@article{10.11648/j.ajlm.20220703.12,
  author = {Tesfalem Israel Korga and Abebe Melis Nisiro and Berhanu Lijalem Yigez and Selamawit Abebe Ayele and Deginesh Dawit Woltamo and Yohannes Zewde and Abebe Sorsa Badacho},
  title = {Histopathologic Patterns of Lymph Node Diseases Among Patients Diagnosed in Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia},
  journal = {American Journal of Laboratory Medicine},
  volume = {7},
  number = {3},
  pages = {43-48},
  doi = {10.11648/j.ajlm.20220703.12},
  url = {https://doi.org/10.11648/j.ajlm.20220703.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20220703.12},
  abstract = {Lymphadenopathy is one of the most typical clinical presentations in patients of all age groups. The causes are different based on age, sex, duration, and patterns of involvement. There is a lack of evidence on histopathologic patterns of lymph node diseases. This study aims to determine the histopathologic pattern of lymph node diseases diagnosed in Hawassa university's comprehensive specialized hospital. An institution-based cross-sectional study was conducted among 188 histopathologically diagnosed lymph node biopsies received from September 2014 to August 2020 at Hawassa university's comprehensive specialized hospital (HUCSH). All the samples collected for the diagnoses at a given period were included in the study. The collected data was cleaned and entered into open Epi- version 3 and exported to SPSS version 20 statistical software for analysis. Descriptive analyses like frequency distribution, proportion and dispersion were calculated. The finding was presented using frequency tables, graphs, and charts. Both univariate and multivariate analyses were done. The Adjusted Odd Ratio (AOR with 95% CI) was used to show the strength of the association, and a P-value of ≤ 0.05 was considered statistically significant. Of the 188 lymph node biopsies, 119 (63.3%) were male cases, and 69 (36.7%) were female cases. The age range of the study subjects is 1 to 84 years, with a mean of 31.28±18. 64 years. Localized lymphadenopathy (LAP) was found in 168 (89.4%) of the patients, and the remaining 20 (10.6%) were generalized. Among localized LN groups, cervical, mesenteric, and inguinal LN groups are the most commonly biopsied groups accounting for 66 (35.1%), 55 (29.3%) and 14 (7.4%), respectively. Regarding the size, 72.2% of benign reactive conditions were less than 2cm, whereas 74.5% of lymphomas have a size of at least 2cm. 86.9% of nonspecific reactive conditions have a duration of less than one month, whereas 89% of malignant conditions collectively presented with LAP of more than 1-month duration. A third of 61 (32.4%) were identified as histopathologically reactive nonspecific conditions and lymphomas consist 44 (23.4%) and metastatic lesions (40, 21.3%) and tuberculosis lymphadenitis (36, 19.1%). This study's histopathologic pattern of Lymph Node (LN) disease was comparable with other developing countries. Reactive nonspecific conditions and tuberculous lymphadenitis are more common before the age of 45 years. Metastatic lesions were found more common after the age of 45 years.},
 year = {2022}
}

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TY  - JOUR
T1  - Histopathologic Patterns of Lymph Node Diseases Among Patients Diagnosed in Hawassa University Comprehensive Specialized Hospital, Southern Ethiopia
AU  - Tesfalem Israel Korga
AU  - Abebe Melis Nisiro
AU  - Berhanu Lijalem Yigez
AU  - Selamawit Abebe Ayele
AU  - Deginesh Dawit Woltamo
AU  - Yohannes Zewde
AU  - Abebe Sorsa Badacho
Y1  - 2022/08/09
PY  - 2022
N1  - https://doi.org/10.11648/j.ajlm.20220703.12
DO  - 10.11648/j.ajlm.20220703.12
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 43
EP  - 48
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20220703.12
AB  - Lymphadenopathy is one of the most typical clinical presentations in patients of all age groups. The causes are different based on age, sex, duration, and patterns of involvement. There is a lack of evidence on histopathologic patterns of lymph node diseases. This study aims to determine the histopathologic pattern of lymph node diseases diagnosed in Hawassa university's comprehensive specialized hospital. An institution-based cross-sectional study was conducted among 188 histopathologically diagnosed lymph node biopsies received from September 2014 to August 2020 at Hawassa university's comprehensive specialized hospital (HUCSH). All the samples collected for the diagnoses at a given period were included in the study. The collected data was cleaned and entered into open Epi- version 3 and exported to SPSS version 20 statistical software for analysis. Descriptive analyses like frequency distribution, proportion and dispersion were calculated. The finding was presented using frequency tables, graphs, and charts. Both univariate and multivariate analyses were done. The Adjusted Odd Ratio (AOR with 95% CI) was used to show the strength of the association, and a P-value of ≤ 0.05 was considered statistically significant. Of the 188 lymph node biopsies, 119 (63.3%) were male cases, and 69 (36.7%) were female cases. The age range of the study subjects is 1 to 84 years, with a mean of 31.28±18. 64 years. Localized lymphadenopathy (LAP) was found in 168 (89.4%) of the patients, and the remaining 20 (10.6%) were generalized. Among localized LN groups, cervical, mesenteric, and inguinal LN groups are the most commonly biopsied groups accounting for 66 (35.1%), 55 (29.3%) and 14 (7.4%), respectively. Regarding the size, 72.2% of benign reactive conditions were less than 2cm, whereas 74.5% of lymphomas have a size of at least 2cm. 86.9% of nonspecific reactive conditions have a duration of less than one month, whereas 89% of malignant conditions collectively presented with LAP of more than 1-month duration. A third of 61 (32.4%) were identified as histopathologically reactive nonspecific conditions and lymphomas consist 44 (23.4%) and metastatic lesions (40, 21.3%) and tuberculosis lymphadenitis (36, 19.1%). This study's histopathologic pattern of Lymph Node (LN) disease was comparable with other developing countries. Reactive nonspecific conditions and tuberculous lymphadenitis are more common before the age of 45 years. Metastatic lesions were found more common after the age of 45 years.
VL  - 7
IS  - 3
ER  - 

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