Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology

Suishan Qiu; Lianfang Xue; Huiting Zhong; Leping Li; Hui Liu

doi:doi:10.11648/j.ijcm.20200404.12

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Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology

Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu

Published in International Journal of Chinese Medicine (Volume 4, Issue 4)

Received: 16 October 2020 Accepted: 2 November 2020 Published: 16 December 2020

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Abstract

Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.

Published in	International Journal of Chinese Medicine (Volume 4, Issue 4)
DOI	10.11648/j.ijcm.20200404.12
Page(s)	82-89
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Yinqiao Antipyreti Granules, Influenza, Network Pharmacology

References

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APA Style

Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu. (2020). Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. International Journal of Chinese Medicine, 4(4), 82-89. https://doi.org/10.11648/j.ijcm.20200404.12

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ACS Style

Suishan Qiu; Lianfang Xue; Huiting Zhong; Leping Li; Hui Liu. Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. Int. J. Chin. Med. 2020, 4(4), 82-89. doi: 10.11648/j.ijcm.20200404.12

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AMA Style

Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu. Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. Int J Chin Med. 2020;4(4):82-89. doi: 10.11648/j.ijcm.20200404.12

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@article{10.11648/j.ijcm.20200404.12,
  author = {Suishan Qiu and Lianfang Xue and Huiting Zhong and Leping Li and Hui Liu},
  title = {Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology},
  journal = {International Journal of Chinese Medicine},
  volume = {4},
  number = {4},
  pages = {82-89},
  doi = {10.11648/j.ijcm.20200404.12},
  url = {https://doi.org/10.11648/j.ijcm.20200404.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20200404.12},
  abstract = {Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.},
 year = {2020}
}

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TY  - JOUR
T1  - Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology
AU  - Suishan Qiu
AU  - Lianfang Xue
AU  - Huiting Zhong
AU  - Leping Li
AU  - Hui Liu
Y1  - 2020/12/16
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcm.20200404.12
DO  - 10.11648/j.ijcm.20200404.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 82
EP  - 89
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20200404.12
AB  - Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.
VL  - 4
IS  - 4
ER  -

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Author Information

Suishan Qiu

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Lianfang Xue

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Huiting Zhong

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Leping Li

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China
Hui Liu

Department of Pharmacy, The First Affiliated Hospital of Jinan University, Guangzhou, China

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APA Style

Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu. (2020). Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. International Journal of Chinese Medicine, 4(4), 82-89. https://doi.org/10.11648/j.ijcm.20200404.12

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ACS Style

Suishan Qiu; Lianfang Xue; Huiting Zhong; Leping Li; Hui Liu. Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. Int. J. Chin. Med. 2020, 4(4), 82-89. doi: 10.11648/j.ijcm.20200404.12

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AMA Style

Suishan Qiu, Lianfang Xue, Huiting Zhong, Leping Li, Hui Liu. Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology. Int J Chin Med. 2020;4(4):82-89. doi: 10.11648/j.ijcm.20200404.12

Copy | Download

@article{10.11648/j.ijcm.20200404.12,
  author = {Suishan Qiu and Lianfang Xue and Huiting Zhong and Leping Li and Hui Liu},
  title = {Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology},
  journal = {International Journal of Chinese Medicine},
  volume = {4},
  number = {4},
  pages = {82-89},
  doi = {10.11648/j.ijcm.20200404.12},
  url = {https://doi.org/10.11648/j.ijcm.20200404.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20200404.12},
  abstract = {Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.},
 year = {2020}
}

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TY  - JOUR
T1  - Study on the Pharmacological Mechanism of Yinqiao Antipyreti Granules Against Influenza Based on Network Pharmacology
AU  - Suishan Qiu
AU  - Lianfang Xue
AU  - Huiting Zhong
AU  - Leping Li
AU  - Hui Liu
Y1  - 2020/12/16
PY  - 2020
N1  - https://doi.org/10.11648/j.ijcm.20200404.12
DO  - 10.11648/j.ijcm.20200404.12
T2  - International Journal of Chinese Medicine
JF  - International Journal of Chinese Medicine
JO  - International Journal of Chinese Medicine
SP  - 82
EP  - 89
PB  - Science Publishing Group
SN  - 2578-9473
UR  - https://doi.org/10.11648/j.ijcm.20200404.12
AB  - Objective: To explore the anti-influenza pharmacological mechanism of Yinqiao Antipyreti Granules by using network pharmacology. Method: Retrieve the main active ingredients, corresponding targets and target genes of Yinqiao Antipyreti Granules on the website of Chinese Medicine System Pharmacology Technology Platform (TCMSP), obtain the relevant target genes of influenza through the Human Gene Database (Gene Cards), and transfer the drugs The target of the active ingredient is mapped to the influenza target, and the intersection target obtained is the predicted target of Yinqiao Ture granules against influenza. Cytoscape 3.8.0 software was used to construct a drug active ingredient-intersection target network model, and key active ingredients were selected. Use the STRING website to construct an intersection target protein interaction network (PPI) and select key target genes. Enriched analysis of GO and KEGG pathways using Metascape on intersection targets. Results: There are 136 active ingredients in Yinqiao Antipyretic Granules and 131 anti-influenza-related targets. Conclusion: The main components of Yinqiao Antipyretic Granules are quercetin, luteolin, naringenin, formononetin, IL-6, STAT3, MAPK14, CASP3 and other gene targets, to suppress inflammatory response, regulate immunity, reduce the symptoms of influenza, and thus play an anti-influenza therapeutic role.
VL  - 4
IS  - 4
ER  -

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