Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal

Raja Chakraverty; Tatini Debnath

doi:doi:10.11648/j.ejcbs.20170301.12

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Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal

Raja Chakraverty, Tatini Debnath

Published in European Journal of Clinical and Biomedical Sciences (Volume 3, Issue 1)

Received: 15 October 2016 Accepted: 12 January 2017 Published: 9 February 2017

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Abstract

Antibody drug conjugates intends to pursue the monoclonal antibodies (mAbs) as the potent source of delivering cytotoxic drugs to more specific site which binds selectively to the antigen expressing tumor cells. Inspite of the facts, various other safety profile must be considered while designing and optimizing ADC such as selecting congruous target antigen and method of conjugation. Each and every component of the ADC i.e antibody, linker and the drug should be optimized to the extent of desirable targeted therapy which will ameliorate as well as enhance tolerability. The past decade had witnessed advances in newer cancer treatments with extremely selective small molecules targeting the specific genetic abnormality causing the disease. The approach of traditional cytotoxic agents in the treatment of cancer, unlike the target specificity, they affect both healthy as well as cancer cells. In order to build a powerful and more specific cytotoxic agent with target oriented mAb’s designing attributes would lead to pertinent and potential breakthrough in cancer treatments. Therefore ADC’s were developed with the intention that antibody would target the specific antigen of the tumor wherein the drug attached to it would induce its cytotoxicity. Developement of new techniques and methods in implementing new generation ADC’s in the past decades incorporated non-immunogenic monoclonal antibodies comprising linkers having equitable stability and distinctly potent cytotoxic agents. Newer challenges although remain but comprehensive clinical accomplishment is generating increased interest in this therapeutic class of drugs.

Published in	European Journal of Clinical and Biomedical Sciences (Volume 3, Issue 1)
DOI	10.11648/j.ejcbs.20170301.12
Page(s)	7-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

ADC, Monoclonal Antibodies, Bioconjugation, Linker

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Raja Chakraverty, Tatini Debnath. (2017). Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal. European Journal of Clinical and Biomedical Sciences, 3(1), 7-12. https://doi.org/10.11648/j.ejcbs.20170301.12

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ACS Style

Raja Chakraverty; Tatini Debnath. Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal. Eur. J. Clin. Biomed. Sci. 2017, 3(1), 7-12. doi: 10.11648/j.ejcbs.20170301.12

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AMA Style

Raja Chakraverty, Tatini Debnath. Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal. Eur J Clin Biomed Sci. 2017;3(1):7-12. doi: 10.11648/j.ejcbs.20170301.12

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@article{10.11648/j.ejcbs.20170301.12,
  author = {Raja Chakraverty and Tatini Debnath},
  title = {Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal},
  journal = {European Journal of Clinical and Biomedical Sciences},
  volume = {3},
  number = {1},
  pages = {7-12},
  doi = {10.11648/j.ejcbs.20170301.12},
  url = {https://doi.org/10.11648/j.ejcbs.20170301.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20170301.12},
  abstract = {Antibody drug conjugates intends to pursue the monoclonal antibodies (mAbs) as the potent source of delivering cytotoxic drugs to more specific site which binds selectively to the antigen expressing tumor cells. Inspite of the facts, various other safety profile must be considered while designing and optimizing ADC such as selecting congruous target antigen and method of conjugation. Each and every component of the ADC i.e antibody, linker and the drug should be optimized to the extent of desirable targeted therapy which will ameliorate as well as enhance tolerability. The past decade had witnessed advances in newer cancer treatments with extremely selective small molecules targeting the specific genetic abnormality causing the disease. The approach of traditional cytotoxic agents in the treatment of cancer, unlike the target specificity, they affect both healthy as well as cancer cells. In order to build a powerful and more specific cytotoxic agent with target oriented mAb’s designing attributes would lead to pertinent and potential breakthrough in cancer treatments. Therefore ADC’s were developed with the intention that antibody would target the specific antigen of the tumor wherein the drug attached to it would induce its cytotoxicity. Developement of new techniques and methods in implementing new generation ADC’s in the past decades incorporated non-immunogenic monoclonal antibodies comprising linkers having equitable stability and distinctly potent cytotoxic agents. Newer challenges although remain but comprehensive clinical accomplishment is generating increased interest in this therapeutic class of drugs.},
 year = {2017}
}

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TY  - JOUR
T1  - Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal
AU  - Raja Chakraverty
AU  - Tatini Debnath
Y1  - 2017/02/09
PY  - 2017
N1  - https://doi.org/10.11648/j.ejcbs.20170301.12
DO  - 10.11648/j.ejcbs.20170301.12
T2  - European Journal of Clinical and Biomedical Sciences
JF  - European Journal of Clinical and Biomedical Sciences
JO  - European Journal of Clinical and Biomedical Sciences
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2575-5005
UR  - https://doi.org/10.11648/j.ejcbs.20170301.12
AB  - Antibody drug conjugates intends to pursue the monoclonal antibodies (mAbs) as the potent source of delivering cytotoxic drugs to more specific site which binds selectively to the antigen expressing tumor cells. Inspite of the facts, various other safety profile must be considered while designing and optimizing ADC such as selecting congruous target antigen and method of conjugation. Each and every component of the ADC i.e antibody, linker and the drug should be optimized to the extent of desirable targeted therapy which will ameliorate as well as enhance tolerability. The past decade had witnessed advances in newer cancer treatments with extremely selective small molecules targeting the specific genetic abnormality causing the disease. The approach of traditional cytotoxic agents in the treatment of cancer, unlike the target specificity, they affect both healthy as well as cancer cells. In order to build a powerful and more specific cytotoxic agent with target oriented mAb’s designing attributes would lead to pertinent and potential breakthrough in cancer treatments. Therefore ADC’s were developed with the intention that antibody would target the specific antigen of the tumor wherein the drug attached to it would induce its cytotoxicity. Developement of new techniques and methods in implementing new generation ADC’s in the past decades incorporated non-immunogenic monoclonal antibodies comprising linkers having equitable stability and distinctly potent cytotoxic agents. Newer challenges although remain but comprehensive clinical accomplishment is generating increased interest in this therapeutic class of drugs.
VL  - 3
IS  - 1
ER  -

