Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology

Hou Jianzhang; Li Yong

doi:doi:10.11648/j.ajcem.20210903.12

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Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology

Hou Jianzhang, Li Yong

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 3)

Received: 20 April 2021 Published: 24 May 2021

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Abstract

Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P<0.001 or P<0.05), while the difference between gastric cancer group and group of chronic atrophic gastritis with atypical hyperplasia has no statistic significance (P>0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ²=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ²=19.662, P<0.001) of S100P invading serosa and invading beyond the serosa, and the difference of positive rate of S100P of Phase I, Phase II, Phase III and Phase IV also has statistic difference (χ²=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ²=13.669, P<0.001) of invasive type; the positive rate (74.42%) of S100P without lymph node metastasis is significantly higher than the positive rate (33.33%, χ²=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 3)
DOI	10.11648/j.ajcem.20210903.12
Page(s)	55-64
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Gastric Cancer, S100P, Degree of Differentiation, Borrmann Classification, TNM Staging, Lymph Node Metastasis

References

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APA Style

Hou Jianzhang, Li Yong. (2021). Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. American Journal of Clinical and Experimental Medicine, 9(3), 55-64. https://doi.org/10.11648/j.ajcem.20210903.12

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ACS Style

Hou Jianzhang; Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am. J. Clin. Exp. Med. 2021, 9(3), 55-64. doi: 10.11648/j.ajcem.20210903.12

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AMA Style

Hou Jianzhang, Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am J Clin Exp Med. 2021;9(3):55-64. doi: 10.11648/j.ajcem.20210903.12

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@article{10.11648/j.ajcem.20210903.12,
  author = {Hou Jianzhang and Li Yong},
  title = {Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {3},
  pages = {55-64},
  doi = {10.11648/j.ajcem.20210903.12},
  url = {https://doi.org/10.11648/j.ajcem.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210903.12},
  abstract = {Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.},
 year = {2021}
}

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TY  - JOUR
T1  - Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology
AU  - Hou Jianzhang
AU  - Li Yong
Y1  - 2021/05/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210903.12
DO  - 10.11648/j.ajcem.20210903.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 55
EP  - 64
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210903.12
AB  - Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.
VL  - 9
IS  - 3
ER  -

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Author Information

Hou Jianzhang

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China
Li Yong

Third Department of Surgery, Fourth Hospital of Hebei Medical University, Shijiazhuang, China

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Hou Jianzhang, Li Yong. (2021). Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. American Journal of Clinical and Experimental Medicine, 9(3), 55-64. https://doi.org/10.11648/j.ajcem.20210903.12

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ACS Style

Hou Jianzhang; Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am. J. Clin. Exp. Med. 2021, 9(3), 55-64. doi: 10.11648/j.ajcem.20210903.12

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AMA Style

Hou Jianzhang, Li Yong. Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology. Am J Clin Exp Med. 2021;9(3):55-64. doi: 10.11648/j.ajcem.20210903.12

Copy | Download

@article{10.11648/j.ajcem.20210903.12,
  author = {Hou Jianzhang and Li Yong},
  title = {Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {3},
  pages = {55-64},
  doi = {10.11648/j.ajcem.20210903.12},
  url = {https://doi.org/10.11648/j.ajcem.20210903.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210903.12},
  abstract = {Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Relationship Between the Expression of S100P in Gastric Cancer Tissue and Clinical Pathology
AU  - Hou Jianzhang
AU  - Li Yong
Y1  - 2021/05/24
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210903.12
DO  - 10.11648/j.ajcem.20210903.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 55
EP  - 64
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210903.12
AB  - Purpose: Discuss the diagnosis value and action mechanism of S100P for gastric cancer and the influence of S100P in tumor metastasis. Method: Collect 100 cases of gastric cancer tissues diagnosed as per histopathology by our hospital, apply immunohistochemistry method, test the positive expression condition of S100P protein, compare with 100 cases of control tissue specimens, and analyze the relationship between S100 protein expression condition in gastric cancer tissue and clinical pathology. Result: the positive rate (51.0%) of S100P in gastric cancer tissue is significantly lower than chronic atrophic gastritis with atypical hyperplasia, superficial gastritis and normal gastric mucosa (P0.05). The difference of positive rate of S100P in gastric cancer tissue with gender, age, tumor size, tumor position and Lauren typing has no statistic significance. In well differentiated adenocarcinoma, moderately differentiated adenocarcinoma, poorly differentiated adenocarcinoma and adenocarcinoma anaplastic, the positive rate (80.56%) of S100P of the three groups has significant difference (χ2=13.912, P=0.001). The positive rate of S100P which doesn’t invade serosa is significantly higher than the positive rate (34.38%, χ2=19.662, P2=13.347, P=0.004), the positive rate (73.17%) of localized S100P protein is significantly higher than the positive rate (35.59%, χ2=13.669, P2=15.020, P<0.001) with lymph node metastasis. Conclusion: the positive rate of S100P protein in gastric cancer tissue is significantly lower than the para-carcinoma tissue; the lower the differentiation degree is, the deeper the invasion is; the patients who have later TNM staging and Borrmanntyping, and lymph node metastasis have lower positive rate of S100P protein, which indicates that the low expression of S100P protein participates in the occurrence, development, invasion and metastasis of gastric cancer, and is an independent dangerous factor affecting the patients’ prognosis.
VL  - 9
IS  - 3
ER  -

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