The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution

Yu Chuan; Liu Penggang; Yang Gang; Wu Qiang

doi:doi:10.11648/j.ijast.20210502.11

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The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang

Published in International Journal of Animal Science and Technology (Volume 5, Issue 2)

Received: 23 March 2021 Accepted: 10 April 2021 Published: 20 April 2021

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Abstract

Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.

Published in	International Journal of Animal Science and Technology (Volume 5, Issue 2)
DOI	10.11648/j.ijast.20210502.11
Page(s)	32-37
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Rabbit, Epidermis, Dermis, Hair Folliclaes, Sebaceous Glands, Pharmacokinetics

References

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APA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. (2021). The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. International Journal of Animal Science and Technology, 5(2), 32-37. https://doi.org/10.11648/j.ijast.20210502.11

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ACS Style

Yu Chuan; Liu Penggang; Yang Gang; Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int. J. Anim. Sci. Technol. 2021, 5(2), 32-37. doi: 10.11648/j.ijast.20210502.11

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AMA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int J Anim Sci Technol. 2021;5(2):32-37. doi: 10.11648/j.ijast.20210502.11

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@article{10.11648/j.ijast.20210502.11,
  author = {Yu Chuan and Liu Penggang and Yang Gang and Wu Qiang},
  title = {The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution},
  journal = {International Journal of Animal Science and Technology},
  volume = {5},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijast.20210502.11},
  url = {https://doi.org/10.11648/j.ijast.20210502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20210502.11},
  abstract = {Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.},
 year = {2021}
}

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TY - JOUR
T1 - The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution
AU - Yu Chuan
AU - Liu Penggang
AU - Yang Gang
AU - Wu Qiang
Y1 - 2021/04/20
PY - 2021
N1 - https://doi.org/10.11648/j.ijast.20210502.11
DO - 10.11648/j.ijast.20210502.11
T2 - International Journal of Animal Science and Technology
JF - International Journal of Animal Science and Technology
JO - International Journal of Animal Science and Technology
SP - 32
EP - 37
PB - Science Publishing Group
SN - 2640-1312
UR - https://doi.org/10.11648/j.ijast.20210502.11
AB - Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.
VL - 5
IS - 2
ER -

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Author Information

Yu Chuan

College of Agricultural, Yibin Vocation & Technical College, Yibin, China
Liu Penggang

College of Veterinary Medicine, Yang Zhou University, Yangzhou, China
Yang Gang

College of Agricultural, Yibin Vocation & Technical College, Yibin, China
Wu Qiang

College of Agricultural, Yibin Vocation & Technical College, Yibin, China

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Plain Text BibTeX RIS

APA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. (2021). The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. International Journal of Animal Science and Technology, 5(2), 32-37. https://doi.org/10.11648/j.ijast.20210502.11

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ACS Style

Yu Chuan; Liu Penggang; Yang Gang; Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int. J. Anim. Sci. Technol. 2021, 5(2), 32-37. doi: 10.11648/j.ijast.20210502.11

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AMA Style

Yu Chuan, Liu Penggang, Yang Gang, Wu Qiang. The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution. Int J Anim Sci Technol. 2021;5(2):32-37. doi: 10.11648/j.ijast.20210502.11

Copy | Download

@article{10.11648/j.ijast.20210502.11,
  author = {Yu Chuan and Liu Penggang and Yang Gang and Wu Qiang},
  title = {The Pharmacokinetics and Skin Changes in Rabbit on Selamectin Solution},
  journal = {International Journal of Animal Science and Technology},
  volume = {5},
  number = {2},
  pages = {32-37},
  doi = {10.11648/j.ijast.20210502.11},
  url = {https://doi.org/10.11648/j.ijast.20210502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijast.20210502.11},
  abstract = {Background: It found that many antiparasitic drugs have a good treatment effect on the pets skin diseases. whether selamectin solutions have a bad effect on skin tissues needs more research. Objective: In order to investigate the effect of selamectin solution on skin changes in rabbit. Method: the skin of rabbit was given different doses of selamectin solution, then the quantity of per unit area of hair follicles and sebaceous glands and the morphology structure of them and the changes of skin thickness, epidermis thickness and dermis thickness were researched through routine paraffin sections and H. E, Evg, Masson’s, Pas, Toluidine blue staining and Image Pro Plus6.0. The concentration of blood and urine were measured by High Performance Liquid Chromatography after administration. Results: The thickness of skin, per unit of hair follicles and sebaceous glands all had an obviously increasing trend with the increasing of doses. 1 day later, the blood and urine concentration of the selamectin and the metabolite avermectin all were in highest. Many selamectin solution were excluded in the form of prototypes and many were in avermectin. There were a higher blood concentration and metabolite avermectin until 72h. Conclusion: The skin appearance changes were insignificant while the skin thickness and accessory organs increased obviously in microscope after given more selamectin. In 24h, the blood and urine concentration all were in highest. This study, which discussed the influences by selamectin solution in rabbit skin and the pharmacokinetics, was to provide the basis for the deeper study of Antiparasitic drugs effects on pet skin diseases.},
 year = {2021}
}

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