Aim: The scientific viewpoint of genetic polymorphisms associated with risk of alcoholism and its adverse individual behavioural reactions is the main focus of this review. A complex syndrome like alcoholism and its idiosyncrasy may not be entirely understood on the basis of pathophysiological concept of neurotransmission alone. While neuropharmacology explains the mechanism behind molecular basis of alcoholism, the variation in alcohol induced abnormal neurotransmission due to presence or absence of different gene variants or isoenzymes of a particular gene on the other hand is a strong indication of genetic predisposition to alcoholism. In this article the term alcohol is used as a generic name for ethanol, which is the main subject of this discussion. Conclusion: The concomitant untoward intrinsic toxicity associated with alcoholism that makes it a potential trigger to a myriad of abnormal behavioural reactions in not only dose dependent pattern but with strong genetic disposition arises majorly due to different modes and levels of genetic variation in metabolic enzymes.
| Published in | European Journal of Clinical and Biomedical Sciences (Volume 2, Issue 6) |
| DOI | 10.11648/j.ejcbs.20160206.12 |
| Page(s) | 63-68 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Alcoholism, Genetic, Polymorphism Neurotransmission, Enzymes, ALDH, ADH, Cytochrome P450
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APA Style
Charles Ejike Osuji. (2016). Genetic Basis of Idiosyncratic Responses to Alcoholism. European Journal of Clinical and Biomedical Sciences, 2(6), 63-68. https://doi.org/10.11648/j.ejcbs.20160206.12
ACS Style
Charles Ejike Osuji. Genetic Basis of Idiosyncratic Responses to Alcoholism. Eur. J. Clin. Biomed. Sci. 2016, 2(6), 63-68. doi: 10.11648/j.ejcbs.20160206.12
AMA Style
Charles Ejike Osuji. Genetic Basis of Idiosyncratic Responses to Alcoholism. Eur J Clin Biomed Sci. 2016;2(6):63-68. doi: 10.11648/j.ejcbs.20160206.12
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Download@article{10.11648/j.ejcbs.20160206.12,
author = {Charles Ejike Osuji},
title = {Genetic Basis of Idiosyncratic Responses to Alcoholism},
journal = {European Journal of Clinical and Biomedical Sciences},
volume = {2},
number = {6},
pages = {63-68},
doi = {10.11648/j.ejcbs.20160206.12},
url = {https://doi.org/10.11648/j.ejcbs.20160206.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ejcbs.20160206.12},
abstract = {Aim: The scientific viewpoint of genetic polymorphisms associated with risk of alcoholism and its adverse individual behavioural reactions is the main focus of this review. A complex syndrome like alcoholism and its idiosyncrasy may not be entirely understood on the basis of pathophysiological concept of neurotransmission alone. While neuropharmacology explains the mechanism behind molecular basis of alcoholism, the variation in alcohol induced abnormal neurotransmission due to presence or absence of different gene variants or isoenzymes of a particular gene on the other hand is a strong indication of genetic predisposition to alcoholism. In this article the term alcohol is used as a generic name for ethanol, which is the main subject of this discussion. Conclusion: The concomitant untoward intrinsic toxicity associated with alcoholism that makes it a potential trigger to a myriad of abnormal behavioural reactions in not only dose dependent pattern but with strong genetic disposition arises majorly due to different modes and levels of genetic variation in metabolic enzymes.},
year = {2016}
}
TY - JOUR T1 - Genetic Basis of Idiosyncratic Responses to Alcoholism AU - Charles Ejike Osuji Y1 - 2016/12/12 PY - 2016 N1 - https://doi.org/10.11648/j.ejcbs.20160206.12 DO - 10.11648/j.ejcbs.20160206.12 T2 - European Journal of Clinical and Biomedical Sciences JF - European Journal of Clinical and Biomedical Sciences JO - European Journal of Clinical and Biomedical Sciences SP - 63 EP - 68 PB - Science Publishing Group SN - 2575-5005 UR - https://doi.org/10.11648/j.ejcbs.20160206.12 AB - Aim: The scientific viewpoint of genetic polymorphisms associated with risk of alcoholism and its adverse individual behavioural reactions is the main focus of this review. A complex syndrome like alcoholism and its idiosyncrasy may not be entirely understood on the basis of pathophysiological concept of neurotransmission alone. While neuropharmacology explains the mechanism behind molecular basis of alcoholism, the variation in alcohol induced abnormal neurotransmission due to presence or absence of different gene variants or isoenzymes of a particular gene on the other hand is a strong indication of genetic predisposition to alcoholism. In this article the term alcohol is used as a generic name for ethanol, which is the main subject of this discussion. Conclusion: The concomitant untoward intrinsic toxicity associated with alcoholism that makes it a potential trigger to a myriad of abnormal behavioural reactions in not only dose dependent pattern but with strong genetic disposition arises majorly due to different modes and levels of genetic variation in metabolic enzymes. VL - 2 IS - 6 ER -
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