Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites

Ahmed A. Obiedallah; Essam Abdelmohsen; Abdalla I. Kelani; Mohamed Mousa

doi:doi:10.11648/j.ajim.20170501.13

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Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites

Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa

Published in American Journal of Internal Medicine (Volume 5, Issue 1)

Received: 1 January 2017 Accepted: 20 January 2017 Published: 20 February 2017

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Abstract

Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.

Published in	American Journal of Internal Medicine (Volume 5, Issue 1)
DOI	10.11648/j.ajim.20170501.13
Page(s)	12-17
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Midodirine, Refractory Ascites, Liver Cirrhosis

References

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APA Style

Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa. (2017). Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. American Journal of Internal Medicine, 5(1), 12-17. https://doi.org/10.11648/j.ajim.20170501.13

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ACS Style

Ahmed A. Obiedallah; Essam Abdelmohsen; Abdalla I. Kelani; Mohamed Mousa. Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. Am. J. Intern. Med. 2017, 5(1), 12-17. doi: 10.11648/j.ajim.20170501.13

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AMA Style

Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa. Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. Am J Intern Med. 2017;5(1):12-17. doi: 10.11648/j.ajim.20170501.13

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@article{10.11648/j.ajim.20170501.13,
  author = {Ahmed A. Obiedallah and Essam Abdelmohsen and Abdalla I. Kelani and Mohamed Mousa},
  title = {Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites},
  journal = {American Journal of Internal Medicine},
  volume = {5},
  number = {1},
  pages = {12-17},
  doi = {10.11648/j.ajim.20170501.13},
  url = {https://doi.org/10.11648/j.ajim.20170501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170501.13},
  abstract = {Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites
AU  - Ahmed A. Obiedallah
AU  - Essam Abdelmohsen
AU  - Abdalla I. Kelani
AU  - Mohamed Mousa
Y1  - 2017/02/20
PY  - 2017
N1  - https://doi.org/10.11648/j.ajim.20170501.13
DO  - 10.11648/j.ajim.20170501.13
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20170501.13
AB  - Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.
VL  - 5
IS  - 1
ER  -

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Author Information

Ahmed A. Obiedallah

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
Essam Abdelmohsen

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
Abdalla I. Kelani

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt
Mohamed Mousa

Department of Internal Medicine, Faculty of Medicine, Assiut University, Assiut City, Egypt

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APA Style

Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa. (2017). Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. American Journal of Internal Medicine, 5(1), 12-17. https://doi.org/10.11648/j.ajim.20170501.13

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ACS Style

Ahmed A. Obiedallah; Essam Abdelmohsen; Abdalla I. Kelani; Mohamed Mousa. Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. Am. J. Intern. Med. 2017, 5(1), 12-17. doi: 10.11648/j.ajim.20170501.13

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AMA Style

Ahmed A. Obiedallah, Essam Abdelmohsen, Abdalla I. Kelani, Mohamed Mousa. Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites. Am J Intern Med. 2017;5(1):12-17. doi: 10.11648/j.ajim.20170501.13

Copy | Download

@article{10.11648/j.ajim.20170501.13,
  author = {Ahmed A. Obiedallah and Essam Abdelmohsen and Abdalla I. Kelani and Mohamed Mousa},
  title = {Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites},
  journal = {American Journal of Internal Medicine},
  volume = {5},
  number = {1},
  pages = {12-17},
  doi = {10.11648/j.ajim.20170501.13},
  url = {https://doi.org/10.11648/j.ajim.20170501.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajim.20170501.13},
  abstract = {Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of Midodrine in Patients with Liver Cirrhosis and Refractory Ascites
AU  - Ahmed A. Obiedallah
AU  - Essam Abdelmohsen
AU  - Abdalla I. Kelani
AU  - Mohamed Mousa
Y1  - 2017/02/20
PY  - 2017
N1  - https://doi.org/10.11648/j.ajim.20170501.13
DO  - 10.11648/j.ajim.20170501.13
T2  - American Journal of Internal Medicine
JF  - American Journal of Internal Medicine
JO  - American Journal of Internal Medicine
SP  - 12
EP  - 17
PB  - Science Publishing Group
SN  - 2330-4324
UR  - https://doi.org/10.11648/j.ajim.20170501.13
AB  - Background: Ascites is the most common complication of liver cirrhosis and about 5-10% of all cases develop refractory ascites, 50% of such patients die within 6 months of its development. Aim of the Work: to assess the usefulness of adding midodrine beside the standard medical treatment for patients with liver cirrhosis and refractory ascites. Patients and Methods: This study included 78 patients with liver cirrhosis and refractory ascites or recurrent ascites, Group A: (n=37) patients on standard medical treatment (SMT) [low sodium diet + diuretic therapy (loop diuretic in a dose 40-160 mg/day and distal acting diuretic in a dose 100-400 mg/day + large volume paracentesis as needed] Group B: (n=41) patients with standard medical treatment (SMT) and midodrine tolerable dose. Results: Statistical significant difference between the SMT group and midodrine group as regard reduction in body weight and increase in mean arterial blood pressure and 24 h-urinary volume where P value was < 0.05. Conclusion, midodrine is a safe treatment for patients with liver cirrhosis and its addition to standard medical treatment is associated with better control of ascites.
VL  - 5
IS  - 1
ER  -

Copy | Download