BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review

Demessa Negessu

doi:doi:10.11648/j.avs.20231101.12

| Peer-Reviewed

BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review

Demessa Negessu

Published in Animal and Veterinary Sciences (Volume 11, Issue 1)

Received: 14 November 2022 Accepted: 4 January 2023 Published: 6 February 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Major histocompatibility complex is the gene complex that exists in all vertebrae like humans (HLA), dogs (DLA), bovine (BLA), ovine (OLA), swine (SLA), and equine (ELA). MHC possesses three regions (I, II, III) that control major specific immune responses and contain variety of genes which influence growth, development, reproduction, odor, and olfaction. Measuring levels of polymorphism of these genes can provide indirect measures of the immunological fitness of populations. As humans and mice, cattle have three MHC gene classes (class I, II, and III). Both BoLA class I and II play a role in antigen presentation, however the function of BoLA class III has been releated with components of the complement system. BoLA class II region is extra separated into class IIa and class IIb. In this gene, the genetic polymorphism of class II α and β genes occurs predominantly in exon 2 encoding the antigen binding site. The BoLa-A locus has 32 serologically defined alleles and minimum four further putative alleles in addition to a high frequency of null alleles. With association allele hold DRB3.2*8 (DRB3*1201) and DRB3.2*16 (DRB3*1501) genes are associated with mastitis susceptibility, and DRB3.2*22 (DRB3*1101), DRB3.2*23 (DRB3*2703) and DRB3.2*24 (DRB3*0101) with mastitis resistance. The A8 specificity and the EIAY sequence are significant markers of resistance, while the serine residue is a marker of susceptibility to dermatophlosis. According to the report 2004, BoLA-DRB3 alleles with the amino acid residues Glu, Arg, and valine (Val) at positions 74, 77, and 78, respectively, give resistance to tumor development by BLV infection. On the other hand, HaeIII CC and HaeIII BC genotypes were actually associated with resistance to FMD in contrast, the HaeIII AA genotype was associated with susceptibility to FMD. Another report on infected Egyptian buffaloes with serotype O FMDV genotype AA for FMD resistance while genotype AC for susceptibility to FMD.

Published in	Animal and Veterinary Sciences (Volume 11, Issue 1)
DOI	10.11648/j.avs.20231101.12
Page(s)	6-10
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Major Histocompatibility Complex, Bovine lymphocyte Antigen, Polymorphism, Susceptibility and Resistivity

