Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech

Lazrak Fatima Zahrae; Skali Hajar; Rahali Fatima Zahra; Yahyaoui Hicham; Sayagh Sanaa; Ait Ameur Mustapha; Chakour Mohamed

doi:doi:10.11648/j.ajlm.20210605.12

Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech

Lazrak Fatima Zahrae, Skali Hajar, Rahali Fatima Zahra, Yahyaoui Hicham, Sayagh Sanaa, Ait Ameur Mustapha, Chakour Mohamed

Published in American Journal of Laboratory Medicine (Volume 6, Issue 5)

Received: 23 September 2021 Accepted: 11 October 2021 Published: 21 October 2021

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Abstract

Thrombocytopenia is defined by a number of circulating platelets less than 150 G/l. Realization of a blood smear is necessary to find out its reality and to study platelet morphology. Several mechanisms may be involved: peripheral thrombocytopenia by destruction, consumption or hypersplenism and central thrombocytopenia dominated by haematological malignancies. The aim of this study is to describe thrombocytopenia in children received at our hospital. This is a prospective study, including all thrombocytopenic children from 0 to 15 years old who received a blood count at the Hematology Laboratory for 1 month. A blood smear will be systematically performed for false thrombocytopenia and for the study of platelet morphology. The etiological determination will be made by the exploitation of the files at the level of clinical services. The average age of patients was 4 years with extremes ranging from 2 daysAt 15 years old, predominantly female, 53% (24 girls/21 boys), with a sex ratio of 0.87. Of the 45 cases, 42% were from a completed follow-up pregnancy, 15% had the concept of consanguinity in their antecedents. The myelogram showed AML in 7% of cases, ALL in 4%, 9% in leishmania, LMMC in 2% and myelofibrosis in 2%. Infection, leukemia and leishmaniasis with 39%, 25% and 11% are the most implicated causes in the development of thrombocytopenia in children in the study population. Thrombocytopenia is defined in children by a platelet count of less than 150 G/L, normal values before the age of 15 years are 95% of children between 165 and 473 G/L with a median value of 299 G/L [1]. The discovery of a fortuitous thrombocytopenia during a hemogram or when the child presents to the emergencies with cutaneo-mucous haemorrhagic manifestations must initiate a rigorous diagnosis.

Published in	American Journal of Laboratory Medicine (Volume 6, Issue 5)
DOI	10.11648/j.ajlm.20210605.12
Page(s)	77-82
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Thrombopenia, Children, Hematology, Blood Smear, Platelet

References

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APA Style

Lazrak Fatima Zahrae, Skali Hajar, Rahali Fatima Zahra, Yahyaoui Hicham, Sayagh Sanaa, et al. (2021). Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech. American Journal of Laboratory Medicine, 6(5), 77-82. https://doi.org/10.11648/j.ajlm.20210605.12

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ACS Style

Lazrak Fatima Zahrae; Skali Hajar; Rahali Fatima Zahra; Yahyaoui Hicham; Sayagh Sanaa, et al. Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech. Am. J. Lab. Med. 2021, 6(5), 77-82. doi: 10.11648/j.ajlm.20210605.12

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AMA Style

Lazrak Fatima Zahrae, Skali Hajar, Rahali Fatima Zahra, Yahyaoui Hicham, Sayagh Sanaa, et al. Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech. Am J Lab Med. 2021;6(5):77-82. doi: 10.11648/j.ajlm.20210605.12

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@article{10.11648/j.ajlm.20210605.12,
  author = {Lazrak Fatima Zahrae and Skali Hajar and Rahali Fatima Zahra and Yahyaoui Hicham and Sayagh Sanaa and Ait Ameur Mustapha and Chakour Mohamed},
  title = {Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {5},
  pages = {77-82},
  doi = {10.11648/j.ajlm.20210605.12},
  url = {https://doi.org/10.11648/j.ajlm.20210605.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210605.12},
  abstract = {Thrombocytopenia is defined by a number of circulating platelets less than 150 G/l. Realization of a blood smear is necessary to find out its reality and to study platelet morphology. Several mechanisms may be involved: peripheral thrombocytopenia by destruction, consumption or hypersplenism and central thrombocytopenia dominated by haematological malignancies. The aim of this study is to describe thrombocytopenia in children received at our hospital. This is a prospective study, including all thrombocytopenic children from 0 to 15 years old who received a blood count at the Hematology Laboratory for 1 month. A blood smear will be systematically performed for false thrombocytopenia and for the study of platelet morphology. The etiological determination will be made by the exploitation of the files at the level of clinical services. The average age of patients was 4 years with extremes ranging from 2 daysAt 15 years old, predominantly female, 53% (24 girls/21 boys), with a sex ratio of 0.87. Of the 45 cases, 42% were from a completed follow-up pregnancy, 15% had the concept of consanguinity in their antecedents. The myelogram showed AML in 7% of cases, ALL in 4%, 9% in leishmania, LMMC in 2% and myelofibrosis in 2%. Infection, leukemia and leishmaniasis with 39%, 25% and 11% are the most implicated causes in the development of thrombocytopenia in children in the study population. Thrombocytopenia is defined in children by a platelet count of less than 150 G/L, normal values before the age of 15 years are 95% of children between 165 and 473 G/L with a median value of 299 G/L [1]. The discovery of a fortuitous thrombocytopenia during a hemogram or when the child presents to the emergencies with cutaneo-mucous haemorrhagic manifestations must initiate a rigorous diagnosis.},
 year = {2021}
}

