Using Soursop Extracts for Natural Gout Treatment

Mufeed Jalil Ewadh; Maha Fadhil Smaism; Ali Mohammed Jawad; Samr Mkhlof; Osama Muzahim Aljubouri; Muna Mufeed Ewadh

doi:doi:10.11648/j.bio.20150305.12

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Using Soursop Extracts for Natural Gout Treatment

Mufeed Jalil Ewadh, Maha Fadhil Smaism, Ali Mohammed Jawad, Samr Mkhlof, Osama Muzahim Aljubouri, Muna Mufeed Ewadh

Published in American Journal of Bioscience and Bioengineering (Volume 3, Issue 5)

Received: 27 July 2015 Accepted: 5 August 2015 Published: 17 September 2015

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Abstract

Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.

Published in	American Journal of Bioscience and Bioengineering (Volume 3, Issue 5)
DOI	10.11648/j.bio.20150305.12
Page(s)	37-39
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Soursop, Gout, Xanthine Oxidase, Trace Elements

References

[1]	http://www.cancerresearchuk.org/about-cancer/cancers-in-general/cancer-questions/can-graviola-cure-cancer
[2]	Arromede, E., Michet, C. J., Crowson, C. S., O’ Fallon, W. M., and Gabriel S.E. Epidemiology of gout: is the incidence rising? J. Rheumatol.; 29, 2403-2406. (2002)
[3]	Kramer, HM., and Curhan, G. The association between gout and nephrolithiasis. Am. J. Kid. Dis.; 40, 37–42. (2002)
[4]	Lin, K. C, Lin, H. Y, and Chou, P. The interaction between uric acidlevel and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study. J. Rheumatol.; 27, 1501–1505. (2000)
[5]	Kong, L. D, Cai, Y., Huang, W. W, Cheng, C. H. K., and Tan, R.X. Inhibition of xanthine oxidase by some Chinese medicinal plants used to treat gout. J. Ethnopharmacol.; 73, 199-207. (2000)
[6]	Abdulsamie, H. Altaee., Mufeed J. Ewadh., Haider K. Zaidan Hormonal contents of two types of Black seed (nigella sativa) oil: comparative study. Medical Journal of Babylon 3 (1-2),17-22,(2006)
[7]	Ganesh N., Sharma S. K., Dubey S. N., and Sanadya J., Phytochemical screening and estimation of total phenolic content in Aegle marmelos seed. International Journal of pharmaceutical and clinical research; 3 (2):27-29. (2011)
[8]	Iswantini, D., N., Darusman, L. K. and T. Inhibition kinetic of Apium graveolen L. ethanol extract and its fraction on the activity of xanthine oxidase and its active compound. (2012)
[9]	Rasero, F. S.: Atomic Absorption Spectrophotometric Method for Determination of Water-Soluble Copper in Water-Insoluble Copper Fungicides: CIPAC Collaborative Study. Comparison with Bathocuproine Method. J. Assoc. Off. Anal. Chem., 64: 75-78.( 1981)
[10]	Intisar R. A Study of some Natural products as inhibitors of Xanthine Oxidase Activity. M. Sc thesis, Babylon University, College of medicine, Clinical biochemistry Dept. IRAQ (2014)
[11]	Umamaheswari, M., Asok Kumar, K., Somasundaram, A., Sivashanmugam, T., Subhadradevi, V. and Ravi, T. K. Xanthine oxidase inhibitory activity of some Indian medicinal plants. Journal of Ethnopharmacology 109 (3): 547-551. (2007).
[12]	Bondet, V., Brand-Williams, W., and Berset, C. Kinetic and mechanisms of antioxidant activity using DPPF free radical method. Lebensmittel-Wissenschaft&technologie.food.Sci.Technol.30, 609-615. (1997)
[13]	Costantino, L., Albasini, A., Rastelli, G., and Benvenuti, S. Activity of polyphenolic crude extracts as scavengers of superoxide radicals and inhibitors of xanthine oxidase. Planta. Med.; 58, 342-344.(1992)
[14]	Cancer treatment center of America, May 30, (2013).

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Mufeed Jalil Ewadh, Maha Fadhil Smaism, Ali Mohammed Jawad, Samr Mkhlof, Osama Muzahim Aljubouri, et al. (2015). Using Soursop Extracts for Natural Gout Treatment. American Journal of Bioscience and Bioengineering, 3(5), 37-39. https://doi.org/10.11648/j.bio.20150305.12

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ACS Style

Mufeed Jalil Ewadh; Maha Fadhil Smaism; Ali Mohammed Jawad; Samr Mkhlof; Osama Muzahim Aljubouri, et al. Using Soursop Extracts for Natural Gout Treatment. Am. J. BioSci. Bioeng. 2015, 3(5), 37-39. doi: 10.11648/j.bio.20150305.12

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AMA Style

Mufeed Jalil Ewadh, Maha Fadhil Smaism, Ali Mohammed Jawad, Samr Mkhlof, Osama Muzahim Aljubouri, et al. Using Soursop Extracts for Natural Gout Treatment. Am J BioSci Bioeng. 2015;3(5):37-39. doi: 10.11648/j.bio.20150305.12

