Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology

Lianfang Xue; Hui Liu; Minghao Chen; Suishan Qiu

doi:doi:10.11648/j.ijcm.20210501.12

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Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology

Lianfang Xue, Hui Liu, Minghao Chen, Suishan Qiu

Published in International Journal of Chinese Medicine (Volume 5, Issue 1)

Received: 27 February 2021 Accepted: 13 March 2021 Published: 22 March 2021

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Abstract

Objective: Hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus 71 (EV71), Coxsackie virus A16 (CA16) and other enteroviruses. For the treatment of HFMD, there are no recognized specific treatment drugs. In recent years, with the continuous development of traditional Chinese medicine, the clinical use of traditional Chinese medicine in the treatment of HFMD reports is increasing. At present, traditional Chinese medicine is mainly used to disperse wind and heat, clear heat and detoxify, clearing damp and dispel evil, but most of them do not know the exact mechanism of treatment. In this paper, the network pharmacology method was adopted to analyze the main active components and action targets of Sang-Ju-Yin (SJY) and to construct corresponding pathways, and to explore the mechanism of action of SJY in the treatment of HFMD. Methods: The active components of SJY were collected and potential targets were searched by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). GeneCards platform was used to find disease targets, and a protein interaction network (PPI) was constructed using the STRING platform. Cytoscape 3.6.0 software was used to screen out the key targets. The enrichment analysis of KEGG pathway and gene function analysis (go) was carried out by R language bioconducor package. Results: There were 151 main active components such as quercetin, luteolin and wogonin, and 15 intersection targets were obtained after 78 targets and 100 hand foot mouth disease targets intersected. Key pathways such as TNF signaling pathway, measures and influenza A were obtained by KEGG analysis. Conclusions: The main active components of SJY are quercetin, luteolin, wogonin, kaempferol, aloe emodin, Licochalcone A. It mainly regulates AKT1, Bax, IKBKB, IL-6, STAT3 and other targets, regulates TNF, influenza A and other signaling pathways to inhibit inflammatory response and regulate immune function, so as to achieve the purpose of treating hand foot mouth disease.

Published in	International Journal of Chinese Medicine (Volume 5, Issue 1)
DOI	10.11648/j.ijcm.20210501.12
Page(s)	6-13
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Sang-Ju-Yin, Hand, Foot and Mouth Disease, Network Pharmacology, Target, Signal Pathway

References

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APA Style

Lianfang Xue, Hui Liu, Minghao Chen, Suishan Qiu. (2021). Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology. International Journal of Chinese Medicine, 5(1), 6-13. https://doi.org/10.11648/j.ijcm.20210501.12

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ACS Style

Lianfang Xue; Hui Liu; Minghao Chen; Suishan Qiu. Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology. Int. J. Chin. Med. 2021, 5(1), 6-13. doi: 10.11648/j.ijcm.20210501.12

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AMA Style

Lianfang Xue, Hui Liu, Minghao Chen, Suishan Qiu. Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology. Int J Chin Med. 2021;5(1):6-13. doi: 10.11648/j.ijcm.20210501.12

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@article{10.11648/j.ijcm.20210501.12,
  author = {Lianfang Xue and Hui Liu and Minghao Chen and Suishan Qiu},
  title = {Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology},
  journal = {International Journal of Chinese Medicine},
  volume = {5},
  number = {1},
  pages = {6-13},
  doi = {10.11648/j.ijcm.20210501.12},
  url = {https://doi.org/10.11648/j.ijcm.20210501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20210501.12},
  abstract = {Objective: Hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus 71 (EV71), Coxsackie virus A16 (CA16) and other enteroviruses. For the treatment of HFMD, there are no recognized specific treatment drugs. In recent years, with the continuous development of traditional Chinese medicine, the clinical use of traditional Chinese medicine in the treatment of HFMD reports is increasing. At present, traditional Chinese medicine is mainly used to disperse wind and heat, clear heat and detoxify, clearing damp and dispel evil, but most of them do not know the exact mechanism of treatment. In this paper, the network pharmacology method was adopted to analyze the main active components and action targets of Sang-Ju-Yin (SJY) and to construct corresponding pathways, and to explore the mechanism of action of SJY in the treatment of HFMD. Methods: The active components of SJY were collected and potential targets were searched by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). GeneCards platform was used to find disease targets, and a protein interaction network (PPI) was constructed using the STRING platform. Cytoscape 3.6.0 software was used to screen out the key targets. The enrichment analysis of KEGG pathway and gene function analysis (go) was carried out by R language bioconducor package. Results: There were 151 main active components such as quercetin, luteolin and wogonin, and 15 intersection targets were obtained after 78 targets and 100 hand foot mouth disease targets intersected. Key pathways such as TNF signaling pathway, measures and influenza A were obtained by KEGG analysis. Conclusions: The main active components of SJY are quercetin, luteolin, wogonin, kaempferol, aloe emodin, Licochalcone A. It mainly regulates AKT1, Bax, IKBKB, IL-6, STAT3 and other targets, regulates TNF, influenza A and other signaling pathways to inhibit inflammatory response and regulate immune function, so as to achieve the purpose of treating hand foot mouth disease.},
 year = {2021}
}