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TY - JOUR
T1 - Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech
AU - Lazrak Fatima Zahrae
AU - Skali Hajar
AU - Rahali Fatima Zahra
AU - Yahyaoui Hicham
AU - Sayagh Sanaa
AU - Ait Ameur Mustapha
AU - Chakour Mohamed
Y1 - 2021/10/21
PY - 2021
N1 - https://doi.org/10.11648/j.ajlm.20210605.12
DO - 10.11648/j.ajlm.20210605.12
T2 - American Journal of Laboratory Medicine
JF - American Journal of Laboratory Medicine
JO - American Journal of Laboratory Medicine
SP - 77
EP - 82
PB - Science Publishing Group
SN - 2575-386X
UR - https://doi.org/10.11648/j.ajlm.20210605.12
AB - Thrombocytopenia is defined by a number of circulating platelets less than 150 G/l. Realization of a blood smear is necessary to find out its reality and to study platelet morphology. Several mechanisms may be involved: peripheral thrombocytopenia by destruction, consumption or hypersplenism and central thrombocytopenia dominated by haematological malignancies. The aim of this study is to describe thrombocytopenia in children received at our hospital. This is a prospective study, including all thrombocytopenic children from 0 to 15 years old who received a blood count at the Hematology Laboratory for 1 month. A blood smear will be systematically performed for false thrombocytopenia and for the study of platelet morphology. The etiological determination will be made by the exploitation of the files at the level of clinical services. The average age of patients was 4 years with extremes ranging from 2 daysAt 15 years old, predominantly female, 53% (24 girls/21 boys), with a sex ratio of 0.87. Of the 45 cases, 42% were from a completed follow-up pregnancy, 15% had the concept of consanguinity in their antecedents. The myelogram showed AML in 7% of cases, ALL in 4%, 9% in leishmania, LMMC in 2% and myelofibrosis in 2%. Infection, leukemia and leishmaniasis with 39%, 25% and 11% are the most implicated causes in the development of thrombocytopenia in children in the study population. Thrombocytopenia is defined in children by a platelet count of less than 150 G/L, normal values before the age of 15 years are 95% of children between 165 and 473 G/L with a median value of 299 G/L [1]. The discovery of a fortuitous thrombocytopenia during a hemogram or when the child presents to the emergencies with cutaneo-mucous haemorrhagic manifestations must initiate a rigorous diagnosis.
VL - 6
IS - 5
ER -

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Author Information

Lazrak Fatima Zahrae

Laboratory of Hematology of University Hospital Mohammed VI of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco
Skali Hajar

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco
Rahali Fatima Zahra

Laboratory of Hematology of University Hospital Mohammed VI of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco
Yahyaoui Hicham

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco
Sayagh Sanaa

Laboratory of Hematology of University Hospital Mohammed VI of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco
Ait Ameur Mustapha

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco
Chakour Mohamed

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medecine and Pharmacy of Marrakech, University of Cadi Ayyad, Marrakech, Morocco

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APA Style

Lazrak Fatima Zahrae, Skali Hajar, Rahali Fatima Zahra, Yahyaoui Hicham, Sayagh Sanaa, et al. (2021). Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech. American Journal of Laboratory Medicine, 6(5), 77-82. https://doi.org/10.11648/j.ajlm.20210605.12

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ACS Style

Lazrak Fatima Zahrae; Skali Hajar; Rahali Fatima Zahra; Yahyaoui Hicham; Sayagh Sanaa, et al. Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech. Am. J. Lab. Med. 2021, 6(5), 77-82. doi: 10.11648/j.ajlm.20210605.12

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AMA Style

Lazrak Fatima Zahrae, Skali Hajar, Rahali Fatima Zahra, Yahyaoui Hicham, Sayagh Sanaa, et al. Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech. Am J Lab Med. 2021;6(5):77-82. doi: 10.11648/j.ajlm.20210605.12

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@article{10.11648/j.ajlm.20210605.12,
  author = {Lazrak Fatima Zahrae and Skali Hajar and Rahali Fatima Zahra and Yahyaoui Hicham and Sayagh Sanaa and Ait Ameur Mustapha and Chakour Mohamed},
  title = {Prevalence and Description of Thrombocytopenia in Children at University Hospital Mohammed VI Marrakech},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {5},
  pages = {77-82},
  doi = {10.11648/j.ajlm.20210605.12},
  url = {https://doi.org/10.11648/j.ajlm.20210605.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210605.12},
  abstract = {Thrombocytopenia is defined by a number of circulating platelets less than 150 G/l. Realization of a blood smear is necessary to find out its reality and to study platelet morphology. Several mechanisms may be involved: peripheral thrombocytopenia by destruction, consumption or hypersplenism and central thrombocytopenia dominated by haematological malignancies. The aim of this study is to describe thrombocytopenia in children received at our hospital. This is a prospective study, including all thrombocytopenic children from 0 to 15 years old who received a blood count at the Hematology Laboratory for 1 month. A blood smear will be systematically performed for false thrombocytopenia and for the study of platelet morphology. The etiological determination will be made by the exploitation of the files at the level of clinical services. The average age of patients was 4 years with extremes ranging from 2 daysAt 15 years old, predominantly female, 53% (24 girls/21 boys), with a sex ratio of 0.87. Of the 45 cases, 42% were from a completed follow-up pregnancy, 15% had the concept of consanguinity in their antecedents. The myelogram showed AML in 7% of cases, ALL in 4%, 9% in leishmania, LMMC in 2% and myelofibrosis in 2%. Infection, leukemia and leishmaniasis with 39%, 25% and 11% are the most implicated causes in the development of thrombocytopenia in children in the study population. Thrombocytopenia is defined in children by a platelet count of less than 150 G/L, normal values before the age of 15 years are 95% of children between 165 and 473 G/L with a median value of 299 G/L [1]. The discovery of a fortuitous thrombocytopenia during a hemogram or when the child presents to the emergencies with cutaneo-mucous haemorrhagic manifestations must initiate a rigorous diagnosis.},
 year = {2021}
}

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