Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease

Safauldeen Ahmed Alhajim; Ahmed Aubed Sherhan

doi:doi:10.11648/j.ajlm.20180306.11

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Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease

Safauldeen Ahmed Alhajim, Ahmed Aubed Sherhan

Published in American Journal of Laboratory Medicine (Volume 3, Issue 6)

Received: 30 October 2018 Accepted: 27 November 2018 Published: 24 December 2018

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Abstract

Measurement of urine albumin excretion rate (AER) over a 24-h period is considered the gold standard technique for detecting albuminuria. However, the procedure is highly inconvenient for most patients. This study aimed to assess the accuracy of albumin to creatinine ratio in spot urine (UACR) as a surrogate to 24-h urine AER in patients with chronic kidney disease (CKD). This cross-sectional study included 92 patients with CKD (51 men and 41 women) admitted to Al-Basrah Teaching Hospital from January to October 2014. The 24-h AER was obtained using 24-h urine samples and the UACR was determined from a morning-void urine sample. Serum creatinine level was determined and general urine examination was performed using standard methods. Patients were divided into three groups according to glomerular filtration rate (GFR; ≥60, 30–59, and 15–29 mL/min/1.73 m2). Pearson’s correlation coefficients for ACR vs. 24-h AER were 0.609 (P < 0.0001) and 0.532 (P < 0.0001) for men and women, respectively. In the GFR groups, Pearson’s correlation coefficients were, in the order listed above, 0.681 (P = 0.0001), 0.820 (P = < 0.001), 0.865 (P = 0.002) in men, and 0.721 (P = 0.01), 0.865 (P = 0.002), and 0.756 (P = 0.04) in women. In conclusion UACR determined using morning urine samples is fairley correlated with 24-h urine AER and is more practical and convenient for both the patient and the physician.

Published in	American Journal of Laboratory Medicine (Volume 3, Issue 6)
DOI	10.11648/j.ajlm.20180306.11
Page(s)	48-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Albuminuria, Chronic Kidney Disease, Diabetes Mellitus, Diabetic Nephropathy, Urine Sample

References

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APA Style

Safauldeen Ahmed Alhajim, Ahmed Aubed Sherhan. (2018). Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease. American Journal of Laboratory Medicine, 3(6), 48-52. https://doi.org/10.11648/j.ajlm.20180306.11

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ACS Style

Safauldeen Ahmed Alhajim; Ahmed Aubed Sherhan. Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease. Am. J. Lab. Med. 2018, 3(6), 48-52. doi: 10.11648/j.ajlm.20180306.11

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AMA Style

Safauldeen Ahmed Alhajim, Ahmed Aubed Sherhan. Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease. Am J Lab Med. 2018;3(6):48-52. doi: 10.11648/j.ajlm.20180306.11

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@article{10.11648/j.ajlm.20180306.11,
  author = {Safauldeen Ahmed Alhajim and Ahmed Aubed Sherhan},
  title = {Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease},
  journal = {American Journal of Laboratory Medicine},
  volume = {3},
  number = {6},
  pages = {48-52},
  doi = {10.11648/j.ajlm.20180306.11},
  url = {https://doi.org/10.11648/j.ajlm.20180306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20180306.11},
  abstract = {Measurement of urine albumin excretion rate (AER) over a 24-h period is considered the gold standard technique for detecting albuminuria. However, the procedure is highly inconvenient for most patients. This study aimed to assess the accuracy of albumin to creatinine ratio in spot urine (UACR) as a surrogate to 24-h urine AER in patients with chronic kidney disease (CKD). This cross-sectional study included 92 patients with CKD (51 men and 41 women) admitted to Al-Basrah Teaching Hospital from January to October 2014. The 24-h AER was obtained using 24-h urine samples and the UACR was determined from a morning-void urine sample. Serum creatinine level was determined and general urine examination was performed using standard methods. Patients were divided into three groups according to glomerular filtration rate (GFR; ≥60, 30–59, and 15–29 mL/min/1.73 m2). Pearson’s correlation coefficients for ACR vs. 24-h AER were 0.609 (P < 0.0001) and 0.532 (P < 0.0001) for men and women, respectively. In the GFR groups, Pearson’s correlation coefficients were, in the order listed above, 0.681 (P = 0.0001), 0.820 (P = < 0.001), 0.865 (P = 0.002) in men, and 0.721 (P = 0.01), 0.865 (P = 0.002), and 0.756 (P = 0.04) in women. In conclusion UACR determined using morning urine samples is fairley correlated with 24-h urine AER and is more practical and convenient for both the patient and the physician.},
 year = {2018}
}

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TY  - JOUR
T1  - Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease
AU  - Safauldeen Ahmed Alhajim
AU  - Ahmed Aubed Sherhan
Y1  - 2018/12/24
PY  - 2018
N1  - https://doi.org/10.11648/j.ajlm.20180306.11
DO  - 10.11648/j.ajlm.20180306.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 48
EP  - 52
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20180306.11
AB  - Measurement of urine albumin excretion rate (AER) over a 24-h period is considered the gold standard technique for detecting albuminuria. However, the procedure is highly inconvenient for most patients. This study aimed to assess the accuracy of albumin to creatinine ratio in spot urine (UACR) as a surrogate to 24-h urine AER in patients with chronic kidney disease (CKD). This cross-sectional study included 92 patients with CKD (51 men and 41 women) admitted to Al-Basrah Teaching Hospital from January to October 2014. The 24-h AER was obtained using 24-h urine samples and the UACR was determined from a morning-void urine sample. Serum creatinine level was determined and general urine examination was performed using standard methods. Patients were divided into three groups according to glomerular filtration rate (GFR; ≥60, 30–59, and 15–29 mL/min/1.73 m2). Pearson’s correlation coefficients for ACR vs. 24-h AER were 0.609 (P < 0.0001) and 0.532 (P < 0.0001) for men and women, respectively. In the GFR groups, Pearson’s correlation coefficients were, in the order listed above, 0.681 (P = 0.0001), 0.820 (P = < 0.001), 0.865 (P = 0.002) in men, and 0.721 (P = 0.01), 0.865 (P = 0.002), and 0.756 (P = 0.04) in women. In conclusion UACR determined using morning urine samples is fairley correlated with 24-h urine AER and is more practical and convenient for both the patient and the physician.
VL  - 3
IS  - 6
ER  -

