Int. J. Cardiovasc. Thorac. Surg. 2022, 8(4), 49-54. doi: 10.11648/j.ijcts.20220804.13

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    AMA Style

    Jose Ruben Lopez Franco, Salvador Narvaez Fernandez, Tania Perez Marmolejo, Gibran Pliego Cervantes, Ventura Molina, et al. Endobronchial Schwannoma: Literature Review in Account of a Case Report. Int J Cardiovasc Thorac Surg. 2022;8(4):49-54. doi: 10.11648/j.ijcts.20220804.13

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  • @article{10.11648/j.ijcts.20220804.13,
      author = {Jose Ruben Lopez Franco and Salvador Narvaez Fernandez and Tania Perez Marmolejo and Gibran Pliego Cervantes and Ventura Molina and Roland Kevin Cethorth Fonseca and Edgard Efren Lozada Hernandez},
      title = {Endobronchial Schwannoma: Literature Review in Account of a Case Report},
      journal = {International Journal of Cardiovascular and Thoracic Surgery},
      volume = {8},
      number = {4},
      pages = {49-54},
      doi = {10.11648/j.ijcts.20220804.13},
      url = {https://doi.org/10.11648/j.ijcts.20220804.13},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20220804.13},
      abstract = {Background: Schwannomas are benign mesenchymal tumor originated in the Schwan cells of peripheral, spinal, or cranial nerve sheaths. They represent approximately 0.2-2% of benign tumors in the tracheobronchial tree. To date, only sporadic case reports exist in western literature. Case presentation: We present a 35-year-old female, whose initial complaints were dyspnea, persistent cough, and chest pain for two months. In a chest CT-scan, a solid tumor was identified in the juncture of the right main bronchus and the emergence of the ipsilateral superior bronchus. Said tumor had both an intra and extra-luminal component, and its dimensions where 2.9×2.6×2.7cm. Results: A right posterolateral thoracotomy was performed with selective intubation. The possibility of preserving the right upper lobe was identified transoperatively, with the right upper bronchus being sutured to the right main bronchus, without complications. The histopathologic report was of a benign bronchial Schwannoma, with the formation of Verocay bodies in the HE stain, and intense positivity for the S100 protein in the subepithelial lesion. Patient follow-up was performed with a new CT-scan and flexible bronchoscopy 3 months after surgery, with no evidence of recurrence. 23 cases of endobronchial Schwannoma reported in the available literature were subsequently analyzed, with emphasis on clinical presentation, treatment offered and follow-up. Conclusions: Endobronchial Schwannomas are an uncommon type of airway tumor, and are rarely thought of as an initial diagnosis. Total resection of the tumor is of upmost importance to avoid recurrence. Surgical resections should be considered in all patients with high probability of residual tumor through endoscopic resection, most notably those with a known or suspected extraluminal component. More case reports are needed to develop a better understanding of the best diagnostic, treatment, and follow-up options.},
     year = {2022}
    }
    

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  • TY  - JOUR
    T1  - Endobronchial Schwannoma: Literature Review in Account of a Case Report
    AU  - Jose Ruben Lopez Franco
    AU  - Salvador Narvaez Fernandez
    AU  - Tania Perez Marmolejo
    AU  - Gibran Pliego Cervantes
    AU  - Ventura Molina
    AU  - Roland Kevin Cethorth Fonseca
    AU  - Edgard Efren Lozada Hernandez
    Y1  - 2022/08/29
    PY  - 2022
    N1  - https://doi.org/10.11648/j.ijcts.20220804.13
    DO  - 10.11648/j.ijcts.20220804.13
    T2  - International Journal of Cardiovascular and Thoracic Surgery
    JF  - International Journal of Cardiovascular and Thoracic Surgery
    JO  - International Journal of Cardiovascular and Thoracic Surgery
    SP  - 49
    EP  - 54
    PB  - Science Publishing Group
    SN  - 2575-4882
    UR  - https://doi.org/10.11648/j.ijcts.20220804.13
    AB  - Background: Schwannomas are benign mesenchymal tumor originated in the Schwan cells of peripheral, spinal, or cranial nerve sheaths. They represent approximately 0.2-2% of benign tumors in the tracheobronchial tree. To date, only sporadic case reports exist in western literature. Case presentation: We present a 35-year-old female, whose initial complaints were dyspnea, persistent cough, and chest pain for two months. In a chest CT-scan, a solid tumor was identified in the juncture of the right main bronchus and the emergence of the ipsilateral superior bronchus. Said tumor had both an intra and extra-luminal component, and its dimensions where 2.9×2.6×2.7cm. Results: A right posterolateral thoracotomy was performed with selective intubation. The possibility of preserving the right upper lobe was identified transoperatively, with the right upper bronchus being sutured to the right main bronchus, without complications. The histopathologic report was of a benign bronchial Schwannoma, with the formation of Verocay bodies in the HE stain, and intense positivity for the S100 protein in the subepithelial lesion. Patient follow-up was performed with a new CT-scan and flexible bronchoscopy 3 months after surgery, with no evidence of recurrence. 23 cases of endobronchial Schwannoma reported in the available literature were subsequently analyzed, with emphasis on clinical presentation, treatment offered and follow-up. Conclusions: Endobronchial Schwannomas are an uncommon type of airway tumor, and are rarely thought of as an initial diagnosis. Total resection of the tumor is of upmost importance to avoid recurrence. Surgical resections should be considered in all patients with high probability of residual tumor through endoscopic resection, most notably those with a known or suspected extraluminal component. More case reports are needed to develop a better understanding of the best diagnostic, treatment, and follow-up options.
    VL  - 8
    IS  - 4
    ER  - 

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Author Information
  • Thoracic Surgery, Department of Cardiothoracic Diseases, Regional Hospital of High Speciality of Bajio, Leon, Mexico

  • Department of Cardiothoracic Diseases, Regional Hospital of High Speciality of Bajio, Leon, Mexico

  • Thoracic Surgery, Department of Cardiothoracic Diseases, Hospital of Medical Specialties, National Medical Center "La Raza", Mexico City, Mexico

  • Department of Thoracic Surgery, National Institute of Respiratory Diseases, Mexico City, Mexico

  • Department of Pathological Anatomy, Regional Hospital of High Speciality of Bajio, Leon, Mexico

  • General Surgery, Department of Diseases of the Digestive Tract, Regional Hospital of High Specialty of Bajio, Leon, Mexico

  • General Surgery, Department of Diseases of the Digestive Tract, Regional Hospital of High Specialty of Bajio, Leon, Mexico

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