References

[1]	Aida Y. (2004). Methods for judging resistance to the onset of bovine leukemia. United States Patent 6815158. [cited 20 April 2006]. Available from URL: http://www.freepatents online.com/6815158.html
[2]	Andersson L. and Davies C. J. (1994): The major histocompatibility complex,” in Cell Mediated Immunity in Ruminants, B. M. L. Goddeeris and W. I. Morrison, Eds., pp. 37–57, CRC Press, Boca Raton, Fla, USA,.
[3]	Ballingall K. T., Ellis S. A., Machugh N. D. and Archibald S. D. (2004): The DY genes of the cattle MHC : expression and comparative analysis of an unusual class II MHC gene pair. March 2016. https://doi.org/10.1007/s00251-004-0641-x
[4]	Baxtera R., Craigmile S. C., Haleya C., Douglasc A. J., Williamsd J. L. and Class E. J. (2009): BoLA-DR peptide binding pockets are fundamental for foot-and-mouth disease virus vaccine design in cattle. Vaccine, 28 (1): 28–37.
[5]	Behl J. D., Verma N. K., Behl R., Mukesh M. and Ahlawat S. P. S. (2007): Characterization of genetic polymorphism of the bovine lymphocyte antigen DRB3.2 locus in Kankrej cattle (Bos indicus). J. Dairy Sci., 90 (6): 2997–3001.
[6]	Behl J. D., Verma N. K., Tyagi N., Mishra P., Behl R., and Joshi B. K. (2012): The major histocompatibility complex in bovines: A review. ISRN Veterinary Science, article ID 872710.
[7]	Bhushan B., Patra B. N., Das P. J., Dutt T., Kumar P., Sharma A., Umang D. S. and Ahlawat S. P. S. (2007): Polymorphism of exon 2-3 of bovine major histocompatibility complex class I BoLa-A gene. Genet. Mol. Biol., 30 (3): 560–566.
[8]	Chaudhary, Y., Khuntia, P. and Kaul, R. (2022): Susceptibility to foot and mouth disease virus infection in vaccinated cattle, and host BoLA A and BoLA DRB3 genes polymorphism. Virus Disease, 33 (1): 65-75.
[9]	Dagong M. I. A., Baba S., Rahim L., Aprilita Bugiwati S. R., Saade M. F. and Purnomo N. (2019): Genetic polymorphism of MHC DRB3 (Major Histocompatibility Complex) of Bali cattle at Maiwa Breeding Center, South Sulawesi Indonesia. IOP Conference Series: Earth and Environmental Science, 247 (1). https://doi.org/10.1088/1755-1315/247/1/012037
[10]	Hedrick P. W., Parker K. M., Miller E. L., and Miller P. S. (1999): Major histocompatibility complex variation in the endangered Przewalski’s horse. Genetics., 152 (4): 1701–1710.
[11]	Ledwidge S. A., Mallard B. A., Gibson J. P., Jansen G. B. and Jiang Z. H. (2001): Multi-primer target PCR for rapid identiﬁcation of bovine DEB3 alleles. Anim Genet., 32: 219–221.
[12]	Lei W., Liang Q., Jing L., Wang C., Wu X. and He H. (2012): BoLA-DRB3 gene polymorphism and FMD resistance or susceptibility in Wanbei cattle. Mol. Biol. Rep., 39 (9): 9203–9209.
[13]	Lo, C. W., Borjigin, L., Saito, S., Fukunaga, K., Saitou, E., Okazaki, K., and Aida, Y. (2020): BoLA-DRB3 polymorphism is associated with differential susceptibility to bovine leukemia virus-induced lymphoma and proviral load. Viruses, 12 (3): 352.