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Author Information

Safauldeen Ahmed Alhajim

Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq
Ahmed Aubed Sherhan

Department of Medicine, College of Medicine, University of Basrah, Basrah, Iraq

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APA Style

Safauldeen Ahmed Alhajim, Ahmed Aubed Sherhan. (2018). Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease. American Journal of Laboratory Medicine, 3(6), 48-52. https://doi.org/10.11648/j.ajlm.20180306.11

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ACS Style

Safauldeen Ahmed Alhajim; Ahmed Aubed Sherhan. Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease. Am. J. Lab. Med. 2018, 3(6), 48-52. doi: 10.11648/j.ajlm.20180306.11

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AMA Style

Safauldeen Ahmed Alhajim, Ahmed Aubed Sherhan. Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease. Am J Lab Med. 2018;3(6):48-52. doi: 10.11648/j.ajlm.20180306.11

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@article{10.11648/j.ajlm.20180306.11,
  author = {Safauldeen Ahmed Alhajim and Ahmed Aubed Sherhan},
  title = {Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease},
  journal = {American Journal of Laboratory Medicine},
  volume = {3},
  number = {6},
  pages = {48-52},
  doi = {10.11648/j.ajlm.20180306.11},
  url = {https://doi.org/10.11648/j.ajlm.20180306.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajlm.20180306.11},
  abstract = {Measurement of urine albumin excretion rate (AER) over a 24-h period is considered the gold standard technique for detecting albuminuria. However, the procedure is highly inconvenient for most patients. This study aimed to assess the accuracy of albumin to creatinine ratio in spot urine (UACR) as a surrogate to 24-h urine AER in patients with chronic kidney disease (CKD). This cross-sectional study included 92 patients with CKD (51 men and 41 women) admitted to Al-Basrah Teaching Hospital from January to October 2014. The 24-h AER was obtained using 24-h urine samples and the UACR was determined from a morning-void urine sample. Serum creatinine level was determined and general urine examination was performed using standard methods. Patients were divided into three groups according to glomerular filtration rate (GFR; ≥60, 30–59, and 15–29 mL/min/1.73 m2). Pearson’s correlation coefficients for ACR vs. 24-h AER were 0.609 (P < 0.0001) and 0.532 (P < 0.0001) for men and women, respectively. In the GFR groups, Pearson’s correlation coefficients were, in the order listed above, 0.681 (P = 0.0001), 0.820 (P = < 0.001), 0.865 (P = 0.002) in men, and 0.721 (P = 0.01), 0.865 (P = 0.002), and 0.756 (P = 0.04) in women. In conclusion UACR determined using morning urine samples is fairley correlated with 24-h urine AER and is more practical and convenient for both the patient and the physician.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Albumin to Creatinine Ratio Is Fairly Correlated with Albumin Excretion Rate in Chronic Kidney Disease
AU  - Safauldeen Ahmed Alhajim
AU  - Ahmed Aubed Sherhan
Y1  - 2018/12/24
PY  - 2018
N1  - https://doi.org/10.11648/j.ajlm.20180306.11
DO  - 10.11648/j.ajlm.20180306.11
T2  - American Journal of Laboratory Medicine
JF  - American Journal of Laboratory Medicine
JO  - American Journal of Laboratory Medicine
SP  - 48
EP  - 52
PB  - Science Publishing Group
SN  - 2575-386X
UR  - https://doi.org/10.11648/j.ajlm.20180306.11
AB  - Measurement of urine albumin excretion rate (AER) over a 24-h period is considered the gold standard technique for detecting albuminuria. However, the procedure is highly inconvenient for most patients. This study aimed to assess the accuracy of albumin to creatinine ratio in spot urine (UACR) as a surrogate to 24-h urine AER in patients with chronic kidney disease (CKD). This cross-sectional study included 92 patients with CKD (51 men and 41 women) admitted to Al-Basrah Teaching Hospital from January to October 2014. The 24-h AER was obtained using 24-h urine samples and the UACR was determined from a morning-void urine sample. Serum creatinine level was determined and general urine examination was performed using standard methods. Patients were divided into three groups according to glomerular filtration rate (GFR; ≥60, 30–59, and 15–29 mL/min/1.73 m2). Pearson’s correlation coefficients for ACR vs. 24-h AER were 0.609 (P < 0.0001) and 0.532 (P < 0.0001) for men and women, respectively. In the GFR groups, Pearson’s correlation coefficients were, in the order listed above, 0.681 (P = 0.0001), 0.820 (P = < 0.001), 0.865 (P = 0.002) in men, and 0.721 (P = 0.01), 0.865 (P = 0.002), and 0.756 (P = 0.04) in women. In conclusion UACR determined using morning urine samples is fairley correlated with 24-h urine AER and is more practical and convenient for both the patient and the physician.
VL  - 3
IS  - 6
ER  -

Copy | Download