The Role of Myelogram in Diagnosis of Malignant Hemopathies

Skali Hajar; Lazrak Fatima Zahrae; Yahyaoui Hicham; Ait Ameur Mustapha; Chakour Mohamed

doi:doi:10.11648/j.ajlm.20210605.11

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The Role of Myelogram in Diagnosis of Malignant Hemopathies

Skali Hajar, Lazrak Fatima Zahrae, Yahyaoui Hicham, Ait Ameur Mustapha, Chakour Mohamed

Published in American Journal of Laboratory Medicine (Volume 6, Issue 5)

Received: 18 September 2021 Accepted: 5 October 2021 Published: 12 October 2021

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Abstract

The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical and other diagnostic findings. This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech over a period of two years, from January 2018 to December 2019, aimed to evaluate the practice and the contribution of the myelogram in diagnosis in patients in the Hematology Laboratory and to report the epidemiological profile of malignant hemopathies diagnosed in our Laboratory. In our study, out of 420 myelograms received in the Hematology Laboratory of the military hospital in Marrakech, 70 cases (17%) of malignant hemopathies were collected. The predominant age range was 61 to 70 years old. The male gender was predominant (64%) with a sex-ratio at 1,8. The clinical indications of myelogram were dominated by anemic syndrome, tumoral syndrome. Biologically, the Peripheral Blood count and smear abnormalities were the most frequent. Acute leukemias were accounted for 35% of all malignant pathologies diagnosed in our laboratory of which 79% myeloid, 21% lymphoid. Multiple myelomas were found in 33%, myelodysplastic syndromes in 17% and Chronic myeloid leukemia in 9%. The role of the myelogram in diagnostic of malignant hemopathies is based on its good interpretation which is directly linked to the rigor of its realization.

Published in	American Journal of Laboratory Medicine (Volume 6, Issue 5)
DOI	10.11648/j.ajlm.20210605.11
Page(s)	70-76
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Myelogram, Bone Marrow Smear, Blood Smear, Malignant Hemopathy, Leukemia