[14]	Maillard J. C., Martinez D. and Bensaid A. (1996): An amino acid sequence coded by the exon 2 of the BoLA DRB3 gene associated with a BoLA class I speciﬁcity constitutes a likely genetic marker of resistance to dermatophilosis in Brahman zebu cattle of Martinique (FWI). Ann NY Acad Sci., 791: 185–197.
[15]	Nassiry M. R., Eftekhar Shahroodi F., Mosafer J., Mohammadi A., Manshad E., Ghazanfari S., Mohammad Abadi M. R. and Sulimova G. E. (2005): Analysis and frequency of Bovine Lymphocyte Antigen (BoLA-DRB3) alleles in Iranian Holstein cattle. Russ. J. Genet., 41 (6): 664-668.
[16]	NMC- National Mastitis council (1997): A Look at physiological and Regulatory SCC Standard in Milk. NMC news latter Udder Topics.
[17]	OIE (2011): Foot and mouth disease. In: OIE Terrestrial Manual 2012, OIE, Paris, Chapter 2.1.5. Nassiry, M. R., Sadeghi, B., Tohidi, R., Afshari, J. T., & Khosravi, M. (2008). Comparison of bovine lymphocyte antigen DRB3.2 allele frequencies between two subpopulations of Iranian holstein cattle. Afr. J. Biotechnol., 7 (15): 2671–2675.
[18]	Onott H., Klein D., Vincek V., Figueroat F., Huigint C. O., Tichyt H., and Kleint J. A. N. (1992): Major histocompatibility complex class II genes of zebrafish. 89 (April, 2012): 11886–11890.
[19]	Othman E., Muhammad G., Khodary A., El-Deeb H. and Hussein A. (2018): Five BoLA-DRB3 genotypes detected in Egyptian buffalo infected with Foot and Mouth disease virus serotype O. Journal of Genetic Engineering and Biotechnology, 67 (4): 239-254.
[20]	Ozdil F., Ilhan F. and Işık, R. (2018): Genetic characterization of some Turkish sheep breeds based on the sequencing of the Ovar-DRB1 gene in the major histocompatibility complex (MHC) gene region. Arch. Anim. Breed, 61 (4), 475–480.
[21]	Pandya, Mital, "Definition of Bovine Leukocyte Antigen Diversity and Peptide Binding Profiles for Epitope Discovery" (2016). Graduate College Dissertations and Theses. 474. https://scholarworks.uvm.edu/graddis/474
[22]	Penn D. J. (2014). Major Histocompatibility Complex (MHC) Major Histocompatibility. April, 2012. https://doi.org/10.1038/npg.els.0000919
[23]	Peters S. O., Hussain T., Adenaike A. S., Adeleke M. A., De Donato M., Hazzard J., Babar M. E. and Imumorin I. G. (2018): Genetic Diversity of Bovine Major Histocompatibility Complex Class II DRB3 locus in cattle breeds from Asia compared to those from Africa and America. J. Genomics., 6: 88–97.
[24]	Pross S. (2007). Major histocompatibility complex. XPharm: The Comprehensive Pharmacology Reference, 1–7. https://doi.org/10.1016/B978-008055232-3.60240-5
[25]	Rothschild M. F., Skow L. and Lamount S. J. (2000): The major histocompatibility complex and its role in disease resistance and immune responsiveness,” in Breeding for Disease Resistance in FarmAnimals, R. F. E. Axford, S. C. Bishop, F. W. Nicholas, and J. B. Owen, Eds., pp. 243–252, CAB International, Wallingord, Wash, USA,.
