Sickle cell disease (SCD) is the co-inheritance of HbS with other abnormal haemoglobin. COVID-19 is a severe acute respiratory distress syndrome caused by coronavirus 2 infections. The immunosuppression and chronic inflammatory states in patients with SCD predispose them to severe form of COVID-19. The few case studies on sickle cell disease patients infected with COVID-19 mostly discuss the pattern of clinical presentations and laboratory changes in patients with SCD infected with COVID-19. This review of literature assesses the prognostic indicators in sickle cell disease patients infected with COVID 19 in three major case series. Some presenting symptoms and signs, presence of comorbidities and certain laboratory parameters were compared with poor outcome of patients. Poor clinical outcomes of patients in this review included: 1. Duration of admission of ≥10 days, 2. A week or more of intensive care unit admission, 3. Death of patient despite intervention while on admission, and 4. Deterioration in the presenting comorbid clinical condition. The presenting symptoms and signs, presence of comorbidities and certain laboratory parameters associated with these poor clinical outcomes were considered as poor prognostic factors. The presence of comorbidities, markedly elevated pro-inflammatory markers such as leukocytosis, IL-6, C-reactive proteins, marked elevated D-Dimer and high serum creatinine are poor prognostic factors in sickle cell disease patients with COVID-19 infection.
| Published in | American Journal of Laboratory Medicine (Volume 5, Issue 4) |
| DOI | 10.11648/j.ajlm.20200504.17 |
| Page(s) | 125-130 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Sickle Cell Disease, COVID-19, Poor prognostic Factors, Comorbidities
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APA Style
Odebiyi Hassan Abiola, Dachi Rufai Abdul, Pindiga Kasim Muhammad. (2020). Poor Prognostic Factors in Sickle Cell Disease Patients Infected with Covid-19 – Review of Literatures. American Journal of Laboratory Medicine, 5(4), 125-130. https://doi.org/10.11648/j.ajlm.20200504.17
ACS Style
Odebiyi Hassan Abiola; Dachi Rufai Abdul; Pindiga Kasim Muhammad. Poor Prognostic Factors in Sickle Cell Disease Patients Infected with Covid-19 – Review of Literatures. Am. J. Lab. Med. 2020, 5(4), 125-130. doi: 10.11648/j.ajlm.20200504.17
AMA Style
Odebiyi Hassan Abiola, Dachi Rufai Abdul, Pindiga Kasim Muhammad. Poor Prognostic Factors in Sickle Cell Disease Patients Infected with Covid-19 – Review of Literatures. Am J Lab Med. 2020;5(4):125-130. doi: 10.11648/j.ajlm.20200504.17
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Download@article{10.11648/j.ajlm.20200504.17,
author = {Odebiyi Hassan Abiola and Dachi Rufai Abdul and Pindiga Kasim Muhammad},
title = {Poor Prognostic Factors in Sickle Cell Disease Patients Infected with Covid-19 – Review of Literatures},
journal = {American Journal of Laboratory Medicine},
volume = {5},
number = {4},
pages = {125-130},
doi = {10.11648/j.ajlm.20200504.17},
url = {https://doi.org/10.11648/j.ajlm.20200504.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200504.17},
abstract = {Sickle cell disease (SCD) is the co-inheritance of HbS with other abnormal haemoglobin. COVID-19 is a severe acute respiratory distress syndrome caused by coronavirus 2 infections. The immunosuppression and chronic inflammatory states in patients with SCD predispose them to severe form of COVID-19. The few case studies on sickle cell disease patients infected with COVID-19 mostly discuss the pattern of clinical presentations and laboratory changes in patients with SCD infected with COVID-19. This review of literature assesses the prognostic indicators in sickle cell disease patients infected with COVID 19 in three major case series. Some presenting symptoms and signs, presence of comorbidities and certain laboratory parameters were compared with poor outcome of patients. Poor clinical outcomes of patients in this review included: 1. Duration of admission of ≥10 days, 2. A week or more of intensive care unit admission, 3. Death of patient despite intervention while on admission, and 4. Deterioration in the presenting comorbid clinical condition. The presenting symptoms and signs, presence of comorbidities and certain laboratory parameters associated with these poor clinical outcomes were considered as poor prognostic factors. The presence of comorbidities, markedly elevated pro-inflammatory markers such as leukocytosis, IL-6, C-reactive proteins, marked elevated D-Dimer and high serum creatinine are poor prognostic factors in sickle cell disease patients with COVID-19 infection.},
year = {2020}
}
TY - JOUR T1 - Poor Prognostic Factors in Sickle Cell Disease Patients Infected with Covid-19 – Review of Literatures AU - Odebiyi Hassan Abiola AU - Dachi Rufai Abdul AU - Pindiga Kasim Muhammad Y1 - 2020/08/17 PY - 2020 N1 - https://doi.org/10.11648/j.ajlm.20200504.17 DO - 10.11648/j.ajlm.20200504.17 T2 - American Journal of Laboratory Medicine JF - American Journal of Laboratory Medicine JO - American Journal of Laboratory Medicine SP - 125 EP - 130 PB - Science Publishing Group SN - 2575-386X UR - https://doi.org/10.11648/j.ajlm.20200504.17 AB - Sickle cell disease (SCD) is the co-inheritance of HbS with other abnormal haemoglobin. COVID-19 is a severe acute respiratory distress syndrome caused by coronavirus 2 infections. The immunosuppression and chronic inflammatory states in patients with SCD predispose them to severe form of COVID-19. The few case studies on sickle cell disease patients infected with COVID-19 mostly discuss the pattern of clinical presentations and laboratory changes in patients with SCD infected with COVID-19. This review of literature assesses the prognostic indicators in sickle cell disease patients infected with COVID 19 in three major case series. Some presenting symptoms and signs, presence of comorbidities and certain laboratory parameters were compared with poor outcome of patients. Poor clinical outcomes of patients in this review included: 1. Duration of admission of ≥10 days, 2. A week or more of intensive care unit admission, 3. Death of patient despite intervention while on admission, and 4. Deterioration in the presenting comorbid clinical condition. The presenting symptoms and signs, presence of comorbidities and certain laboratory parameters associated with these poor clinical outcomes were considered as poor prognostic factors. The presence of comorbidities, markedly elevated pro-inflammatory markers such as leukocytosis, IL-6, C-reactive proteins, marked elevated D-Dimer and high serum creatinine are poor prognostic factors in sickle cell disease patients with COVID-19 infection. VL - 5 IS - 4 ER -
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