Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases

Ilham Karrati; Hanane Mouhib; Hicham Yahyaoui; Radia Amaddah; Mustapha Aitameur; Mohamed Chakour

doi:doi:10.11648/j.ajlm.20190405.11

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Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases

Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, Mohamed Chakour

Published in American Journal of Laboratory Medicine (Volume 4, Issue 5)

Received: 31 July 2019 Accepted: 30 August 2019 Published: 19 September 2019

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Abstract

Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.

Published in	American Journal of Laboratory Medicine (Volume 4, Issue 5)
DOI	10.11648/j.ajlm.20190405.11
Page(s)	79-86
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Thrombophilia Assessment, Protein C, Protein S, Antithrombin, Factor V mutation, Factor II Mutation

References

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APA Style

Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, et al. (2019). Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. American Journal of Laboratory Medicine, 4(5), 79-86. https://doi.org/10.11648/j.ajlm.20190405.11

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ACS Style

Ilham Karrati; Hanane Mouhib; Hicham Yahyaoui; Radia Amaddah; Mustapha Aitameur, et al. Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. Am. J. Lab. Med. 2019, 4(5), 79-86. doi: 10.11648/j.ajlm.20190405.11

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AMA Style

Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, et al. Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. Am J Lab Med. 2019;4(5):79-86. doi: 10.11648/j.ajlm.20190405.11

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@article{10.11648/j.ajlm.20190405.11,
  author = {Ilham Karrati and Hanane Mouhib and Hicham Yahyaoui and Radia Amaddah and Mustapha Aitameur and Mohamed Chakour},
  title = {Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {5},
  pages = {79-86},
  doi = {10.11648/j.ajlm.20190405.11},
  url = {https://doi.org/10.11648/j.ajlm.20190405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190405.11},
  abstract = {Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.},
 year = {2019}
}

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TY  - JOUR
T1  - Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases
AU  - Ilham Karrati
AU  - Hanane Mouhib
AU  - Hicham Yahyaoui
AU  - Radia Amaddah
AU  - Mustapha Aitameur
AU  - Mohamed Chakour
Y1  - 2019/09/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190405.11
DO  - 10.11648/j.ajlm.20190405.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 79
EP  - 86
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190405.11
AB  - Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.
VL  - 4
IS  - 5
ER  -

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Author Information

Ilham Karrati

Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco
Hanane Mouhib

Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco
Hicham Yahyaoui

Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco
Radia Amaddah

Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco
Mustapha Aitameur

Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco
Mohamed Chakour

Haematology Laboratory of Avicenne Military Hospital, University Hospital Mohamed VI, Marrakech, Morocco

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Plain Text BibTeX RIS

APA Style

Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, et al. (2019). Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. American Journal of Laboratory Medicine, 4(5), 79-86. https://doi.org/10.11648/j.ajlm.20190405.11

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ACS Style

Ilham Karrati; Hanane Mouhib; Hicham Yahyaoui; Radia Amaddah; Mustapha Aitameur, et al. Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. Am. J. Lab. Med. 2019, 4(5), 79-86. doi: 10.11648/j.ajlm.20190405.11

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AMA Style

Ilham Karrati, Hanane Mouhib, Hicham Yahyaoui, Radia Amaddah, Mustapha Aitameur, et al. Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases. Am J Lab Med. 2019;4(5):79-86. doi: 10.11648/j.ajlm.20190405.11

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@article{10.11648/j.ajlm.20190405.11,
  author = {Ilham Karrati and Hanane Mouhib and Hicham Yahyaoui and Radia Amaddah and Mustapha Aitameur and Mohamed Chakour},
  title = {Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases},
  journal = {American Journal of Laboratory Medicine},
  volume = {4},
  number = {5},
  pages = {79-86},
  doi = {10.11648/j.ajlm.20190405.11},
  url = {https://doi.org/10.11648/j.ajlm.20190405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20190405.11},
  abstract = {Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.},
 year = {2019}
}

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TY  - JOUR
T1  - Epidemiological Profile of Thrombophilia in Marrakech (Morocco): About 200 Cases
AU  - Ilham Karrati
AU  - Hanane Mouhib
AU  - Hicham Yahyaoui
AU  - Radia Amaddah
AU  - Mustapha Aitameur
AU  - Mohamed Chakour
Y1  - 2019/09/19
PY  - 2019
N1  - https://doi.org/10.11648/j.ajlm.20190405.11
DO  - 10.11648/j.ajlm.20190405.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 79
EP  - 86
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20190405.11
AB  - Thrombophilia is a situation characterized by an increased tendency to thrombosis. The main objective of this work is to report on the experience of the Haematology Laboratory of the Avicenne Military Hospital of Marrakech, through a retrospective descriptive study carried out over a period of 9 years, on 200 requests for a thrombophilia check-up; and secondly, to discuss its indications and interest in the etiological diagnosis of unexplained thrombosis in the light of the latest recommendations. The thrombogenic risk factor most commonly found in our study was PS deficiency, in contrast to the predominance of Factor V mutation in Western countries, hence the importance of emphasizing that in clinical practice, the first-line thrombophilia assessment should always combine, in accordance with the latest recommendations: inhibitor deficiencies, F V and F II mutations, antiphospholipid antibodies and possibly F VIII determination.
VL  - 4
IS  - 5
ER  -

Copy | Download