[26]	Rupp R., Hernandez A. and Mallard B. A. (2007): Association of Bovine Leukocyte Antigen (BoLA) DRB3.2 with Immune Response, Mastitis, and Production and Type Traits in Canadian Holsteins. J. Dairy Sci., 90: 1029-1038.
[27]	Sharif S., Mallard B. A., Wilkie B. N., Sargeant J. M., Scott H. M., Dekkers J. C. M. and Leslie K. E. (1998): Associations of the bovine major histocompatibility complex DRB3 (BoLA DRB3) alleles with occurrence of disease and milk somatic cell score in Canadian dairy cattle. Anim. Genet., 29: 185–193.
[28]	Sharif S., Mallard B. A. and Sargeant J. M. (2000): Presence of glutamine at position 74 of pocket 4 in the BoLA-DR antigen binding groove is associated with occurrence of clinical mastitis caused by Staphylococcus species. Vet. Immunol. Immunopathol, 76: 231–238.
[29]	Sharma P., Kumar P. and Sharma R. (2017): The major histocompatibility complex: A review. Asian J. Pharm. Clin. Res, 10 (2): 33–36.
[30]	Shin-n. Takeshima 1, Claudia C., Guillermo G. and Yoko A. (2018): Genetic diversity of BoLA-DRB3 in South American Zebu cattle populations. BMC Genetics, 19: 33.
[31]	Shi X. J., Wang B., Zhang C. and Wang M. (2006): Expressions of bovine IFN-γand footand-mouth disease VP1 antigen in P. pastoris and their effects on mouse immune response to FMD antigens. Vaccine., 24: 82-89.
[32]	Sommer S. (2005). The importance of immune gene variability (MHC) in evolutionary ecology and conservation. Front. Zool., 2: 1–18.
[33]	Starkenburg R. J., Hansen L. B., Kehrli M. E. and Chester-Jones H. (1997): Frequencies and effects of alternative DRB3.2 alleles of bovine lymphocyte antigen for Holsteins milk selection and control lines. J. Dairy Sci., 80: 3411–3419.
[34]	Stern L. J., Brown J. H., Jardetzky T. S., Gorga J. C., Urban R. G. and Strominger J. L. (1994): Crystal-structure of the human class-II MHC protein HLA-DR1 complexed with an influenza-virus peptide. Nature, 368 (6468): 215–21.
[35]	Takeshima S., Nakai Y., Ohta M. and Aida Y. (2002): Short communication: characterization of DRB3 alleles in the MHC of Japanese Shorthorn cattle by polymerase chain reactionsequence-based typing. J. Dairy Sci., 85 (6): 1630–1632.
[36]	Ujvari B. and Belov K. (2011). Major histocompatibility complex (MHC) markers in conservation biology. Int. J. Mol. Sci., 12 (8): 5168–5186.
[37]	Vansaceghem R. (1915). Dermatose contagieuse (impetigo contagieux). Bull. SOC. Pathol. EXO., 8: 354-359.
[38]	Wei L., Qinglong L., Luo J., Chengmin W., Xiaobing W. and Hongxuan H. (2012): BoLA-DRB3 gene polymorphism and FMD resistance or susceptibility in Wanbei cattle. Mol Biol Rep., 39: 9203–9209.
[39]	Xu A., van Eijk M. J., Park C. and Lewin H. A. (1993): Polymorphism in BoLA-DRB3 exon 2 correlates with resistance to persistent lymphocytosis caused by bovine leukemia virus. J Immunol, 151: 6977–6985.
[40]	Yoshida T., Furuta H., Kondo Y. and Mukoyama H. (2012): Association of BoLA-DRB3 alleles with mastitis resistance and susceptibility in Japanese Holstein cowsaTatsuyuki. Anim. Sci. J., 83: 359–366.