References

[1]	Thiam D, Diop TM, Tallarmin F, Toure AO, Diakhate L. (1996) Epidemiology and therapy of malignant hemopathies in Senegal. Hematol Cell Ther; 38: 187-91.
[2]	Ouédraogo SM, Hien F, Bazié W, Millogo A, Drabo YJ. (2011) Place des hémopathies malignes en service de Médecine interne du CHU SouroSanou (Burkina Faso). [Place of Hematologic malignancies in internal medicine UHC Souro Sanou (Burkina Faso)] Mali Médical; XXVI: 17-21.
[3]	Mufuta NJP, Mbayo K, Kayembe NZ, Gini EK, Mbuyi M. (2013) Cytologie des hémopathies malignes dans deux formations médi- cales de Kinshasa. [Cytological profil of hematological malignancies in two medical institutions in Kinshasa]. Ann AfrMed; 6.
[4]	Elloumi M, Hafsia R, Omri EL, et al. (2002) Caractéristiques épidémiologiques, cliniques et cytohématologiques des leucémies aigués lymphoblastiques de l’adulte en Tunisie. [Epidemiological, clinical and cytohematological characteristics of acute lymphoblastic leukemia in adults in Tunisia ]. Tunis Me ́dical; 80: 199-202.
[5]	Sebahoun G, Sainty D, Horschowski N. (1991) Ponction médullaire et biopsie médullaire. [Medullary puncture and bone marrow biopsy]. Editions techniques. Encycl. Méd. Chir. (Paris, France), Hématologie 13000, A30, 7p.
[6]	Téa D, Yao T, Abissey A, Anoh J, Rain JD. Panorama des hé- mopathies diagnostiquées au laboratoire central du CHU de Treichville bilan de 10 années d’activité.[Overview of hemopathies diagnosed at the central laboratory of the University Hospital of Treichville assessment of 10 years of activity]. Médecine d’Afrique Noire: 39-43.
[7]	Goldberg C et al. Bone marrow aspiration and biopsy transfusion. http://emedicine.medscape.com/article/207575, consulté le 24 oct. 2017.
[8]	Riley RS, Hogan TF, Pavot DR, et al. A pathologist’s perspective on bone marrow aspiration and biopsy: (2004) I. Performing a bone marrow examination. J Clin Lab Anal; 18 (2): 70–90.
[9]	Lee S-H, Erber WN, Porwit A, Tomonaga M, Peterson LC. (2008) International Council for Standardization In Hematology. ICSH guidelines for the standardization of bone marrow specimens and reports. Int J Lab Hematol; 30 (5): 349–64.
[10]	McFadden S., Briggs C., Davis B., Jou J. & Machin S. (2008) The reformed International Council for Standardization in Hematology (ICSH). International Journal Journal of Laboratory Hematology 30, 89– 90.
[11]	HUGARD L., ABDOU SOULEY A., NDOYE B., SACCHARIN C. (1995) Affections hématologiques et myélogramme. Bilan de 5 ans à l’hôpital principal de Dakar (Sénégal). [ Blood disorders and myelogram. 5-year review at the main hospital in Dakar (Senegal) ]. Méd. Afr. Noire- 42, (11): 605-611.
[12]	Ouattara S, Danho B, Kone M, Tea D. (2000) La pratique du myélogramme au chu de Treichville: bilan de 19 années d’activité. [The practice of the myelogram at the University hospital of Treichville: review of 19 years of activity] Médecine d'Afrique Noire; 47, 5.
[13]	El Hamdaoui O. (2018) Apport du myélogramme dans le diagnostic des hémopathies: expérience du laboratoire central d’hématologie de l’Hôpital IBN SINA RABAT. [Contribution of the myelogram in the diagnosis of hemopathies: experience of the central hematology laboratory of the IBN SINA RABAT Hospital]. Thèse de médecine, Rabat; N 22.
[14]	Diallo D. A, Cissoko L. S, Cissoko Y, Baby M et al.(2005) Epidémiologie actuelle des hémopathies malignes dans les services d’hématologie oncologie médicale et de médecine interne de l’hôpital du Point G, Bamako, Mali. [Updated epidemiology of haematological malignancies in the haematology & oncology and the internal medicine wards of the hospital of Point G, Bamako, Mali]. Mali Médical; 4-8.
[15]	Moueleu Ngalagou P. T, Ngouadjeu Dongho Tsakeu E, Ngo Sack F, Eboumbou Moukoko E. C et al. (2018) Epidemiology of malignant hemopathies recorded in hospitals in Cameroon. Medecine et santé Tropicales Janvier 2018; 28, 1: 61-66.
[16]	Bachir Bouiadjra S, Moulessehoul S, Sebaa A, Snouci A et al. (2009) Apport de la cytogénétique moléculaire à l’étude des hémopathies malignes chez des patients hospitalisés à l’hôpital de Sidi-Bel-Abbès (Algérie). [Contribution of the molecular cytogenetics being studied of the hematological malignacies among patients hospitalized in hospital of Sidi-Bel-Abbès]. African Journal of Cancer; 1, 4: 188–192.
[17]	KHALKI H. (2017) Profil épidémiologique et diagnostique des hémopathies malignes: expérience du laboratoire d’hématologie du CHU Hassan II de Fès. [Epidemiological and diagnostic profile of hematologic malignancies: experience of the hematology laboratory of the university hospital Hassan II in Fez]. Thèse de médecine, Fès.
[18]	RHAFEL A. (2014) Bilan d’activité de service d’hématologie CHU MARRAKECH (2009-2013). [The University Hospital of MARRAKECH hematology department activity report (2009-2013)]. Thèse de médecine, Marrakech; N 47.
[19]	Troussard X, Duchenet V, Cornet E, Mouchel D et al. (2009) Épidémiologie des hémopathies malignes en Basse-Normandie. [Epidemiology of malignant hemopathies in Lower Normandy]. Revue d’Épidémiologie et de Santé Publique; 57, 3: 151-158.
[20]	Jmili N. B, SENDI S. H, KHELIF A, SAAD A. (2010) Leucémies aiguës myéloïdes en Tunisie: caractéristiques épidémiologiques et cliniques et classification OMS.[Acute myeloid leukemia in Tunisia: epidemiological and clinical characteristics and WHO classification]. Journal Africain du Cancer; 2, 1: 25-32.
[21]	Rindy LJ, Chambers AR. Bone Marrow Aspiration And Biopsy. 2021 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 32644658.

