Oxidative Stress and Human Psoriasis Diseases

Asrat Endrias; Menakath Menon; Mihretu Wodeyes; Tamrat Abebe; Mohammed Mehdi; Ezra Belay; Daniel Seifu

doi:doi:10.11648/j.ajlm.20200504.16

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Oxidative Stress and Human Psoriasis Diseases

Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, Ezra Belay, Daniel Seifu

Published in American Journal of Laboratory Medicine (Volume 5, Issue 4)

Received: 15 July 2020 Accepted: 28 July 2020 Published: 10 August 2020

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Abstract

Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (p<0.001) as well as Oxidative Stress Index (p<0.001) in psoriasis patients as compared to controls and positively correlated with severity and duration of the disease. Total Anti-oxidant capacity levels were significantly (p<0.001) lower in patients than in controls and negatively correlated with severity and duration of the disease. Conclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.

Published in	American Journal of Laboratory Medicine (Volume 5, Issue 4)
DOI	10.11648/j.ajlm.20200504.16
Page(s)	118-124
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Total Oxidant Capacity, Total Antioxidant Capacity, Oxidative Stress Index, Psoriasis

References

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APA Style

Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, et al. (2020). Oxidative Stress and Human Psoriasis Diseases. American Journal of Laboratory Medicine, 5(4), 118-124. https://doi.org/10.11648/j.ajlm.20200504.16

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ACS Style

Asrat Endrias; Menakath Menon; Mihretu Wodeyes; Tamrat Abebe; Mohammed Mehdi, et al. Oxidative Stress and Human Psoriasis Diseases. Am. J. Lab. Med. 2020, 5(4), 118-124. doi: 10.11648/j.ajlm.20200504.16

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AMA Style

Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, et al. Oxidative Stress and Human Psoriasis Diseases. Am J Lab Med. 2020;5(4):118-124. doi: 10.11648/j.ajlm.20200504.16

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@article{10.11648/j.ajlm.20200504.16,
  author = {Asrat Endrias and Menakath Menon and Mihretu Wodeyes and Tamrat Abebe and Mohammed Mehdi and Ezra Belay and Daniel Seifu},
  title = {Oxidative Stress and Human Psoriasis Diseases},
  journal = {American Journal of Laboratory Medicine},
  volume = {5},
  number = {4},
  pages = {118-124},
  doi = {10.11648/j.ajlm.20200504.16},
  url = {https://doi.org/10.11648/j.ajlm.20200504.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200504.16},
  abstract = {Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (pConclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.},
 year = {2020}
}

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TY  - JOUR
T1  - Oxidative Stress and Human Psoriasis Diseases
AU  - Asrat Endrias
AU  - Menakath Menon
AU  - Mihretu Wodeyes
AU  - Tamrat Abebe
AU  - Mohammed Mehdi
AU  - Ezra Belay
AU  - Daniel Seifu
Y1  - 2020/08/10
PY  - 2020
N1  - https://doi.org/10.11648/j.ajlm.20200504.16
DO  - 10.11648/j.ajlm.20200504.16
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 118
EP  - 124
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20200504.16
AB  - Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (pConclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
VL  - 5
IS  - 4
ER  -

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Author Information

Asrat Endrias

Department of Biochemistry, Mekelle University, Mekelle, Ethiopia
Menakath Menon

Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Mihretu Wodeyes

Department of Dermatology, Addis Ababa University, Addis Ababa, Ethiopia
Tamrat Abebe

Department of Microbiology, Parasitology and Immunology, Addis Ababa University, Addis Ababa, Ethiopia
Mohammed Mehdi

Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Ezra Belay

Department of Biochemistry, Mekelle University, Mekelle, Ethiopia
Daniel Seifu

Department of Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia

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APA Style

Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, et al. (2020). Oxidative Stress and Human Psoriasis Diseases. American Journal of Laboratory Medicine, 5(4), 118-124. https://doi.org/10.11648/j.ajlm.20200504.16

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ACS Style

Asrat Endrias; Menakath Menon; Mihretu Wodeyes; Tamrat Abebe; Mohammed Mehdi, et al. Oxidative Stress and Human Psoriasis Diseases. Am. J. Lab. Med. 2020, 5(4), 118-124. doi: 10.11648/j.ajlm.20200504.16

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AMA Style

Asrat Endrias, Menakath Menon, Mihretu Wodeyes, Tamrat Abebe, Mohammed Mehdi, et al. Oxidative Stress and Human Psoriasis Diseases. Am J Lab Med. 2020;5(4):118-124. doi: 10.11648/j.ajlm.20200504.16

Copy | Download

@article{10.11648/j.ajlm.20200504.16,
  author = {Asrat Endrias and Menakath Menon and Mihretu Wodeyes and Tamrat Abebe and Mohammed Mehdi and Ezra Belay and Daniel Seifu},
  title = {Oxidative Stress and Human Psoriasis Diseases},
  journal = {American Journal of Laboratory Medicine},
  volume = {5},
  number = {4},
  pages = {118-124},
  doi = {10.11648/j.ajlm.20200504.16},
  url = {https://doi.org/10.11648/j.ajlm.20200504.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20200504.16},
  abstract = {Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (pConclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.},
 year = {2020}
}

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TY  - JOUR
T1  - Oxidative Stress and Human Psoriasis Diseases
AU  - Asrat Endrias
AU  - Menakath Menon
AU  - Mihretu Wodeyes
AU  - Tamrat Abebe
AU  - Mohammed Mehdi
AU  - Ezra Belay
AU  - Daniel Seifu
Y1  - 2020/08/10
PY  - 2020
N1  - https://doi.org/10.11648/j.ajlm.20200504.16
DO  - 10.11648/j.ajlm.20200504.16
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 118
EP  - 124
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20200504.16
AB  - Psoriasis is a chronic inflammatory skin disease characterized by the immune system activation due to genetic and environmental factors that leads to the development of skin lesions. Reactive oxygen species produced as a result of skin inflammation may cause disorders of the antioxidant defense systems and increased oxidative stress in psoriasis which was proposed to have a consequent function in psoriasis. The study was planned to evaluate oxidative stress by measuring Total Oxidant Capacity, Total Anti-oxidant capacity and Oxidative Stress Index in psoriatic patients. Methodology: A comparative cross-sectional study design was used. A total of 90 participants between age of 18-65 years comprising 45 newly diagnosed psoriatic patients and 45 sex and age matched control groups were enrolled in the study. Result: The present study showed significantly increased levels of serum Total Oxidant Capacity (pConclusion: These results provide evidences regarding the role of increased reactive oxygen species with decreased antioxidant activity in psoriatic patients.
VL  - 5
IS  - 4
ER  -

Copy | Download