Cite This Article

Plain Text BibTeX RIS

APA Style

Demessa Negessu. (2023). BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review. Animal and Veterinary Sciences, 11(1), 6-10. https://doi.org/10.11648/j.avs.20231101.12

Copy | Download

ACS Style

Demessa Negessu. BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review. Anim. Vet. Sci. 2023, 11(1), 6-10. doi: 10.11648/j.avs.20231101.12

Copy | Download

AMA Style

Demessa Negessu. BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review. Anim Vet Sci. 2023;11(1):6-10. doi: 10.11648/j.avs.20231101.12

Copy | Download

@article{10.11648/j.avs.20231101.12,
  author = {Demessa Negessu},
  title = {BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review},
  journal = {Animal and Veterinary Sciences},
  volume = {11},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.avs.20231101.12},
  url = {https://doi.org/10.11648/j.avs.20231101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20231101.12},
  abstract = {Major histocompatibility complex is the gene complex that exists in all vertebrae like humans (HLA), dogs (DLA), bovine (BLA), ovine (OLA), swine (SLA), and equine (ELA). MHC possesses three regions (I, II, III) that control major specific immune responses and contain variety of genes which influence growth, development, reproduction, odor, and olfaction. Measuring levels of polymorphism of these genes can provide indirect measures of the immunological fitness of populations. As humans and mice, cattle have three MHC gene classes (class I, II, and III). Both BoLA class I and II play a role in antigen presentation, however the function of BoLA class III has been releated with components of the complement system. BoLA class II region is extra separated into class IIa and class IIb. In this gene, the genetic polymorphism of class II α and β genes occurs predominantly in exon 2 encoding the antigen binding site. The BoLa-A locus has 32 serologically defined alleles and minimum four further putative alleles in addition to a high frequency of null alleles. With association allele hold DRB3.2*8 (DRB3*1201) and DRB3.2*16 (DRB3*1501) genes are associated with mastitis susceptibility, and DRB3.2*22 (DRB3*1101), DRB3.2*23 (DRB3*2703) and DRB3.2*24 (DRB3*0101) with mastitis resistance. The A8 specificity and the EIAY sequence are significant markers of resistance, while the serine residue is a marker of susceptibility to dermatophlosis. According to the report 2004, BoLA-DRB3 alleles with the amino acid residues Glu, Arg, and valine (Val) at positions 74, 77, and 78, respectively, give resistance to tumor development by BLV infection. On the other hand, HaeIII CC and HaeIII BC genotypes were actually associated with resistance to FMD in contrast, the HaeIII AA genotype was associated with susceptibility to FMD. Another report on infected Egyptian buffaloes with serotype O FMDV genotype AA for FMD resistance while genotype AC for susceptibility to FMD.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review
AU  - Demessa Negessu
Y1  - 2023/02/06
PY  - 2023
N1  - https://doi.org/10.11648/j.avs.20231101.12
DO  - 10.11648/j.avs.20231101.12
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20231101.12
AB  - Major histocompatibility complex is the gene complex that exists in all vertebrae like humans (HLA), dogs (DLA), bovine (BLA), ovine (OLA), swine (SLA), and equine (ELA). MHC possesses three regions (I, II, III) that control major specific immune responses and contain variety of genes which influence growth, development, reproduction, odor, and olfaction. Measuring levels of polymorphism of these genes can provide indirect measures of the immunological fitness of populations. As humans and mice, cattle have three MHC gene classes (class I, II, and III). Both BoLA class I and II play a role in antigen presentation, however the function of BoLA class III has been releated with components of the complement system. BoLA class II region is extra separated into class IIa and class IIb. In this gene, the genetic polymorphism of class II α and β genes occurs predominantly in exon 2 encoding the antigen binding site. The BoLa-A locus has 32 serologically defined alleles and minimum four further putative alleles in addition to a high frequency of null alleles. With association allele hold DRB3.2*8 (DRB3*1201) and DRB3.2*16 (DRB3*1501) genes are associated with mastitis susceptibility, and DRB3.2*22 (DRB3*1101), DRB3.2*23 (DRB3*2703) and DRB3.2*24 (DRB3*0101) with mastitis resistance. The A8 specificity and the EIAY sequence are significant markers of resistance, while the serine residue is a marker of susceptibility to dermatophlosis. According to the report 2004, BoLA-DRB3 alleles with the amino acid residues Glu, Arg, and valine (Val) at positions 74, 77, and 78, respectively, give resistance to tumor development by BLV infection. On the other hand, HaeIII CC and HaeIII BC genotypes were actually associated with resistance to FMD in contrast, the HaeIII AA genotype was associated with susceptibility to FMD. Another report on infected Egyptian buffaloes with serotype O FMDV genotype AA for FMD resistance while genotype AC for susceptibility to FMD.
VL  - 11
IS  - 1
ER  -

Copy | Download

Author Information

Demessa Negessu

Animal Health Institute, Sebeta, Ethiopia

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Demessa Negessu. (2023). BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review. Animal and Veterinary Sciences, 11(1), 6-10. https://doi.org/10.11648/j.avs.20231101.12

Copy | Download

ACS Style

Demessa Negessu. BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review. Anim. Vet. Sci. 2023, 11(1), 6-10. doi: 10.11648/j.avs.20231101.12

Copy | Download

AMA Style

Demessa Negessu. BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review. Anim Vet Sci. 2023;11(1):6-10. doi: 10.11648/j.avs.20231101.12