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APA Style

Skali Hajar, Lazrak Fatima Zahrae, Yahyaoui Hicham, Ait Ameur Mustapha, Chakour Mohamed. (2021). The Role of Myelogram in Diagnosis of Malignant Hemopathies. American Journal of Laboratory Medicine, 6(5), 70-76. https://doi.org/10.11648/j.ajlm.20210605.11

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ACS Style

Skali Hajar; Lazrak Fatima Zahrae; Yahyaoui Hicham; Ait Ameur Mustapha; Chakour Mohamed. The Role of Myelogram in Diagnosis of Malignant Hemopathies. Am. J. Lab. Med. 2021, 6(5), 70-76. doi: 10.11648/j.ajlm.20210605.11

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AMA Style

Skali Hajar, Lazrak Fatima Zahrae, Yahyaoui Hicham, Ait Ameur Mustapha, Chakour Mohamed. The Role of Myelogram in Diagnosis of Malignant Hemopathies. Am J Lab Med. 2021;6(5):70-76. doi: 10.11648/j.ajlm.20210605.11

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@article{10.11648/j.ajlm.20210605.11,
  author = {Skali Hajar and Lazrak Fatima Zahrae and Yahyaoui Hicham and Ait Ameur Mustapha and Chakour Mohamed},
  title = {The Role of Myelogram in Diagnosis of Malignant Hemopathies},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {5},
  pages = {70-76},
  doi = {10.11648/j.ajlm.20210605.11},
  url = {https://doi.org/10.11648/j.ajlm.20210605.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210605.11},
  abstract = {The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical and other diagnostic findings. This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech over a period of two years, from January 2018 to December 2019, aimed to evaluate the practice and the contribution of the myelogram in diagnosis in patients in the Hematology Laboratory and to report the epidemiological profile of malignant hemopathies diagnosed in our Laboratory. In our study, out of 420 myelograms received in the Hematology Laboratory of the military hospital in Marrakech, 70 cases (17%) of malignant hemopathies were collected. The predominant age range was 61 to 70 years old. The male gender was predominant (64%) with a sex-ratio at 1,8. The clinical indications of myelogram were dominated by anemic syndrome, tumoral syndrome. Biologically, the Peripheral Blood count and smear abnormalities were the most frequent. Acute leukemias were accounted for 35% of all malignant pathologies diagnosed in our laboratory of which 79% myeloid, 21% lymphoid. Multiple myelomas were found in 33%, myelodysplastic syndromes in 17% and Chronic myeloid leukemia in 9%. The role of the myelogram in diagnostic of malignant hemopathies is based on its good interpretation which is directly linked to the rigor of its realization.},
 year = {2021}
}

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TY  - JOUR
T1  - The Role of Myelogram in Diagnosis of Malignant Hemopathies
AU  - Skali Hajar
AU  - Lazrak Fatima Zahrae
AU  - Yahyaoui Hicham
AU  - Ait Ameur Mustapha
AU  - Chakour Mohamed
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ajlm.20210605.11
DO  - 10.11648/j.ajlm.20210605.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 70
EP  - 76
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20210605.11
AB  - The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical and other diagnostic findings. This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech over a period of two years, from January 2018 to December 2019, aimed to evaluate the practice and the contribution of the myelogram in diagnosis in patients in the Hematology Laboratory and to report the epidemiological profile of malignant hemopathies diagnosed in our Laboratory. In our study, out of 420 myelograms received in the Hematology Laboratory of the military hospital in Marrakech, 70 cases (17%) of malignant hemopathies were collected. The predominant age range was 61 to 70 years old. The male gender was predominant (64%) with a sex-ratio at 1,8. The clinical indications of myelogram were dominated by anemic syndrome, tumoral syndrome. Biologically, the Peripheral Blood count and smear abnormalities were the most frequent. Acute leukemias were accounted for 35% of all malignant pathologies diagnosed in our laboratory of which 79% myeloid, 21% lymphoid. Multiple myelomas were found in 33%, myelodysplastic syndromes in 17% and Chronic myeloid leukemia in 9%. The role of the myelogram in diagnostic of malignant hemopathies is based on its good interpretation which is directly linked to the rigor of its realization.
VL  - 6
IS  - 5
ER  -

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Author Information

Skali Hajar

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Lazrak Fatima Zahrae

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Yahyaoui Hicham

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Ait Ameur Mustapha

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco
Chakour Mohamed

Hematology Laboratory Military Hospital Avicenna of Marrakech, Faculty of Medicine and Pharmacy of Marrakech, University of Cadi Ayyad of Marrakech, Marrakech, Morocco

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APA Style

Skali Hajar, Lazrak Fatima Zahrae, Yahyaoui Hicham, Ait Ameur Mustapha, Chakour Mohamed. (2021). The Role of Myelogram in Diagnosis of Malignant Hemopathies. American Journal of Laboratory Medicine, 6(5), 70-76. https://doi.org/10.11648/j.ajlm.20210605.11