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TY  - JOUR
T1  - Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology
AU  - Lianfang Xue
AU  - Hui Liu
AU  - Minghao Chen
AU  - Suishan Qiu
Y1  - 2021/03/22
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcm.20210501.12
DO  - 10.11648/j.ijcm.20210501.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 6
EP  - 13
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20210501.12
AB  - Objective: Hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus 71 (EV71), Coxsackie virus A16 (CA16) and other enteroviruses. For the treatment of HFMD, there are no recognized specific treatment drugs. In recent years, with the continuous development of traditional Chinese medicine, the clinical use of traditional Chinese medicine in the treatment of HFMD reports is increasing. At present, traditional Chinese medicine is mainly used to disperse wind and heat, clear heat and detoxify, clearing damp and dispel evil, but most of them do not know the exact mechanism of treatment. In this paper, the network pharmacology method was adopted to analyze the main active components and action targets of Sang-Ju-Yin (SJY) and to construct corresponding pathways, and to explore the mechanism of action of SJY in the treatment of HFMD. Methods: The active components of SJY were collected and potential targets were searched by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). GeneCards platform was used to find disease targets, and a protein interaction network (PPI) was constructed using the STRING platform. Cytoscape 3.6.0 software was used to screen out the key targets. The enrichment analysis of KEGG pathway and gene function analysis (go) was carried out by R language bioconducor package. Results: There were 151 main active components such as quercetin, luteolin and wogonin, and 15 intersection targets were obtained after 78 targets and 100 hand foot mouth disease targets intersected. Key pathways such as TNF signaling pathway, measures and influenza A were obtained by KEGG analysis. Conclusions: The main active components of SJY are quercetin, luteolin, wogonin, kaempferol, aloe emodin, Licochalcone A. It mainly regulates AKT1, Bax, IKBKB, IL-6, STAT3 and other targets, regulates TNF, influenza A and other signaling pathways to inhibit inflammatory response and regulate immune function, so as to achieve the purpose of treating hand foot mouth disease.
VL  - 5
IS  - 1
ER  -

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Author Information

Lianfang Xue

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Hui Liu

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Minghao Chen

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Suishan Qiu

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

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Plain Text BibTeX RIS

APA Style

Lianfang Xue, Hui Liu, Minghao Chen, Suishan Qiu. (2021). Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology. International Journal of Chinese Medicine, 5(1), 6-13. https://doi.org/10.11648/j.ijcm.20210501.12

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ACS Style

Lianfang Xue; Hui Liu; Minghao Chen; Suishan Qiu. Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology. Int. J. Chin. Med. 2021, 5(1), 6-13. doi: 10.11648/j.ijcm.20210501.12

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AMA Style

Lianfang Xue, Hui Liu, Minghao Chen, Suishan Qiu. Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology. Int J Chin Med. 2021;5(1):6-13. doi: 10.11648/j.ijcm.20210501.12

