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Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway

Received: 28 March 2017     Accepted: 10 April 2017     Published: 15 June 2017
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Abstract

Objective To observe the abnormal expression of IL-1βin hippocampus after bilateral common carotid artery ligation and to evaluate its effects on memory impairment induced by chronic cerebral ischemia. Methods Bilateral common carotid artery ligation (2-vessel occlusion, 2VO) was performed in wild type (Wild Type WT) and interleukin -1 receptor knock-out (IL-1 Resept Knock Out, IL-1R KO) C57 mice (male) to produce chronic cerebral ischemia mouse models. After the operation, their memory was detected with eight-arm radial maze test and the novel object recognition test, and the level of IL-1β and BDNF in hippocampus was detected with Western Blot. Results The average number of working memory errors of the KO-2VO mice was significantly decreased (P<0.05), and the recognition index was significantly increased (P<0.05) compared with those of the WT-2VO mice. Dramatic decrease in IL-1β in hippocampus (P<0.05) and substantial increase in BDNF (P<0.05) were observed in the KO-2VO mice. In the behavioral experiment and Western Blot, there was no significant difference between the KO-sham mice and the WT-sham controls. Conclusion Increase in the level of the IL-1β in hippocampus after bilateral common carotid artery ligation can lead to decrease in the level of the BDNF, which may cause memory impairment.

Published in American Journal of Internal Medicine (Volume 5, Issue 4)
DOI 10.11648/j.ajim.20170504.11
Page(s) 52-56
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Chronic Cerebral Ischemia, Bilateral Common Carotid Artery Ligation, Microglia, Interleukin-1β,Brain-Derived Neurotrophic Factor (BDNF), Working Memory Impairment

References
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Cite This Article
  • APA Style

    Lan Xian-wu, Cui Liang, Gui Wen-shan. (2017). Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway. American Journal of Internal Medicine, 5(4), 52-56. https://doi.org/10.11648/j.ajim.20170504.11

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    ACS Style

    Lan Xian-wu; Cui Liang; Gui Wen-shan. Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway. Am. J. Intern. Med. 2017, 5(4), 52-56. doi: 10.11648/j.ajim.20170504.11

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    AMA Style

    Lan Xian-wu, Cui Liang, Gui Wen-shan. Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway. Am J Intern Med. 2017;5(4):52-56. doi: 10.11648/j.ajim.20170504.11

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  • @article{10.11648/j.ajim.20170504.11,
      author = {Lan Xian-wu and Cui Liang and Gui Wen-shan},
      title = {Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway},
      journal = {American Journal of Internal Medicine},
      volume = {5},
      number = {4},
      pages = {52-56},
      doi = {10.11648/j.ajim.20170504.11},
      url = {https://doi.org/10.11648/j.ajim.20170504.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170504.11},
      abstract = {Objective To observe the abnormal expression of IL-1βin hippocampus after bilateral common carotid artery ligation and to evaluate its effects on memory impairment induced by chronic cerebral ischemia. Methods Bilateral common carotid artery ligation (2-vessel occlusion, 2VO) was performed in wild type (Wild Type WT) and interleukin -1 receptor knock-out (IL-1 Resept Knock Out, IL-1R KO) C57 mice (male) to produce chronic cerebral ischemia mouse models. After the operation, their memory was detected with eight-arm radial maze test and the novel object recognition test, and the level of IL-1β and BDNF in hippocampus was detected with Western Blot. Results The average number of working memory errors of the KO-2VO mice was significantly decreased (P<0.05), and the recognition index was significantly increased (P<0.05) compared with those of the WT-2VO mice. Dramatic decrease in IL-1β in hippocampus (P<0.05) and substantial increase in BDNF (P<0.05) were observed in the KO-2VO mice. In the behavioral experiment and Western Blot, there was no significant difference between the KO-sham mice and the WT-sham controls. Conclusion Increase in the level of the IL-1β in hippocampus after bilateral common carotid artery ligation can lead to decrease in the level of the BDNF, which may cause memory impairment.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Chronic Cerebral Ischemia-Induced Memory Impairment After Inhibition of BDNF by Interleukin-1 Signaling Pathway
    AU  - Lan Xian-wu
    AU  - Cui Liang
    AU  - Gui Wen-shan
    Y1  - 2017/06/15
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ajim.20170504.11
    DO  - 10.11648/j.ajim.20170504.11
    T2  - American Journal of Internal Medicine
    JF  - American Journal of Internal Medicine
    JO  - American Journal of Internal Medicine
    SP  - 52
    EP  - 56
    PB  - Science Publishing Group
    SN  - 2330-4324
    UR  - https://doi.org/10.11648/j.ajim.20170504.11
    AB  - Objective To observe the abnormal expression of IL-1βin hippocampus after bilateral common carotid artery ligation and to evaluate its effects on memory impairment induced by chronic cerebral ischemia. Methods Bilateral common carotid artery ligation (2-vessel occlusion, 2VO) was performed in wild type (Wild Type WT) and interleukin -1 receptor knock-out (IL-1 Resept Knock Out, IL-1R KO) C57 mice (male) to produce chronic cerebral ischemia mouse models. After the operation, their memory was detected with eight-arm radial maze test and the novel object recognition test, and the level of IL-1β and BDNF in hippocampus was detected with Western Blot. Results The average number of working memory errors of the KO-2VO mice was significantly decreased (P<0.05), and the recognition index was significantly increased (P<0.05) compared with those of the WT-2VO mice. Dramatic decrease in IL-1β in hippocampus (P<0.05) and substantial increase in BDNF (P<0.05) were observed in the KO-2VO mice. In the behavioral experiment and Western Blot, there was no significant difference between the KO-sham mice and the WT-sham controls. Conclusion Increase in the level of the IL-1β in hippocampus after bilateral common carotid artery ligation can lead to decrease in the level of the BDNF, which may cause memory impairment.
    VL  - 5
    IS  - 4
    ER  - 

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Author Information
  • Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China

  • Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China

  • Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou, People’s Republic of China

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