The alterations in bone metabolism were associated with food and nutrition. Regrettably is that no studies have analyzed the bone microstructure subjected to complete fasting in mammals. Our study aimed to identify the effects and alterations of complete fasting on bones via histomorphometric analysis in adult female mice. Twelve-week-old C57BL/6J female mice were randomly divided into ad libitum (AL) and two-day complete fasting (FA) groups. Histomorphometry was carried out to analyze the differences in the microstructure of femurs after the experiment period. The histomorphometric data indicated that the bone resorption parameters, including the number of osteoclasts (Mu.N.Oc/B.Pm), osteoclast surface (Oc.S/BS), and eroded surface (ES/BS), were similar between the two groups. However, the bone formation parameters, including the number of osteoblasts (N.Ob/B.Pm) and osteoblast surface (Ob.S/BS), were markedly decreased in the FA group compared with the AL group. Thus, bone formation but not bone resorption was severely impaired following complete fasting. Furthermore, the osteoid surface (OS/BS) was observably reduced, which indicates that the bone mass should be reduced. However, there was no dramatic reduction in the osteoid thickness (O.Th); thus, the bone mass remained relatively stable between the two groups. These findings provide new insights in the increased incidence of osteoporosis in individuals on weight-reduction diets and other bone diseases associated with undernutrition.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 4, Issue 6) |
| DOI | 10.11648/j.ajcem.20160406.19 |
| Page(s) | 212-215 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Boneformation, Osteoblast, Bone Resorption, Osteoclast, Histomorphometry
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APA Style
Jiajing Chen, Rui He, Juan Li, Yan Zhang, Jinwei Qi, et al. (2016). Severe Impaired Bone Formation was Induced by Short-Term Fasting in Adult Mice. American Journal of Clinical and Experimental Medicine, 4(6), 212-215. https://doi.org/10.11648/j.ajcem.20160406.19
ACS Style
Jiajing Chen; Rui He; Juan Li; Yan Zhang; Jinwei Qi, et al. Severe Impaired Bone Formation was Induced by Short-Term Fasting in Adult Mice. Am. J. Clin. Exp. Med. 2016, 4(6), 212-215. doi: 10.11648/j.ajcem.20160406.19
AMA Style
Jiajing Chen, Rui He, Juan Li, Yan Zhang, Jinwei Qi, et al. Severe Impaired Bone Formation was Induced by Short-Term Fasting in Adult Mice. Am J Clin Exp Med. 2016;4(6):212-215. doi: 10.11648/j.ajcem.20160406.19
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Download@article{10.11648/j.ajcem.20160406.19,
author = {Jiajing Chen and Rui He and Juan Li and Yan Zhang and Jinwei Qi and Xianghui Meng and Yuying Wang},
title = {Severe Impaired Bone Formation was Induced by Short-Term Fasting in Adult Mice},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {4},
number = {6},
pages = {212-215},
doi = {10.11648/j.ajcem.20160406.19},
url = {https://doi.org/10.11648/j.ajcem.20160406.19},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160406.19},
abstract = {The alterations in bone metabolism were associated with food and nutrition. Regrettably is that no studies have analyzed the bone microstructure subjected to complete fasting in mammals. Our study aimed to identify the effects and alterations of complete fasting on bones via histomorphometric analysis in adult female mice. Twelve-week-old C57BL/6J female mice were randomly divided into ad libitum (AL) and two-day complete fasting (FA) groups. Histomorphometry was carried out to analyze the differences in the microstructure of femurs after the experiment period. The histomorphometric data indicated that the bone resorption parameters, including the number of osteoclasts (Mu.N.Oc/B.Pm), osteoclast surface (Oc.S/BS), and eroded surface (ES/BS), were similar between the two groups. However, the bone formation parameters, including the number of osteoblasts (N.Ob/B.Pm) and osteoblast surface (Ob.S/BS), were markedly decreased in the FA group compared with the AL group. Thus, bone formation but not bone resorption was severely impaired following complete fasting. Furthermore, the osteoid surface (OS/BS) was observably reduced, which indicates that the bone mass should be reduced. However, there was no dramatic reduction in the osteoid thickness (O.Th); thus, the bone mass remained relatively stable between the two groups. These findings provide new insights in the increased incidence of osteoporosis in individuals on weight-reduction diets and other bone diseases associated with undernutrition.},
year = {2016}
}
TY - JOUR T1 - Severe Impaired Bone Formation was Induced by Short-Term Fasting in Adult Mice AU - Jiajing Chen AU - Rui He AU - Juan Li AU - Yan Zhang AU - Jinwei Qi AU - Xianghui Meng AU - Yuying Wang Y1 - 2016/12/07 PY - 2016 N1 - https://doi.org/10.11648/j.ajcem.20160406.19 DO - 10.11648/j.ajcem.20160406.19 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 212 EP - 215 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20160406.19 AB - The alterations in bone metabolism were associated with food and nutrition. Regrettably is that no studies have analyzed the bone microstructure subjected to complete fasting in mammals. Our study aimed to identify the effects and alterations of complete fasting on bones via histomorphometric analysis in adult female mice. Twelve-week-old C57BL/6J female mice were randomly divided into ad libitum (AL) and two-day complete fasting (FA) groups. Histomorphometry was carried out to analyze the differences in the microstructure of femurs after the experiment period. The histomorphometric data indicated that the bone resorption parameters, including the number of osteoclasts (Mu.N.Oc/B.Pm), osteoclast surface (Oc.S/BS), and eroded surface (ES/BS), were similar between the two groups. However, the bone formation parameters, including the number of osteoblasts (N.Ob/B.Pm) and osteoblast surface (Ob.S/BS), were markedly decreased in the FA group compared with the AL group. Thus, bone formation but not bone resorption was severely impaired following complete fasting. Furthermore, the osteoid surface (OS/BS) was observably reduced, which indicates that the bone mass should be reduced. However, there was no dramatic reduction in the osteoid thickness (O.Th); thus, the bone mass remained relatively stable between the two groups. These findings provide new insights in the increased incidence of osteoporosis in individuals on weight-reduction diets and other bone diseases associated with undernutrition. VL - 4 IS - 6 ER -
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