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Author Information

Raja Chakraverty

Department of Pharmaceutical Technology, Bengal School of Technology (A College of Pharmacy) Hooghly, West Bengal, India
Tatini Debnath

Department of Quality Control, Abate Medicaments, Barasat, West Bengal, India

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APA Style

Raja Chakraverty, Tatini Debnath. (2017). Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal. European Journal of Clinical and Biomedical Sciences, 3(1), 7-12. https://doi.org/10.11648/j.ejcbs.20170301.12

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ACS Style

Raja Chakraverty; Tatini Debnath. Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal. Eur. J. Clin. Biomed. Sci. 2017, 3(1), 7-12. doi: 10.11648/j.ejcbs.20170301.12

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AMA Style

Raja Chakraverty, Tatini Debnath. Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal. Eur J Clin Biomed Sci. 2017;3(1):7-12. doi: 10.11648/j.ejcbs.20170301.12

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@article{10.11648/j.ejcbs.20170301.12,
  author = {Raja Chakraverty and Tatini Debnath},
  title = {Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal},
  journal = {European Journal of Clinical and Biomedical Sciences},
  volume = {3},
  number = {1},
  pages = {7-12},
  doi = {10.11648/j.ejcbs.20170301.12},
  url = {https://doi.org/10.11648/j.ejcbs.20170301.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20170301.12},
  abstract = {Antibody drug conjugates intends to pursue the monoclonal antibodies (mAbs) as the potent source of delivering cytotoxic drugs to more specific site which binds selectively to the antigen expressing tumor cells. Inspite of the facts, various other safety profile must be considered while designing and optimizing ADC such as selecting congruous target antigen and method of conjugation. Each and every component of the ADC i.e antibody, linker and the drug should be optimized to the extent of desirable targeted therapy which will ameliorate as well as enhance tolerability. The past decade had witnessed advances in newer cancer treatments with extremely selective small molecules targeting the specific genetic abnormality causing the disease. The approach of traditional cytotoxic agents in the treatment of cancer, unlike the target specificity, they affect both healthy as well as cancer cells. In order to build a powerful and more specific cytotoxic agent with target oriented mAb’s designing attributes would lead to pertinent and potential breakthrough in cancer treatments. Therefore ADC’s were developed with the intention that antibody would target the specific antigen of the tumor wherein the drug attached to it would induce its cytotoxicity. Developement of new techniques and methods in implementing new generation ADC’s in the past decades incorporated non-immunogenic monoclonal antibodies comprising linkers having equitable stability and distinctly potent cytotoxic agents. Newer challenges although remain but comprehensive clinical accomplishment is generating increased interest in this therapeutic class of drugs.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Emerging Role of Antibody Drug Conjugates (ADCs) in Therapeutics: An Appraisal
AU  - Raja Chakraverty
AU  - Tatini Debnath
Y1  - 2017/02/09
PY  - 2017
N1  - https://doi.org/10.11648/j.ejcbs.20170301.12
DO  - 10.11648/j.ejcbs.20170301.12
T2  - European Journal of Clinical and Biomedical Sciences
JF  - European Journal of Clinical and Biomedical Sciences
JO  - European Journal of Clinical and Biomedical Sciences
SP  - 7
EP  - 12
PB  - Science Publishing Group
SN  - 2575-5005
UR  - https://doi.org/10.11648/j.ejcbs.20170301.12
AB  - Antibody drug conjugates intends to pursue the monoclonal antibodies (mAbs) as the potent source of delivering cytotoxic drugs to more specific site which binds selectively to the antigen expressing tumor cells. Inspite of the facts, various other safety profile must be considered while designing and optimizing ADC such as selecting congruous target antigen and method of conjugation. Each and every component of the ADC i.e antibody, linker and the drug should be optimized to the extent of desirable targeted therapy which will ameliorate as well as enhance tolerability. The past decade had witnessed advances in newer cancer treatments with extremely selective small molecules targeting the specific genetic abnormality causing the disease. The approach of traditional cytotoxic agents in the treatment of cancer, unlike the target specificity, they affect both healthy as well as cancer cells. In order to build a powerful and more specific cytotoxic agent with target oriented mAb’s designing attributes would lead to pertinent and potential breakthrough in cancer treatments. Therefore ADC’s were developed with the intention that antibody would target the specific antigen of the tumor wherein the drug attached to it would induce its cytotoxicity. Developement of new techniques and methods in implementing new generation ADC’s in the past decades incorporated non-immunogenic monoclonal antibodies comprising linkers having equitable stability and distinctly potent cytotoxic agents. Newer challenges although remain but comprehensive clinical accomplishment is generating increased interest in this therapeutic class of drugs.
VL  - 3
IS  - 1
ER  -

Copy | Download