The ameliorative tendency of the leaves of Alchornea cordifolia has been reported against ailments ranging from conjunctivitis to yaws and certain parasitic infections. This necessitated investigating the in vitro antibacterial efficacy of methanol-extracted leaves of Alchornea cordifolia on hematological and histopathological of organ of toxicity on albino rats. The rats were randomly segregated into four groups of five animals in each cage. The groups were orally administered with 250, 500 and 750 mg/kg body weight and 10% Tween 80 control for 28 days. Blood samples were collected for hematological analysis and organs (liver and spleen) for histopathological analysis. The data obtained were analyzed by ANOVA and Dunnett’s test at P>0.05 levels of significance. Methanol leaf extract had a significantly higher inhibitory zone in E. coli and K. pneumonia ranging 35.00± 1.73 and 35.67± 3.48 at all the concentrations tested. There was no significant effect on hematological parameters. Liver necrosis was noticed in the harvested organs of the experimental rats. The liver sections of rat treated with 750mg/kg of the leaf extract showed cloudy swelling of hepatocytes and mild Kupffer cell hyperplasia. These results suggest that Alchornea cordifolia is non-toxic but has the propensity to induce hepatic injury at high doses. Conclusively, successful antibacterial activity at all concentrations and the slight pathological effects could be indicative low toxicity and high efficacy of this plant if taken at lower doses.
| Published in | Ecology and Evolutionary Biology (Volume 5, Issue 2) |
| DOI | 10.11648/j.eeb.20200502.12 |
| Page(s) | 22-28 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Alchornea Cordifolia, Hyperplasia, Conjunctivitis, Antibacterial, Histopathological
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APA Style
Komolafe Kafilat Adenike, Adeoti Olatunde Micheal, Olaoye Opeyemi Joy, Olufemi Olutope Samson, Adedokun Elizabeth Olajumoke, et al. (2020). Oral Toxicity Assessment and In vitro Antimicrobial Profile of Methanolic Leaf Extract of Alchornea Cordifolia on Albino Rats. Ecology and Evolutionary Biology, 5(2), 22-28. https://doi.org/10.11648/j.eeb.20200502.12
ACS Style
Komolafe Kafilat Adenike; Adeoti Olatunde Micheal; Olaoye Opeyemi Joy; Olufemi Olutope Samson; Adedokun Elizabeth Olajumoke, et al. Oral Toxicity Assessment and In vitro Antimicrobial Profile of Methanolic Leaf Extract of Alchornea Cordifolia on Albino Rats. Ecol. Evol. Biol. 2020, 5(2), 22-28. doi: 10.11648/j.eeb.20200502.12
AMA Style
Komolafe Kafilat Adenike, Adeoti Olatunde Micheal, Olaoye Opeyemi Joy, Olufemi Olutope Samson, Adedokun Elizabeth Olajumoke, et al. Oral Toxicity Assessment and In vitro Antimicrobial Profile of Methanolic Leaf Extract of Alchornea Cordifolia on Albino Rats. Ecol Evol Biol. 2020;5(2):22-28. doi: 10.11648/j.eeb.20200502.12
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Download@article{10.11648/j.eeb.20200502.12,
author = {Komolafe Kafilat Adenike and Adeoti Olatunde Micheal and Olaoye Opeyemi Joy and Olufemi Olutope Samson and Adedokun Elizabeth Olajumoke and Adedoja Sulaiman Aderogba and Adesina David Ademola and Abiola Adebiyi Oladepo},
title = {Oral Toxicity Assessment and In vitro Antimicrobial Profile of Methanolic Leaf Extract of Alchornea Cordifolia on Albino Rats},
journal = {Ecology and Evolutionary Biology},
volume = {5},
number = {2},
pages = {22-28},
doi = {10.11648/j.eeb.20200502.12},
url = {https://doi.org/10.11648/j.eeb.20200502.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.eeb.20200502.12},
abstract = {The ameliorative tendency of the leaves of Alchornea cordifolia has been reported against ailments ranging from conjunctivitis to yaws and certain parasitic infections. This necessitated investigating the in vitro antibacterial efficacy of methanol-extracted leaves of Alchornea cordifolia on hematological and histopathological of organ of toxicity on albino rats. The rats were randomly segregated into four groups of five animals in each cage. The groups were orally administered with 250, 500 and 750 mg/kg body weight and 10% Tween 80 control for 28 days. Blood samples were collected for hematological analysis and organs (liver and spleen) for histopathological analysis. The data obtained were analyzed by ANOVA and Dunnett’s test at P>0.05 levels of significance. Methanol leaf extract had a significantly higher inhibitory zone in E. coli and K. pneumonia ranging 35.00± 1.73 and 35.67± 3.48 at all the concentrations tested. There was no significant effect on hematological parameters. Liver necrosis was noticed in the harvested organs of the experimental rats. The liver sections of rat treated with 750mg/kg of the leaf extract showed cloudy swelling of hepatocytes and mild Kupffer cell hyperplasia. These results suggest that Alchornea cordifolia is non-toxic but has the propensity to induce hepatic injury at high doses. Conclusively, successful antibacterial activity at all concentrations and the slight pathological effects could be indicative low toxicity and high efficacy of this plant if taken at lower doses.},
year = {2020}
}
TY - JOUR T1 - Oral Toxicity Assessment and In vitro Antimicrobial Profile of Methanolic Leaf Extract of Alchornea Cordifolia on Albino Rats AU - Komolafe Kafilat Adenike AU - Adeoti Olatunde Micheal AU - Olaoye Opeyemi Joy AU - Olufemi Olutope Samson AU - Adedokun Elizabeth Olajumoke AU - Adedoja Sulaiman Aderogba AU - Adesina David Ademola AU - Abiola Adebiyi Oladepo Y1 - 2020/08/05 PY - 2020 N1 - https://doi.org/10.11648/j.eeb.20200502.12 DO - 10.11648/j.eeb.20200502.12 T2 - Ecology and Evolutionary Biology JF - Ecology and Evolutionary Biology JO - Ecology and Evolutionary Biology SP - 22 EP - 28 PB - Science Publishing Group SN - 2575-3762 UR - https://doi.org/10.11648/j.eeb.20200502.12 AB - The ameliorative tendency of the leaves of Alchornea cordifolia has been reported against ailments ranging from conjunctivitis to yaws and certain parasitic infections. This necessitated investigating the in vitro antibacterial efficacy of methanol-extracted leaves of Alchornea cordifolia on hematological and histopathological of organ of toxicity on albino rats. The rats were randomly segregated into four groups of five animals in each cage. The groups were orally administered with 250, 500 and 750 mg/kg body weight and 10% Tween 80 control for 28 days. Blood samples were collected for hematological analysis and organs (liver and spleen) for histopathological analysis. The data obtained were analyzed by ANOVA and Dunnett’s test at P>0.05 levels of significance. Methanol leaf extract had a significantly higher inhibitory zone in E. coli and K. pneumonia ranging 35.00± 1.73 and 35.67± 3.48 at all the concentrations tested. There was no significant effect on hematological parameters. Liver necrosis was noticed in the harvested organs of the experimental rats. The liver sections of rat treated with 750mg/kg of the leaf extract showed cloudy swelling of hepatocytes and mild Kupffer cell hyperplasia. These results suggest that Alchornea cordifolia is non-toxic but has the propensity to induce hepatic injury at high doses. Conclusively, successful antibacterial activity at all concentrations and the slight pathological effects could be indicative low toxicity and high efficacy of this plant if taken at lower doses. VL - 5 IS - 2 ER -
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