The present study was performed to assess the antioxidant capacity of different doses of Zingiber officinale extract and its efficacy in alleviating the biochemical alterations induced by aluminum chloride in rabbits. Twenty-eight male rabbits were allocated into four groups (7 rabbits in each); Group I: served as normal control, Group II: treated with aluminum chloride (AlCl3) (150 mg/kg body weight), Group III: treated with AlCl3 and Zingiber officinale extract (100mg/kg. bw) and Group IV: treated with AlCl3 and Zingiber officinale extract (200mg/kg. bw). Rabbits in groups III and IV were orally treated daily with Zingiber officinale extract for 4 weeks. Aluminum exposure caused a significant elevation of BUN, creatinine, lipid profile, ALT, ALP, TNF-α, and amylase activity. All these parameters showed the reverse trend following oral Zingiber officinale treatment. Aluminum exposure showed a significant decrease in hepatic GSH and catalase activity. Treatment with Zingiber officinale extract significantly reversed aluminum effects, in the level of GSH content and hepatic catalase activity. Zingiber officinale is effective in alleviating the oxidative stress and inflammation and is thus effective in improving lipid profile and hepatotoxicity and nephrotoxicity in AlCl3 administration.
| Published in | International Journal of Chinese Medicine (Volume 1, Issue 4) |
| DOI | 10.11648/j.ijcm.20170104.14 |
| Page(s) | 124-131 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Aluminum Chloride, Zingiber officinale, GSH, Antioxidant, Catalase, TNF-α, ALT
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APA Style
Nabil A. Hasona, Mohammed Q. Ahmed. (2017). Antioxidant and Ameliorative Effects of Zingiber officinale Against Aluminum Chloride Toxicity. International Journal of Chinese Medicine, 1(4), 124-131. https://doi.org/10.11648/j.ijcm.20170104.14
ACS Style
Nabil A. Hasona; Mohammed Q. Ahmed. Antioxidant and Ameliorative Effects of Zingiber officinale Against Aluminum Chloride Toxicity. Int. J. Chin. Med. 2017, 1(4), 124-131. doi: 10.11648/j.ijcm.20170104.14
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Download@article{10.11648/j.ijcm.20170104.14,
author = {Nabil A. Hasona and Mohammed Q. Ahmed},
title = {Antioxidant and Ameliorative Effects of Zingiber officinale Against Aluminum Chloride Toxicity},
journal = {International Journal of Chinese Medicine},
volume = {1},
number = {4},
pages = {124-131},
doi = {10.11648/j.ijcm.20170104.14},
url = {https://doi.org/10.11648/j.ijcm.20170104.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170104.14},
abstract = {The present study was performed to assess the antioxidant capacity of different doses of Zingiber officinale extract and its efficacy in alleviating the biochemical alterations induced by aluminum chloride in rabbits. Twenty-eight male rabbits were allocated into four groups (7 rabbits in each); Group I: served as normal control, Group II: treated with aluminum chloride (AlCl3) (150 mg/kg body weight), Group III: treated with AlCl3 and Zingiber officinale extract (100mg/kg. bw) and Group IV: treated with AlCl3 and Zingiber officinale extract (200mg/kg. bw). Rabbits in groups III and IV were orally treated daily with Zingiber officinale extract for 4 weeks. Aluminum exposure caused a significant elevation of BUN, creatinine, lipid profile, ALT, ALP, TNF-α, and amylase activity. All these parameters showed the reverse trend following oral Zingiber officinale treatment. Aluminum exposure showed a significant decrease in hepatic GSH and catalase activity. Treatment with Zingiber officinale extract significantly reversed aluminum effects, in the level of GSH content and hepatic catalase activity. Zingiber officinale is effective in alleviating the oxidative stress and inflammation and is thus effective in improving lipid profile and hepatotoxicity and nephrotoxicity in AlCl3 administration.},
year = {2017}
}
TY - JOUR T1 - Antioxidant and Ameliorative Effects of Zingiber officinale Against Aluminum Chloride Toxicity AU - Nabil A. Hasona AU - Mohammed Q. Ahmed Y1 - 2017/10/11 PY - 2017 N1 - https://doi.org/10.11648/j.ijcm.20170104.14 DO - 10.11648/j.ijcm.20170104.14 T2 - International Journal of Chinese Medicine JF - International Journal of Chinese Medicine JO - International Journal of Chinese Medicine SP - 124 EP - 131 PB - Science Publishing Group SN - 2578-9473 UR - https://doi.org/10.11648/j.ijcm.20170104.14 AB - The present study was performed to assess the antioxidant capacity of different doses of Zingiber officinale extract and its efficacy in alleviating the biochemical alterations induced by aluminum chloride in rabbits. Twenty-eight male rabbits were allocated into four groups (7 rabbits in each); Group I: served as normal control, Group II: treated with aluminum chloride (AlCl3) (150 mg/kg body weight), Group III: treated with AlCl3 and Zingiber officinale extract (100mg/kg. bw) and Group IV: treated with AlCl3 and Zingiber officinale extract (200mg/kg. bw). Rabbits in groups III and IV were orally treated daily with Zingiber officinale extract for 4 weeks. Aluminum exposure caused a significant elevation of BUN, creatinine, lipid profile, ALT, ALP, TNF-α, and amylase activity. All these parameters showed the reverse trend following oral Zingiber officinale treatment. Aluminum exposure showed a significant decrease in hepatic GSH and catalase activity. Treatment with Zingiber officinale extract significantly reversed aluminum effects, in the level of GSH content and hepatic catalase activity. Zingiber officinale is effective in alleviating the oxidative stress and inflammation and is thus effective in improving lipid profile and hepatotoxicity and nephrotoxicity in AlCl3 administration. VL - 1 IS - 4 ER -
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