Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris

Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi; Johanes Widodo

doi:doi:10.11648/j.ajcem.20170502.11

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Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, Johanes Widodo

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 2)

Received: 25 January 2017 Accepted: 10 February 2017 Published: 1 March 2017

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Abstract

Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 2)
DOI	10.11648/j.ajcem.20170502.11
Page(s)	30-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Acne Vulgaris, Autologous Serum, Doxycycline, Estradiol

References

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APA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. (2017). Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. American Journal of Clinical and Experimental Medicine, 5(2), 30-35. https://doi.org/10.11648/j.ajcem.20170502.11

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ACS Style

Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am. J. Clin. Exp. Med. 2017, 5(2), 30-35. doi: 10.11648/j.ajcem.20170502.11

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AMA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am J Clin Exp Med. 2017;5(2):30-35. doi: 10.11648/j.ajcem.20170502.11

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@article{10.11648/j.ajcem.20170502.11,
  author = {Muhlis Yunus and Anis Irawan Anwar and Siswanto Wahab and Farida Tabri and Ilhamjaya Patellongi and Johanes Widodo},
  title = {Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.ajcem.20170502.11},
  url = {https://doi.org/10.11648/j.ajcem.20170502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170502.11},
  abstract = {Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris
AU  - Muhlis Yunus
AU  - Anis Irawan Anwar
AU  - Siswanto Wahab
AU  - Farida Tabri
AU  - Ilhamjaya Patellongi
AU  - Johanes Widodo
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170502.11
DO  - 10.11648/j.ajcem.20170502.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170502.11
AB  - Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.
VL  - 5
IS  - 2
ER  -

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Author Information

Muhlis Yunus

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Anis Irawan Anwar

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Farida Tabri

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi

Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Johanes Widodo

Department of Dermatology and Venereology, Medical Faculty, Gadjah Mada University, Jogjakarta, Indonesia

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APA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. (2017). Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. American Journal of Clinical and Experimental Medicine, 5(2), 30-35. https://doi.org/10.11648/j.ajcem.20170502.11

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ACS Style

Muhlis Yunus; Anis Irawan Anwar; Siswanto Wahab; Farida Tabri; Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am. J. Clin. Exp. Med. 2017, 5(2), 30-35. doi: 10.11648/j.ajcem.20170502.11

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AMA Style

Muhlis Yunus, Anis Irawan Anwar, Siswanto Wahab, Farida Tabri, Ilhamjaya Patellongi, et al. Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris. Am J Clin Exp Med. 2017;5(2):30-35. doi: 10.11648/j.ajcem.20170502.11

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@article{10.11648/j.ajcem.20170502.11,
  author = {Muhlis Yunus and Anis Irawan Anwar and Siswanto Wahab and Farida Tabri and Ilhamjaya Patellongi and Johanes Widodo},
  title = {Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {2},
  pages = {30-35},
  doi = {10.11648/j.ajcem.20170502.11},
  url = {https://doi.org/10.11648/j.ajcem.20170502.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170502.11},
  abstract = {Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effect of Doxycycline in Autologous Serum to Improvement Clinical Manifestation of Acne Vulgaris
AU  - Muhlis Yunus
AU  - Anis Irawan Anwar
AU  - Siswanto Wahab
AU  - Farida Tabri
AU  - Ilhamjaya Patellongi
AU  - Johanes Widodo
Y1  - 2017/03/01
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170502.11
DO  - 10.11648/j.ajcem.20170502.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 30
EP  - 35
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170502.11
AB  - Acne vulgaris (AV) is an inflammatory disease of skin on the follicle polisebasea frequent and considered dermatological problems the most common worldwide. This study investigates the relationship topical therapy using autologous serum containing doxycycline in women with moderate to severe acne vulgaris. Research conducted in Makassar, South Sulawesi, as many as 13 samples that met the inclusion criteria. Clinical examination in patients with moderate acne vulgaris to severe and based on clinical manifestations, level of sebum measured before, and levels of estradiol. All patients given the autologous serum after being given doxycycline 200 mg single dose oral which will be applied every night. Furthermore monitored on day to 14 and day to 28. The data were processed using paired Wilcoxon test. Results improvement in clinical manifestations and levels of sebum on days 14 and 28 compared to day 1 was significantly (p <0.05). There were improvements in clinical manifestations and decrease sebum levels in patients with moderate to severe AV after application of autologous serum containing doxycycline.
VL  - 5
IS  - 2
ER  -

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