Copy | Download

@article{10.11648/j.ijcm.20210501.12,
  author = {Lianfang Xue and Hui Liu and Minghao Chen and Suishan Qiu},
  title = {Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology},
  journal = {International Journal of Chinese Medicine},
  volume = {5},
  number = {1},
  pages = {6-13},
  doi = {10.11648/j.ijcm.20210501.12},
  url = {https://doi.org/10.11648/j.ijcm.20210501.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20210501.12},
  abstract = {Objective: Hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus 71 (EV71), Coxsackie virus A16 (CA16) and other enteroviruses. For the treatment of HFMD, there are no recognized specific treatment drugs. In recent years, with the continuous development of traditional Chinese medicine, the clinical use of traditional Chinese medicine in the treatment of HFMD reports is increasing. At present, traditional Chinese medicine is mainly used to disperse wind and heat, clear heat and detoxify, clearing damp and dispel evil, but most of them do not know the exact mechanism of treatment. In this paper, the network pharmacology method was adopted to analyze the main active components and action targets of Sang-Ju-Yin (SJY) and to construct corresponding pathways, and to explore the mechanism of action of SJY in the treatment of HFMD. Methods: The active components of SJY were collected and potential targets were searched by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). GeneCards platform was used to find disease targets, and a protein interaction network (PPI) was constructed using the STRING platform. Cytoscape 3.6.0 software was used to screen out the key targets. The enrichment analysis of KEGG pathway and gene function analysis (go) was carried out by R language bioconducor package. Results: There were 151 main active components such as quercetin, luteolin and wogonin, and 15 intersection targets were obtained after 78 targets and 100 hand foot mouth disease targets intersected. Key pathways such as TNF signaling pathway, measures and influenza A were obtained by KEGG analysis. Conclusions: The main active components of SJY are quercetin, luteolin, wogonin, kaempferol, aloe emodin, Licochalcone A. It mainly regulates AKT1, Bax, IKBKB, IL-6, STAT3 and other targets, regulates TNF, influenza A and other signaling pathways to inhibit inflammatory response and regulate immune function, so as to achieve the purpose of treating hand foot mouth disease.},
 year = {2021}
}

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TY  - JOUR
T1  - Mechanism of Sang-Ju-Yin on Hand, Foot and Mouth Disease Based on Network Pharmacology
AU  - Lianfang Xue
AU  - Hui Liu
AU  - Minghao Chen
AU  - Suishan Qiu
Y1  - 2021/03/22
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcm.20210501.12
DO  - 10.11648/j.ijcm.20210501.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 6
EP  - 13
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20210501.12
AB  - Objective: Hand, foot and mouth disease (HFMD) is an acute infectious disease caused by enterovirus 71 (EV71), Coxsackie virus A16 (CA16) and other enteroviruses. For the treatment of HFMD, there are no recognized specific treatment drugs. In recent years, with the continuous development of traditional Chinese medicine, the clinical use of traditional Chinese medicine in the treatment of HFMD reports is increasing. At present, traditional Chinese medicine is mainly used to disperse wind and heat, clear heat and detoxify, clearing damp and dispel evil, but most of them do not know the exact mechanism of treatment. In this paper, the network pharmacology method was adopted to analyze the main active components and action targets of Sang-Ju-Yin (SJY) and to construct corresponding pathways, and to explore the mechanism of action of SJY in the treatment of HFMD. Methods: The active components of SJY were collected and potential targets were searched by the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). GeneCards platform was used to find disease targets, and a protein interaction network (PPI) was constructed using the STRING platform. Cytoscape 3.6.0 software was used to screen out the key targets. The enrichment analysis of KEGG pathway and gene function analysis (go) was carried out by R language bioconducor package. Results: There were 151 main active components such as quercetin, luteolin and wogonin, and 15 intersection targets were obtained after 78 targets and 100 hand foot mouth disease targets intersected. Key pathways such as TNF signaling pathway, measures and influenza A were obtained by KEGG analysis. Conclusions: The main active components of SJY are quercetin, luteolin, wogonin, kaempferol, aloe emodin, Licochalcone A. It mainly regulates AKT1, Bax, IKBKB, IL-6, STAT3 and other targets, regulates TNF, influenza A and other signaling pathways to inhibit inflammatory response and regulate immune function, so as to achieve the purpose of treating hand foot mouth disease.
VL  - 5
IS  - 1
ER  -

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