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ACS Style

Skali Hajar; Lazrak Fatima Zahrae; Yahyaoui Hicham; Ait Ameur Mustapha; Chakour Mohamed. The Role of Myelogram in Diagnosis of Malignant Hemopathies. Am. J. Lab. Med. 2021, 6(5), 70-76. doi: 10.11648/j.ajlm.20210605.11

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AMA Style

Skali Hajar, Lazrak Fatima Zahrae, Yahyaoui Hicham, Ait Ameur Mustapha, Chakour Mohamed. The Role of Myelogram in Diagnosis of Malignant Hemopathies. Am J Lab Med. 2021;6(5):70-76. doi: 10.11648/j.ajlm.20210605.11

Copy | Download

@article{10.11648/j.ajlm.20210605.11,
  author = {Skali Hajar and Lazrak Fatima Zahrae and Yahyaoui Hicham and Ait Ameur Mustapha and Chakour Mohamed},
  title = {The Role of Myelogram in Diagnosis of Malignant Hemopathies},
  journal = {American Journal of Laboratory Medicine},
  volume = {6},
  number = {5},
  pages = {70-76},
  doi = {10.11648/j.ajlm.20210605.11},
  url = {https://doi.org/10.11648/j.ajlm.20210605.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20210605.11},
  abstract = {The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical and other diagnostic findings. This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech over a period of two years, from January 2018 to December 2019, aimed to evaluate the practice and the contribution of the myelogram in diagnosis in patients in the Hematology Laboratory and to report the epidemiological profile of malignant hemopathies diagnosed in our Laboratory. In our study, out of 420 myelograms received in the Hematology Laboratory of the military hospital in Marrakech, 70 cases (17%) of malignant hemopathies were collected. The predominant age range was 61 to 70 years old. The male gender was predominant (64%) with a sex-ratio at 1,8. The clinical indications of myelogram were dominated by anemic syndrome, tumoral syndrome. Biologically, the Peripheral Blood count and smear abnormalities were the most frequent. Acute leukemias were accounted for 35% of all malignant pathologies diagnosed in our laboratory of which 79% myeloid, 21% lymphoid. Multiple myelomas were found in 33%, myelodysplastic syndromes in 17% and Chronic myeloid leukemia in 9%. The role of the myelogram in diagnostic of malignant hemopathies is based on its good interpretation which is directly linked to the rigor of its realization.},
 year = {2021}
}

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TY  - JOUR
T1  - The Role of Myelogram in Diagnosis of Malignant Hemopathies
AU  - Skali Hajar
AU  - Lazrak Fatima Zahrae
AU  - Yahyaoui Hicham
AU  - Ait Ameur Mustapha
AU  - Chakour Mohamed
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ajlm.20210605.11
DO  - 10.11648/j.ajlm.20210605.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 70
EP  - 76
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20210605.11
AB  - The myelogram is an essential investigation for the diagnosis and management of malignant hemopathies. The final interpretation requires the integration of peripheral blood count and smear, with the results of supplementary tests such as immunophenotyping, cytogenetic analysis and molecular genetic studies as appropriate, in the context of clinical and other diagnostic findings. This retrospective study conducted at the Hematology Laboratory of the Military hospital Avicenna in Marrakech over a period of two years, from January 2018 to December 2019, aimed to evaluate the practice and the contribution of the myelogram in diagnosis in patients in the Hematology Laboratory and to report the epidemiological profile of malignant hemopathies diagnosed in our Laboratory. In our study, out of 420 myelograms received in the Hematology Laboratory of the military hospital in Marrakech, 70 cases (17%) of malignant hemopathies were collected. The predominant age range was 61 to 70 years old. The male gender was predominant (64%) with a sex-ratio at 1,8. The clinical indications of myelogram were dominated by anemic syndrome, tumoral syndrome. Biologically, the Peripheral Blood count and smear abnormalities were the most frequent. Acute leukemias were accounted for 35% of all malignant pathologies diagnosed in our laboratory of which 79% myeloid, 21% lymphoid. Multiple myelomas were found in 33%, myelodysplastic syndromes in 17% and Chronic myeloid leukemia in 9%. The role of the myelogram in diagnostic of malignant hemopathies is based on its good interpretation which is directly linked to the rigor of its realization.
VL  - 6
IS  - 5
ER  -

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