Copy | Download

@article{10.11648/j.avs.20231101.12,
  author = {Demessa Negessu},
  title = {BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review},
  journal = {Animal and Veterinary Sciences},
  volume = {11},
  number = {1},
  pages = {6-10},
  doi = {10.11648/j.avs.20231101.12},
  url = {https://doi.org/10.11648/j.avs.20231101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.avs.20231101.12},
  abstract = {Major histocompatibility complex is the gene complex that exists in all vertebrae like humans (HLA), dogs (DLA), bovine (BLA), ovine (OLA), swine (SLA), and equine (ELA). MHC possesses three regions (I, II, III) that control major specific immune responses and contain variety of genes which influence growth, development, reproduction, odor, and olfaction. Measuring levels of polymorphism of these genes can provide indirect measures of the immunological fitness of populations. As humans and mice, cattle have three MHC gene classes (class I, II, and III). Both BoLA class I and II play a role in antigen presentation, however the function of BoLA class III has been releated with components of the complement system. BoLA class II region is extra separated into class IIa and class IIb. In this gene, the genetic polymorphism of class II α and β genes occurs predominantly in exon 2 encoding the antigen binding site. The BoLa-A locus has 32 serologically defined alleles and minimum four further putative alleles in addition to a high frequency of null alleles. With association allele hold DRB3.2*8 (DRB3*1201) and DRB3.2*16 (DRB3*1501) genes are associated with mastitis susceptibility, and DRB3.2*22 (DRB3*1101), DRB3.2*23 (DRB3*2703) and DRB3.2*24 (DRB3*0101) with mastitis resistance. The A8 specificity and the EIAY sequence are significant markers of resistance, while the serine residue is a marker of susceptibility to dermatophlosis. According to the report 2004, BoLA-DRB3 alleles with the amino acid residues Glu, Arg, and valine (Val) at positions 74, 77, and 78, respectively, give resistance to tumor development by BLV infection. On the other hand, HaeIII CC and HaeIII BC genotypes were actually associated with resistance to FMD in contrast, the HaeIII AA genotype was associated with susceptibility to FMD. Another report on infected Egyptian buffaloes with serotype O FMDV genotype AA for FMD resistance while genotype AC for susceptibility to FMD.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - BOLA Gene Polymorphism and Determination of Disease Severity and Susceptibility: Review
AU  - Demessa Negessu
Y1  - 2023/02/06
PY  - 2023
N1  - https://doi.org/10.11648/j.avs.20231101.12
DO  - 10.11648/j.avs.20231101.12
T2  - Animal and Veterinary Sciences
JF  - Animal and Veterinary Sciences
JO  - Animal and Veterinary Sciences
SP  - 6
EP  - 10
PB  - Science Publishing Group
SN  - 2328-5850
UR  - https://doi.org/10.11648/j.avs.20231101.12
AB  - Major histocompatibility complex is the gene complex that exists in all vertebrae like humans (HLA), dogs (DLA), bovine (BLA), ovine (OLA), swine (SLA), and equine (ELA). MHC possesses three regions (I, II, III) that control major specific immune responses and contain variety of genes which influence growth, development, reproduction, odor, and olfaction. Measuring levels of polymorphism of these genes can provide indirect measures of the immunological fitness of populations. As humans and mice, cattle have three MHC gene classes (class I, II, and III). Both BoLA class I and II play a role in antigen presentation, however the function of BoLA class III has been releated with components of the complement system. BoLA class II region is extra separated into class IIa and class IIb. In this gene, the genetic polymorphism of class II α and β genes occurs predominantly in exon 2 encoding the antigen binding site. The BoLa-A locus has 32 serologically defined alleles and minimum four further putative alleles in addition to a high frequency of null alleles. With association allele hold DRB3.2*8 (DRB3*1201) and DRB3.2*16 (DRB3*1501) genes are associated with mastitis susceptibility, and DRB3.2*22 (DRB3*1101), DRB3.2*23 (DRB3*2703) and DRB3.2*24 (DRB3*0101) with mastitis resistance. The A8 specificity and the EIAY sequence are significant markers of resistance, while the serine residue is a marker of susceptibility to dermatophlosis. According to the report 2004, BoLA-DRB3 alleles with the amino acid residues Glu, Arg, and valine (Val) at positions 74, 77, and 78, respectively, give resistance to tumor development by BLV infection. On the other hand, HaeIII CC and HaeIII BC genotypes were actually associated with resistance to FMD in contrast, the HaeIII AA genotype was associated with susceptibility to FMD. Another report on infected Egyptian buffaloes with serotype O FMDV genotype AA for FMD resistance while genotype AC for susceptibility to FMD.
VL  - 11
IS  - 1
ER  -

Copy | Download