Jintan hitam (Nigella sativa) has been widely used in traditional medicine to treat several diseases, including gastric ulcer. However, there are no scientific data demonstrating anti-ulcerogenic activity conferred by use of jintan hitam. The present study aimed to evaluate the antiulcer properties of oil extract from jintan hitam. In the gastric ulcer induced by administration of 80% ethanol model, observation made for ulcer score and index, level of ulcer erosion, total amount of polymorphonuclear cells and morphological change of 80% ethanol induced gastric ulcer of mice. Research was conducted on laboratory in Faculty of Medicine Universitas Hasanuddin from April to September 2015, with post test only experimental group design. There were 40 mice used in this research, divided into five groups, each group consisted of 8 mice: negative control group, positive control group, and three different doses of oil extract (0.1, 0.2 and 0.3 ml per 20g bw of mice). Observation made for 4 and 7 days. The oil extract of jintan hitam showed significant differences on doses of 0.1 ml per 20g bw of mice given in 4 days, with p = 0.034 (p<0.05) based on score and index of gastric ulcer.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 4, Issue 6) |
| DOI | 10.11648/j.ajcem.20160406.14 |
| Page(s) | 179-184 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2016. Published by Science Publishing Group |
Oil Extract of Jintan Hitam, Ulcer Score, Ulcer Index, Ulcer Erosion, Polymorphonuclear Cells, Morphological Change of Gastric
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APA Style
Syamsu Rijal, Upik Anderiani Miskad, Djumadi Achmad, Rina Masadah, Dasril Daud, et al. (2016). Evaluation of Anti-ulcerogenic Activity in Oil Extract of Jintan Hitam (Nigella sativa) Against Ethanol Induced Gastric Ulcer in Mice (Mus musculus). American Journal of Clinical and Experimental Medicine, 4(6), 179-184. https://doi.org/10.11648/j.ajcem.20160406.14
ACS Style
Syamsu Rijal; Upik Anderiani Miskad; Djumadi Achmad; Rina Masadah; Dasril Daud, et al. Evaluation of Anti-ulcerogenic Activity in Oil Extract of Jintan Hitam (Nigella sativa) Against Ethanol Induced Gastric Ulcer in Mice (Mus musculus). Am. J. Clin. Exp. Med. 2016, 4(6), 179-184. doi: 10.11648/j.ajcem.20160406.14
AMA Style
Syamsu Rijal, Upik Anderiani Miskad, Djumadi Achmad, Rina Masadah, Dasril Daud, et al. Evaluation of Anti-ulcerogenic Activity in Oil Extract of Jintan Hitam (Nigella sativa) Against Ethanol Induced Gastric Ulcer in Mice (Mus musculus). Am J Clin Exp Med. 2016;4(6):179-184. doi: 10.11648/j.ajcem.20160406.14
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Download@article{10.11648/j.ajcem.20160406.14,
author = {Syamsu Rijal and Upik Anderiani Miskad and Djumadi Achmad and Rina Masadah and Dasril Daud and Cahyono Kaelan and Halida Rahawarin and Swandari Paramita and Yadi Yasir},
title = {Evaluation of Anti-ulcerogenic Activity in Oil Extract of Jintan Hitam (Nigella sativa) Against Ethanol Induced Gastric Ulcer in Mice (Mus musculus)},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {4},
number = {6},
pages = {179-184},
doi = {10.11648/j.ajcem.20160406.14},
url = {https://doi.org/10.11648/j.ajcem.20160406.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160406.14},
abstract = {Jintan hitam (Nigella sativa) has been widely used in traditional medicine to treat several diseases, including gastric ulcer. However, there are no scientific data demonstrating anti-ulcerogenic activity conferred by use of jintan hitam. The present study aimed to evaluate the antiulcer properties of oil extract from jintan hitam. In the gastric ulcer induced by administration of 80% ethanol model, observation made for ulcer score and index, level of ulcer erosion, total amount of polymorphonuclear cells and morphological change of 80% ethanol induced gastric ulcer of mice. Research was conducted on laboratory in Faculty of Medicine Universitas Hasanuddin from April to September 2015, with post test only experimental group design. There were 40 mice used in this research, divided into five groups, each group consisted of 8 mice: negative control group, positive control group, and three different doses of oil extract (0.1, 0.2 and 0.3 ml per 20g bw of mice). Observation made for 4 and 7 days. The oil extract of jintan hitam showed significant differences on doses of 0.1 ml per 20g bw of mice given in 4 days, with p = 0.034 (p<0.05) based on score and index of gastric ulcer.},
year = {2016}
}
TY - JOUR T1 - Evaluation of Anti-ulcerogenic Activity in Oil Extract of Jintan Hitam (Nigella sativa) Against Ethanol Induced Gastric Ulcer in Mice (Mus musculus) AU - Syamsu Rijal AU - Upik Anderiani Miskad AU - Djumadi Achmad AU - Rina Masadah AU - Dasril Daud AU - Cahyono Kaelan AU - Halida Rahawarin AU - Swandari Paramita AU - Yadi Yasir Y1 - 2016/11/14 PY - 2016 N1 - https://doi.org/10.11648/j.ajcem.20160406.14 DO - 10.11648/j.ajcem.20160406.14 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 179 EP - 184 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20160406.14 AB - Jintan hitam (Nigella sativa) has been widely used in traditional medicine to treat several diseases, including gastric ulcer. However, there are no scientific data demonstrating anti-ulcerogenic activity conferred by use of jintan hitam. The present study aimed to evaluate the antiulcer properties of oil extract from jintan hitam. In the gastric ulcer induced by administration of 80% ethanol model, observation made for ulcer score and index, level of ulcer erosion, total amount of polymorphonuclear cells and morphological change of 80% ethanol induced gastric ulcer of mice. Research was conducted on laboratory in Faculty of Medicine Universitas Hasanuddin from April to September 2015, with post test only experimental group design. There were 40 mice used in this research, divided into five groups, each group consisted of 8 mice: negative control group, positive control group, and three different doses of oil extract (0.1, 0.2 and 0.3 ml per 20g bw of mice). Observation made for 4 and 7 days. The oil extract of jintan hitam showed significant differences on doses of 0.1 ml per 20g bw of mice given in 4 days, with p = 0.034 (p<0.05) based on score and index of gastric ulcer. VL - 4 IS - 6 ER -
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