Abamectin (avermectin) is a natural fermentation product of Streptomyces avermitilis and is widely used as a pesticide. Recently, it has been used as an antiparasitic agent. This study aims at assessing the impact of abamectin on hamsters infected with Schistosoma mansoni. Parasitological, histopathological parameters, glycolytic enzymes, liver function enzymes and cytokines were assessed in an infected hamster model. The data indicated that a significant decrease in the number of worms in Abamectin treated group as well as in the number of mature and live ova in the treated group. Also, treatment of the infected hamster with Abamectin recorded no significant difference in all glycolytic enzymes (PK, GPI and HK). Furthermore, Abamectin recorded no significant difference in the level of LDH, AST and ALT (liver function enzymes) as compared to S. mansoni infected group. In addition, immunization caused a slight decline in granuloma diameter, an increase in the immunoglobulins and cytokines. Also, histopathological results showed that Abamectin caused multinucleated histolytic inflammatory giant cell with cytoplasmic engulfed foreign bilharzial pigment in the liver tissue without viable bilharzial egg. In conclusion, the present data indicated that significant decline of parasitological parameters and no side effects of most parameters compared to the normal healthy control group.
| Published in | International Journal of Chinese Medicine (Volume 1, Issue 3) |
| DOI | 10.11648/j.ijcm.20170103.14 |
| Page(s) | 92-101 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Abamectin, Schistosoma mansoni, Product of Streptomyces avermitilis, Liver Function Enzymes, Glycolytic Enzymes
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APA Style
Amira I. El-Kabbany, Rania S. Hamza, Somaya M. Ismail, Khaled I. Ghaled. (2017). Effect of Abamectin on Biochemical, Immunological and Histological Parameters of Hamster Infected with Schistosoma mansoni. International Journal of Chinese Medicine, 1(3), 92-101. https://doi.org/10.11648/j.ijcm.20170103.14
ACS Style
Amira I. El-Kabbany; Rania S. Hamza; Somaya M. Ismail; Khaled I. Ghaled. Effect of Abamectin on Biochemical, Immunological and Histological Parameters of Hamster Infected with Schistosoma mansoni. Int. J. Chin. Med. 2017, 1(3), 92-101. doi: 10.11648/j.ijcm.20170103.14
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Download@article{10.11648/j.ijcm.20170103.14,
author = {Amira I. El-Kabbany and Rania S. Hamza and Somaya M. Ismail and Khaled I. Ghaled},
title = {Effect of Abamectin on Biochemical, Immunological and Histological Parameters of Hamster Infected with Schistosoma mansoni},
journal = {International Journal of Chinese Medicine},
volume = {1},
number = {3},
pages = {92-101},
doi = {10.11648/j.ijcm.20170103.14},
url = {https://doi.org/10.11648/j.ijcm.20170103.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcm.20170103.14},
abstract = {Abamectin (avermectin) is a natural fermentation product of Streptomyces avermitilis and is widely used as a pesticide. Recently, it has been used as an antiparasitic agent. This study aims at assessing the impact of abamectin on hamsters infected with Schistosoma mansoni. Parasitological, histopathological parameters, glycolytic enzymes, liver function enzymes and cytokines were assessed in an infected hamster model. The data indicated that a significant decrease in the number of worms in Abamectin treated group as well as in the number of mature and live ova in the treated group. Also, treatment of the infected hamster with Abamectin recorded no significant difference in all glycolytic enzymes (PK, GPI and HK). Furthermore, Abamectin recorded no significant difference in the level of LDH, AST and ALT (liver function enzymes) as compared to S. mansoni infected group. In addition, immunization caused a slight decline in granuloma diameter, an increase in the immunoglobulins and cytokines. Also, histopathological results showed that Abamectin caused multinucleated histolytic inflammatory giant cell with cytoplasmic engulfed foreign bilharzial pigment in the liver tissue without viable bilharzial egg. In conclusion, the present data indicated that significant decline of parasitological parameters and no side effects of most parameters compared to the normal healthy control group.},
year = {2017}
}
TY - JOUR T1 - Effect of Abamectin on Biochemical, Immunological and Histological Parameters of Hamster Infected with Schistosoma mansoni AU - Amira I. El-Kabbany AU - Rania S. Hamza AU - Somaya M. Ismail AU - Khaled I. Ghaled Y1 - 2017/06/20 PY - 2017 N1 - https://doi.org/10.11648/j.ijcm.20170103.14 DO - 10.11648/j.ijcm.20170103.14 T2 - International Journal of Chinese Medicine JF - International Journal of Chinese Medicine JO - International Journal of Chinese Medicine SP - 92 EP - 101 PB - Science Publishing Group SN - 2578-9473 UR - https://doi.org/10.11648/j.ijcm.20170103.14 AB - Abamectin (avermectin) is a natural fermentation product of Streptomyces avermitilis and is widely used as a pesticide. Recently, it has been used as an antiparasitic agent. This study aims at assessing the impact of abamectin on hamsters infected with Schistosoma mansoni. Parasitological, histopathological parameters, glycolytic enzymes, liver function enzymes and cytokines were assessed in an infected hamster model. The data indicated that a significant decrease in the number of worms in Abamectin treated group as well as in the number of mature and live ova in the treated group. Also, treatment of the infected hamster with Abamectin recorded no significant difference in all glycolytic enzymes (PK, GPI and HK). Furthermore, Abamectin recorded no significant difference in the level of LDH, AST and ALT (liver function enzymes) as compared to S. mansoni infected group. In addition, immunization caused a slight decline in granuloma diameter, an increase in the immunoglobulins and cytokines. Also, histopathological results showed that Abamectin caused multinucleated histolytic inflammatory giant cell with cytoplasmic engulfed foreign bilharzial pigment in the liver tissue without viable bilharzial egg. In conclusion, the present data indicated that significant decline of parasitological parameters and no side effects of most parameters compared to the normal healthy control group. VL - 1 IS - 3 ER -
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