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@article{10.11648/j.bio.20150305.12,
  author = {Mufeed Jalil Ewadh and Maha Fadhil Smaism and Ali Mohammed Jawad and Samr Mkhlof and Osama Muzahim Aljubouri and Muna Mufeed Ewadh},
  title = {Using Soursop Extracts for Natural Gout Treatment},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {5},
  pages = {37-39},
  doi = {10.11648/j.bio.20150305.12},
  url = {https://doi.org/10.11648/j.bio.20150305.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20150305.12},
  abstract = {Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.},
 year = {2015}
}

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TY  - JOUR
T1  - Using Soursop Extracts for Natural Gout Treatment
AU  - Mufeed Jalil Ewadh
AU  - Maha Fadhil Smaism
AU  - Ali Mohammed Jawad
AU  - Samr Mkhlof
AU  - Osama Muzahim Aljubouri
AU  - Muna Mufeed Ewadh
Y1  - 2015/09/17
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20150305.12
DO  - 10.11648/j.bio.20150305.12
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 37
EP  - 39
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20150305.12
AB  - Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.
VL  - 3
IS  - 5
ER  -

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Author Information

Mufeed Jalil Ewadh

Biochemistry Dept., College of Medicine, University of Babylon, Babylon, Iraq
Maha Fadhil Smaism

Biochemistry Dept., College of Medicine, University of Babylon, Babylon, Iraq
Ali Mohammed Jawad

Ministry of Science and Technology, Baghdad, Iraq
Samr Mkhlof

Tishreen University, Faculty of Medicine, Lattakia, Syria
Osama Muzahim Aljubouri

Babylon Health Office, Merjan Taching Hospital, Diabetology Center Medical Laboratory, Babylon, Iraq
Muna Mufeed Ewadh

Biochemistry Dept., College of Medicine, University of Babylon, Babylon, Iraq

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APA Style

Mufeed Jalil Ewadh, Maha Fadhil Smaism, Ali Mohammed Jawad, Samr Mkhlof, Osama Muzahim Aljubouri, et al. (2015). Using Soursop Extracts for Natural Gout Treatment. American Journal of Bioscience and Bioengineering, 3(5), 37-39. https://doi.org/10.11648/j.bio.20150305.12

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ACS Style

Mufeed Jalil Ewadh; Maha Fadhil Smaism; Ali Mohammed Jawad; Samr Mkhlof; Osama Muzahim Aljubouri, et al. Using Soursop Extracts for Natural Gout Treatment. Am. J. BioSci. Bioeng. 2015, 3(5), 37-39. doi: 10.11648/j.bio.20150305.12

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AMA Style

Mufeed Jalil Ewadh, Maha Fadhil Smaism, Ali Mohammed Jawad, Samr Mkhlof, Osama Muzahim Aljubouri, et al. Using Soursop Extracts for Natural Gout Treatment. Am J BioSci Bioeng. 2015;3(5):37-39. doi: 10.11648/j.bio.20150305.12

Copy | Download

@article{10.11648/j.bio.20150305.12,
  author = {Mufeed Jalil Ewadh and Maha Fadhil Smaism and Ali Mohammed Jawad and Samr Mkhlof and Osama Muzahim Aljubouri and Muna Mufeed Ewadh},
  title = {Using Soursop Extracts for Natural Gout Treatment},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {5},
  pages = {37-39},
  doi = {10.11648/j.bio.20150305.12},
  url = {https://doi.org/10.11648/j.bio.20150305.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20150305.12},
  abstract = {Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Using Soursop Extracts for Natural Gout Treatment
AU  - Mufeed Jalil Ewadh
AU  - Maha Fadhil Smaism
AU  - Ali Mohammed Jawad
AU  - Samr Mkhlof
AU  - Osama Muzahim Aljubouri
AU  - Muna Mufeed Ewadh
Y1  - 2015/09/17
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20150305.12
DO  - 10.11648/j.bio.20150305.12
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 37
EP  - 39
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20150305.12
AB  - Soursop extract used to show its effects on the xanthine oxidase activity by inhibition its ability to produce uric acid, the principal reason for the gout and other inflammatory diseases. The fractionation results shows that the major fraction of phenolic compounds is cumarin separated by revise phase high performance chromatography (HPLC) which shows by in vitro test a considerable inhibition of the xanthine oxidase activity equal to 72.15 ± 0.70 compared with positive control (Allopurinol) (P < 0.05) which lead to reduce production of uric acid. The atomic absorption analysis (AA) of trace elements (Fe, Zn, Mg, P) shows the presence of such metals in soursop sample in an amount nessacery for many metabolic processes in human body. In conclusion the cumarin can used as treatment for gout instead of allpurinol because of its side effect. Further histopathological studies need to explore such study to show the effect of cumarin and trace elements on liver and other organs in animal samples.
VL  - 3
IS  - 5
ER  -

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